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  1. AU="Timpson, N J"
  2. AU="Nathan, Ashwin S"
  3. AU="Lovestone, S"
  4. AU="Dass, Bhagwan"
  5. AU="Suhlrie, Adriana"
  6. AU="Palència, Laia"
  7. AU="Crump, Michael"
  8. AU="Noyori, Osamu"
  9. AU="Atibordee Meesing"

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  1. Artikel ; Online: Heritability of Caries Scores, Trajectories, and Disease Subtypes.

    Haworth, S / Esberg, A / Lif Holgerson, P / Kuja-Halkola, R / Timpson, N J / Magnusson, P K E / Franks, P W / Johansson, I

    Journal of dental research

    2020  Band 99, Heft 3, Seite(n) 264–270

    Abstract: Previous studies report that dental caries is partially heritable, but there is uncertainty in the magnitude of genetic effects and little understanding of how genetic factors might influence caries progression or caries subtypes. This study aimed to ... ...

    Abstract Previous studies report that dental caries is partially heritable, but there is uncertainty in the magnitude of genetic effects and little understanding of how genetic factors might influence caries progression or caries subtypes. This study aimed to estimate the relative importance of genetic and environmental factors in the etiology of different caries outcomes using a twin-based design. Analysis included up to 41,678 twins in the Swedish Twin Register aged 7 to 97 y, and dental data were obtained from preexisting dental records. The outcome measures were 1) summary indices of caries experience, 2) parameters representing trajectory in caries progression derived from longitudinal modeling, and 3) caries scores in groups of biologically similar tooth surfaces derived from hierarchical clustering of tooth surfaces (termed
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Cluster Analysis ; Cross-Sectional Studies ; Dental Caries/epidemiology ; Dental Caries/genetics ; Humans ; Middle Aged ; Molar ; Tooth ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-01-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Twin Study
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/0022034519897910
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  2. Artikel ; Online: Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes.

    Zhou, Y / McNeil, D W / Haworth, S / Dudding, T / Chernus, J M / Liu, C / Liu, D / Wright, C D / Brumbaugh, J / Randall, C L / Weyant, R J / Crout, R J / Foxman, B / Reis, S / Timpson, N J / Marazita, M L / Shaffer, J R

    Journal of dental research

    2022  Band 101, Heft 12, Seite(n) 1526–1536

    Abstract: Dental care-related fear and anxiety (DFA) is prevalent, affects oral health care utilization, and is related to poor oral health and decreased quality of life. In addition to learned and cultural factors, genetics is hypothesized to contribute to DFA. ... ...

    Abstract Dental care-related fear and anxiety (DFA) is prevalent, affects oral health care utilization, and is related to poor oral health and decreased quality of life. In addition to learned and cultural factors, genetics is hypothesized to contribute to DFA. Therefore, we performed a genome-wide association study to identify genetic variants contributing to DFA. Adult and adolescent participants were from 4 cohorts (3 from the US-based Center for Oral Health Research in Appalachia,
    Mesh-Begriff(e) Dental Anxiety/genetics ; Dental Anxiety/psychology ; Genome-Wide Association Study ; Longitudinal Studies ; Neurotensin ; Quality of Life ; Humans ; Adolescent ; Adult
    Chemische Substanzen Neurotensin (39379-15-2)
    Sprache Englisch
    Erscheinungsdatum 2022-06-30
    Erscheinungsland United States
    Dokumenttyp Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345221105226
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  3. Artikel ; Online: Ten years on: Is dental general anaesthesia in childhood a risk factor for caries and anxiety?

    Haworth, S / Dudding, T / Waylen, A / Thomas, S J / Timpson, N J

    British dental journal

    2017  Band 222, Heft 4, Seite(n) 299–304

    Abstract: Objectives To identify whether dental general anaesthesia (DGA) status is informative in assessing risk of caries or dental anxiety by (a) describing long-term oral health and dental anxiety for people who underwent DGA in childhood and (b) testing ... ...

