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Article ; Online: Tenascin-R Autoimmunity: Isolated Tremor Reversed with Immunotherapy.

Yang, Binxia / Brown, Andrew / McKeon, Andrew / Ahlskog, J Eric / Tipton, Philip / Guo, Yong / Lucchinetti, Claudia / Pittock, Sean J / Zekeridou, Anastasia

Annals of neurology

2023 Volume 94, Issue 3, Page(s) 502–507

Abstract: Autoimmune movement disorders are increasingly recognized, but isolated tremor is extremely rare. We describe a 70-year-old male with rapidly progressive, severe postural and intention tremor and weight loss. His cerebrospinal fluid was inflammatory and ... ...

Abstract	Autoimmune movement disorders are increasingly recognized, but isolated tremor is extremely rare. We describe a 70-year-old male with rapidly progressive, severe postural and intention tremor and weight loss. His cerebrospinal fluid was inflammatory and harbored a neural tissue-restricted antibody. The autoantigen was identified by immunoprecipitation and mass spectrometry and confirmed by antigen-specific assays to be specific for tenascin-R. He was investigated for cancer and diagnosed with follicular lymphoma that expressed tenascin-R suggesting a paraneoplastic origin; cancer treatment and immunotherapy led to complete recovery. With this individualized patient approach and antibody discovery, we expand the spectrum of antibodies accompanying autoimmune hyperkinetic movement disorders. ANN NEUROL 2023;94:502-507.
MeSH term(s)	Male ; Humans ; Aged ; Tremor ; Autoimmunity ; Autoimmune Diseases ; Autoantibodies ; Immunotherapy
Chemical Substances	tenascin R (147604-77-1) ; Autoantibodies
Language	English
Publishing date	2023-07-14
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.26730
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Zs.MO 478: Show issues

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Article ; Online: Assembly of PGAM5 into Multimeric Complexes Provides a Mechanism for Allosteric Regulation of Phosphatase Activity.

Tipton, Peter / Su, Tong / Hannink, Mark

Methods in enzymology

2018 Volume 607, Page(s) 353–372

Abstract: Phosphoglycerate mutase family member 5 (PGAM5) is a serine/threonine phosphatase that has been localized to both inner and outer mitochondrial membranes. PGAM5 has been suggested to regulate multiple aspects of mitochondrial dynamics, including fission/ ... ...

Abstract	Phosphoglycerate mutase family member 5 (PGAM5) is a serine/threonine phosphatase that has been localized to both inner and outer mitochondrial membranes. PGAM5 has been suggested to regulate multiple aspects of mitochondrial dynamics, including fission/fusion and mitophagy, through phosphatase-dependent and phosphatase-independent mechanisms. Understanding how the phosphatase activity of PGAM5 is regulated will provide new insight into signaling mechanisms that link changes in cell physiology with mitochondrial function. In this chapter, we describe methods for obtaining both multimeric and dimeric complexes of PGAM5 and for characterizing their kinetic properties. The ability to purify different PGAM5 complexes and to characterize their kinetic properties will enable detailed biophysical studies of the quaternary structures of the various PGAM5-containing complexes. The phosphatase activity of different PGAM5 complexes varies over three orders of magnitude. We suggest that the ability to generate PGAM5 complexes that have a wide range of phosphatase activities will facilitate screens to identify small molecules that modulate the phosphatase activity of PGAM5.
MeSH term(s)	Allosteric Regulation ; Allosteric Site/genetics ; Chromatography, Gel/instrumentation ; Chromatography, Gel/methods ; Chromatography, High Pressure Liquid/instrumentation ; Chromatography, High Pressure Liquid/methods ; Enzyme Assays/instrumentation ; Enzyme Assays/methods ; Kinetics ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/isolation & purification ; Mitochondrial Proteins/metabolism ; Phosphopeptides/chemical synthesis ; Phosphopeptides/metabolism ; Phosphoprotein Phosphatases/genetics ; Phosphoprotein Phosphatases/isolation & purification ; Phosphoprotein Phosphatases/metabolism ; Protein Multimerization ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism
Chemical Substances	Mitochondrial Proteins ; Phosphopeptides ; Recombinant Proteins ; PGAM5 protein, human (EC 3.1.3.16) ; Phosphoprotein Phosphatases (EC 3.1.3.16)
Language	English
Publishing date	2018-06-23
Publishing country	United States
Document type	Journal Article
ISSN	1557-7988 ; 0076-6879
ISSN (online)	1557-7988
ISSN	0076-6879
DOI	10.1016/bs.mie.2018.05.017
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Article ; Online: Deep Brain Stimulation for Tremor: Direct Targeting of a Novel Imaging Biomarker.

Middlebrooks, Erik H / Tipton, Philip / Okromelidze, Lela / Greco, Elena / Mendez, Julio A / Uitti, Ryan / Grewal, Sanjeet S

Annals of neurology

2022 Volume 92, Issue 2, Page(s) 341–342

MeSH term(s)	Biomarkers ; Deep Brain Stimulation/methods ; Essential Tremor/therapy ; Humans ; Thalamus ; Treatment Outcome ; Tremor/diagnostic imaging ; Tremor/therapy
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-06-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.26422
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Article: Aesthetic tooth alignment using etched porcelain restorations.

