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Article ; Online: New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents

Kuo-Ting Chen / Yann Seimbille

International Journal of Molecular Sciences, Vol 23, Iss 6125, p

2022 Volume 6125

Abstract: Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical ... ...

Abstract	Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical applications. Nuclear imaging is a powerful tool for the non-invasive diagnosis of primary and metastatic CAIX-positive tumors and for the assessment of responses to antineoplastic treatment. Intraoperative optical fluorescence imaging provides improved visualization for surgeons to increase the discrimination of tumor lesions, allowing for safer surgical treatment. Over the past decades, many CAIX-targeted molecular imaging probes, based on monoclonal antibodies, antibody fragments, peptides, and small molecules, have been reported. In this review, we outline the recent development of CAIX-targeted probes for single-photon emission computerized tomography (SPECT), positron emission tomography (PET), and near-infrared fluorescence imaging (NIRF), and we discuss issues yet to be addressed.
Keywords	carbonic anhydrase IX ; cancer ; imaging agents ; PET ; SPECT ; fluorescence imaging ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mouse tail skin wholemount staining and intravital calcium imaging

Yuhua Xie / Ting Chen

STAR Protocols, Vol 3, Iss 1, Pp 101235- (2022)

2022

Abstract: Summary: Mouse tail skin offers multiple benefits for skin research. Here, we present a protocol detailing high resolution tail skin whole mount staining and in vivo calcium imaging of hair follicle stem cells (HFSCs) using Sox9creERT2, GCaMP6s, and Ai14 ...

Abstract	Summary: Mouse tail skin offers multiple benefits for skin research. Here, we present a protocol detailing high resolution tail skin whole mount staining and in vivo calcium imaging of hair follicle stem cells (HFSCs) using Sox9creERT2, GCaMP6s, and Ai14 mice. This approach enables the study of hair follicles and stem cells in different physiological and pathological conditions. The applications of the protocol include visualization of calcium signaling in other cell types with Cre/CreER lines or analyzing other cellular features with different reporter lines.For complete details on the use and execution of this protocol, please refer to Xie et al. (2022).
Keywords	Developmental biology ; Microscopy ; Model Organisms ; Stem Cells ; Science (General) ; Q1-390
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of the CD16low CD56low CD38pos Natural Killer Cell as a Key Subset in Patients with Multiple Myeloma

Ting Chen / Zhenghong Yu

Iranian Journal of Immunology, Vol 19, Iss 4, Pp 358-

2022 Volume 368

Abstract: Background: Natural killer (NK) cells are classified as innate immune cells which can directly recognize and kill tumor cells without antigen sensitization. NK cell-based adoptive immunotherapy for blood malignancies has attracted more attention in ... ...

Abstract	Background: Natural killer (NK) cells are classified as innate immune cells which can directly recognize and kill tumor cells without antigen sensitization. NK cell-based adoptive immunotherapy for blood malignancies has attracted more attention in recent years. Objective: To analyze different NK cell subsets in the peripheral blood and bone marrow (BM) of patients with multiple myeloma (MM). Methods: Using flow cytometry we analyzed: (i) the distribution of distinct NK cell subpopulations (i.e. CD16low CD56low, CD16pos CD56high, CD16neg CD56high, CD16high CD56low, CD16neg CD56low, CD16low CD56low CD38pos) in the BM from MM patients at distinct disease stages. (ii) the expression of NKG2D, DNAM-1 and NKp30, and (iii) the expression of CD107a in CD16low CD56low CD38pos and CD16low CD56low CD38neg NK cells subsets. Results: CD16low CD56low CD38pos was the dominant subset in BM from patients with MM at the CR stage with a decreased expression of NKp30. CD16low CD56low CD38pos subset showed a higher proportion of CD107a expression compared to CD16low CD56low CD38neg cells. In vitro experiments indicated that the CD16low CD56low CD38pos NK cell subset possesses more cytotoxicity than CD16low CD56low CD38neg NK cells. Conclusion: Our data suggest that CD16low CD56low CD38pos NK cells may reflect as an effector population with the potential therapeutic target in patients with MM. This group of cells may be useful for adoptive immunotherapy in MM in the future.
Keywords	cell immunology ; multiple myeloma ; natural killer (nk) cells ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Response to letter to the editor “Air-containing necrosis as the imaging predictor for imminent carotid blowout in patients with head and neck cancer”