    Abstract Objectives To identify whether dental general anaesthesia (DGA) status is informative in assessing risk of caries or dental anxiety by (a) describing long-term oral health and dental anxiety for people who underwent DGA in childhood and (b) testing whether DGA status in childhood is associated with incident future dental caries or anxiety independently of preconceived risk factors.Design Analysis of prospectively obtained data.Setting An established population based cohort in the UK, the Avon Longitudinal Study of Parents and Children.Participants and methods In total 1,695 participants with dental data in childhood and adolescence were included in analysis. DGA status by age 7 and oral health measures at age 17 were identified from questionnaire data.Main outcome measures Filled or extracted permanent teeth at age 17, Corah Dental Anxiety Scale.Results One hundred and twenty-eight (7.6%) participants underwent DGA in childhood. Individuals who underwent DGA had higher measures of filled or extracted permanent teeth in adolescence (0.36 more affected teeth in fully-adjusted model [95% confidence interval: 0.27, 0.55; P <0.001]).Conclusions DGA in childhood predicts burden of treated caries in adolescence, independently of other risk factors. DGA status may be a clinically useful adjunct in identifying young people at high risk of further disease.
    Mesh-Begriff(e) Adolescent ; Anesthesia, Dental ; Anesthesia, General ; Child ; Dental Anxiety/epidemiology ; Dental Caries/epidemiology ; Female ; Follow-Up Studies ; Humans ; Male ; Prospective Studies ; Risk Assessment ; Risk Factors ; Self Report ; Time Factors
    Sprache Englisch
    Erscheinungsdatum 2017-02-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/sj.bdj.2017.175
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  4. Artikel: The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture May-July 2020

    Northstone, K. / Smith, D. / Bowring, C. / Wells, N. / Crawford, M. / Haworth, S. / Timpson, N. J.

    Wellcome Open Res

    Abstract: The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners and their offspring ever since The study reacted rapidly ... ...

    Abstract The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners and their offspring ever since The study reacted rapidly to the coronavirus disease 2019 (COVID-19) pandemic, deploying an online questionnaire early on during lockdown (from 9 (th) April to 15 (th) May) In late May 2020, a second questionnaire was developed asking about physical and mental health, lifestyle and behaviours, employment and finances The online questionnaire was deployed across the parent and offspring generations between the 26th May and 5 (th) July 2020 6482 participants completed the questionnaire (2639 original mothers, 1039 original fathers/partners, 2711 offspring (mean age ~28 years) and 93 partners of offspring) 1039 new participants who did not respond to the first questionnaire deployed in April completed the second questionnaire A positive COVID-19 was reported by 36 (0 6%) participants (12 G0 and 24 G1), 91 (1 4%;35 G0 and 56 G1) reported that they had been told by a doctor they likely had COVID-19 and 838 (13%;422 G0 and 416 G1) suspected that they have had COVID-19 Using algorithmically estimated cases based on symptoms, we estimate that the predicted prevalence of COVID-19 from mid-April to time of questionnaire completion was 3 1% Data from both COVID questionnaires will be complemented with linkage to health records and results of biological testing as they become available Data has been released as an update to the original dataset released in May 2020 It comprises: 1) a standard dataset containing all participant responses to both questionnaires with key sociodemographic factors and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study This data note describes the second questionnaire and the data obtained from it
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #807098
    Datenquelle COVID19

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  5. Artikel ; Online: Lack of association between DRD2 and OPRM1 genotypes and adiposity.

    Hardman, C A / Rogers, P J / Timpson, N J / Munafò, M R

    International journal of obesity (2005)

    2013  Band 38, Heft 5, Seite(n) 730–736

    Abstract: Background: Dopaminergic and opioid systems are both involved in food intake and appetite control. The dopamine D2 receptor gene (DRD2) and the μ-opioid receptor gene (OPRM1) therefore represent plausible candidates for association with obesity.: ... ...