Tipton, P A

Practical procedures & aesthetic dentistry : PPAD

2001 Volume 13, Issue 7, Page(s) 551–5; quiz 556–8

Abstract: In restorative dentistry, aesthetics often depends upon the creation of symmetry at the patient's midline. This concept can be taken further in that an aesthetic smile has symmetry and harmony between horizontal and vertical planes. This article ... ...

Abstract	In restorative dentistry, aesthetics often depends upon the creation of symmetry at the patient's midline. This concept can be taken further in that an aesthetic smile has symmetry and harmony between horizontal and vertical planes. This article demonstrates a prosthodontic alternative to orthodontic therapy for patients who require an immediate change to their smile rather than submitting to the latter's extended treatment period. While orthodontic treatment remains the standard for the majority of these cases, other modalities are required for patients who refuse it.
MeSH term(s)	Adult ; Dental Porcelain ; Dental Prosthesis Design ; Dental Restoration, Temporary ; Dental Veneers ; Dentin-Bonding Agents ; Diastema/therapy ; Esthetics, Dental ; Female ; Humans ; Resin Cements ; Tooth Preparation
Chemical Substances	Dentin-Bonding Agents ; Resin Cements ; Dental Porcelain (12001-21-7)
Language	English
Publishing date	2001-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2050402-0
ISSN	1534-6846 ; 1042-2722
ISSN	1534-6846 ; 1042-2722
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Zs.A 4082: Show issues

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Article: Nightmare from the sixties.

Tipton, P J

Annals of internal medicine

2000 Volume 132, Issue 12, Page(s) 1002–1003

MeSH term(s)	Abortion, Induced/adverse effects ; Abortion, Induced/methods ; Burns/etiology ; Female ; Humans ; Pain/etiology ; Physician-Patient Relations ; Potassium Permanganate/adverse effects ; Vagina/injuries
Chemical Substances	Potassium Permanganate (00OT1QX5U4)
Language	English
Publishing date	2000-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/0003-4819-132-12-200006200-00016
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Article ; Online: Boost your staff's understanding and utilization of EBP.

Tipton, Phyllis / Ucci, Debra K

Nursing management

2008 Volume 39, Issue 9, Page(s) 12–14

MeSH term(s)	Career Mobility ; Education, Nursing, Continuing ; Ethics Committees, Research ; Evidence-Based Medicine/education ; Humans ; Interprofessional Relations ; Nursing Staff/education ; Staff Development/methods ; United States
Language	English
Publishing date	2008-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	605889-9
ISSN	1538-8670 ; 0744-6314
ISSN (online)	1538-8670
ISSN	0744-6314
DOI	10.1097/01.NUMA.0000335252.23789.d1
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Zs.B 2735: Show issues

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Article: Rounding to increase retention.

Generals, Jamie / Tipton, Phyllis

Nursing management

2008 Volume 39, Issue 5, Page(s) 10–12

MeSH term(s)	Attitude of Health Personnel ; Humans ; Job Satisfaction ; Nursing Assessment/organization & administration ; Nursing Staff, Hospital/organization & administration ; Nursing Staff, Hospital/psychology ; Patient Satisfaction ; Personnel Turnover ; Time Management/organization & administration ; Time Management/psychology ; Workload/psychology
Language	English
Publishing date	2008-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	605889-9
ISSN	1538-8670 ; 0744-6314
ISSN (online)	1538-8670
ISSN	0744-6314
DOI	10.1097/01.NUMA.0000318058.10598.b1
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Article: Transient-state kinetic analysis of the oxidative decarboxylation of D-malate catalyzed by tartrate dehydrogenase.

Tipton, P A

Biochemistry

1996 Volume 35, Issue 9, Page(s) 3108–3114

Abstract: The oxidative decarboxylation of D-malate catalyzed by tartrate dehydrogenase has been analyzed by transient-state kinetic methods and kinetic isotope effect measurements. The reaction time courses show a burst of NADH formation prior to the attainment ... ...

