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Article ; Online: COVID-19 guidelines and its perceived effect on seafarers' health and wellbeing: A qualitative study.

Timilsina, Amit / Baygi, Fereshteh

2023 Volume 18, Issue 4, Page(s) e0284155

Abstract: Background: The COVID-19 pandemic and its guidelines have had a profound impact on the social life, health, and wellbeing of people around the world. Very little is known if the guidelines are put into action effectively by seafarers. Also, the effects ... ...

Abstract	Background: The COVID-19 pandemic and its guidelines have had a profound impact on the social life, health, and wellbeing of people around the world. Very little is known if the guidelines are put into action effectively by seafarers. Also, the effects of such guidelines on seafarers' health and wellbeing have not been studied so far. Therefore, this study aimed to explore the perceived effects of the COVID-19 guidelines on seafarers' health and wellbeing. Materials & methods: A qualitative research method was adopted using in-depth interviews. A total of 13 international male seafarers were interviewed until data saturation was achieved. Purposive sampling was used to recruit the respondents. The data was inductively coded using NVivo 12 and manifest content analysis was conducted. Results: Once seafarers had access to COVID-19 guidelines, seafarers followed the guideline as suggested by companies under the guidance of captain. The majority of the participants reported that available guidelines could decrease their stress and anxiety levels, while some reported that implementing the COVID-19 guidelines had no significant effect on their health and wellbeing. The results of this study also showed a delay in repatriation, which had an impact on the seafarers' mental health. Conclusion: The guidelines could not address seafarers' psychological needs to ensure their good health and wellbeing. Therefore, it is recommended that shipping companies address the mental health needs of seafarers during the COVID-19 pandemic and similar infectious diseases emerging in the future.
MeSH term(s)	Humans ; Male ; Pandemics ; COVID-19/epidemiology ; Ships ; Mental Health ; Qualitative Research
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0284155
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring the healthcare access challenges faced by visually impaired young women in Nepal: Navigating sexual harassment and stigma within healthcare settings.

Timilsina, Amit / Neupane, Pabitra / Pandey, Janaki / Subedi, Aastha / Thapa, Subash

Dialogues in health

2024 Volume 4, Page(s) 100171

Abstract: Introduction: Despite global progress in gender equality, still not every woman has access to safe and the highest quality health care. Visually impaired young adult women represent one of the most vulnerable groups with a poorer ability to access ... ...

Abstract	Introduction: Despite global progress in gender equality, still not every woman has access to safe and the highest quality health care. Visually impaired young adult women represent one of the most vulnerable groups with a poorer ability to access necessary healthcare services. This study aims to explore and comprehend the experiences of visually impaired young adult women in accessing healthcare services in Nepal. Methods: A descriptive phenomenological study was conducted among 16 visually impaired women aged 20 to 35 years who had utilized healthcare services within the past 12 months. Face-to-face, in-depth interviews were conducted for data collection, and thematic analysis was conducted for data analysis. Results: Our study revealed a range of challenges faced by visually impaired young women that impeded their healthcare-seeking. These challenges included sexual harassment by male healthcare providers, disability-related stigma, financial difficulties, limited autonomy in decision-making, and a lack of disability-friendly healthcare facilities and services. Particularly, experiencing sexual harassment from male healthcare providers, coupled with underlying disability-related stigma, profoundly influenced the avoidance of healthcare. To navigate these challenges, some women sought support by having family members or friends accompany them or by requesting to be seen by a female healthcare provider. Nevertheless, financial dependence on families and women lacking employment and income led to a feeling of burden on the family, contributing to a reluctance among women to seek expensive healthcare. Social organization-based, collaborative efforts and peer support networks played a significant role in breaking down barriers and improving overall healthcare experiences. Conclusions: While integrating disability-friendly healthcare services and infrastructure is essential, fostering attitudinal and behavioral change-particularly among male healthcare providers-is more important to ensure safety for young women in healthcare settings. The implementation of anti-sexual harassment policies is imperative to ensure a safe and respectful environment. Community mobilizing and peer group-based programs can be tested for increasing visually impaired women's utilization of relevant healthcare services.
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ISSN	2772-6533
ISSN (online)	2772-6533
DOI	10.1016/j.dialog.2024.100171
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Article: A Case of Successful Direct Oral Anticoagulant Use for the Treatment of Warfarin-Induced Vasculitis in a Patient With Left Ventricular Thrombus.