Bo-Ching Lee / Chao-Ting Chen

Journal of the Formosan Medical Association, Vol 122, Iss 4, Pp 360- (2023)

2023

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High sensitivity temperature sensor based on polymer-liquid modified anti-resonant reflecting guidance in silica capillary

Wei Cheng / Shuhui Liu / Panting Niu / Ting Chen

Heliyon, Vol 9, Iss 2, Pp e13358- (2023)

2023

Abstract: A high sensitivity temperature sensor based on polymer and liquid modified anti-resonant reflection principle is proposed. The sensor is made of a section of liquid-filled and UV-curable adhesive coated silica capillary, sandwiched between single mode ... ...

Abstract	A high sensitivity temperature sensor based on polymer and liquid modified anti-resonant reflection principle is proposed. The sensor is made of a section of liquid-filled and UV-curable adhesive coated silica capillary, sandwiched between single mode fibers. The guiding mechanism of the waveguide is affected by both the liquid inside the hollow core, and the adhesive outside the silica cladding. The location of the resonant dips are influenced by the refractive index (RI) of the liquid, while the fringe visibility (resonant strength) is tuned by the both the liquid and the adhesive. By carefully selecting the refractive index value of the infiltrated liquid, and controlling the curing time of the adhesive, sharp resonant dips can be obtained. The sensor exhibits very high temperature sensitivity against temperature. A high sensitivity of 3.369 nm/°C is achieved with an infiltration index of 1.39, in the temperature range from 25 °C to 60 °C. The detection limit of the proposed sensors are 0.04 °C. Moreover, the temperature sensitivity of the sensor is found to be decreasing with the order of resonance. The sensor is easy to fabricate and cost effective, and is applicable in both dry and wet environments, which can find wide applications in biochemical and pharmaceutical industry.
Keywords	Anti-resonant reflecting guidance ; UV-Curable adhesive ; Temperature sensor ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	535
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Improvement of brain–computer interface in motor imagery training through the designing of a dynamic experiment and FBCSP

Chun-Ling Lin / Liang-Ting Chen

Heliyon, Vol 9, Iss 3, Pp e13745- (2023)

2023

Abstract: Motor imagery (MI) can produce a specific brain pattern when the subject imagines performing a particular action without any actual body movements. According to related previous research, the improvement of the training of MI brainwaves can be adopted by ...

Abstract	Motor imagery (MI) can produce a specific brain pattern when the subject imagines performing a particular action without any actual body movements. According to related previous research, the improvement of the training of MI brainwaves can be adopted by feedback methods in which the analysis of brainwave characteristics is very important. The aim of this study was to improve the subject's MI and the accuracy of classification. In order to ameliorate the accuracy of the MI of the left and right hand, the present study designed static and dynamic visual stimuli in experiments so as to evaluate which one can improve subjects' imagination training. Additionally, the filter bank common spatial pattern (FBCSP) method was used to divide the frequency band range of the brainwaves into multiple segments, following which linear discriminant analysis (LDA) was adopted for classification. The results revealed that the averaged false positive rate (FPR) under FBCSP–LDA in the dynamic MI experiment was the lowest FPR (23.76%). As such, this study suggested that a combination of the dynamic MI experiment and the FBCSP–LDA method improved the overall prediction error rate and ameliorated the performance of the MI brain–computer interface.
Keywords	Motor imagery ; Filter bank common spatial pattern (FBCSP) ; Linear discriminant analysis (LDA) ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	796
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Divergence time of mites of the family Laelapidae based on mitochondrial barcoding region.

Huijuan Yang / Ting Chen / Wenge Dong

PLoS ONE, Vol 18, Iss 2, p e

2023 Volume 0279598

Abstract: Using the mitochondrial barcoding region to correlate research with 58 species in 19 genera of the family Laelapidae with the aim of determining the origin, phylogenetic relationships, and biogeographic historical distribution characteristics of mites in ...

