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Article ; Online: Comprehensive Chemical Characterization of Qingkailing Capsules by Ultra-High-Performance Liquid Chromatography Combined with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Ting Liu / Shu Lin

Separations, Vol 10, Iss 12, p

2023 Volume 588

Abstract: Qingkailing capsules are a classic traditional Chinese medicine prescription with remarkable clinical effects for the treatment of fevers. However, the chemical components of Qingkailing capsules are still unclear. To obtain and characterize the chemical ...

Abstract	Qingkailing capsules are a classic traditional Chinese medicine prescription with remarkable clinical effects for the treatment of fevers. However, the chemical components of Qingkailing capsules are still unclear. To obtain and characterize the chemical profile of Qingkailing capsules, the present study applied a rapid, accurate, and sensitive method using ultra-high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) to perform a comprehensive chemical characterization of Qingkailing capsules. Leveraging the high separation speed and good separation of UHPLC, the accurate mass data (within 5 ppm) and fragment ions, a total of 276 compounds, including 67 flavonoids and their glycosides, 52 organic acids, 75 terpenoids, 23 steroids, 22 phenylpropanoids, and 37 other compounds, were unambiguously or tentatively identified. This comprehensive analysis of the chemical components of Qingkailing capsules contributes to the quality evaluation and provides a scientific and reasonable basis for further study of prototype components and metabolites in vivo and pharmacological research, ultimately facilitating the advancement of Qingkailing capsules for further development and the therapeutic use of Qingkailing capsules in clinical applications.
Keywords	Qingkailing capsules ; UHPLC-FT-ICR-MS ; chemical characterization ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Stock Market Opening and Environment Protecting Information with Computational Technologies

Juan Zhang / Ting Liu

Security and Communication Networks, Vol

Evidence from China

2022 Volume 2022

Abstract: Stock market plays a leading and crucial role in the market mechanism, which connects the savers and investors. So far, there is no uniform regulation on the disclosure requirement of environmental protection information in China. But companies are ... ...

Abstract	Stock market plays a leading and crucial role in the market mechanism, which connects the savers and investors. So far, there is no uniform regulation on the disclosure requirement of environmental protection information in China. But companies are increasingly concerned about environmental protection and are committed to disclosing more information about environmental protection. It is important to analyze the information on stock market opening and environmental protection by computing technology. For the stock market, as voluntary disclosure of non-financial information, environmental protection information is an important supplement to financial information and is essential for the investors to make decisions. And it is the important content of capital market information. This article through the capital market opening opportunity: Shanghai (Shenzhen) Hong Kong stock connect (the stock market opening mentioned later in this paper all refers to the Shanghai (Shenzhen) Hong Kong stock connect), empirically investigates the stock market opening that affects the environmental protection information disclosure of the company. Our conclusion supports the views that the stock market opening improved the environmental protection information disclosure of the company and promotes the environmental protection behavior of enterprises. Through further analysis, this paper finds that after the officially carried out the stock market opening policy, the attention of many analysts and the participation of foreign institutional investors urge the management to take the initiative to reduce agency costs, which is an important influence mechanism for the stock market opening to affect the disclosure of enterprises’ environmental protection information. The evidence of this study indicates that the stock market opening has an important impact on enterprises in China from the following aspects: improving the information disclosure of environmental protection, thus enhancing the company’s awareness of environment protecting, and ...
Keywords	Technology (General) ; T1-995 ; Science (General) ; Q1-390
Subject code	340
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pedagogical Design in Technology-Enhanced Language Education Research

Ting Liu / Zhipeng Zhang / Xuesong (Andy) Gao

Sustainability, Vol 15, Iss 6069, p

A Scoping Review

2023 Volume 6069

Abstract: This scoping literature review aims to explore how language teachers incorporate technology into their teaching and learning experiences. It does this by reviewing studies related to language teachers’ technology use and applications of technology in ... ...