Nader, Georgette / Yavari, Majid / Timilsina, Anisha / Rayamajhi, Sumugdha

Cureus

2023 Volume 15, Issue 12, Page(s) e50885

Abstract: Cutaneous small vessel leukocytoclastic vasculitis (LCV) is isolated to the dependent areas of the skin. LCV can be induced by pharmaceutical drugs, and management requires abrupt discontinuation of the offending drug. Warfarin is a rare medication to ... ...

Abstract	Cutaneous small vessel leukocytoclastic vasculitis (LCV) is isolated to the dependent areas of the skin. LCV can be induced by pharmaceutical drugs, and management requires abrupt discontinuation of the offending drug. Warfarin is a rare medication to cause LCV, with sparse literature to date. Here, we present a case of warfarin-induced LCV, complicated by a patient's comorbid left ventricular thrombus, and successful treatment with discontinuation of warfarin and replacement with a direct oral anticoagulant (apixaban).
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.50885
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Article ; Online: Foliar application of green synthesized ZnO nanoparticles reduced Cd content in shoot of lettuce.

Timilsina, Anil / Adhikari, Kaushik / Chen, Hao

Chemosphere

2023 Volume 338, Page(s) 139589

Abstract: Though Zinc (Zn) supplementation can mitigate root-based Cadmium (Cd) uptake in plants, the impact of foliar-applied Zinc Oxide nanoparticles (ZnO NPs) on this process remains under-explored. This study investigates the influence of foliar-applied ZnO ... ...

Abstract	Though Zinc (Zn) supplementation can mitigate root-based Cadmium (Cd) uptake in plants, the impact of foliar-applied Zinc Oxide nanoparticles (ZnO NPs) on this process remains under-explored. This study investigates the influence of foliar-applied ZnO NPs on the growth of lettuce and its Cd uptake in Cd-contaminated soil in greenhouse setting. Green synthesized ZnO (G-ZnO) NPs (10 and 100 mg/L) using sweet potato leaf extracts were used, and compared with commercially available ZnO (C-ZnO) NPs (100 mg/L) for their efficacy. Scanning electron microscopy and Fourier-transform infrared spectroscopy were used for G-ZnO NPs characterization. Shoot dry weight, antioxidant activity, and chlorophyll content were all negatively affected by Cd but positively affected by ZnO NPs application. ZnO NPs application resulted in a notable reduction in lettuce Cd uptake, with the highest reduction (43%) observed at 100 mg/L G-ZnO NPs. In the lettuce shoot, Zn and Cd concentration showed a significant inverse correlation (R
MeSH term(s)	Zinc Oxide/pharmacology ; Zinc Oxide/chemistry ; Cadmium/analysis ; Lactuca ; Zinc/pharmacology ; Nanoparticles/chemistry ; Soil Pollutants/analysis
Chemical Substances	Zinc Oxide (SOI2LOH54Z) ; Cadmium (00BH33GNGH) ; Zinc (J41CSQ7QDS) ; Soil Pollutants
Language	English
Publishing date	2023-07-19
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139589
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Book ; Online: $\textit{e-Uber}$

Timilsina, Ashutosh / Silvestri, Simone

A Crowdsourcing Platform for Electric Vehicle-based Ride- and Energy-sharing

2023

Abstract: The sharing-economy-based business model has recently seen success in the transportation and accommodation sectors with companies like Uber and Airbnb. There is growing interest in applying this model to energy systems, with modalities like peer-to-peer ( ...

