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  1. Article: Technological innovation, crude oil volatility, and renewable energy dimensions in N11 countries: Analysis based on advance panel estimation techniques

    Li, Zeyun / Qadus, Abdul / Maneengam, Apichit / Mabrouk, Fatma / Shahid, Muhammad Sadiq / Timoshin, Anton

    Renewable energy. 2022 May, v. 191

    2022  

    Abstract: Deterioration of natural environment is a serious threat to all the communities on earth. However, green and contemporary innovations reduce the adverse environmental outcomes generated through higher greenhouse gas emissions. Therefore, this study ... ...

    Abstract Deterioration of natural environment is a serious threat to all the communities on earth. However, green and contemporary innovations reduce the adverse environmental outcomes generated through higher greenhouse gas emissions. Therefore, this study examines the role of technological innovationand renewable energy dimensions towards improving environmental quality. At the same time, the role of oil price volatilityis also observed during the study period from 1995 to 2018 for N11 countries with the help of advanced panel estimation. More specifically, this research applies second-generation panel cointegration technique along with continuously updated fully modified and continuously updated bias-corrected (Cup-BC) techniques. The results show that technological innovation and renewable energy dimensions like hydro and thermal power play a major role in reducing environmental threats. However, crude oil price volatility plays a major role in environmental deterioration. Besides, this research offers valuable recommendations for environmentalists.
    Keywords energy costs ; environmental degradation ; environmental quality ; greenhouse gases ; oils ; petroleum ; prices ; renewable energy sources ; technology
    Language English
    Dates of publication 2022-05
    Size p. 204-212.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2001449-1
    ISSN 1879-0682 ; 0960-1481
    ISSN (online) 1879-0682
    ISSN 0960-1481
    DOI 10.1016/j.renene.2022.04.014
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: How Investors Attitudes Shape Stock Market Participation in the Presence of Financial Self-Efficacy.

    Nadeem, Muhammad Asif / Qamar, Muhammad Ali Jibran / Nazir, Mian Sajid / Ahmad, Israr / Timoshin, Anton / Shehzad, Khurram

    Frontiers in psychology

    2020  Volume 11, Page(s) 553351

    Abstract: The purpose of this study is to investigate how investor's money attitudes shape their stock market participation (SMP) decisions. This study followed the theory of planned behavior (TPB), and a survey was conducted to collect the responses from active ... ...

    Abstract The purpose of this study is to investigate how investor's money attitudes shape their stock market participation (SMP) decisions. This study followed the theory of planned behavior (TPB), and a survey was conducted to collect the responses from active investors. Structural equation modeling (SEM) was used for the analysis of proposed relationships among the constructs, and a confirmatory factor analysis (CFA) was conducted to check the interrelation of the variables and validity of the constructs. This research has concluded that investor's money attitudes are significant to affect their stock market participation decisions. Further, it was found that risk attitudes partially mediate the relationship between money attitudes and stock market participation. Moreover, financial knowledge and financial self-efficacy positively moderated the relationship between money attitudes and stock market participation. This research is one of the early attempts at studying the money attitudes of investors and introduces financial self-efficacy as a moderating construct between money attitudes and stock market participation. The sample size for this study was 250 respondents which can be increased in future research, and the same relationships can be tested by using a larger sample. Moreover, this study has used money attitudes as predictors of stock market participation. Still, many other variables, like personal value, can also be taken to investigate their influence on stock market participation.
    Language English
    Publishing date 2020-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2020.553351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions.

    Fang, Yu / Zekiy, Angelina Olegovna / Ghaedrahmati, Farhoodeh / Timoshin, Anton / Farzaneh, Maryam / Anbiyaiee, Amir / Khoshnam, Seyed Esmaeil

    Cell communication and signaling : CCS

    2021  Volume 19, Issue 1, Page(s) 41

    Abstract: The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a scaffold or adaptor in various physiological and ...

    Abstract The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a scaffold or adaptor in various physiological and pathological processes. Trib2 can interact with E3 ubiquitin ligases and control protein stability of downstream effectors. This protein is induced by mitogens and enhances the propagation of several cancer cells, including myeloid leukemia, liver, lung, skin, bone, brain, and pancreatic. Thus, Trib2 can be a predictive and valuable biomarker for the diagnosis and treatment of cancer. Recent studies have illustrated that Trib2 plays a major role in cell fate determination of stem cells. Stem cells have the capacity to self-renew and differentiate into specific cell types. Stem cells are important sources for cell-based regenerative medicine and drug screening. Trib2 has been found to increase the self-renewal ability of embryonic stem cells, the reprogramming efficiency of somatic cells, and chondrogenesis. In this review, we will focus on the recent advances of Trib2 function in tumorigenesis and stem cell fate decisions. Video abstract.
    MeSH term(s) Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Lineage ; Humans ; Models, Biological ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/metabolism ; Stem Cells/cytology
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-021-00725-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Optical and Electrochemical Aptasensors Developed for the Detection of Alpha-Fetoprotein.