Abstract	This scoping literature review aims to explore how language teachers incorporate technology into their teaching and learning experiences. It does this by reviewing studies related to language teachers’ technology use and applications of technology in technology-enhanced language education that were published between 2012 and 2022. By using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines to analyze 51 empirical studies, this review categorizes and identifies 4 clusters of topics that these studies focused on: teachers’ perceptions, technological application practice and experience, technological pedagogical content knowledge (TPACK), and teachers’ designing/developing scale for the promotion of language learning in pedagogical design in technology-enhanced language education research. The review concludes that researchers have mainly investigated language teachers’ perceptions and experience of technology-enhanced language education, not their pedagogical design processes. The results suggest that more studies are needed to explore the role of language teachers as pedagogical designers in technology-enhanced language education in order to integrate technology into language education and facilitate sustainable language teaching and learning.
Keywords	technology-enhanced language education ; pedagogical design ; language teacher ; technological application practice ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	420
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reducing Model Error Effects in El Niño–Southern Oscillation Prediction Using Ensemble Coupled Data Assimilation

Yanqiu Gao / Youmin Tang / Ting Liu

Remote Sensing, Vol 15, Iss 762, p

2023 Volume 762

Abstract: Model error is an important source of uncertainty that significantly reduces the accuracy of El Niño–Southern Oscillation (ENSO) prediction. In this study, ensemble coupled data assimilation was employed to estimate the tendency error of the fifth- ... ...

Abstract	Model error is an important source of uncertainty that significantly reduces the accuracy of El Niño–Southern Oscillation (ENSO) prediction. In this study, ensemble coupled data assimilation was employed to estimate the tendency error of the fifth-generation Lamont–Doherty Earth observation (LDEO5) model, which represented the comprehensive effect of different sources of errors. Then, the estimated tendency error was applied to an ensemble prediction system for ENSO prediction. Assimilation experiments showed that tendency error estimation yielded better analysis than state estimation only. With tendency error estimation, simulated state variables such as zonal wind stress anomalies and subsurface temperature anomalies in the Niño3.4 region and upper layer depth anomalies along the equator showed good agreement with their reanalyzed counterparts. The ensemble ENSO prediction system with tendency error estimation demonstrated significantly better prediction skill than the ensemble system without tendency error estimation or the original LDEO5 model, especially for long lead times. The tendency error estimation improved the prediction skill for El Niño more than for La Niña. This study provides a promising approach to further improve prediction skill by reducing model error effects in an ensemble prediction.
Keywords	El Niño–Southern Oscillation ; model error effect ; ensemble adjustment Kalman filter ; data assimilation ; simulation and prediction ; Science ; Q
Subject code	310
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Same MYH7 gene mutation but different phenotypes of cardiomyopathy in one family

Ting Liu / Yuan Yao / Yu Kang / Qing Zhang

Kaohsiung Journal of Medical Sciences, Vol 39, Iss 10, Pp 1052-

2023 Volume 1053

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Reconstitution of Early Paclitaxel Biosynthetic Network.

Chun-Ting Liu, Jack / De La Pena, Ricardo / Tocol, Christian / Sattely, Elizabeth S

bioRxiv : the preprint server for biology

2023

Abstract: Paclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades, a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the propensity of heterologously expressed pathway cytochromes P450, ... ...

Abstract	Paclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades, a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the propensity of heterologously expressed pathway cytochromes P450, including taxadiene 5α-hydroxylase (T5αH), to form multiple products. This diverts metabolic flux away from the paclitaxel precursor, taxadien-5α-ol, thus previous attempts of reconstitution have not yielded sufficient material for characterization, regardless of the heterologous host. Here, we structurally characterized four new products of T5αH, many of which appear to be over-oxidation of the primary mono-oxidized products. By tuning the promoter strength for T5αH expression, levels of these proposed byproducts decrease with a concomitant increase in the accumulation of taxadien-5α-ol by four-fold. This engineered system enabled the reconstitution of a six step biosynthetic pathway to produce isolatable 5α,10β-diacetoxy-taxadien-13α-ol. Furthermore, we showed that this pathway may function as a metabolic network rather than a linear pathway. The engineering of the paclitaxel biosynthetic network demonstrates that
Language	English
Publishing date	2023-09-28
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.27.559859
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Research on the impact of ship traffic flow on the restricted channel segment of the middle Yangtze River based on traffic wave theory

