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  1. Article ; Online: Use of essential oils from plants of Araripe National Forest against Aedes aegypti (Diptera: Culicidae).

    Azevedo, F R / Ferreira, R C A B / Leandro, C S / Araújo, I M / Tintino, S R

    Brazilian journal of biology = Revista brasleira de biologia

    2023  Volume 83, Page(s) e275062

    Abstract: Aedes aegypti control is achieved with chemical insecticides that can promote insecticide resistance. In the search for new forms of control, the use of botanical products is currently growing and many tests with oils have already been performed. The ... ...

    Abstract Aedes aegypti control is achieved with chemical insecticides that can promote insecticide resistance. In the search for new forms of control, the use of botanical products is currently growing and many tests with oils have already been performed. The plant diversity of Araripe National Forest enables the study of several species against this vector. To evaluate the larvicidal effect of essential oils from plants of this forest, we used field rosemary, copaiba, bay leaf, cashew and pequi. The work was divided into three stages: all oils with the same dosage; the best oil at dosages of 0, 5, 10, 20, 50 and 75 µg/mL; and the best dosage at temperatures of 15, 20, 25, 30 and 35 °C. The oils of field rosemary, copaiba, bay leaf, cashew and pequi were good insecticides when used at dosages above 5 μg/mL. The bay leaf oil showed high larvicidal activity at all dosages tested, showing the highest efficiency at 75 μg/mL. Temperatures of 15 and 35 °C increased the susceptibility of the insect to the effect of the bay leaf oil. The essential oils of field rosemary, copaiba, bay leaf, cashew and pequi, from Araripe National Forest, applied at a dosage of 5μg/mL, showed insecticidal action, although with low efficiency.
    MeSH term(s) Animals ; Oils, Volatile/pharmacology ; Aedes ; Insecticides/pharmacology ; Larva ; Mosquito Vectors ; Plant Oils/pharmacology
    Chemical Substances Oils, Volatile ; Insecticides ; Plant Oils
    Language English
    Publishing date 2023-12-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2036257-2
    ISSN 1678-4375 ; 1519-6984
    ISSN (online) 1678-4375
    ISSN 1519-6984
    DOI 10.1590/1519-6984.275062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 652: Show issues Location:
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  2. Article ; Online: The antioxidative effects of bioactive products from Sargassum polycystum C. Agardh and Sargassum duplicatum J. Agardh against inflammation and other pathological issues.

    Johnson, M / Kanimozhi, S Asha / Joy Jeba Malar, T Renisheya / Shibila, T / Freitas, P R / Tintino, S R / Menezes, I R A / da Costa, J G M / Coutinho, H D M

    Complementary therapies in medicine

    2019  Volume 46, Page(s) 19–23

    Abstract: The present study was aimed to determine the phenol, total flavonoids and antioxidant potentials of Sargassum polycystum C. Agardh and Sargassum duplicatum J. Agardh from south east coast of Tamil Nadu and India using DPPH, phophomolybdenum and hydrogen ... ...

    Abstract The present study was aimed to determine the phenol, total flavonoids and antioxidant potentials of Sargassum polycystum C. Agardh and Sargassum duplicatum J. Agardh from south east coast of Tamil Nadu and India using DPPH, phophomolybdenum and hydrogen peroxide scavenging activity. The total phenols, total flavonoids and antioxidant activities of S. polycystum and S. duplicatum were determined. Highest phenols (33.49 and 149.52 mg GAE/g) were observed in chloroform extracts of S. polycystum and methanolic extracts of S. duplicatum. The acetone extracts of S. polycystumand S. duplicatum demonstrated maximum amount of flavonoids compared to other studied extracts. Maximum amount of phosphomolybdenum reduction was observed in acetone extracts of S. polycystum and methanolic extracts of S. duplicatum. The DPPH radical scavenging activity of different extracts of S. polycystum and S. duplicatum were as follows acetone > chloroform > Petroleum ether > methanol and acetone > chloroform > methanol >Petroleum ether respectively. The H
    MeSH term(s) Antioxidants/pharmacology ; Flavonoids/pharmacology ; Humans ; Inflammation/drug therapy ; Phenols/chemistry ; Phytochemicals/pharmacology ; Plant Extracts/pharmacology ; Sargassum/chemistry
    Chemical Substances Antioxidants ; Flavonoids ; Phenols ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2019-07-10
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1155895-7
    ISSN 1873-6963 ; 0965-2299
    ISSN (online) 1873-6963
    ISSN 0965-2299
    DOI 10.1016/j.ctim.2019.06.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3726: Show issues Location:
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  3. Article ; Online: Cholesterol and ergosterol affect the activity of Staphylococcus aureus antibiotic efflux pumps.