    Tran Ngoc Huy, Dinh / Iswanto, A Heri / Catalan Opulencia, Maria Jade / Al-Saikhan, Fahad / Timoshin, Anton / Abed, Azher M / Ahmad, Irfan / Blinova, Sofiya A / Hammid, Ali Thaeer / Mustafa, Yasser Fakri / Van Tuan, Pham

    Critical reviews in analytical chemistry

    2022  , Page(s) 1–15

    Abstract: Early diagnosis of hepatocellular carcinoma (HCC), a leading cause of cancer mortality, is decisive for successful treatment of this type of cancer and increasing the patients' survival rate. Alpha-fetoprotein (AFP) is a glycoprotein that has been ... ...

    Abstract Early diagnosis of hepatocellular carcinoma (HCC), a leading cause of cancer mortality, is decisive for successful treatment of this type of cancer and increasing the patients' survival rate. Alpha-fetoprotein (AFP) is a glycoprotein that has been currently employed as a potential serological biomarker for determination of HCC and several other cancers. Achieving highly sensitive and specific detection of this biomarker is an effective strategy to inhibit developing issues caused by the cancer. Though, traditional procedures cannot meet the requirements due to the technical drawbacks. Recently, growing number of aptamer-based biosensors (aptasensors) attracted important attention as superior diagnostic tools because of their unique properties such as high stability, target versatility and remarkable affinity and selectivity. Nanomaterials, which broadly employed in the structure of these aptasensors, can considerably enhance the detection limit and sensitivity of analytes determination. Therefore, this review selectively investigated the recent progresses in several different optical and electrochemical aptasensors and nano-aptasensors designed for AFP assay.
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2030019-0
    ISSN 1547-6510 ; 1040-8347
    ISSN (online) 1547-6510
    ISSN 1040-8347
    DOI 10.1080/10408347.2022.2099221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Emotional Regulation as a Remedy for Teacher Burnout in Special Schools: Evaluating School Climate, Teacher's Work-Life Balance and Children Behavior.

    Mulyani, Sri / Salameh, Anas A / Komariah, Aan / Timoshin, Anton / Hashim, Nik Alif Amri Nik / Fauziah, R Siti Pupu / Mulyaningsih, Mulyaningsih / Ahmad, Israr / Ul Din, Sajid Mohy

    Frontiers in psychology

    2021  Volume 12, Page(s) 655850

    Abstract: This research aimed to identify whether improvement in working conditions, children's classroom behavior and work-life balance can lower teacher burnout ratio in Pakistan's special schools by using techniques such as emotions regulation. The researcher ... ...

    Abstract This research aimed to identify whether improvement in working conditions, children's classroom behavior and work-life balance can lower teacher burnout ratio in Pakistan's special schools by using techniques such as emotions regulation. The researcher employed a quantitative research methodology to fulfill the research's purpose. The data for this research was collected using a questionnaire-based instrument. The confirmatory factor analysis and structural equation modeling techniques were used to test the construct validity and underlying structural relationships. The findings demonstrated that the impacts of all three variables are significant in reducing job burnout in teachers. Emotional regulation helps decrease the impact of working conditions and the children's behavior. Nevertheless, it does not aid work-life balance as it requires other techniques of emotional regulation. The research is significant as it highlights the importance of overall working conditions' improvement for teachers working with special needs children. The improvements are essential because the teachers must take extra effort and emotions into their job compared to a typical teacher. The researcher has highlighted the key finding, implications and limitations of this research besides suggesting directions for future research to facilitate peer researchers.
    Language English
    Publishing date 2021-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.655850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immunomodulatory effects of nanocurcumin on Th17 cell responses in mild and severe COVID-19 patients.

    Tahmasebi, Safa / El-Esawi, Mohamed A / Mahmoud, Zaid Hameed / Timoshin, Anton / Valizadeh, Hamed / Roshangar, Leila / Varshoch, Mojtaba / Vaez, Aydin / Aslani, Saeed / Navashenaq, Jamshid G / Aghebati-Maleki, Leili / Ahmadi, Majid

    Journal of cellular physiology

    2020  Volume 236, Issue 7, Page(s) 5325–5338

    Abstract: In novel coronavirus disease 2019 (COVID-19), the increased frequency and overactivation of T helper (Th) 17 cells and subsequent production of large amounts of proinflammatory cytokines result in hyperinflammation and disease progression. The current ... ...