Abstract	The oxidative decarboxylation of D-malate catalyzed by tartrate dehydrogenase has been analyzed by transient-state kinetic methods and kinetic isotope effect measurements. The reaction time courses show a burst of NADH formation prior to the attainment of the steady-state velocity. The binding of the inhibitor tartronate to the enzyme was examined by monitoring the quenching of the protein's intrinsic fluorescence; the tartronate concentration dependence of the observed rate constant for association was hyperbolic, supporting a two-step model for inhibitor binding. Analysis of the time courses for D-malate oxidation yielded values for many of the microscopic rate constants governing the reaction. The range of possible solutions for the microscopic rate constants was constrained by comparison of the time course for oxidation of unlabeled malate with that of deuterated malate; this analysis relied on the determination of the intrinsic isotope effect on hydride transfer via measurement of D(V/K), T(V/K), and the oxaloacetate partition ratio. The results of the transient-state kinetic analyses suggest that the rate of D-malate oxidation is largely limited by the rate of decarboxylation of the intermediate oxaloacetate which occurs at 11 s-1. Hydride transfer from D-malate to NAD+ occurs with a rate constant of 300 s-1, and (D)k for this step is 5.5. The agreement between experimentally measured steady-state kinetic parameters and kinetic isotope effects and their values calculated from the microscopic rate constants derived from the transient-state kinetic analyses was quite good.
MeSH term(s)	Alcohol Oxidoreductases/isolation & purification ; Alcohol Oxidoreductases/metabolism ; Catalysis ; Decarboxylation ; Escherichia coli/enzymology ; Kinetics ; Malates/metabolism ; Models, Chemical ; Oxidation-Reduction ; Plasmids ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Tartronates/metabolism
Chemical Substances	Malates ; Recombinant Proteins ; Tartronates ; tartronic acid (34T0025E0L) ; malic acid (817L1N4CKP) ; Alcohol Oxidoreductases (EC 1.1.-) ; tartrate dehydrogenase (EC 1.1.1.93)
Language	English
Publishing date	1996-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi9518454
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Zs.A 217: Show issues

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Article: Intermediate partitioning in the tartrate dehydrogenase-catalyzed oxidative decarboxylation of D-malate.

Tipton, P A

Biochemistry

1993 Volume 32, Issue 11, Page(s) 2822–2827

Abstract: The oxidative decarboxylation of D-malate catalyzed by tartrate dehydrogenase has been examined in detail. Enzyme-catalyzed partitioning of oxalacetate has been determined to proceed with formation of pyruvate and D-malate in a ratio of 3.7 to 1. These ... ...

Abstract	The oxidative decarboxylation of D-malate catalyzed by tartrate dehydrogenase has been examined in detail. Enzyme-catalyzed partitioning of oxalacetate has been determined to proceed with formation of pyruvate and D-malate in a ratio of 3.7 to 1. These data, along with the deuterium and tritium kinetic isotope effects on hydride transfer, allow exact calculation of the intrinsic isotope effect and the forward and reverse commitments to catalysis, which have values of 5.1 +/- 0.8, 6.3 +/- 1.0, and 2.0 +/- 0.3, respectively. The viscosity dependence of the tritium isotope effect was measured, which allowed determination of the internal and external components of the commitment factors. The reverse commitment has no external portion, but the forward commitment can be divided into external and internal portions of 3.7 +/- 1.2 and 2.6 +/- 1.6, respectively. These data indicate that the reaction becomes committed to catalysis in the forward direction by formation of the Michaelis complex; reverse hydride transfer from NADH to OAA is twice as fast as decarboxylation of OAA, and recarboxylation of pyruvate occurs at a negligible rate. The rate constant for dissociation of OAA from the enzyme active site was estimated to be approximately 4 orders of magnitude slower than that for dissociation of oxaloglycolate, which is the product of the enzyme-catalyzed oxidation of (+)-tartrate.
MeSH term(s)	Alcohol Oxidoreductases/metabolism ; Deuterium ; Kinetics ; Malates/metabolism ; Mathematics ; Oxidation-Reduction ; Pseudomonas putida/enzymology ; Radioisotope Dilution Technique ; Tritium
Chemical Substances	Malates ; Tritium (10028-17-8) ; malic acid (817L1N4CKP) ; Deuterium (AR09D82C7G) ; Alcohol Oxidoreductases (EC 1.1.-) ; tartrate dehydrogenase (EC 1.1.1.93)
Language	English
Publishing date	1993-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi00062a013
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Zs.A 217: Show issues

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Article ; Online: The temporal onset of the core features in dementia with Lewy bodies.

Alzheimer's & dementia : the journal of the Alzheimer's Association

2021 Volume 18, Issue 4, Page(s) 591–601

Abstract: Introduction: We examined the temporal sequence of the core features in probable dementia with Lewy bodies (DLB).: Methods: In 488 patients with probable DLB, the onset of each core feature and time to diagnosis was determined for men and women, and ... ...

Abstract	Introduction: We examined the temporal sequence of the core features in probable dementia with Lewy bodies (DLB). Methods: In 488 patients with probable DLB, the onset of each core feature and time to diagnosis was determined for men and women, and a pathologic subgroup (n = 209). Results: REM sleep behavior disorder (RBD) developed before the other core features in men and women. Men were more likely to have RBD and were diagnosed with probable DLB earlier than women. Visual hallucinations developed after the other core features in men, but in women, they appeared earlier and concurrently with fluctuations and parkinsonism. Women were older and more cognitively impaired at first visit, were less likely to have RBD, more likely to be diagnosed with probable DLB later than men, and more likely to have neocortical tangles. Discussion: An earlier latency to probable DLB was associated with men, RBD, and Lewy body disease without neocortical tangles.
MeSH term(s)	Female ; Humans ; Lewy Body Disease/pathology ; Male ; Parkinsonian Disorders ; REM Sleep Behavior Disorder/complications ; REM Sleep Behavior Disorder/diagnosis
Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.12411
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Zs.MO 540: Show issues

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