Abstract	Using the mitochondrial barcoding region to correlate research with 58 species in 19 genera of the family Laelapidae with the aim of determining the origin, phylogenetic relationships, and biogeographic historical distribution characteristics of mites in the family Laelapidae. Phylogenetic trees were obtained using Bayesian inference (BI) and Maximum-likelihood (ML) methods, based on three fossil records calibrated as molecular clock nodes, to estimate the divergence time of mites in the family Laelapidae as well as to apply Dispersal-Extinction-Cladogenesis (DEC) analyses to obtain biogeographic history inferences. The result showed species of the genera Hyperlaelaps and Haemolaelaps and some species of the genus Androlaelaps in the family Laelapidae were divided into clades of the genus Laelaps in both the BI and ML trees. Divergence time estimates and biogeographic history analysis revealed that the family Laelapidae likely diverged from other taxa during the Middle Jurassic (ca. 156.73 Mya), with Asia considered the most likely ancestral region for the family Laelapidae. Species of various genera began to undergo massive diversification events during the Cenozoic Tertiary. The results suggest that some genera in the family Laelapidae need to be re-defined or new genera need to be established; the Late Cretaceous to Late Neogene warm period would have promoted the divergence and expansion of species in the family Laelapidae. The divergence and dispersal of the family Laelapidae species is most likely a joint response to the continued northward drift of the Indian plate away from the Gondwana paleo-continent and gradually closer to Asia during the Late Cretaceous and the geological activity of the Tibetan Plateau during the Cenozoic Tertiary. The results strengthen our understanding of the origin and evolution of species in the family Laelapidae.
Keywords	Medicine ; R ; Science ; Q
Subject code	590
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Environmental self-identity, self-efficacy, and the emergence of green opinion leaders

Wei-Ting Chen / Ming-Huei Hsieh

Heliyon, Vol 9, Iss 6, Pp e17351- (2023)

An exploratory study

2023

Abstract: Environmental issues have gradually become one of the most challenging global issues. In this Information Age where individualism is on the rise and self-media is prevalent, if we can use the power of individuals and make ordinary people become self- ... ...

Abstract	Environmental issues have gradually become one of the most challenging global issues. In this Information Age where individualism is on the rise and self-media is prevalent, if we can use the power of individuals and make ordinary people become self-driven Green ambassadors to influence everyone around them, their power will be incomparable. This bottom-up force may even shake the entire society. However, how these “Green Opinion Leaders (GOLs)” are created is still an unresolved question. If we can understand the formation process of these GOLs, we may have the opportunity to generate more GOLs in the future. Therefore, this study applied participant observation methods to penetrate three local mountain hiking societies in Taiwan and conduct long-term tracking and unstructured in-depth interviews with five mountain hikers to understand why they eventually became Green Opinion Leaders (GOLs). The results show that “environmental self-identity” and the related “self-efficacies” of social and marketing abilities are the key elements making ordinary mountain hikers become GOLs. The four essential elements that form an environmental self-identity include (1) love of nature, (2) environmental consciousness, (3) environmental self-efficacy, and (4) nature self-identity. Finally, the research summarizes a series of efficient prescriptions for encouraging ordinary people to become Green Opinion Leaders (GOLs).
Keywords	Social marketing ; Opinion leaders ; Self-identity ; Environmental self-identity ; Self-efficacy ; Green behavior ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	320 ; 910
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influenza vaccine hesitancy and influencing factors among university students in China

Haiyan Zou / Yan Huang / Ting Chen / Luying Zhang

Annals of Medicine, Vol 55, Iss

a multicenter cross-sectional survey

2023 Volume 1

Abstract: AbstractAim Highly mutable and contagious influenza poses a serious health threat to university students and their close contacts. Although annual influenza vaccination is an effective way to prevent influenza, influenza vaccination rates among Chinese ... ...