    Abstract Background: Dopaminergic and opioid systems are both involved in food intake and appetite control. The dopamine D2 receptor gene (DRD2) and the μ-opioid receptor gene (OPRM1) therefore represent plausible candidates for association with obesity.
    Objective: Previous studies of these variants have yielded inconsistent findings, which are likely due to insufficient statistical power. The aim of the current study was to determine whether, in a large population-based sample, there are associations between adiposity and (i) the A1 (T) allele of the Taq1A polymorphism (rs1800497) in DRD2 and (ii) the G allele of the A118G polymorphism (rs1799971) in OPRM1.
    Study population: Annual clinic-based measures of body mass index (BMI) and waist circumference were taken from children (N=3720) at 5 measurement time points from ages 7 through to 11 years. BMI was also recorded in their mothers (N=2460) at comparable time points and at pre-pregnancy. All participants were genotyped. Our study was powered (at 80%) to detect per-allele effects on BMI of 0.21 kg m(-2).
    Results: Our results indicate a lack of association between DRD2 and OPRM1 genotypes and adiposity. Combining the data across mothers and children found per-allele effects on BMI of 0.02 kg m(-2) (95% confidence interval (CI): -0.17, 0.20), P=0.9 for rs1800497 and -0.08 kg m(-2) (95% CI: -0.29, 0.22), P=0.4 for rs1799971. As a positive control, we also examined the effect of FTO genotype over the same time period and confirmed the expected relationship between variability at this locus and higher adiposity.
    Conclusion: Our findings question existing evidence suggesting associations at DRD2 and OPRM1 loci and adiposity. They also highlight the caution required when employing candidate gene approaches to further our understanding of the neurobiology of eating and obesity.
    Mesh-Begriff(e) Adiposity/genetics ; Adult ; Alleles ; Appetite Regulation/genetics ; Body Mass Index ; Child ; Eating/genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetic Variation ; Genotype ; Humans ; Male ; Pregnancy ; Receptors, Dopamine D2 ; Receptors, Opioid, mu
    Chemische Substanzen DRD2 protein, human ; OPRM1 protein, human ; Receptors, Dopamine D2 ; Receptors, Opioid, mu
    Sprache Englisch
    Erscheinungsdatum 2013-08-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/ijo.2013.144
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Novel Genetic Determinants of Dental Maturation in Children.

    Grgic, O / Prijatelj, V / Dudakovic, A / Vucic, S / Dhamo, B / Trajanoska, K / Monnereau, C / Zrimsek, M / Gautvik, K M / Reppe, S / Shimizu, E / Haworth, S / Timpson, N J / Jaddoe, V W V / Jarvelin, M-R / Evans, D / Uitterlinden, A G / Ongkosuwito, E M / van Wijnen, A J /
    Medina-Gomez, C / Rivadeneira, F / Wolvius, E B

    Journal of dental research

    2022  Band 102, Heft 3, Seite(n) 349–356

    Abstract: Dental occlusion requires harmonious development of teeth, jaws, and other elements of the craniofacial complex, which are regulated by environmental and genetic factors. We performed the first genome-wide association study (GWAS) on dental development ( ... ...

    Abstract Dental occlusion requires harmonious development of teeth, jaws, and other elements of the craniofacial complex, which are regulated by environmental and genetic factors. We performed the first genome-wide association study (GWAS) on dental development (DD) using the Demirjian radiographic method. Radiographic assessments from participants of the Generation R Study (primary study population,
    Mesh-Begriff(e) Infant ; Humans ; Child ; Animals ; Mice ; Genome-Wide Association Study ; Tooth ; Alleles ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide/genetics ; Genetic Loci
    Sprache Englisch
    Erscheinungsdatum 2022-11-27
    Erscheinungsland United States
    Dokumenttyp Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345221132268
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  7. Artikel ; Online: Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts

    Kwong, A. S. F. / Pearson, R. M. / Adams, M. J. / Northstone, K. / Tilling, K. / Smith, D. / Fawns-Ritchie, C. / Bould, H. / Warne, N. / Zammit, S. / Gunnell, D. J. / Moran, P. / Micali, N. / Reichenberg, A. / Hickman, M. / Rai, D. / Haworth, S. / Campbell, A. / Altschul, D. /
    Flaig, R. / McIntosh, A. M. / Lawlor, D. A. / Porteous, D. / Timpson, N. J.