    Tintino, S R / Oliveira-Tintino, C D M / Campina, F F / Costa, M S / Cruz, R P / Pereira, R L S / Andrade, J C / Sousa, E O / Siqueira-Junior, J P / Coutinho, H D M / Leal-Balbino, T C / Balbino, V Q

    Microbial pathogenesis

    2017  Volume 104, Page(s) 133–136

    Abstract: The aim of this study is to evaluate the effect of ergosterol on steroids and cholesterol efflux pumps in multidrug resistant strains of S. aureus. Were used RN4220 harboring plasmid pUL5054, which carries the gene encoding the MsrA macrolide efflux ... ...

    Abstract The aim of this study is to evaluate the effect of ergosterol on steroids and cholesterol efflux pumps in multidrug resistant strains of S. aureus. Were used RN4220 harboring plasmid pUL5054, which carries the gene encoding the MsrA macrolide efflux protein; and IS-58, which possesses the TetK tetracycline efflux protein; 1199B resists hydrophilic fluoroquinolones via a NorA-mediated mechanism and wild strain 1199B. The Minimal Inhibitory Concentration (MIC) was determined and the evaluation of possible inhibition of efflux pumps by reduction of MIC. Some of the detrimental effects on bacterial cells can be attributed to the detergent properties of cholesterol and ergosterol on account of their amphipathic structure. Besides the cholesterol did not affect directly the pump structure, a synergism was observed, maybe due the interaction with the cell membrane and interference in the lipid bilayer.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Cholesterol/chemistry ; Cholesterol/pharmacology ; Drug Antagonism ; Ergosterol/chemistry ; Ergosterol/pharmacology ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/physiology
    Chemical Substances Anti-Bacterial Agents ; Cholesterol (97C5T2UQ7J) ; Ergosterol (Z30RAY509F)
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2017.01.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: Cholesterol and ergosterol affect the activity of Staphylococcus aureus antibiotic efflux pumps

    Tintino, S.R / C.D.M. Oliveira-Tintino / E.O. Sousa / F.F. Campina / H.D.M. Coutinho / J.C. Andrade / J.P. Siqueira-Junior / M.S. Costa / R.L.S. Pereira / R.P. Cruz / T.C. Leal-Balbino / V.Q. Balbino

    Microbial pathogenesis. 2017 Mar., v. 104

    2017  

    Abstract: The aim of this study is to evaluate the effect of ergosterol on steroids and cholesterol efflux pumps in multidrug resistant strains of S. aureus. Were used RN4220 harboring plasmid pUL5054, which carries the gene encoding the MsrA macrolide efflux ... ...

