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Article ; Online: Editing Cytoprotective Autophagy in Glioma: An Unfulfilled Potential for Therapy.

Ulasov, Ilya / Fares, Jawad / Timashev, Petr / Lesniak, Maciej S

2019 Volume 26, Issue 3, Page(s) 252–262

Abstract: Glioblastoma (GBM) resistance to the standard of care is prompting scientists to develop better targeted therapeutic strategies. Autophagy is one of the many signaling mechanisms that regulate tumor regrowth. Despite the extensive in vitro and in vivo ... ...

Abstract	Glioblastoma (GBM) resistance to the standard of care is prompting scientists to develop better targeted therapeutic strategies. Autophagy is one of the many signaling mechanisms that regulate tumor regrowth. Despite the extensive in vitro and in vivo studies published, knowledge on autophagic modulation remains scarce. This hinders the development of novel treatment modalities that employ autophagic mechanisms for the clinical benefit of patients with GBM. Clinical trials for GBM continue to fall short of showing significant survival or clinical benefit, with the complex glioma heterogeneity often being the reason to blame. Here, we propose that a combination therapy of current antiglioma regimens and autophagic mediators or suppressors can allow us to overcome GBM regrowth in the context of tumor heterogeneity.
MeSH term(s)	Animals ; Apoptosis/physiology ; Autophagy/physiology ; Brain Neoplasms/pathology ; Cytoprotection/physiology ; Glioma/pathology ; Humans ; Signal Transduction/physiology
Language	English
Publishing date	2019-11-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2019.11.001
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Zs.A 4345: Show issues

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Article ; Online: Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance.

Belyaeva, Elizaveta / Kharwar, Rajesh Kumar / Ulasov, Ilya V / Karlina, Irina / Timashev, Petr / Mohammadinejad, Reza / Acharya, Arbind

Molecular and cellular biochemistry

2021 Volume 477, Issue 2, Page(s) 593–604

Abstract: Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to ...

Abstract	Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or insufficient supply of nutrients in the cell environment to maintain their homeostasis. Autophagy is currently seen as a form of programmed cell death along with apoptosis and necroptosis. In recent years multiple studies have considered the autophagy as a potential mechanism of anticancer therapy in malignant glioma. Although, subsequent steps in autophagy development are known and well-described, on molecular level the mechanism of autophagosome initiation and maturation using autophagy-related proteins is under investigation. This article reviews current state about the mechanism of autophagy, its molecular pathways and the most recent studies on roles of autophagy-related proteins and their isoforms in glioma progression and its treatment.
MeSH term(s)	Apoptosis ; Autophagosomes/genetics ; Autophagosomes/metabolism ; Autophagy ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Glioma/genetics ; Glioma/metabolism ; Glioma/therapy ; Humans ; Neoplasm Proteins/metabolism
Chemical Substances	Autophagy-Related Proteins ; Neoplasm Proteins
Language	English
Publishing date	2021-12-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-021-04308-w
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Zs.A 892: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Effect of Chitosan and Amphiphilic Polymers on the Photosensitizing and Spectral Properties of Rose Bengal.

Kuryanova, Anastasia S / Savko, Marina A / Kaplin, Vladislav S / Aksenova, Nadezhda A / Timofeeva, Victoria A / Chernyak, Aleksandr V / Glagolev, Nicolay N / Timashev, Petr S / Solovieva, Anna B

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 20

Abstract: The influence of chitosan (CS) and amphiphilic polymers (AP: pluronic F108 and polyvinylpyrrolidone (PVP)) on the photocatalytic activity of rose bengal (RB) in a model reaction of tryptophan photo-oxidation in phosphate-buffered saline (PBS) was studied. ...