    Abstract: Background: The impact of COVID-19 on mental health is unclear. Evidence from longitudinal studies with pre pandemic data are needed to address (1) how mental health has changed from pre-pandemic levels to during the COVID-19 pandemic and (2), whether ... ...

    Abstract Background: The impact of COVID-19 on mental health is unclear. Evidence from longitudinal studies with pre pandemic data are needed to address (1) how mental health has changed from pre-pandemic levels to during the COVID-19 pandemic and (2), whether there are groups at greater risk of poorer mental health during the pandemic? Methods: We used data from COVID-19 surveys (completed through April/May 2020), nested within two large longitudinal population cohorts with harmonised measures of mental health: two generations of the Avon Longitudinal Study of Parents and Children (ALPSAC): the index generation ALSPAC-G1 (n= 2850, mean age 28) and the parents generation ALSPAC-G0 (n= 3720, mean age = 59) and Generation Scotland: Scottish Family Health Study (GS, (n= 4233, mean age = 59), both with validated pre-pandemic measures of mental health and baseline factors. To answer question 1, we used ALSPAC-G1, which has identical mental health measures before and during the pandemic. Question 2 was addressed using both studies, using pre-pandemic and COVID-19 specific factors to explore associations with depression and anxiety in COVID-19. Findings: In ALSPAC-G1 there was evidence that anxiety and lower wellbeing, but not depression, had increased in COVID-19 from pre-pandemic assessments. The percentage of individuals with probable anxiety disorder was almost double during COVID-19: 24% (95% CI 23%, 26%) compared to pre-pandemic levels (13%, 95% CI 12%, 14%), with clinically relevant effect sizes. In both ALSPAC and GS, depression and anxiety were greater in younger populations, women, those with pre-existing mental and physical health conditions, those living alone and in socio-economic adversity. We did not detect evidence for elevated risk in key workers or health care workers. Interpretation: These results suggest increases in anxiety and lower wellbeing that may be related to the COVID-19 pandemic and/or its management, particularly in young people. This research highlights that specific groups may be disproportionally at risk of elevated levels of depression and anxiety during COVID-19 and supports recent calls for increasing funds for mental health services. Funding: The UK Medical Research Council (MRC), the Wellcome Trust and University of Bristol.
    Schlagwörter covid19
    Verlag MedRxiv; WHO
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2020.06.16.20133116
    Datenquelle COVID19

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  8. Artikel: C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

    Timpson, N.J / Nordestgaard, B.G / Harbord, R.M / Zacho, J / Frayling, T.M / Tybjærg-Hansen, A / Smith, G. Davey

    International journal of obesity. 2011 Feb., v. 35, no. 2

    2011  

    Abstract: Context: The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is ... ...