Abstract	The sharing-economy-based business model has recently seen success in the transportation and accommodation sectors with companies like Uber and Airbnb. There is growing interest in applying this model to energy systems, with modalities like peer-to-peer (P2P) Energy Trading, Electric Vehicles (EV)-based Vehicle-to-Grid (V2G), Vehicle-to-Home (V2H), Vehicle-to-Vehicle (V2V), and Battery Swapping Technology (BST). In this work, we exploit the increasing diffusion of EVs to realize a crowdsourcing platform called e-Uber that jointly enables ride-sharing and energy-sharing through V2G and BST. e-Uber exploits spatial crowdsourcing, reinforcement learning, and reverse auction theory. Specifically, the platform uses reinforcement learning to understand the drivers' preferences towards different ride-sharing and energy-sharing tasks. Based on these preferences, a personalized list is recommended to each driver through CMAB-based Algorithm for task Recommendation System (CARS). Drivers bid on their preferred tasks in their list in a reverse auction fashion. Then e-Uber solves the task assignment optimization problem that minimizes cost and guarantees V2G energy requirement. We prove that this problem is NP-hard and introduce a bipartite matching-inspired heuristic, Bipartite Matching-based Winner selection (BMW), that has polynomial time complexity. Results from experiments using real data from NYC taxi trips and energy consumption show that e-Uber performs close to the optimum and finds better solutions compared to a state-of-the-art approach Comment: Preprint, under review
Keywords	Computer Science - Artificial Intelligence ; Computer Science - Computer Science and Game Theory ; Computer Science - Human-Computer Interaction ; Computer Science - Machine Learning ; Electrical Engineering and Systems Science - Systems and Control
Subject code	629
Publishing date	2023-03-31
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Foliar application of green synthesized ZnO nanoparticles reduced Cd content in shoot of lettuce

Timilsina, Anil / Adhikari, Kaushik / Chen, Hao

Chemosphere. 2023 Oct., v. 338 p.139589-

2023

Abstract	Though Zinc (Zn) supplementation can mitigate root-based Cadmium (Cd) uptake in plants, the impact of foliar-applied Zinc Oxide nanoparticles (ZnO NPs) on this process remains under-explored. This study investigates the influence of foliar-applied ZnO NPs on the growth of lettuce and its Cd uptake in Cd-contaminated soil in greenhouse setting. Green synthesized ZnO (G-ZnO) NPs (10 and 100 mg/L) using sweet potato leaf extracts were used, and compared with commercially available ZnO (C–ZnO) NPs (100 mg/L) for their efficacy. Scanning electron microscopy and Fourier-transform infrared spectroscopy were used for G-ZnO NPs characterization. Shoot dry weight, antioxidant activity, and chlorophyll content were all negatively affected by Cd but positively affected by ZnO NPs application. ZnO NPs application resulted in a notable reduction in lettuce Cd uptake, with the highest reduction (43%) observed at 100 mg/L G-ZnO NPs. In the lettuce shoot, Zn and Cd concentration showed a significant inverse correlation (R² = 0.79–0.9, P < 0.05). This study offers insights into the impact of chemical and green synthesized ZnO NPs on enhancing crop growth under stress conditions, and their role in modulating Cd uptake in plants, indicating potential implications for sustainable agricultural practices.
Keywords	Fourier transform infrared spectroscopy ; antioxidant activity ; cadmium ; chlorophyll ; electron microscopy ; foliar application ; greenhouses ; leaves ; lettuce ; nanoparticles ; soil ; sweet potatoes ; zinc ; zinc oxide ; ZnO nanoparticles ; Nanoparticles green synthesis ; Cadmium uptake ; Cadmium bioavailability ; Cadmium-zinc interaction
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139589
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Quantification of Quinones in Environmental Media by Chemical Tagging with Cysteine-Containing Peptides Coupled to Size Exclusionary Separation.

Timilsina, Anil / Lokesh, Srinidhi / Shahriar, Abrar / Numan, Travis / Yang, Yu

Analytical chemistry

2023 Volume 95, Issue 34, Page(s) 12575–12579

Abstract: Quinones are one of the most important redox-reactive organic compounds in natural environments, such as soil, water, and sediment, playing an important role in regulating the environmental processes and biogeochemical cycles of critical elements under ... ...

