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  1. Book ; Thesis: Der Cannabinoid-CB 1 -Rezeptor am dopaminergen Neuron der Retina und am noradrenergen Neuron des ZNS im funktionellen Modell

    Timm, Jörg

    2000  

    Author's details vorgelegt von Jörg Timm
    Size 71 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 2000
    HBZ-ID HT011210098
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 D 1623 order for loan Magazin

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  2. Book ; Online ; Thesis: Analyse der Sequenzvariabilität des Hepatitis B Virus unter dem Einfluss der CD8 T-Zellantwort auf Populationsebene

    Schwarz, Tatjana [Verfasser] / Timm, Jörg [Gutachter] / Hegemann, Johannes [Gutachter]

    2023  

    Author's details Tatjana Schwarz ; Gutachter: Jörg Timm, Johannes Hegemann
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  3. Book ; Online ; Thesis: Analyse zytotoxischer Lymphozyten im Myelodysplastischen Syndrom (MDS) und der Akuten Myeloischen Leukämie (AML) unter Berücksichtigung des Zytomegalievirus-Status

    Moskorz, Wiebke [Verfasser] / Timm, Jörg [Gutachter] / Lang, Philipp [Gutachter]

    2023  

    Author's details Wiebke Moskorz ; Gutachter: Jörg Timm, Philipp Lang
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Online ; Thesis: The human antibody response to tick-borne flaviviruses

    Kapoor, Tania [Verfasser] / Timm, Jörg [Gutachter] / Feldt, Thorsten [Gutachter]

    2023  

    Author's details Tania Kapoor ; Gutachter: Jörg Timm, Thorsten Feldt
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  5. Article: Characterization of CD34

    Nollmann, Cathrin / Moskorz, Wiebke / Wimmenauer, Christian / Jäger, Paul S / Cadeddu, Ron P / Timm, Jörg / Heinzel, Thomas / Haas, Rainer

    Cancers

    2024  Volume 16, Issue 7

    Abstract: Using multi-color flow cytometry analysis, we studied the immunophenotypical differences between leukemic cells from patients with AML/MDS and hematopoietic stem and progenitor cells (HSPCs) from patients in complete remission (CR) following their ... ...

    Abstract Using multi-color flow cytometry analysis, we studied the immunophenotypical differences between leukemic cells from patients with AML/MDS and hematopoietic stem and progenitor cells (HSPCs) from patients in complete remission (CR) following their successful treatment. The panel of markers included CD34, CD38, CD45RA, CD123 as representatives for a hierarchical hematopoietic stem and progenitor cell (HSPC) classification as well as programmed death ligand 1 (PD-L1). Rather than restricting the evaluation on a 2- or 3-dimensional analysis, we applied a t-distributed stochastic neighbor embedding (t-SNE) approach to obtain deeper insight and segregation between leukemic cells and normal HPSCs. For that purpose, we created a t-SNE map, which resulted in the visualization of 27 cell clusters based on their similarity concerning the composition and intensity of antigen expression. Two of these clusters were "leukemia-related" containing a great proportion of CD34
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Epidemiological measures for assessing the dynamics of the SARS-CoV-2-outbreak: Simulation study about bias by incomplete case-detection.

    Brinks, Ralph / Küchenhoff, Helmut / Timm, Jörg / Kurth, Tobias / Hoyer, Annika

    PloS one

    2022  Volume 17, Issue 10, Page(s) e0276311

    Abstract: During the SARS-CoV-2 outbreak, several epidemiological measures, such as cumulative case-counts (CCC), incidence rates, effective reproduction numbers (Reff) and doubling times, have been used to inform the general public and to justify interventions ... ...

    Abstract During the SARS-CoV-2 outbreak, several epidemiological measures, such as cumulative case-counts (CCC), incidence rates, effective reproduction numbers (Reff) and doubling times, have been used to inform the general public and to justify interventions such as lockdown. It has been very likely that not all infectious people have been identified during the course of the epidemic, which lead to incomplete case-detection. We compare CCC, incidence rates, Reff and doubling times in the presence of incomplete case-detection. For this, an infection-age-structured SIR model is used to simulate a SARS-CoV-2 outbreak followed by a lockdown in a hypothetical population. Different scenarios about temporal variations in case-detection are applied to the four measures during outbreak and lockdown. The biases resulting from incomplete case-detection on the four measures are compared in terms of relative errors. CCC is most prone to bias by incomplete case-detection in all of our settings. Reff is the least biased measure. The possibly biased CCC may lead to erroneous conclusions in cross-country comparisons. With a view to future reporting about this or other epidemics, we recommend including and placing an emphasis on Reff in those epidemiological measures used for informing the general public and policy makers.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; Communicable Disease Control/methods ; Disease Outbreaks ; Bias
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0276311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; Thesis: Analysis of invariant natural killer T cells in health and disease: lessons from acute hepatitis C virus infection