Ting Liu / Gabriel Lodewijks

SN Applied Sciences, Vol 3, Iss 8, Pp 1-

2021 Volume 21

Abstract: Abstract Abstract On the basis of the influence of dry season on ship traffic flow, the gathering and dissipating process of ship traffic flow was researched with Greenshields linear flow—density relationship model, the intrinsic relationship between the ...

Abstract	Abstract Abstract On the basis of the influence of dry season on ship traffic flow, the gathering and dissipating process of ship traffic flow was researched with Greenshields linear flow—density relationship model, the intrinsic relationship between the ship traffic congestion state and traffic wave in the unclosed restricted channel segment was emphatically explored when the ship traffic flow in a tributary channel inflows, and the influence law of multiple traffic waves on the ship traffic flow characteristics in unclosed restricted segment is revealed. On this basis, the expressions of traffic wave speed and direction, dissipation time of queued ships and the number of ships affected were provided, and combined with Monte Carlo method, the ship traffic flow simulation model in the restricted channel segment was built. The simulation results show that in closed restricted channel segment the dissipation time of ships queued is mainly related to the ship traffic flow rate of segments A and C, and the total number of ships affected to the ship traffic flow rate of segment A. And in unclosed restricted channel segment, the dissipation time and the total number of ships affected are also determined by the meeting time of the traffic waves in addition to the ship traffic flow rate of segments. The research results can provide the theoretical support for further studying the ship traffic flow in unclosed restricted channel segment with multiple tributaries Article Highlights 1. The inflow of tributaries' ship traffic flows has an obvious impact on the traffic conditions in the unenclosed restricted channel segment. 2. The interaction and influence between multiple ship traffic waves and the mechanism of generating new traffic waves are explained. 3. The expression of both dissipation time of queued ships and the total number of ships affected in the closed and unclosed restricted channel segment are given.
Keywords	Ship traffic flow ; Restricted channel segment ; Wavefront ; Wave speed ; Gathering wave ; Dissipating wave ; Science ; Q ; Technology ; T
Subject code	551
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Springer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A New Design of Sydney’s Frontport Check-in System

Ting Liu / Gabriel Lodewijks

Sustainability, Vol 13, Iss 3850, p

2021 Volume 3850

Abstract: This paper proposed a scheme design for Sydney’s frontport check-in system, which completes check-in and baggage drop-off at Sydney’s Circular Quay, and transports the baggage to Sydney Kingsford Smith Airport by waterway, and provided a strengths, ... ...

Abstract	This paper proposed a scheme design for Sydney’s frontport check-in system, which completes check-in and baggage drop-off at Sydney’s Circular Quay, and transports the baggage to Sydney Kingsford Smith Airport by waterway, and provided a strengths, weaknesses, opportunities and threats (SWOT) analysis of Sydney’s frontport check-in system. Using the process method of quality management, the frontport check-in process was divided into three sub-processes: baggage consignment, baggage packing and transportation, and airport baggage handling. The eight key elements of each sub-process such as input, output, resources, and methods, etc. were discussed, the key factors influencing the cost of baggage transportation were analyzed, and the cost control measures such as adopting economic speed, reducing fuel consumption of the main engine, improving the ship loading rate, and raising loading and unloading efficiency were proposed. At the same time, two different types of baggage transportation ships and other parameters that affect the cost such as the number of berths, ships, lifting machineries, and the yard area were analyzed and calculated through calculation cases. This scheme is a beneficial addition to the existing in-town check-in system.
Keywords	check-in ; baggage drop-off ; SWOT ; scheme ; process ; cost ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	670
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PI3K/Akt signaling pathway mediates the effect of low-dose boron on barrier function, proliferation and apoptosis in rat intestinal epithelial cells

Shuqin Chen / Jialiang Huang / Ting Liu / Feng Zhang / Chunfang Zhao / Erhui Jin / Shenghe Li

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 12

Abstract: Abstract Boron is an essential trace element with roles in growth, development, and physiological functions; however, its mechanism of action is still unclear. In this study, the regulatory roles of the PI3K/Akt signaling pathway on boron-induced changes ...