    Abstract Context: The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed. Objective: Using reciprocal Mendelian randomization, we aim to assess the direction of causality in relationships between BMI and CRP and to demonstrate this as a promising analytical technique. Participants and methods: The study was based on a large, cross-sectional European study from Copenhagen, Denmark. Genetic associates of BMI (FTO(rs9939609)) and circulating CRP (CRP(rs3091244)) have been used to reexamine observational associations between them. Results: Observational analyses showed a strong, positive association between circulating CRP and BMI (change in BMI for a doubling in logCRP of 1.03 kg m−2 (95% confidence interval (95% CI): 1.00, 1.07), P<0.0001). Analysis using CRP(rs3091244) to re-estimate the causal effect of circulating CRP on BMI yielded null effects (change in BMI for a doubling in logCRP of −0.24 kg m−2 (95% CI: −0.58, 0.11), P=0.2). In contrast, analysis using FTO(rs9939609) to assess the causal effect of BMI on circulating CRP confirmed observational associations (ratio of geometric means of CRP per s.d. increase in BMI 1.41 (95% CI: 1.10, 1.80), P=0.006). Conclusions: Taken together, these data suggest that the observed association between circulating CRP and measured BMI is likely to be driven by BMI, with CRP being a marker of elevated adiposity. More generally, the method of reciprocal randomization has general applicability in determining the direction of causation within inter-correlated networks of metabolic components.
    Schlagwörter C-reactive protein ; adiposity ; body mass index ; confidence interval ; Denmark
    Sprache Englisch
    Umfang p. 300-308.
    Erscheinungsort Nature Publishing Group
    Dokumenttyp Artikel
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/ijo.2010.137
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel: Propagation of Embothrium coccineum, Carpenteria californica, and Fremontodendron 'California Glory'

    Timpson, N.J

    Combined proceedings - International Plant Propagators' Society. 1987. v. 36

    1987  

    Schlagwörter Carpentaria ; Malvaceae ; insect pests ; plant propagation
    Sprache Englisch
    Umfang p. 272-276.
    Dokumenttyp Artikel
    Anmerkung Great Britain and Ireland Region 19th Annual Meeting held July 21-26, 1986, Dublin, Ireland.
    ZDB-ID 406379-x
    ISSN 0538-9143
    ISSN 0538-9143
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization.

    Timpson, N J / Nordestgaard, B G / Harbord, R M / Zacho, J / Frayling, T M / Tybjærg-Hansen, A / Smith, G Davey

    International journal of obesity (2005)

    2010  Band 35, Heft 2, Seite(n) 300–308

    Abstract: Context: The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is ... ...

    Abstract Context: The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed.
    Objective: Using reciprocal Mendelian randomization, we aim to assess the direction of causality in relationships between BMI and CRP and to demonstrate this as a promising analytical technique.
    Participants and methods: The study was based on a large, cross-sectional European study from Copenhagen, Denmark. Genetic associates of BMI (FTO(rs9939609)) and circulating CRP (CRP(rs3091244)) have been used to reexamine observational associations between them.
    Results: Observational analyses showed a strong, positive association between circulating CRP and BMI (change in BMI for a doubling in log CRP of 1.03 kg m(-2) (95% confidence interval (95% CI): 1.00, 1.07), P<0.0001). Analysis using CRP(rs3091244) to re-estimate the causal effect of circulating CRP on BMI yielded null effects (change in BMI for a doubling in log CRP of -0.24 kg m(-2) (95% CI: -0.58, 0.11), P=0.2). In contrast, analysis using FTO(rs9939609) to assess the causal effect of BMI on circulating CRP confirmed observational associations (ratio of geometric means of CRP per s.d. increase in BMI 1.41 (95% CI: 1.10, 1.80), P=0.006).
    Conclusions: Taken together, these data suggest that the observed association between circulating CRP and measured BMI is likely to be driven by BMI, with CRP being a marker of elevated adiposity. More generally, the method of reciprocal randomization has general applicability in determining the direction of causation within inter-correlated networks of metabolic components.
    Mesh-Begriff(e) Adiposity/genetics ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/metabolism ; Body Mass Index ; C-Reactive Protein/genetics ; C-Reactive Protein/metabolism ; Cross-Sectional Studies ; Denmark ; Female ; Genetic Variation/genetics ; Genotype ; Humans ; Male ; Mendelian Randomization Analysis/methods ; Middle Aged ; Obesity/genetics ; Obesity/metabolism ; Sex Factors ; Young Adult
    Chemische Substanzen Biomarkers ; C-Reactive Protein (9007-41-4)
    Sprache Englisch
    Erscheinungsdatum 2010-08-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/ijo.2010.137
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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