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Article ; Online: The functions of polycomb group proteins in T cells

Ting Li

Cell Insight, Vol 1, Iss 5, Pp 100048- (2022)

2022

Abstract: T cells are involved in many aspects of adaptive immunity, including autoimmunity, anti-tumor activity, and responses to allergenic substances and pathogens. T cells undergo comprehensive epigenome remodeling in response to signals. Polycomb group (PcG) ... ...

Abstract	T cells are involved in many aspects of adaptive immunity, including autoimmunity, anti-tumor activity, and responses to allergenic substances and pathogens. T cells undergo comprehensive epigenome remodeling in response to signals. Polycomb group (PcG) proteins are a well-studied complex of chromatin regulators, conserved in animals, and function in various biological processes. PcG proteins are divided into two distinct complexes: PRC1 (Polycomb repressive complex 1) and PRC2. PcG is correlated with the regulation of T cell development, phenotypic transformation, and function. In contrast, PcG dysregulation is correlated with pathogenesis of immune-mediated diseases and compromised anti-tumor responses. This review discusses recent findings on the involvement of PcG proteins in T cell maturation, differentiation, and activation. In addition, we explore implications in the development of the immune system diseases and cancer immunity, which offers promising targets for various treatment protocols.
Keywords	Polycomb group ; T cell ; Epigenetics ; Biology (General) ; QH301-705.5 ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protective effect of astragaloside IV on cardiac hypertrophy in rats and its mechanism

Ting Li

Journal of Hainan Medical University, Vol 27, Iss 18, Pp 1-

2021 Volume 6

Abstract: Objective: To investigate the effect of astragaloside IV on cardiac hypertrophy and its regulation on autophagy. Methods: Fifty male Sprague-Dawley rats were randomly divided into sham operation group and abdominal aortic coarctation group(AAC group) ... ...

Abstract	Objective: To investigate the effect of astragaloside IV on cardiac hypertrophy and its regulation on autophagy. Methods: Fifty male Sprague-Dawley rats were randomly divided into sham operation group and abdominal aortic coarctation group(AAC group).There were 10 rats in sham operation group and 40 rats in the AAC group. One week after the operation, there were 32 rats in AAC group,10 rats in sham group. AAC group was randomly divided into model group,low-dose astragaloside group, high-dose astragaloside group and rapamycin group,8 rats in each group.Rapamycin group was a positive autophagy contrast agent group.They were given the corresponding solvents once a day by gavage for six weeks. At the end of study,three rats were randomly selected from each group, left ventricular mass index(LVW/BW) ,cardiac mass index(HW/BW) and the content of hydroxyproline were measured.HE staining,masson staining and sirius red staining were used to observe the morphological changes of myocardium.The expression of LC3II,LC3I,Beclin1,AMPK and mTOR were detected by western blot. Results: Compared with the sham operation group,AAC group showed hypertrophy,LVW/BW,HW/BW,HYP and p-mTOR/mTOR were significantly increased(P<0.05),p-AMPK/AMPK,LC3II/LC3I,Beclin1 were significantly decreased(P<0.05).Compared with the model group, the low-dose astragaloside IV group showed the hypertrophy of cardiomyocytes was relatively light, LVW/BW and HW/BW were significantly decreased (P<0.05), there was no significant difference in HYP and p-mTOR/ mTOR(P>0.05), LC3II/LC3I,Beclin1 and p-AMPK/AMPK were significantly increased (P<0.05).Compared with the model group, high-dose astragaloside IV group and rapamycin group showed reduced myocardial hypertrophy, LVW/BW,HW/BW,HYP and p-mTOR/ mTOR were significantly decreased (P<0.05),LC3II/LC3I, Beclin1 and p-AMPK/AMPK were significantly increased(P<0.05). Compared with the low-dose astragaloside group, the high-dose astragaloside group showed reduced myocardial hypertrophy,there were ...
Keywords	astragaloside iv ; cardiac hypertrophy ; autophagy ; abdominal aortic coarctation ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Subcutaneous Emphysema Following Facial Bone Fracture Aggravated by Nose Blowing.

Hung, Ting-Li / Chen, Hsin-Chien

Ear, nose, & throat journal

2024 , Page(s) 1455613241233749

Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613241233749
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Article ; Online: Is farmland financial innovation narrowing the urban-rural income gap? A cross-regional study of China

Ting Li / Jing-Ya Li

PLoS ONE, Vol 17, Iss

2022 Volume 6

Abstract: Over the past four decades, China’s economy has experienced tremendous economic growth but also a widening urban-rural income gap. Given the dilemma of the urban-rural income gap in China explained by neoclassical equilibrium theory, this paper attempts ... ...