Abstract	AbstractAim Highly mutable and contagious influenza poses a serious health threat to university students and their close contacts. Although annual influenza vaccination is an effective way to prevent influenza, influenza vaccination rates among Chinese university students are still low due to vaccine hesitancy. This study investigated Chinese university students’ hesitancy to receive influenza vaccine and its influencing factors during the COVID-19 pandemics based on WHO’s vaccine hesitancy matrix.Methods A multicenter cross-sectional study of university students in four cities across China was conducted via a web-based questionnaire in June 2022. Binary logistic regression was adopted to determine the factors around contextual influences, individual and group influences, and vaccines/vaccination specific issues. The reliability and validity of the questionnaire were good, with a Kronbach alpha coefficient of 0.892 and a KMO coefficient of 0.957.Results Of the 2261 Chinese university students surveyed, 44.7% had influenza vaccine hesitancy. Binary logistic regression showed that students considering high severity (OR = 0.946) or probability (OR = 0.942) of getting influenza, trusting vaccine-related advice from medical personnel (OR = 0.495) had lower odds of hesitancy. The odds of influenza vaccine hesitancy were higher if the students believed that vaccination was not necessary (OR = 4.040), had not been recommended by people around (OR = 1.476) and had no previous vaccinations or appointments (OR = 2.685).Conclusions Medical staff are suggested to provide health education, improve doctor-patient communication and recommend vaccinations to university students to increase their risk perception and willingness to get an influenza vaccination. Collective vaccination strategies can be implemented to reduce the vaccine hesitancy for students.
Keywords	Influenza vaccine ; vaccine hesitancy ; hesitancy matrix ; influencing factors ; university students ; Medicine ; R
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of a novel hand-held retractor-assisted transforaminal lumbar interbody fusion by the wiltse approach and posterior TLIF: a one-year prospective controlled study.

Shen, Xing / Li, Fu Tao / Quan Cheng, Yong / Zheng, Ming Hui / Yao, Xin Qiang / Wang, Hai Ming / Ting Chen, Jian / Jiang, Hui

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 142

Abstract: Background: This study aims to compare the clinical outcomes and safety of a novel hand-held retractor system-assisted Wiltse TLIF with that P-TLIF and assess whether this hand-held retractor system assisted Wiltse TLIF can yield less paraspinal muscle ... ...

Abstract	Background: This study aims to compare the clinical outcomes and safety of a novel hand-held retractor system-assisted Wiltse TLIF with that P-TLIF and assess whether this hand-held retractor system assisted Wiltse TLIF can yield less paraspinal muscle injury. Methods: 56 patients (P-TLIF: 26, Wiltse TLIF: 30) were included in this one year prospective controlled study. The operation time, intraoperative blood loss, postoperative drainage, mobilization time, and discharge time were recorded. The clinical outcomes were evaluated by ODI, VAS, JOA, and SF-36 scores (7 days, 3, 6, and 12 months after surgery). Paraspinal muscle injury was assessed by postoperative MRI (6 months after surgery). CK and C-reaction protein were measured pre and postoperatively, and CT or X-ray (one year postoperatively) was used to assess bony union/non-union. Results: The Wiltse (study) group was associated with significantly less estimated blood loss (79.67 ± 28.59 ml vs 192.31 ± 59.48 ml, P = 0.000), postoperative drainage (43.33 ± 27.89 ml vs 285.57 ± 123.05 ml, P = 0.000), and shorter mobilization (4.1 ± 1.2 d vs. 3.0 ± 0.9 d, P < 0.05) and discharge times (7.7 ± 1.9 d vs. 6.1 ± 1.2 d, P = 0.002) than the P-TLIF (control) group. Serum CK activity at 24 h postoperatively in the study group was significantly lower than in the control group (384.10 ± 141.99 U/L vs 532.76 ± 225.76 U/L, P = 0.018). At 7 days after surgery, VAS (2.3 ± 0.6 vs 3.2 ± 0.7, P = 0.000)and ODI scores (43.9 ± 11.9 vs 55.2 ± 12.9, P = 0.001) were lower, while the JOA scores (18.4 ± 3.4 vs 16.3 ± 4.2, P = 0.041) was higher in the control group than in the study group. Results observed at 3 months of follow-up were consistent with those at 7 days. After six months postoperatively, paraspinal muscle degeneration in the control group was more significant than in the study group (P = 0.008). Conclusion: Our study showed that this novel hand-held retractor system assisted Wiltse approach TLIF can significantly reduce paraspinal muscle injury, postoperative drainage, and intraoperative blood loss, mobilization and discharge time, as well as yield better short-term outcomes compared to P-TLIF. Trial registration: 25/09/2023 NCT06052579.
MeSH term(s)	Humans ; Treatment Outcome ; Prospective Studies ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Spinal Fusion/adverse effects ; Spinal Fusion/methods ; Minimally Invasive Surgical Procedures/methods ; Blood Loss, Surgical ; Retrospective Studies
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07248-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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