Abstract	The influence of chitosan (CS) and amphiphilic polymers (AP: pluronic F108 and polyvinylpyrrolidone (PVP)) on the photocatalytic activity of rose bengal (RB) in a model reaction of tryptophan photo-oxidation in phosphate-buffered saline (PBS) was studied. It was shown that in the presence of CS, the effective rate constant
MeSH term(s)	Rose Bengal ; Chitosan ; Poloxamer ; Polymers ; Micelles ; Povidone ; Tryptophan ; Protons ; Lactones ; Phosphates ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/chemistry
Chemical Substances	Rose Bengal (1ZPG1ELY14) ; Chitosan (9012-76-4) ; Poloxamer (106392-12-5) ; Polymers ; Micelles ; Povidone (FZ989GH94E) ; Tryptophan (8DUH1N11BX) ; Protons ; Lactones ; Phosphates ; Photosensitizing Agents
Language	English
Publishing date	2022-10-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27206796
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Zs.MO 81: Show issues

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Article ; Online: Therapeutic Potential of Mesenchymal Stem Cells for Postmastectomy Lymphedema: A Literature Review.

Chen, Kuo / Sinelnikov, Mikhail Y / Reshetov, Igor V / Timashev, Petr / Gu, Yuanting / Mu, Lan / Lu, Pengwei / Zhang, Yuanyuan

Clinical and translational science

2020 Volume 14, Issue 1, Page(s) 54–61

Abstract: Upper limb lymphedema is one of the most common complications after breast cancer surgery and radiotherapy. Despite various physical therapy and surgical options available, the impaired lymph fluid drainage may be progressive due to lymphatic vascular ... ...

Abstract	Upper limb lymphedema is one of the most common complications after breast cancer surgery and radiotherapy. Despite various physical therapy and surgical options available, the impaired lymph fluid drainage may be progressive due to lymphatic vascular insufficiency making treatment more difficulty. Stem cell therapy provides a promising alternative in the treatment of various chronic diseases. The wide applicability of cell therapy has been reviewed throughout literature. This review provides an overview of recent progress in the therapeutic effect of adult stem cells for primary and secondary lymphedema after breast surgery in preclinical studies and clinical cases. We start with a brief introduction about the pathophysiological mechanisms of postmastectomy lymphedema. Regarding existing treatments, we systematically summarize the benefits and limitations of recent progress. Because of their multidirectional differentiation potential and growth factor secretion, stem cell therapy shows promising results in the management of light to severe lymphedema. Increasing evidences have demonstrated a noticeable reduction in postmastectomy lymphedema and increased lymph-angiogenesis after specific stem cell therapy. Current data suggests that stem cell therapy in lymphedema treatment provides reversal of pathological reorganization associated with lymphedema progression. Finally, we propose potential strategies for overcoming the challenges in the development of multipotent progenitor cells for the treatment and prevention of lymphedema in clinical practice.
MeSH term(s)	Adult Stem Cells/transplantation ; Animals ; Breast Cancer Lymphedema/diagnosis ; Breast Cancer Lymphedema/etiology ; Breast Cancer Lymphedema/therapy ; Breast Neoplasms/surgery ; Combined Modality Therapy/methods ; Disease Models, Animal ; Female ; Humans ; Mastectomy/adverse effects ; Mesenchymal Stem Cell Transplantation/methods ; Severity of Illness Index ; Treatment Outcome
Language	English
Publishing date	2020-08-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.12864
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Article ; Online: Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum.

Kurkov, Alexandr / Guller, Anna / Fayzullin, Alexey / Fayzullinа, Nafisa / Plyakin, Vladimir / Kotova, Svetlana / Timashev, Petr / Frolova, Anastasia / Kurtak, Nikita / Paukov, Vyacheslav / Shekhter, Anatoly

PloS one

2021 Volume 16, Issue 1, Page(s) e0245159

Abstract: Background: It is unclear if amianthoid transformation (AT) of costal cartilage extracellular matrix (ECM) has an impact on the development of pectus excavatum (PE) and pectus carinatum (PC).: Methods: AT foci were examined in intrasurgical biopsy ... ...