Abstract	Over the past four decades, China’s economy has experienced tremendous economic growth but also a widening urban-rural income gap. Given the dilemma of the urban-rural income gap in China explained by neoclassical equilibrium theory, this paper attempts to provide a new theoretical explanation for the large-income gap between urban and rural areas in China. We select data from 30 provinces(cities) in China over the period from 2006 to 2017 as a sample to investigate whether and how the degree of farmland financial innovation narrows the urban-rural income gap. The results show that the coefficient for farmland financial innovation is significantly negative at the 1% level, signifying that financial innovation can narrow the urban-rural income gap in China. The mediation effect test provides evidence that farmland financial innovation narrows the urban-rural income gap by promoting the permanent migration of the labor force and upgrading the industrial structure. Our results indicate that the government should promote various forms of farmland financial innovation, establish rural property rights transaction system and free farmers from deep farmer-land attachment to realize permanent labor migration.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Message framing to promote solar panels

Dominik Bär / Stefan Feuerriegel / Ting Li / Markus Weinmann

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract Green technologies, such as solar panels, foster the use of clean energy, yet often involve large-scale investments. Hence, adoption by retail consumers has been a key barrier. Here, we show that message framing can significantly increase ... ...

Abstract	Abstract Green technologies, such as solar panels, foster the use of clean energy, yet often involve large-scale investments. Hence, adoption by retail consumers has been a key barrier. Here, we show that message framing can significantly increase customers’ serious commitment to adopting solar panels by providing empirical evidence in the field from a large-scale randomized controlled trial with a nationwide online retailer in the Netherlands (N = 26,873 participants). We design four messages aimed at promoting the purchase behavior of solar panel installations. Our messages present outcomes for oneself or for the environment and highlight cost savings versus earnings (for oneself) or reducing emissions versus generating green electricity (for the environment). Across all messages, we observe a higher rate of customers committing to solar panels compared to the baseline. However, the framing in terms of financial savings for oneself was by far the most effective, resulting in a 40% higher level of commitment than the baseline and 30% higher than the average of the other three messages, which were not significantly different in effect from each other. Our results show that message framing is cost-efficient and scalable among retail consumers to promote large-scale investments in green technologies and thus clean energy.
Keywords	Science ; Q
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unraveling implicit human behavioral effects on dynamic characteristics of Covid-19 daily infection rates in Taiwan.

Chen, Ting-Li / Chou, Elizabeth P / Chen, Min-Yi / Hsieh, Fushing

PloS one

2024 Volume 19, Issue 2, Page(s) e0298049

Abstract: We investigate the dynamic characteristics of Covid-19 daily infection rates in Taiwan during its initial surge period, focusing on 79 districts within the seven largest cities. By employing computational techniques, we extract 18 features from each ... ...

Abstract	We investigate the dynamic characteristics of Covid-19 daily infection rates in Taiwan during its initial surge period, focusing on 79 districts within the seven largest cities. By employing computational techniques, we extract 18 features from each district-specific curve, transforming unstructured data into structured data. Our analysis reveals distinct patterns of asymmetric growth and decline among the curves. Utilizing theoretical information measurements such as conditional entropy and mutual information, we identify major factors of order-1 and order-2 that influence the peak value and curvature at the peak of the curves, crucial features characterizing the infection rates. Additionally, we examine the impact of geographic and socioeconomic factors on the curves by encoding each of the 79 districts with two binary characteristics: North-vs-South and Urban-vs-Suburban. Furthermore, leveraging this data-driven understanding at the district level, we explore the fine-scale behavioral effects on disease spread by examining the similarity among 96 age-group-specific curves within urban districts of Taipei and suburban districts of New Taipei City, which collectively represent a substantial portion of the nation's population. Our findings highlight the implicit influence of human behaviors related to living, traveling, and working on the dynamics of Covid-19 transmission in Taiwan.
MeSH term(s)	Humans ; Taiwan/epidemiology ; COVID-19/epidemiology ; Socioeconomic Factors ; Cities/epidemiology ; Employment
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298049
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Application of a feedforward control-based intervention for preventing hypothermia in trauma patients in a pre-hospital emergency setting.

Xu, Ting-Li / Jiang, Yan-Lin / Zhou, Gui-Xiu / Wu, Chang-Hua

American journal of translational research

2024 Volume 16, Issue 4, Page(s) 1155–1164

Abstract: Objective: To investigate the efficacy of a feedforward control-based intervention strategy for preventing hypothermia among trauma patients during pre-hospital emergency care.: Methods: We conducted a retrospective analysis comparing trauma patients ...

Abstract	Objective: To investigate the efficacy of a feedforward control-based intervention strategy for preventing hypothermia among trauma patients during pre-hospital emergency care. Methods: We conducted a retrospective analysis comparing trauma patients treated before and after implementing the intervention, with 40 cases in each group. All patients received emergency care from the Fuzhou Emergency Center on the scene. Multivariate analysis was used to explore the risk factors for hypothermia. The effective rate, incidence of adverse reactions, quality of body temperature management, medical staff's knowledge, attitudes, and behaviors regarding mild hypothermia prevention, coagulation function, treatment time at various stages, prognosis score, and treatment situation were compared between the two groups. Results: The adverse reactions, intervention methods, and degree of cognitive improvement were influencing factors for hypothermia. The effective rate (92.50%) in the feedforward control group was higher than that in the non-feedforward control group (65.00%), with a lower incidence of adverse reactions (2.50%). The temperature management quality score of the feedforward control group (6.23±0.62) was higher. The feedforward control group achieved a higher quality score for temperature management (6.23±0.62) and exhibited a greater understanding of hypothermia prevention among trauma patients (P<0.05). Compared to the non-feedforward control group, the feedforward control group showed improved coagulation function, better performance in treatment time at each node, and higher prognosis scores. Conclusion: The intervention model based on feedforward control can effectively improve the standard of pre-hospital emergency care and prevent the incidence of hypothermia in trauma patients.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
DOI	10.62347/IRMG4893
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An Object-Oriented Approach of Keyword Querying over Fuzzy XML

