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  1. Book ; Online: Regulation of Central Carbon and Amino Acid Metabolism in Plants

    Timm, Stefan / Arrivault, Stéphanie

    2021  

    Keywords Research & information: general ; Technology: general issues ; Arabidopsis ; abiotic stress response ; photosynthesis ; phosphoglycolate phosphatase ; photorespiration ; 2-phosphoglycolate ; Arabidopsis thaliana ; glycolate oxidase ; protein phosphorylation ; Zea mays ; Portulaca grandiflora ; C4 photosynthesis ; Crassulacean acid metabolism (CAM), evolution ; development ; PEP carboxylase ; Portulacaceae ; glycine decarboxylase ; metabolite signaling/acclimation ; TCA cycle ; Calvin-Benson cycle ; photoperiodic changes ; redox-regulation ; environmental adaptation ; Glycolate oxidase ; evolution ; Archaeplastida ; Cyanobacteria ; MCF ; oxidative phosphorylation ; mitochondrial carriers ; transporters ; energy balancing ; cyclic electron flux ; malate valve ; C3 cycle ; acclimation ; chlorophyll a fluorescence ; fluctuating light ; natural variation ; pyruvate kinase ; glycolysis ; respiratory metabolism ; n/a
    Size 1 electronic resource (182 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021289771
    ISBN 9783036511054 ; 3036511059
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Kulturelle Bildung

    Timm, Susanne / Kühn, Claudia / Costa, Jana / Scheunpflug, Annette

    2020  

    Abstract: Kultureller Bildung wird als Erfahrungs- und Lernbereich ein bedeutsames Potenzial zugesprochen. Es besteht jedoch keine hinreichende empirische Evidenz bezüglich vieler mit kultureller Bildung verbundener Fragen: Mit welchen Angeboten kultureller ... ...

    Abstract Kultureller Bildung wird als Erfahrungs- und Lernbereich ein bedeutsames Potenzial zugesprochen. Es besteht jedoch keine hinreichende empirische Evidenz bezüglich vieler mit kultureller Bildung verbundener Fragen: Mit welchen Angeboten kultureller Bildung an welchen Orten können welche Ergebnisse für wen erzielt werden? Wie können Prozesse und das komplexe Zusammenspiel ihrer Voraussetzungen und Wirkungen wissenschaftlich solide untersucht werden? In diesem Band werden in 24 Beiträgen Ergebnisse aus Forschungsprojekten präsentiert, die sich diesen Fragen widmen. Die Studien zu verschiedenen Genres, Räumen, Akteuren und Formen der kulturellen Bildungspraxis wie ihrer Grundlagen und Implikationen eröffnen neue Diskussionslinien zur Bedeutung und Komplexität kultureller Bildung. Methodologisch werden neue Wege ausgelotet und ausgehend von den empirischen Befunden vorliegende Erkenntnisse theoretisch erweitert. Die Studien wurden vom Bundesministerium für Bildung und Forschung gefördert
    Keywords Education (General) ; Theory and practice of education
    Size 1 electronic resource (424 pages)
    Publisher Waxmann Verlag
    Document type Book ; Online
    Note german ; Open Access
    HBZ-ID HT020678748
    ISBN 9783830941507 ; 3830941501
    DOI 10.31244/9783830991502
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: The impact of photorespiration on plant primary metabolism through metabolic and redox regulation.

    Timm, Stefan

    Biochemical Society transactions

    2021  Volume 48, Issue 6, Page(s) 2495–2504

    Abstract: Photorespiration is an inevitable trait of all oxygenic phototrophs, being the only known metabolic route that converts the inhibitory side-product of Rubisco's oxygenase activity 2-phosphoglycolate (2PG) back into the Calvin-Benson (CB) cycle's ... ...