Abstract	Quinones are one of the most important redox-reactive organic compounds in natural environments, such as soil, water, and sediment, playing an important role in regulating the environmental processes and biogeochemical cycles of critical elements under climate change, including the influences of extreme events such as wildfires. However, to date, no existing methods can quantify quinones in complex environmental media. To overcome this challenge, a quantification method was developed by coupling chemical tagging of quinones by cysteine-containing nonaromatic peptides (Cpep) through a Michael addition reaction with size exclusionary chromatography (SEC) separation and ultraviolet (UV) analysis─leveraging on the characteristic absorbance of aromatic rings at 254 nm and molecular size of peptide. The method was demonstrated using model quinones, including 1,4-benzoquinone (BQ), 1,4-naphthoquinone (NQ), and 1,4-anthraquinone (AQ), with a detection limit of 3.3, 0.7, and 0.2 μM, respectively. Concentrations of quinones in water extractions of biochars, soils, and wildfire-derived ashes were determined to range from 0.8 to 14 μM and were positively correlated with their redox reactivity determined by a chemical assay. This method provides a novel rapid quantification of quinones in complex environmental media as well as a quick assessment for redox reactivity and opens up new avenues for studying environmental transformation and remediation of contaminants.
MeSH term(s)	Quinones/chemistry ; Cysteine/chemistry ; Naphthoquinones ; Peptides ; Oxidation-Reduction
Chemical Substances	Quinones ; Cysteine (K848JZ4886) ; Naphthoquinones ; Peptides
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c01224
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Book ; Online: Prospect Theory-inspired Automated P2P Energy Trading with Q-learning-based Dynamic Pricing

Timilsina, Ashutosh / Silvestri, Simone

2022

Abstract: The widespread adoption of distributed energy resources, and the advent of smart grid technologies, have allowed traditionally passive power system users to become actively involved in energy trading. Recognizing the fact that the traditional centralized ...

Abstract	The widespread adoption of distributed energy resources, and the advent of smart grid technologies, have allowed traditionally passive power system users to become actively involved in energy trading. Recognizing the fact that the traditional centralized grid-driven energy markets offer minimal profitability to these users, recent research has shifted focus towards decentralized peer-to-peer (P2P) energy markets. In these markets, users trade energy with each other, with higher benefits than buying or selling to the grid. However, most researches in P2P energy trading largely overlook the user perception in the trading process, assuming constant availability, participation, and full compliance. As a result, these approaches may result in negative attitudes and reduced engagement over time. In this paper, we design an automated P2P energy market that takes user perception into account. We employ prospect theory to model the user perception and formulate an optimization framework to maximize the buyer's perception while matching demand and production. Given the non-linear and non-convex nature of the optimization problem, we propose Differential Evolution-based Algorithm for Trading Energy called DEbATE. Additionally, we introduce a risk-sensitive Q-learning algorithm, named Pricing mechanism with Q-learning and Risk-sensitivity (PQR), which learns the optimal price for sellers considering their perceived utility. Results based on real traces of energy consumption and production, as well as realistic prospect theory functions, show that our approach achieves a 26% higher perceived value for buyers and generates 7% more reward for sellers, compared to a recent state of the art approach.
Keywords	Computer Science - Artificial Intelligence ; Computer Science - Machine Learning ; Computer Science - Neural and Evolutionary Computing
Subject code	381
Publishing date	2022-08-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quantification of Quinones in Environmental Media by Chemical Tagging with Cysteine-Containing Peptides Coupled to Size Exclusionary Separation

