Article ; Online: Transmissão perinatal do vírus da hepatite C - Hospital Santo André, Leiria 2002-2006.
2010 Volume 23, Issue 3, Page(s) 391–398
Abstract: Background: Vertical transmission of hepatitis C virus (HCV) is the main route of infection in children, occurring in few cases (five percent). Current recommendations for HCV screening include first anti-HCV testing at age > 18 months, reducing false ... ...
| Title translation | Perinatal transmission of hepatitis C virus - Santo André Hospital, Leiria 2002-2006. |
|---|---|
| Abstract | Background: Vertical transmission of hepatitis C virus (HCV) is the main route of infection in children, occurring in few cases (five percent). Current recommendations for HCV screening include first anti-HCV testing at age > 18 months, reducing false positives and false negatives. Positive results must be confirmed by the presence of HCV RNA on two different occasions. Aims: To characterize the population of children born to HCV-positive mothers, to identify risk factors for perinatal HCV transmission and to improve the approach to HCV screening. Methods: The study was conducted in two phases. An analytic retrospective study enrolling children born to HCV-positive mothers between January 2002 and December 2006 was done, followed by a transversal analysis in order to repeat anti-HCV testing, in cases that didn't meet current recommendations for HCV screening and in those without any HCV screening. Results: Fifty-nine children born to HCV-positive mothers in a total of 12 985 births were included, corresponding to a prevalence of 0,45%. A high rate of inadequate pregnancy surveillance, prematurity and low birth weight, mainly in children born to addicted mothers was found. A child with HCV infection without any risk factor for perinatal transmission was found. Among children with negative anti-HCV at age 18 months, half had done anti-HCV prior to nine months of age, all were positive. Children discharged because of negative anti-HCV at nine months of age were called in a second phase of the study, for new anti-HCV at age > 18 months. All were negative. Conclusions: Perinatal HCV transmission rate was 2,9%. There was no identified risk factor for perinatal transmission in the single case of HCV infection. A high rate of prematurity, low birth weight and inadequate surveillance of pregnancy was found, with statistical significance to relation with mother addiction. Regarding anti-HCV at age < 18 months, a high rate of false positives but no false negative results were found. This study has enabled the detection and correction of mistakes in the approach to HCV screening. |
| MeSH term(s) | Cross-Sectional Studies ; Female ; Hepatitis C/epidemiology ; Hepatitis C/transmission ; Hospitals ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/statistics & numerical data ; Male ; Portugal ; Retrospective Studies ; Time Factors |
| Language | Portuguese |
| Publishing date | 2010-05 |
| Publishing country | Portugal |
| Document type | English Abstract ; Journal Article |
| ZDB-ID | 603078-6 |
| ISSN | 1646-0758 ; 0870-399X |
| ISSN (online) | 1646-0758 |
| ISSN | 0870-399X |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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