    Abstract Photorespiration is an inevitable trait of all oxygenic phototrophs, being the only known metabolic route that converts the inhibitory side-product of Rubisco's oxygenase activity 2-phosphoglycolate (2PG) back into the Calvin-Benson (CB) cycle's intermediate 3-phosphoglycerate (3PGA). Through this function of metabolite repair, photorespiration is able to protect photosynthetic carbon assimilation from the metabolite intoxication that would occur in the present-day oxygen-rich atmosphere. In recent years, much plant research has provided compelling evidence that photorespiration safeguards photosynthesis and engages in cross-talk with a number of subcellular processes. Moreover, the potential of manipulating photorespiration to increase the photosynthetic yield potential has been demonstrated in several plant species. Considering this multifaceted role, it is tempting to presume photorespiration itself is subject to a suite of regulation mechanisms to eventually exert a regulatory impact on other processes, and vice versa. The identification of potential pathway interactions and underlying regulatory aspects has been facilitated via analysis of the photorespiratory mutant phenotype, accompanied by the emergence of advanced omics' techniques and biochemical approaches. In this mini-review, I focus on the identification of enzymatic steps which control the photorespiratory flux, as well as levels of transcriptional, posttranslational, and metabolic regulation. Most importantly, glycine decarboxylase (GDC) and 2PG are identified as being key photorespiratory determinants capable of controlling photorespiratory flux and communicating with other branches of plant primary metabolism.
    MeSH term(s) Biochemical Phenomena ; Carbon/metabolism ; Carbon Dioxide/metabolism ; Gene Expression Regulation, Plant ; Glycine Dehydrogenase (Decarboxylating)/metabolism ; Glycolates/metabolism ; Light ; Oxidation-Reduction ; Oxygen/metabolism ; Phenotype ; Photochemistry ; Photosynthesis/physiology ; Plant Physiological Phenomena ; Plants/metabolism ; Protein Processing, Post-Translational ; Ribulose-Bisphosphate Carboxylase/metabolism ; Up-Regulation
    Chemical Substances Glycolates ; Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0) ; Glycine Dehydrogenase (Decarboxylating) (EC 1.4.4.2) ; Ribulose-Bisphosphate Carboxylase (EC 4.1.1.39) ; phosphoglycolate (H8593JOP13) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20200055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 944: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Four plus one: vacuoles serve in photorespiration.

    Timm, Stefan / Eisenhut, Marion

    Trends in plant science

    2023  Volume 28, Issue 12, Page(s) 1340–1343

    Abstract: Photorespiration is inevitable for oxygenic photosynthesis. It has fascinated researchers over decades because of its multicompartmental organization. Recently, Lin and Tsay identified a vacuole glycerate transporter contributing to photorespiratory ... ...

    Abstract Photorespiration is inevitable for oxygenic photosynthesis. It has fascinated researchers over decades because of its multicompartmental organization. Recently, Lin and Tsay identified a vacuole glycerate transporter contributing to photorespiratory metabolism under short-term nitrogen depletion. This key finding adds a fifth interacting subcellular compartment and extends the photorespiratory metabolic repair module.
    MeSH term(s) Vacuoles/metabolism ; Photosynthesis ; Membrane Transport Proteins/metabolism ; Oxygen/metabolism ; Nitrogen/metabolism
    Chemical Substances Membrane Transport Proteins ; Oxygen (S88TT14065) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2023-08-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1305448-x
    ISSN 1878-4372 ; 1360-1385
    ISSN (online) 1878-4372
    ISSN 1360-1385
    DOI 10.1016/j.tplants.2023.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2005/719: Show issues

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  5. Book ; Online: Towards an HPC Complementary Computing Facility

    Herner, K. / Kirby, M. / Timm, S.

    2022  

    Abstract: This Letter considers the design for computing facilities that are complementary to the leadership class High Performance Computing (HPC) facilities. This design envisions a future where funding agencies are allocating greater resources for leadership ... ...

    Abstract This Letter considers the design for computing facilities that are complementary to the leadership class High Performance Computing (HPC) facilities. This design envisions a future where funding agencies are allocating greater resources for leadership class facilities and these facilities will provide a significant part of the total compute cycles for HEP Experiments. While a leadership class facility (LCF) may provide cycles and advanced architectures, the facility does not necessarily provide all of the services needed to help HEP users make the best use of the HPC facility, as well as the services needed to provide computing for workflows that are not a good fit for the HPC facilities. This Letter outlines some of the necessary components of a facility designed to provide those services and capabilities.