Ting Li

Journal of Computing and Information Technology, Vol 24, Iss 3, Pp 293-

2016 Volume 309

Abstract: As the fuzzy data management has become one of the main research topics and directions, the question of how to obtain the useful information by means of keyword query from fuzzy XML documents is becoming a subject of an increasing needed investigation. ... ...

Abstract	As the fuzzy data management has become one of the main research topics and directions, the question of how to obtain the useful information by means of keyword query from fuzzy XML documents is becoming a subject of an increasing needed investigation. Considering the keyword query methods on crisp XML documents, smallest lowest common ancestor (SLCA) semantics is one of the most widely accepted semantics. When users propose the keyword query on fuzzy XML documents with the SLCA semantics, the query results are always incomplate, with low precision, and with no possibilities values returned. Most of keyword query semantics on XML documents only consider query results matching all keywords, yet users may also be interested in the query results matching partial keywords. To overcome these limitations, in this paper, we investigate how to obtain more comprehensive and meaningful results of keyword querying on fuzzy XML documents. We propose a semantics of object-oriented keyword querying on fuzzy XML documents. First, we introduce the concept of "object tree", analyze different types of matching result object trees and find the "minimum result object trees" which contain all keywords and "result object trees" which contain partial keywords. Then an object-oriented keyword query algorithm ROstack is proposed to obtain the root nodes of these matching result object trees, together with their possibilities. At last, experiments are conducted to verify the effectiveness and efficiency of our proposed algorithm.
Keywords	fuzzy XML ; keyword ; query ; object-oriented ; possibility ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	005 ; 006
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	University of Zagreb Faculty of Electrical Engineering and Computing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of LEEP on the cervical microcirculation and HPV in patients with moderate and severe cervical erosion

Ting Li

Journal of Hainan Medical University, Vol 22, Iss 6, Pp 57-

2016 Volume 59

Abstract: Objective: To explore the effect of LEEP on the cervical microcirculation and HPV in patients with moderate and severe cervical erosion. Methods: A total of 100 patients with moderate and severe cervical erosion who were admitted in our hospital from ... ...

Abstract	Objective: To explore the effect of LEEP on the cervical microcirculation and HPV in patients with moderate and severe cervical erosion. Methods: A total of 100 patients with moderate and severe cervical erosion who were admitted in our hospital from September, 2014 to September, 2015 were included in the study and randomized into the observation group and the control group. The patients in the control group were treated with microwave therapy apparatus. The patients in the observation group were given LEEP. The patients in the two groups were given one treatment and examined on the 3rd week. The cervical local microcirculation, cervical color, and HPV expression before and after treatment were observed. Results: After 3-week treatment, the local blood perfusion, and the diameters of blood capillaries and microvessels in the observation group were significantly greater than those in the control group. After treatment, the occurrence rate of light red is significantly greater than that in the control group, while the occurrence rate of dark red and cyanosis was significantly less than that in the control group. After treatment, the expressions of HPV-DMA16 and HPV-DNA18 in the observation group were significantly lower than those in the control group. Conclusions: LEEP in the treatment of patients with moderate and severe cervical erosion can effectively improve the cervical local microcirculation, reduce HPV replication, is beneficial for the recovery, and can inhibit a further progression of the disease.
Keywords	Moderate and severe cervical erosion ; Cervical microcirculation ; HPV ; Medicine ; R
Subject code	630
Language	English
Publishing date	2016-03-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Disease-Associated Streptococcus pneumoniae Genetic Variation

Shimin Yang / Jianyu Chen / Jinjian Fu / Jiayin Huang / Ting Li / Zhenjiang Yao / Xiaohua Ye

Emerging Infectious Diseases, Vol 30, Iss 1, Pp 39-

2024 Volume 49

Abstract: Streptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially. To determine the ... ...

Abstract	Streptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially. To determine the evolutionary mechanisms of opportunistic pathogenicity, we conducted a genomic surveillance study in China. We collected 783 S. pneumoniae isolates from infected and asymptomatic children. By using a 2-stage genomewide association study process, we compared genomic differences between infection and carriage isolates to address genomic variation associated with pathogenicity. We identified 8 consensus k-mers associated with adherence, antimicrobial resistance, and immune modulation, which were unevenly distributed in the infection isolates. Classification accuracy of the best k-mer predictor for S. pneumoniae infection was good, giving a simple target for predicting pathogenic isolates. Our findings suggest that S. pneumoniae pathogenicity is complex and multifactorial, and we provide genetic evidence for precise targeted interventions.
Keywords	Streptococcus pneumoniae ; genome-wide association study ; bacterial genomes ; pathogenicity ; bacteria ; China ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Subject code	572
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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