    Abstract The aim of this study is to evaluate the effect of ergosterol on steroids and cholesterol efflux pumps in multidrug resistant strains of S. aureus. Were used RN4220 harboring plasmid pUL5054, which carries the gene encoding the MsrA macrolide efflux protein; and IS-58, which possesses the TetK tetracycline efflux protein; 1199B resists hydrophilic fluoroquinolones via a NorA-mediated mechanism and wild strain 1199B. The Minimal Inhibitory Concentration (MIC) was determined and the evaluation of possible inhibition of efflux pumps by reduction of MIC. Some of the detrimental effects on bacterial cells can be attributed to the detergent properties of cholesterol and ergosterol on account of their amphipathic structure. Besides the cholesterol did not affect directly the pump structure, a synergism was observed, maybe due the interaction with the cell membrane and interference in the lipid bilayer.
    Keywords bacteria ; cholesterol ; detergents ; ergosterol ; fluoroquinolones ; genes ; hydrophilicity ; lipid bilayers ; macrolides ; minimum inhibitory concentration ; multiple drug resistance ; plasmids ; Staphylococcus aureus ; synergism ; tetracycline ; transporters
    Language English
    Dates of publication 2017-03
    Size p. 133-136.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2017.01.019
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Phenolic compounds and interaction between aminoglycosides and natural products of Lygodium venustum SW against multiresistant bacteria.

    Morais-Braga, M F B / Souza, T M / Santos, K K A / Guedes, G M M / Andrade, J C / Tintino, S R / Sobral-Souza, C E / Costa, J G M / Saraiva, A A F / Coutinho, H D M

    Chemotherapy

    2012  Volume 58, Issue 5, Page(s) 337–340

    Abstract: Background: The aim of this work was to evaluate the interactions between aminoglycosides and the ethyl-acetate fraction of the fern Lygodium venustum SW (EAFLV) METHODS: The ethyl-acetate fraction was obtained from the ethanol extract of L. venustum ... ...

    Abstract Background: The aim of this work was to evaluate the interactions between aminoglycosides and the ethyl-acetate fraction of the fern Lygodium venustum SW (EAFLV) METHODS: The ethyl-acetate fraction was obtained from the ethanol extract of L. venustum and was assayed via the checkerboard method associated with aminoglycosides against two bacterial strains multiresistant to antibiotics.
    Results: The antibiotic activity of all drugs, when associated with the ethyl-acetate fraction, was enhanced in an additive manner, except for the association between EAFLV and amikacin, which showed a synergistic interaction against the Escherichia coli strain.
    Conclusions: The results indicated that L. venustum can be a source of secondary metabolites to be used in association with antibiotics like aminoglycosides in antibiotic chemotherapy against resistant bacteria.
    MeSH term(s) Amikacin/pharmacology ; Aminoglycosides/chemistry ; Aminoglycosides/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Biological Products/chemistry ; Biological Products/pharmacology ; Drug Resistance, Multiple, Bacterial/drug effects ; Drug Synergism ; Escherichia coli/drug effects ; Ferns/chemistry ; Microbial Sensitivity Tests ; Phenols/chemistry ; Phenols/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Staphylococcus aureus/drug effects
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents ; Biological Products ; Phenols ; Plant Extracts ; Amikacin (84319SGC3C)
    Language English
    Publishing date 2012
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 6708-8
    ISSN 1421-9794 ; 0009-3157
    ISSN (online) 1421-9794
    ISSN 0009-3157
    DOI 10.1159/000343044
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Trypanocide, antileishmania and cytotoxic activities of the essential oil from Rosmarinus officinalis L in vitro

    Pereira, P. S. / Maia, A. J. / Tintino, S. R. / d. M. Oliveira-Tintino, C. D. / d. S. Raulino, I. S. / Vega, M. C. / Rolón, M. / Coronel, C. / Barros, L. M. / Duarte, A. E. / de Menezes, I. R. A. / Coutinho, H. D. M. / da Silva, T. G.

    Industrial crops and products

    2017  Volume -, Issue Bd. 109, Page(s) 724

    Language English
    Document type Article
    ZDB-ID 1132158-1
    ISSN 0926-6690
    Database Current Contents Nutrition, Environment, Agriculture

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    Z 5577: Show issues

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  7. Article ; Online: Enhancement of the Norfloxacin Antibiotic Activity by Gaseous Contact with the Essential Oil of Croton zehntneri.