Abstract	Abstract Boron is an essential trace element with roles in growth, development, and physiological functions; however, its mechanism of action is still unclear. In this study, the regulatory roles of the PI3K/Akt signaling pathway on boron-induced changes in barrier function, proliferation, and apoptosis in rat intestinal epithelial cells were evaluated. Occludin levels, the proportion of cells in the G2/M phase, cell proliferation rate, and mRNA and protein expression levels of PCNA were higher, while the proportions of cells in the G0/G1 and S phases, apoptosis rate, and caspase-3 mRNA and protein expression levels were lower in cells treated with 0.8 mmol/L boron than in control IEC-6 cells (P < 0.01 or P < 0.05). However, 40 mmol/L boron decreased ZO-1 and Occludin levels, the proportion of cells in the G2/M phase, cell proliferation rate, and mRNA and protein levels of PCNA and increased the apoptosis rate and caspase-3 mRNA expression (P < 0.01 or P < 0.05). After specifically blocking PI3K and Akt signals (using LY294002 and MK-2206 2HCL), 0.8 mmol/L boron had no effects on Occludin, PCNA level, apoptosis rates, and caspase-3 levels (P < 0.05); however, the proliferation rate and PCNA levels decreased significantly (P < 0.01 or P < 0.05). The addition of 40 mmol/L boron did not affect ZO-1 and Occludin levels and did not affect the apoptosis rate or PCNA and caspase-3 levels. These results suggested that the PI3K/Akt signaling pathway mediates the effects of low-dose boron on IEC-6 cells.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Health Status on the Labor Supply of Older Adults with Different Socioeconomic Status

Yan-Ting Liu / Yao-Dong Zhou / Jiao-Li Cai

Sustainability, Vol 15, Iss 1511, p

2023 Volume 1511

Abstract: Based on the panel data of the China Health and Retirement Longitudinal Study (CHARLS) collected from 2011 to 2018, this paper establishes a model using the instrumental variables method to investigate the effects of poor health on labor participation, ... ...

Abstract	Based on the panel data of the China Health and Retirement Longitudinal Study (CHARLS) collected from 2011 to 2018, this paper establishes a model using the instrumental variables method to investigate the effects of poor health on labor participation, labor hours, agricultural labor participation, agricultural labor hours, off-farm labor participation, and off-farm labor hours of older adults with different economic statuses. This paper conducts an empirical analysis to examine how subjective, self-rated poor health and objective poor health measured using the number of chronic diseases can affect the labor supply of older adults. The study of its influence on labor supply from the perspective of health can help to maintain the labor supply of the aged from the perspective of improving the health of the aged, provide a certain reference for the labor shortage caused by China’s aging society, and enrich the content of health economics. According to the research findings, subjective, self-rated poor health significantly reduces the labor participation of older adults. Although self-rated poor health does not affect the off-farm labor participation of older adults, it significantly reduces the likelihood of older adults engaging in agricultural labor. In addition, self-rated poor health also reduces the overall labor hours and off-farm labor hours of older adults, although no effects were observed on their agricultural labor hours. On the other hand, chronic diseases also reduce the overall likelihood of labor participation for older adults, resulting in significantly lower off-farm labor participation, although no effects were observed on their agricultural labor participation. The number of chronic diseases found in older adults does not affect their off-farm labor hours, but it does increase the hours they invest in agricultural labor.
Keywords	socioeconomic status ; labor supply ; labor participation ; self-rated poor health ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	331 ; 338
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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