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  1. Article ; Online: Galactosylsphingamides

    Joren Guillaume / Jing Wang / Jonas Janssens / Soumya G. Remesh / Martijn D. P. Risseeuw / Tine Decruy / Mathy Froeyen / Dirk Elewaut / Dirk M. Zajonc / Serge Van Calenbergh

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    new α-GalCer analogues to probe the F’-pocket of CD1d

    2017  Volume 18

    Abstract: Abstract Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we present a ... ...

    Abstract Abstract Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we present a synthesis that allows swift modification of the phytosphingosine side chain by amidation of an advanced methyl ester precursor. The resulting KRN7000 derivatives, termed α-galactosylsphingamides, were evaluated for their capacity to stimulate iNKT-cells. While introduction of the amide-motif in the phytosphingosine chain is tolerated for CD1d binding and TCR recognition, the studied α-galactosylsphingamides showed compromised antigenic properties.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

    Koen Venken / Peggy Jacques / Céline Mortier / Mark E. Labadia / Tine Decruy / Julie Coudenys / Kathleen Hoyt / Anita L. Wayne / Robert Hughes / Michael Turner / Sofie Van Gassen / Liesbet Martens / Dustin Smith / Christian Harcken / Joseph Wahle / Chao-Ting Wang / Eveline Verheugen / Nadia Schryvers / Gaëlle Varkas /
    Heleen Cypers / Ruth Wittoek / Yves Piette / Lieve Gyselbrecht / Serge Van Calenbergh / Filip Van den Bosch / Yvan Saeys / Gerald Nabozny / Dirk Elewaut

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have ... ...

    Abstract The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

    Koen Venken / Peggy Jacques / Céline Mortier / Mark E. Labadia / Tine Decruy / Julie Coudenys / Kathleen Hoyt / Anita L. Wayne / Robert Hughes / Michael Turner / Sofie Van Gassen / Liesbet Martens / Dustin Smith / Christian Harcken / Joseph Wahle / Chao-Ting Wang / Eveline Verheugen / Nadia Schryvers / Gaëlle Varkas /
    Heleen Cypers / Ruth Wittoek / Yves Piette / Lieve Gyselbrecht / Serge Van Calenbergh / Filip Van den Bosch / Yvan Saeys / Gerald Nabozny / Dirk Elewaut

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have ... ...

    Abstract The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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