    Comment: 4 pages, contribution to Snowmass 2021
    Keywords Computer Science - Distributed ; Parallel ; and Cluster Computing ; High Energy Physics - Experiment
    Subject code 000
    Publishing date 2022-03-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Regulation of Central Carbon and Amino Acid Metabolism in Plants.

    Timm, Stefan / Arrivault, Stéphanie

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: Fluctuations in the prevailing environmental conditions, including light availability and intensity, ... ...

    Abstract Fluctuations in the prevailing environmental conditions, including light availability and intensity, CO
    Language English
    Publishing date 2021-02-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10030430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The impact of COVID-19 lockdown on glycaemic control and use of health services among children followed at a Danish diabetes clinic.

    Kofoed, Poul-Erik / Timm, Signe

    Acta paediatrica (Oslo, Norway : 1992)

    2021  Volume 111, Issue 2, Page(s) 368–375

    Abstract: Aim: During COVID-19 restrictions, the paediatric clinic only accepted essential outpatient visits, schools closed, sports activities and social life were limited. Most employees worked at home. This quasi-experiment evaluates how this affected ... ...

    Abstract Aim: During COVID-19 restrictions, the paediatric clinic only accepted essential outpatient visits, schools closed, sports activities and social life were limited. Most employees worked at home. This quasi-experiment evaluates how this affected glycaemic control and use of health services among children with diabetes.
    Methods: Paired t-tests were used to compare HbA1c-values before, during and after lockdown. Sub-analyses were stratified by pre-lockdown HbA1c-values.
    Results: Overall mean HbA1c decreased from 58.3 to 56.9 mmol/mol (p = 0.025) from pre- to post-lockdown, a decrease also seen during the same season the previous year. HbA1c decreased by -4.2 mmol/mol (p = 0.002) for patients with pre-lockdown HbA1c > 59 mmol/mol, but increased slightly by 0.8 mmol/mol (p = 0.176) for patients with HbA1c < 52 mmol/mol. HbA1c measured 8 months post-lockdown increased again, most pronounced for patients with lowest HbA1c. During lockdown, virtual contacts increased from 0.1 to 0.5 contacts/patient/month and stayed post-lockdown at 0.3 contacts/patient/month.
    Conclusion: Compared to 2019, overall the COVID-19 restrictions did not influence the glycaemic control negatively. However, patients with pre-lockdown HbA1c < 52 mmol/mol experienced a deterioration, whereas those with HbA1c > 59 mmol/mol experienced an improvement. Less stress and more contact with parents may contribute to the last-mentioned finding. The lockdown enforced more virtual contacts between patients and the clinic.
    MeSH term(s) Blood Glucose ; COVID-19/prevention & control ; Child ; Communicable Disease Control ; Denmark ; Diabetes Mellitus/therapy ; Glycated Hemoglobin A/analysis ; Glycemic Control ; Health Services ; Humans
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A
    Language English
    Publishing date 2021-10-05
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.95: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Methylated Cell-Free Tumor DNA in Sputum as a Tool for Diagnosing Lung Cancer-A Systematic Review and Meta-Analysis.

    Wen, Sara Witting Christensen / Borg, Morten / Timm, Signe / Hansen, Torben Frøstrup / Hilberg, Ole / Andersen, Rikke Fredslund

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Lung cancer is the leading cause of cancer-related mortality worldwide. Early diagnosis is pivotal for the prognosis. There is a notable overlap between lung cancer and chronic bronchitis, and the potential use of methylated tumor DNA in sputum as a ... ...

