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  1. Article: Therapeutic Options in Unresectable Oral Squamous Cell Carcinoma: A Systematic Review.

    Madera, Meisser / Tirado Amador, Lesbia / Leal Acosta, Carlos

    Cancer management and research

    2021  Volume 13, Page(s) 6705–6719

    Abstract: Purpose: This review describes the current scientific evidence of therapeutic options in unresectable oral squamous cell carcinoma.: Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We ... ...

    Abstract Purpose: This review describes the current scientific evidence of therapeutic options in unresectable oral squamous cell carcinoma.
    Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched MEDLINE (Via PubMed) to identify studies assessing treatments for unresectable oral squamous cell carcinoma. The methodological quality assessment of the included studies was performed using the Joanna Briggs Institute (JBI) checklist tool. The evidence was organized and presented using tables and narrative synthesis.
    Results: Thirty-three studies met the eligibility criteria. Most studies had an observational design. The sample size varied from 16 to 916 participants. The methodology quality of the included studies ranged from 2.5 to 10 using the JBI tool. Overall, the optimal treatment of patients with unresectable oral cancer is challenging, so there is a sprinkling of studies assessing a variety of therapeutic options, such as radiotherapy, chemotherapy, concurrent chemoradiotherapy, immunotherapy, targeted therapy plus chemotherapy or radiotherapy, and gene therapy plus chemotherapy.
    Conclusion: There is lacking evidence about the benefits of some therapeutic options for unresectable oral squamous cell carcinoma. Overall, these patients can be treated using a multimodal approach such as concurrent chemoradiotherapy or induction chemotherapy followed by chemoradiotherapy, which have shown good clinical outcomes. However, other options could be considered depending on the assessment of risk/benefits, tumor extension, and patient values and preferences.
    Language English
    Publishing date 2021-08-25
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S283204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Treatments for non-small cell lung cancer: a systematic quality assessment of clinical practice guidelines.

    Cortés-Jofré, Marcela / Madera, Meisser / Tirado-Amador, Lesbia / Asenjo-Lobos, Claudia / Bonfill-Cosp, Xavier

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2023  Volume 25, Issue 12, Page(s) 3541–3555

    Abstract: Aim: To evaluate the methodological quality of clinical practice guidelines (CPGs) on treatments for non-small cell lung cancer (NSCLC).: Methods: We searched MEDLINE, CPG developer websites, lung cancer societies, and oncology organizations to ... ...

    Abstract Aim: To evaluate the methodological quality of clinical practice guidelines (CPGs) on treatments for non-small cell lung cancer (NSCLC).
    Methods: We searched MEDLINE, CPG developer websites, lung cancer societies, and oncology organizations to identify CPGs providing recommendations on treatments for NSCLC. The methodological quality for each CPG was determined independently by three appraisers using the AGREE II (Appraisal of Guidelines for Research and Evaluation II) instrument.
    Results: Twenty-two CPGs met the eligibility criteria. The median scores per AGREE II domain were: scope and purpose 90.7% (64.8-100%), stakeholder involvement 76.9% (27.8-96.3%); rigor of development 80.9% (27.1-92.4%); clarity of presentation 89.8% (50-100%); applicability 46.5% (12.5-87.5%); and editorial independence 91.7% (27.8-100%). Most of the CPGs (54.5%) were rated as "recommended with modifications" for clinical use.
    Conclusions: Overall, the methodological quality of CPGs proving recommendations on the management of NSCLC is moderate, but there is still room for improvement in their development and implementation.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/therapy ; Lung Neoplasms/therapy ; Medical Oncology ; Practice Guidelines as Topic
    Language English
    Publishing date 2023-05-30
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-023-03223-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Enamel fluorosis related with fluoride-containing water ingestion and urinary excretion in schoolchildren.

    González-Martínez, Farith / Gómez-Scarpetta, Ruth / Salcedo, Olga-Bibiana / Bermúdez-Reyes, Patricia / Castro-Villamizar, Patricia / Cerezo, María Del Pilar / Martínez, Carmen / Tirado-Amador, Lesbia / Salas-Zambrano, Andrés / Saldarriaga, Alexandra / Sánchez-Molina, Marisol / Vila, Luis-Armando

    Journal of clinical and experimental dentistry

    2024  Volume 16, Issue 1, Page(s) e51–e61

    Abstract: Background: Natural water sources are considered as the major environmental exposure of fluoride, resulting in increased prevalence of enamel fluorosis. This type of natural exposure should be permanently monitored to avoid the interactions with other ... ...