Timilsina, Anil / Lokesh, Srinidhi / Shahriar, Abrar / Numan, Travis / Yang, Yu

Analytical Chemistry. 2023 Aug. 04, v. 95, no. 34 p.12575-12579

2023

Abstract	Quinones are one of the most important redox-reactive organic compounds in natural environments, such as soil, water, and sediment, playing an important role in regulating the environmental processes and biogeochemical cycles of critical elements under climate change, including the influences of extreme events such as wildfires. However, to date, no existing methods can quantify quinones in complex environmental media. To overcome this challenge, a quantification method was developed by coupling chemical tagging of quinones by cysteine-containing nonaromatic peptides (Cpep) through a Michael addition reaction with size exclusionary chromatography (SEC) separation and ultraviolet (UV) analysis—leveraging on the characteristic absorbance of aromatic rings at 254 nm and molecular size of peptide. The method was demonstrated using model quinones, including 1,4-benzoquinone (BQ), 1,4-naphthoquinone (NQ), and 1,4-anthraquinone (AQ), with a detection limit of 3.3, 0.7, and 0.2 μM, respectively. Concentrations of quinones in water extractions of biochars, soils, and wildfire-derived ashes were determined to range from 0.8 to 14 μM and were positively correlated with their redox reactivity determined by a chemical assay. This method provides a novel rapid quantification of quinones in complex environmental media as well as a quick assessment for redox reactivity and opens up new avenues for studying environmental transformation and remediation of contaminants.
Keywords	absorbance ; analytical chemistry ; biochar ; chemical reactions ; chromatography ; climate change ; detection limit ; molecular weight ; peptides ; quinones ; remediation ; sediments ; soil
Language	English
Dates of publication	2023-0804
Size	p. 12575-12579.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c01224
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of microplastics and nanoplastics in shrimp: Mechanisms of plastic particle and contaminant distribution and subsequent effects after uptake

Timilsina, Anil / Adhikari, Kaushik / Yadav, Amit Kumar / Joshi, Pabitra / Ramena, Grace / Bohara, Kailash

Science of the Total Environment. 2023 Oct., v. 894 p.164999-

2023

Abstract: To date, previous studies have reported the adverse effects of microplastics (MPs) and nanoplastics (NPs) on both freshwater and marine organisms. However, the information on MPs' and NPs' effects on shrimp species is scarce. In addition, the factors ... ...

Abstract	To date, previous studies have reported the adverse effects of microplastics (MPs) and nanoplastics (NPs) on both freshwater and marine organisms. However, the information on MPs' and NPs' effects on shrimp species is scarce. In addition, the factors influencing the distribution of these particles in aquatic systems have been explained, yet the mechanisms behind MPs and NPs distribution and consumption, specifically to crustaceans and shrimp, have not been elucidated in detail. The effects of MPs and NPs as well as plastic-carried contaminants and pathogens on shrimp are critical to shrimp production and subsequent human consumption. Recent findings are required to review and discuss to open up new avenues for emerging Shrimp and crustacean research for sustainability. This review summarizes the distribution and fate of MPs and NPs along with contaminants and pathogens and identifies potential risks to shrimp health. The transport of MPs and NPs is influenced by their plastic properties, hydrodynamics, and water properties. Additionally, the fate of these particles on a plastic surface (plastisphere) is regulated by contaminant properties. Pathogens thriving on plastic surfaces and contaminants adsorbed can reach aquatic organisms directly with plastic particles or indirectly after release to an aquatic environment. MPs and NPs can be absorbed by shrimp through their gills and mouth and accumulate in their internal organs. Innate immunity influenced the degree of survival rate, tissue damage, alteration of gut microbiota, and increased oxidative stress caused by MPs and NPs accumulation. The studies on the effects of MPs and NPs are still not sufficient to understand how these particles are absorbed from various parts of the shrimp body and the fate of these plastics inside the body.
Keywords	Crustacea ; aquatic environment ; freshwater ; humans ; hydrodynamics ; innate immunity ; intestinal microorganisms ; mouth ; nanoplastics ; oxidative stress ; shrimp ; survival rate ; Plastic pollution ; Microplastics ; Distribution ; Shrimp health ; Gut microbiome ; Immune response
Language	English
Dates of publication	2023-10
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164999
Database	NAL-Catalogue (AGRICOLA)

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