Abstract	Background: It is unclear if amianthoid transformation (AT) of costal cartilage extracellular matrix (ECM) has an impact on the development of pectus excavatum (PE) and pectus carinatum (PC). Methods: AT foci were examined in intrasurgical biopsy specimens of costal cartilages of children (8-17 years old) with PE (n = 12) and PC (n = 12) and in age-matching autopsy control samples (n = 10) using histological and immunohistochemical staining, atomic force and nonlinear optical microscopy, transmission and scanning electron microscopy, morphometry and statistics. Results: AT areas were identified in the costal cartilage ECM in children with normal chest, PE and PC. Each type of the AT areas ("canonical", "intertwined", "fine-fibred" and "intralacunary") had a unique morphological pattern of thickness and alignment of amianthoid fibers (AFs). AFs were formed via lateral aggregation of collagen type II fibrils in the intact ECM. Foci of the AT were observed significantly more frequently in the PE and PC groups. The AT areas had unique quantitative features in each study group. Conclusion: AT is a structurally diverse form of ECM alteration present in healthy and pathological costal cartilage. PE and PC are associated with specific AT disorders.
MeSH term(s)	Adolescent ; Cartilage/metabolism ; Cartilage/ultrastructure ; Child ; Extracellular Matrix/metabolism ; Extracellular Matrix/ultrastructure ; Female ; Funnel Chest/metabolism ; Funnel Chest/pathology ; Humans ; Male ; Pectus Carinatum/metabolism ; Pectus Carinatum/pathology
Language	English
Publishing date	2021-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0245159
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Article ; Online: TMZ regulates GBM stemness via MMP14-DLL4-Notch3 pathway.

Ulasov, Ilya V / Mijanovic, Olja / Savchuk, Solomiia / Gonzalez-Buendia, Edgar / Sonabend, Adam / Xiao, Ting / Timashev, Petr / Lesniak, Maciej S

International journal of cancer

2019 Volume 146, Issue 8, Page(s) 2218–2228

Abstract: Glioblastoma (GBM) is one of the most aggressive primary brain tumors with frequent recurrences following the standard methods of treatment-temozolomide (TMZ), ionizing radiation and surgical resection. The objective of our study was to investigate GBM ... ...

Abstract	Glioblastoma (GBM) is one of the most aggressive primary brain tumors with frequent recurrences following the standard methods of treatment-temozolomide (TMZ), ionizing radiation and surgical resection. The objective of our study was to investigate GBM resistance mediated via MMP14 (matrix metalloproteinase 14). We used multiple PDX GBM models and established glioma cell lines to characterize expression and subcellular localization of MMP14 after TMZ treatment. We performed a Kiloplex ELISA-based array to evaluate changes in cellular proteins induced by MMP14 expression and translocation. Lastly, we conducted functional and mechanistic studies to elucidate the role of DLL4 (delta-like canonical notch ligand 4) in regulation of glioma stemness, particularly in the context of its relationship to MMP14. We detected that TMZ treatment promotes nuclear translocation of MMP14 followed by extracellular release of DLL4. DLL4 in turn stimulates cleavage of Notch3, its nuclear translocation and induction of sphering capacity and stemness.
MeSH term(s)	Animals ; Biomarkers, Tumor/biosynthesis ; Biomarkers, Tumor/metabolism ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Early Growth Response Protein 1/metabolism ; Fibroblast Growth Factors/metabolism ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Matrix Metalloproteinase 14/biosynthesis ; Matrix Metalloproteinase 14/metabolism ; Membrane Proteins/metabolism ; Mice ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Receptor, Notch3/metabolism ; Signal Transduction/drug effects ; Temozolomide/pharmacology ; Xenograft Model Antitumor Assays
Chemical Substances	Biomarkers, Tumor ; EGR1 protein, human ; Early Growth Response Protein 1 ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; NOTCH3 protein, human ; Receptor, Notch3 ; delta protein ; Fibroblast Growth Factors (62031-54-3) ; MMP14 protein, human (EC 3.4.24.80) ; Matrix Metalloproteinase 14 (EC 3.4.24.80) ; Temozolomide (YF1K15M17Y)
Language	English
Publishing date	2019-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.32636
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article: Solvent-free synthesis and characterization of allyl chitosan derivatives

Akopova, Tatiana A / Demina, Tatiana S / Cherkaev, Georgii V / Khavpachev, Mukhamed A / Bardakova, Kseniya N / Grachev, Andrey V / Vladimirov, Leonid V / Zelenetskii, Alexander N / Timashev, Petr S

RSC advances. 2019 July 04, v. 9, no. 36

2019

Abstract: The solvent-free synthesis of allyl-substituted chitosan derivatives through reactive co-extrusion of chitosan powder with allyl bromide at shear deformation was performed. For the structural characterization, FTIR and NMR methods were employed. The ... ...