    Abstract In novel coronavirus disease 2019 (COVID-19), the increased frequency and overactivation of T helper (Th) 17 cells and subsequent production of large amounts of proinflammatory cytokines result in hyperinflammation and disease progression. The current study aimed to investigate the therapeutic effects of nanocurcumin on the frequency and responses of Th17 cells in mild and severe COVID-19 patients. In this study, 40 severe COVID-19 intensive care unit-admitted patients and 40 patients in mild condition were included. The frequency of Th17 cells, the messenger RNA expression of Th17 cell-related factors (RAR-related orphan receptor γt, interleukin [IL]-17, IL-21, IL-23, and granulocyte-macrophage colony-stimulating factor), and the serum levels of cytokines were measured in both nanocurcumin and placebo-treated groups before and after treatment. A significant decrease in the number of Th17 cells, downregulation of Th17 cell-related factors, and decreased levels of Th17 cell-related cytokines were found in mild and severe COVID-19 patients treated by nanocurcumin compared to the placebo group. Moreover, the abovementioned parameters were significantly decreased in the nanocurcumin-treated group after treatment versus before treatment. Curcumin could reduce the frequency of Th17 cells and their related inflammatory factors in both mild and severe COVID-19 patients. Hence, it could be considered as a potential modulatory compound in improving the patient's inflammatory condition.
    MeSH term(s) Adult ; COVID-19/drug therapy ; Curcumin/therapeutic use ; Cytokines/metabolism ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Immunomodulation/drug effects ; Male ; Middle Aged ; Nanoparticles/administration & dosage ; Nanoparticles/therapeutic use ; SARS-CoV-2/drug effects ; Severity of Illness Index ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/virology ; Th17 Cells/drug effects ; Th17 Cells/metabolism
    Chemical Substances Cytokines ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2020-12-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.30233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth.

    Budi, Hendrik Setia / Izadi, Sepideh / Timoshin, Anton / Asl, Sima Heydarzadeh / Beyzai, Behzad / Ghaderpour, Amir / Alian, Fatemeh / Eshaghi, Farzaneh Sadat / Mousavi, Seyedeh Mahboubeh / Rafiee, Behnam / Nikkhoo, Afshin / Ahmadi, Armin / Hassannia, Hadi / Ahmadi, Majid / Sojoodi, Mozhdeh / Jadidi-Niaragh, Farhad

    Nanomedicine : nanotechnology, biology, and medicine

    2021  Volume 34, Page(s) 102373

    Abstract: HIF-1α and STAT3 are two of the critical factors in the growth, proliferation, and metastasis of cancer cells and play a crucial role in inhibiting anti-cancer immune responses. Therefore, we used superparamagnetic iron oxide (SPION) nanoparticles (NPs) ... ...

    Abstract HIF-1α and STAT3 are two of the critical factors in the growth, proliferation, and metastasis of cancer cells and play a crucial role in inhibiting anti-cancer immune responses. Therefore, we used superparamagnetic iron oxide (SPION) nanoparticles (NPs) coated with thiolated chitosan (ChT) and trimethyl chitosan (TMC) and functionalized with hyaluronate (H) and TAT peptide for delivery of siRNA molecules against STAT3 and HIF-1α to cancer cells both in vivo and in vitro. The results indicated that tumor cell transfection with siRNA-encapsulated NPs robustly inhibited proliferation and migration and induced apoptosis in tumor cells. Furthermore, simultaneous silencing of HIF-1α and STAT3 significantly repressed cancer development in two different tumor types (4T1 breast cancer and CT26 colon cancer) which were associated with upregulation of cytotoxic T lymphocytes and IFN-γ secretion. The findings suggest inhibiting the HIF-1α/STAT3 axis by SPION-TMC-ChT-TAT-H NPs as an effective way to treat cancer.
    MeSH term(s) Animals ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Chitosan/chemistry ; Colonic Neoplasms/pathology ; Female ; Humans ; Hyaluronic Acid/chemistry ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Magnetic Iron Oxide Nanoparticles/administration & dosage ; Magnetic Iron Oxide Nanoparticles/chemistry ; Mice ; Mice, Inbred BALB C ; RNA, Small Interfering/administration & dosage ; STAT3 Transcription Factor/antagonists & inhibitors
    Chemical Substances HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; RNA, Small Interfering ; STAT3 Transcription Factor ; STAT3 protein, human ; Hyaluronic Acid (9004-61-9) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2183417-9
    ISSN 1549-9642 ; 1549-9634
    ISSN (online) 1549-9642
    ISSN 1549-9634
    DOI 10.1016/j.nano.2021.102373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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