    Abstract Background: Natural water sources are considered as the major environmental exposure of fluoride, resulting in increased prevalence of enamel fluorosis. This type of natural exposure should be permanently monitored to avoid the interactions with other non-natural fluoride sources. We evaluated the prevalence of enamel fluorosis in Colombian schoolchildren and its relationship with fluoride-containing water ingestion exposure dose and urinary fluoride excretion.
    Material and methods: We included 923 schoolchildren aged 7-12 years residing in eight municipalities in Colombia. Sampling of consumption water was performed in major aquifers used for daily supply. Samples were collected in 98 polyethylene containers and refrigerated until analysis. Water and urine fluoride concentrations were measured using the fluoride selective electrode method. Enamel fluorosis was evaluated using Thylstrup and Ferjerskov Index (TFI). Demographic and anthropometric characteristics were assessed. Besides, other exposures to non-natural fluoride were also evaluated. Logistic regression was applied for multiple analyses.
    Results: The median fluoride concentration in water and urine samples was 10.5 mg/L and 0.63 mg/L respectively, with the highest value found in Algarrobo-Magdalena, and the lowest value found in Manzanares-Caldas. The overall prevalence of enamel fluorosis was 86.1%, being more frequent the mild codes with TFI-1 to TFI-2. The highest prevalence was found in Margarita-Bolívar and Manzanares-Caldas, and the most severe codes (TFI-5 to TFI-9) were detected in Manzanares-Caldas. The multiple analysis revealed water ingestion exposure dose, urinary excretion, involuntary intake of toothpaste, amount of table salt consumption and sex as significant factors (
    Conclusions: The fluoride ingestion exposure dose and its subsequent urinary excretion could be used as estimators of past fluoride exposure, explaining the current prevalence of enamel fluorosis in Colombian schoolchildren.
    Language English
    Publishing date 2024-01-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.61052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Factores relacionados con la empatía en estudiantes de Enfermería de la Universidad de Cartagena.

    Madera-Anaya, Meisser / Tirado-Amador, Lesbia / González-Martínez, Farith

    Enfermeria clinica

    2016  Volume 26, Issue 5, Page(s) 282–289

    Abstract: Objective: To determine empathy levels and its relationship with sociodemographic, academic and family factors in nursing students.: Method: Cross-sectional study, 196 nursing students were randomly selected at the University of Cartagena, Colombia. ... ...

    Title translation Empathy-related factors in Nursing students of the Cartagena University.
    Abstract Objective: To determine empathy levels and its relationship with sociodemographic, academic and family factors in nursing students.
    Method: Cross-sectional study, 196 nursing students were randomly selected at the University of Cartagena, Colombia. A questionnaire that asked about sociodemographic, family and academic factors and the Scale of Physician Empathy Jefferson-version S were applied. Shapiro-Wilk test was used to assess the normality assumption. t Student, ANOVA, Pearson test and simple linear regression were used to establish the relationship (p<0.05).
    Results: The global empathy score was 108.6±14.6; statistically significant associations between global empathy with the training year (p=0.004) and grade point average (R(2)=0.058; p=0.001; r=0.240) were found. Moreover, the "perspective taking" dimension with provenance (rural/urban) (p=0.010) and family functioning (p=0.003); the "compassionate care" dimension with the training year (p=0.002) and the "putting themselves in the place of the patient" dimension with academic performance (p=0.034).
    Conclusion: The empathy levels in nursing students may vary depending on various personal and academic factors,these characteristics should be taken into account for implementing teaching strategies to promote higher empathy levels since the early training years.
    Language Spanish
    Publishing date 2016-09
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ISSN 1579-2013
    ISSN (online) 1579-2013
    DOI 10.1016/j.enfcli.2016.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Common Mental Disorders and Associated Factors in Dental Students From Cartagena, Colombia.

    Arrieta-Vergara, Katherine / Fortich-Mesa, Natalia / Tirado-Amador, Lesbia / Simancas-Pallares, Miguel

    Revista Colombiana de psiquiatria (English ed.)

    2017  Volume 48, Issue 1, Page(s) 10–16

    Abstract: Introduction: Psychological morbidity assessments are of interest since mental health is part of a person's overall health and early detection promotes emotional well-being.: Aim: To determine the association between common mental disorders and ... ...

