Article ; Online: Differential roles of RIG-I like receptors in SARS-CoV-2 infection
Military Medical Research, Vol 8, Iss 1, Pp 1-
2021 Volume 3
Abstract: Abstract Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial ... ...
| Abstract | Abstract Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A deficiency in MDA5, RIG-I or mitochondrial antiviral signaling protein (MAVS) enhanced viral replication. The expression of the type I/III interferon (IFN) during infection was impaired in MDA5 −/− and MAVS −/−, but not in RIG-I −/−, when compared to wild type (WT) cells. The mRNA level of full-length angiotensin-converting enzyme 2 (ACE2), the cellular entry receptor for SARS-CoV-2, was ~ 2.5-fold higher in RIG-I −/− than WT cells. These data demonstrate MDA5 as the predominant SARS-CoV-2 sensor, IFN-independent induction of ACE2 and anti-SARS-CoV-2 role of RIG-I in epithelial cells. |
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| Keywords | SARS-CoV-2 ; Pathogen pattern recognition receptor ; Melanoma differentiation-associated protein 5 ; Retinoic acid-inducible gene I ; Medicine (General) ; R5-920 ; Military Science ; U |
| Subject code | 570 |
| Language | English |
| Publishing date | 2021-09-01T00:00:00Z |
| Publisher | BMC |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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