    Menne, Christopher [Verfasser] / Timm, Jörg [Gutachter] / Lang, Philipp [Gutachter]

    2022  

    Author's details Christopher Menne ; Gutachter: Jörg Timm, Philipp Lang
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  8. Article: Comparison of commercial SARS-CoV-2 surrogate neutralization assays with a full virus endpoint dilution neutralization test in two different cohorts

    Adams, Ortwin / Andrée, Marcel / Hermsen, Derik / Lübke, Nadine / Timm, Jörg / Schaal, Heiner / Müller, Lisa

    Journal of virological methods. 2022 June 14,

    2022  

    Abstract: Determination of neutralizing antibody titers is still considered the gold standard for infection protection. A full virus neutralization test (VNT) with replication-competent, infectious SARS-CoV-2, is labour-intensive and requires Biosafety Level 3 ... ...

    Abstract Determination of neutralizing antibody titers is still considered the gold standard for infection protection. A full virus neutralization test (VNT) with replication-competent, infectious SARS-CoV-2, is labour-intensive and requires Biosafety Level 3 certified laboratories. Therefore, several commercial SARS-CoV-2 surrogate virus neutralization tests (sVNTs) have been developed that aim to detect neutralizing antibodies targeting the receptor binding domain (RBD) of the viral spike glycoprotein (S). Neutralizing antibodies to the RBD block its interaction with the angiotensin-converting enzyme 2 (ACE2) receptor protein. Here, we compared a full virus neutralization test (VNT) with two SARS-CoV-2 surrogate virus neutralization tests (sVNT) and validated them in two cohorts of i) convalescent SARS-CoV-2-infected individuals and ii) COVID vaccinated individuals. The sVNTs showed highly different results both, compared to the VNT-titers and also between the two cohorts. This indicates that currently, sVNT provide a qualitative instead of a quantitative measurement of neutralizing antibodies. The findings in this work show that the cutoff levels for sVNTs might need to be readjusted for convalescent and vaccinated individuals.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; biosafety ; glycoproteins ; neutralization ; neutralization tests ; peptidyl-dipeptidase A ; quantitative analysis ; viruses
    Language English
    Dates of publication 2022-0614
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2022.114569
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Erfolg durch körpereigene "Krieger*innen". Natürliche Killerzellen im Kampf gegen eine Hepatitis-C-Virus-Infektion Die in diesem Beitrag beschriebene immunologische Grundlagenforschung möchte dazu beitragen, ein besseres Verständms der HCV-Infektion zu erlangen und die komplexen Mechanismen aufklären, die bei einigen Menschen zu einer spontanen Ausheilung einer HCV-Infektion führen beziehungsweise Individuen vor einer Infektion schützen. Ein besseres Verständnis der Rolle des angeborenen und erworbenen Immunsystems für den HCV-Infektionsverlauf könnte für die Entwicklung einer prophylaktischen Impfung helfen

    Senff, Tina / Timm, Jörg

    Unikate / Universitä Duisburg-Essen

    2020  Volume 54, Issue 54, Page(s) 38

    Language German
    Document type Article
    ZDB-ID 2467342-0
    ISSN 1869-3881
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5504: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Comparison of commercial SARS-CoV-2 surrogate neutralization assays with a full virus endpoint dilution neutralization test in two different cohorts.

    Adams, Ortwin / Andrée, Marcel / Hermsen, Derik / Lübke, Nadine / Timm, Jörg / Schaal, Heiner / Müller, Lisa

    Journal of virological methods

    2022  Volume 307, Page(s) 114569

    Abstract: Determination of neutralizing antibody titers is still considered the gold standard for infection protection. A full virus neutralization test (VNT) with replication-competent, infectious SARS-CoV-2, is labor-intensive and requires Biosafety Level 3 ... ...

    Abstract Determination of neutralizing antibody titers is still considered the gold standard for infection protection. A full virus neutralization test (VNT) with replication-competent, infectious SARS-CoV-2, is labor-intensive and requires Biosafety Level 3 certified laboratories. Therefore, several commercial SARS-CoV-2 surrogate virus neutralization tests (sVNTs) have been developed that aim to detect neutralizing antibodies targeting the receptor binding domain (RBD) of the viral spike glycoprotein (S). Neutralizing antibodies to the RBD block its interaction with the angiotensin-converting enzyme 2 (ACE2) receptor protein. Here, we compared a full virus neutralization test (VNT) with two SARS-CoV-2 surrogate virus neutralization tests (sVNT) and validated them in two cohorts of i) convalescent SARS-CoV-2-infected individuals and ii) COVID vaccinated individuals. The sVNTs showed highly different results both, compared to the VNT-titers and also between the two cohorts. This indicates that currently, sVNT provide a qualitative instead of a quantitative measurement of neutralizing antibodies. The findings in this work show that the cutoff levels for sVNTs might need to be readjusted for convalescent and vaccinated individuals.
    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/diagnosis ; Humans ; Neutralization Tests ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-06-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2022.114569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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