    Abstract Lung cancer is the leading cause of cancer-related mortality worldwide. Early diagnosis is pivotal for the prognosis. There is a notable overlap between lung cancer and chronic bronchitis, and the potential use of methylated tumor DNA in sputum as a biomarker for lung cancer detection is appealing. This systematic review and meta-analysis followed the PRISMA 2020 statement. A comprehensive search was conducted in Embase, Medline, Web of Science, and the Cochrane Library, using these search strings: Lung cancer, sputum, and methylated tumor DNA. A total of 15 studies met the eligibility criteria. Studies predominantly utilized a case-control design, with sensitivity ranging from 10 to 93% and specificity from 8 to 100%. A meta-analysis of all genes across studies resulted in a summary sensitivity of 54.3% (95% CI 49.4-59.2%) and specificity of 79.7% (95% CI 75.0-83.7%). Notably, two less explored genes (TAC1, SOX17) demonstrated sensitivity levels surpassing 85%. The study's findings highlight substantial variations in the sensitivity and specificity of methylated tumor DNA in sputum for lung cancer detection. Challenges in reproducibility could stem from differences in tumor site, sample acquisition, extraction methods, and methylation measurement techniques. This meta-analysis provides a foundation for prioritizing high-performing genes, calling for a standardization and refinement of methodologies before potential application in clinical trials.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Missingness mechanisms and generalizability of patient reported outcome measures in colorectal cancer survivors - assessing the reasonableness of the "missing completely at random" assumption.

    Lyhne, Johanne Dam / Smith, Allan 'Ben' / Jensen, Lars Henrik / Hansen, Torben Frøstrup / Frostholm, Lisbeth / Timm, Signe

    BMC medical research methodology

    2024  Volume 24, Issue 1, Page(s) 104

    Abstract: Background: Patient-Reported Outcome Measures (PROM) provide important information, however, missing PROM data threaten the interpretability and generalizability of findings by introducing potential bias. This study aims to provide insight into ... ...

    Abstract Background: Patient-Reported Outcome Measures (PROM) provide important information, however, missing PROM data threaten the interpretability and generalizability of findings by introducing potential bias. This study aims to provide insight into missingness mechanisms and inform future researchers on generalizability and possible methodological solutions to overcome missing PROM data problems during data collection and statistical analyses.
    Methods: We identified 10,236 colorectal cancer survivors (CRCs) above 18y, diagnosed between 2014 and 2018 through the Danish Clinical Registries. We invited a random 20% (2,097) to participate in a national survey in May 2023. We distributed reminder e-mails at day 10 and day 20, and compared Initial Responders (response day 0-9), Subsequent Responders (response day 10-28) and Non-responders (no response after 28 days) in demographic and cancer-related characteristics and PROM-scores using linear regression.
    Results: Of the 2,097 CRCs, 1,188 responded (57%). Of these, 142 (7%) were excluded leaving 1,955 eligible CRCs. 628 (32%) were categorized as initial responders, 418 (21%) as subsequent responders, and 909 (47%) as non-responders. Differences in demographic and cancer-related characteristics between the three groups were minor and PROM-scores only marginally differed between initial and subsequent responders.
    Conclusion: In this study of long-term colorectal cancer survivors, we showed that initial responders, subsequent responders, and non-responders exhibit comparable demographic and cancer-related characteristics. Among respondents, Patient-Reported Outcome Measures were also similar, indicating generalizability. Assuming Patient-Reported Outcome Measures of subsequent responders represent answers by the non-responders (would they be available), it may be reasonable to judge the missingness mechanism as Missing Completely At Random.
    MeSH term(s) Humans ; Colorectal Neoplasms/therapy ; Patient Reported Outcome Measures ; Female ; Male ; Cancer Survivors/statistics & numerical data ; Aged ; Middle Aged ; Denmark ; Surveys and Questionnaires ; Registries/statistics & numerical data ; Adult ; Quality of Life ; Aged, 80 and over
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041362-2
    ISSN 1471-2288 ; 1471-2288
    ISSN (online) 1471-2288
    ISSN 1471-2288
    DOI 10.1186/s12874-024-02236-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Audio / Video ; Thesis: Weichteilsarkome bei Kindern und Jugendlichen

    Timm, Stephanie

    eine retrospektive Analyse des Patientengutes der Universitätskinder- und Jugendklinik Rostock der Jahre 1980-2000

    2005  

    Author's details Stephanie Timm
    Language German
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Rostock, Univ., Med. Fak., Diss., 2007
    HBZ-ID HT015280695
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 MO 534 order for loan Magazin

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