Abstract	The solvent-free synthesis of allyl-substituted chitosan derivatives through reactive co-extrusion of chitosan powder with allyl bromide at shear deformation was performed. For the structural characterization, FTIR and NMR methods were employed. The results were confirmed by chemical analysis. The total content of allyl substituents from 5 to 50 per 100 chitosan units as a function of the component ratio in the reactive mixtures was revealed. Carrying out the reaction without any additives leads to the selective formation of N-alkylated derivatives, whereas in the presence of alkali the ethers of chitosan were preferentially formed. The results suggest that the proposed approach allows significantly higher yield of products to be obtained at high process speeds and significantly lower reagent consumption as compared with the liquid-phase synthesis in organic medium. The synthesized unsaturated derivatives are promising photosensitive components for use in laser stereolithography for fabrication of three-dimensional biocompatible structures with well-defined architectonics.
Keywords	Fourier transform infrared spectroscopy ; additives ; bromides ; chemical analysis ; chitosan ; deformation ; ethers ; nuclear magnetic resonance spectroscopy ; organobromine compounds ; photosensitivity
Language	English
Dates of publication	2019-0704
Size	p. 20968-20975.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c9ra03830b
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Solvent-free synthesis and characterization of allyl chitosan derivatives.

Akopova, Tatiana A / Demina, Tatiana S / Cherkaev, Georgii V / Khavpachev, Mukhamed A / Bardakova, Kseniya N / Grachev, Andrey V / Vladimirov, Leonid V / Zelenetskii, Alexander N / Timashev, Petr S

RSC advances

2019 Volume 9, Issue 36, Page(s) 20968–20975

Abstract	The solvent-free synthesis of allyl-substituted chitosan derivatives through reactive co-extrusion of chitosan powder with allyl bromide at shear deformation was performed. For the structural characterization, FTIR and NMR methods were employed. The results were confirmed by chemical analysis. The total content of allyl substituents from 5 to 50 per 100 chitosan units as a function of the component ratio in the reactive mixtures was revealed. Carrying out the reaction without any additives leads to the selective formation of
Language	English
Publishing date	2019-07-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra03830b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering.

Evlashin, Stanislav / Dyakonov, Pavel / Tarkhov, Mikhail / Dagesyan, Sarkis / Rodionov, Sergey / Shpichka, Anastasia / Kostenko, Mikhail / Konev, Stepan / Sergeichev, Ivan / Timashev, Petr / Akhatov, Iskander

Materials (Basel, Switzerland)

2019 Volume 12, Issue 18

Abstract: Developing bone scaffolds can greatly improve the patient's quality of life by accelerating the rehabilitation process. In this paper, we studied the process of composite polycaprolactone supercritical foaming for tissue engineering. The influence of ... ...

Abstract	Developing bone scaffolds can greatly improve the patient's quality of life by accelerating the rehabilitation process. In this paper, we studied the process of composite polycaprolactone supercritical foaming for tissue engineering. The influence of graphene oxide and reduced graphene oxide on the foaming parameters was studied. The structural and mechanical properties were studied. The scaffolds demonstrated mechanical flexibility and endurance. The co-culturing and live/dead tests demonstrated that the obtained scaffolds are biocompatible. Different composite scaffolds induced various surface cell behaviors. The experimental data demonstrate that composite foams are promising candidates for in vivo medical trials.
Language	English
Publishing date	2019-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma12182991
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Article ; Online: Publisher Correction: Carbon nanowalls as a platform for biological SERS studies.

Dyakonov, Pavel / Mironovich, Kirill / Svyakhovskiy, Sergey / Voloshina, Olga / Dagesyan, Sarkis / Panchishin, Andrey / Suetin, Nikolay / Bagratashvili, Victor / Timashev, Petr / Shirshin, Evgeny / Evlashin, Stanislav

Scientific reports

2018 Volume 8, Issue 1, Page(s) 4210

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

Abstract	A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Language	English
Publishing date	2018-03-06
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-21794-z
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