    Title translation Trastornos mentales comunes y factores asociados en estudiantes de Odontología en Cartagena, Colombia.
    Abstract Introduction: Psychological morbidity assessments are of interest since mental health is part of a person's overall health and early detection promotes emotional well-being.
    Aim: To determine the association between common mental disorders and related factors in dental students from Cartagena, Colombia.
    Methods: We conducted a cross-sectional study in 858 dental students from Cartagena, Colombia; who answered a structured anonymous self-report questionnaire to assess the presence of common mental disorders (CMD) (General Health Questionnaire-12), problematic alcohol consumption (CAGE), sociodemographic and other related variables. Data were analyzed using descriptive statistics and bivariate analysis was conducted later using χ
    Results: The average age was 20.8±3.01 years of age, and more than half were females. CMD overall prevalence was 30.3% (95%CI, 27.3-33.5). The regression model suggested as associated factors: sex (PR, 1.54; 95%CI, 1.21-1.96), recent economic changes (PR, 1.70; 95%CI, 1.37-2.12), family conflicts [PR, 2.29; 95%CI, 1.89-2.77), abandonment (PR, 1.58; 95%CI, 1.23-2.03), history of abuse (PR, 2.05; 95%CI, 1.27-3.31), and problematic alcohol consumption (PR, 1.35; 95%CI, 1.02-1.78).
    Conclusions: CMD prevalence was high. Being female, family conflicts, history of abuse and problematic alcohol consumption are considered as risk factors for CMD development and should be carefully assessed to predict emotional well-being.
    MeSH term(s) Adolescent ; Alcohol Drinking/epidemiology ; Colombia/epidemiology ; Cross-Sectional Studies ; Family Conflict/psychology ; Female ; Humans ; Male ; Mental Disorders/epidemiology ; Prevalence ; Regression Analysis ; Risk Factors ; Sex Factors ; Students, Dental/psychology ; Students, Dental/statistics & numerical data ; Surveys and Questionnaires ; Young Adult
    Language Spanish
    Publishing date 2017-06-27
    Document type Journal Article
    ISSN 2530-3120
    ISSN (online) 2530-3120
    DOI 10.1016/j.rcp.2017.05.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Distribución de la orientación empática en estudiantes de odontología. Cartagena, Colombia.

    González-Martínez, Farith D / Díaz-Narváez, Víctor P / Arrieta-Vergara, Katherine / Díaz-Cárdenas, Shyrley / Tirado-Amador, Lesbia R / Madera-Anaya, Meisser

    Revista de salud publica (Bogota, Colombia)

    2015  Volume 17, Issue 3, Page(s) 404–415

    Abstract: Objective To describe the level of empathy of dental students at the University of Cartagena. Methods A descriptive, quantitative study on a sample of 360 students from 1st to 5th year of Dentistry at the University of Cartagena (Colombia) during the ... ...

    Title translation Distribution of empathetic orientation among dentistry students of Cartagena, Colombia.
    Abstract Objective To describe the level of empathy of dental students at the University of Cartagena. Methods A descriptive, quantitative study on a sample of 360 students from 1st to 5th year of Dentistry at the University of Cartagena (Colombia) during the second academic period of 2012. The Spanish version for students (S version) of the Jefferson Scale of Physician Empathy (JSPE) was administered to them. The analysis consisted of calculating descriptive statistics, the arithmetic mean, and standard deviation of all the factors and their corresponding levels. The comparison of means was performed through bifactorial analysis of variance model III, with first-order interaction and application of the Duncan multiple comparison test. Results Statistically significant differences were found for the "year" variables (p<0.005) and gender (p <0.001). Lower empathic orientation values were found for 1st year students and higher value were found for women. No significance was found in the interaction between these two factors (p>0.05). Conclusions Empathic orientation values in the dental students assessed were different depending on the level or year of study and the student's gender. This may influence the comprehensive training promoted by higher education institutions as part of their educational projects. It also provides an imperative for the promotion of interpersonal skills interpersonal skills among students starting in the first years of their training to help improve the quality of health care provided.
    Language Spanish
    Publishing date 2015-05
    Publishing country Colombia
    Document type English Abstract ; Journal Article
    ZDB-ID 2060572-9
    ISSN 0124-0064
    ISSN 0124-0064
    DOI 10.15446/rsap.v17n3.37591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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