    Coutinho, Hdm / Matias, Eff / Santos, Kka / Tintino, S R / Souza, Ces / Guedes, Gmm / Santos, Fad / Costa, Jgm / Falcão-Silva, Vs / Siqueira-Júnior, Jp

    Journal of young pharmacists : JYP

    2011  Volume 2, Issue 4, Page(s) 362–364

    Abstract: This is the first on the modulation of norfloxacin antibiotic activity by the volatile compounds of an essential oil. We report the chemical composition and antibiotic modifying activity of the essential oil extracted from the leaves of Croton zehntneri ... ...

    Abstract This is the first on the modulation of norfloxacin antibiotic activity by the volatile compounds of an essential oil. We report the chemical composition and antibiotic modifying activity of the essential oil extracted from the leaves of Croton zehntneri Pax et Hoffm (variety estragole), using the minimal inhibitory dose method and gaseous contact. The leaves of Croton zehntneri Pax et Hoffm (Euphorbiaceae) were subjected to hydrodistillation, and the essential oil extracted was examined with respect to the chemical composition, by gas chromatography-mass spectrometry (GC/MS), and to inhibitory activity of efflux pump by gaseous contact. The main component of the essential oil of C. zehntneri was estragole (76,8%). The gaseous components of the oil enhanced the inhibition zone of norfloxacin in 39,5%. This result shows that this oil influences the antibiotic activity of norfloxacin, possibly affecting the bacterial NorA efflux system, and may be used as an adjuvant in the antibiotic therapy of multidrug resistant pathogens.
    Language English
    Publishing date 2011-01-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2503424-8
    ISSN 0975-1505 ; 0975-1505
    ISSN (online) 0975-1505
    ISSN 0975-1505
    DOI 10.4103/0975-1483.71625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Phenolic Compounds and Interaction between Aminoglycosides and Natural Products of ; SW against Multiresistant Bacteria

    Morais-Braga, M.F.B. / Souza, T.M. / Santos, K.K.A. / Guedes, G.M.M. / Andrade, J.C. / Tintino, S.R. / Sobral-Souza, C.E. / Costa, J.G.M. / Saraiva, A.A.F. / Coutinho, H.D.M.

    Chemotherapy

    2012  Volume 58, Issue 5, Page(s) 337–340

    Abstract: Background: The aim of this work was to evaluate the interactions between aminoglycosides and the ethyl-acetate fraction of the fern Lygodium venustum SW (EAFLV) Methods: The ethyl-acetate fraction was obtained from the ethanol extract of L. venustum and ...

    Institution Laboratories of Microbiology and Molecular Biology Natural Products Research, and Paleontology, Regional University of Cariri, Crato, Brazil
    Abstract Background: The aim of this work was to evaluate the interactions between aminoglycosides and the ethyl-acetate fraction of the fern Lygodium venustum SW (EAFLV) Methods: The ethyl-acetate fraction was obtained from the ethanol extract of L. venustum and was assayed via the checkerboard method associated with aminoglycosides against two bacterial strains multiresistant to antibiotics. Results: The antibiotic activity of all drugs, when associated with the ethyl-acetate fraction, was enhanced in an additive manner, except for the association between EAFLV and amikacin, which showed a synergistic interaction against the Escherichia coli strain. Conclusions: The results indicated that L. venustum can be a source of secondary metabolites to be used in association with antibiotics like aminoglycosides in antibiotic chemotherapy against resistant bacteria.
    Keywords Aminoglycosides ; Ethyl-acetate fraction ; Checkerboard method
    Language English
    Publishing date 2012-11-16
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Microbiology
    ZDB-ID 6708-8
    ISSN 1421-9794 ; 0009-3157
    ISSN (online) 1421-9794
    ISSN 0009-3157
    DOI 10.1159/000343044
    Database Karger publisher's database

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