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  1. Article ; Online: Ornithodoros hermsi.

    Sousa-Paula, Lucas C de / Schwan, Tom G / Tirloni, Lucas

    Trends in parasitology

    2024  

    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2024.04.008
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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  2. Article ; Online: Tick Salivary Kunitz-Type Inhibitors: Targeting Host Hemostasis and Immunity to Mediate Successful Blood Feeding.

    Jmel, Mohamed Amine / Voet, Hanne / Araújo, Ricardo N / Tirloni, Lucas / Sá-Nunes, Anderson / Kotsyfakis, Michail

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Kunitz domain-containing proteins are ubiquitous serine protease inhibitors with promising therapeutic potential. They target key proteases involved in major cellular processes such as inflammation or hemostasis through competitive inhibition in a ... ...

    Abstract Kunitz domain-containing proteins are ubiquitous serine protease inhibitors with promising therapeutic potential. They target key proteases involved in major cellular processes such as inflammation or hemostasis through competitive inhibition in a substrate-like manner. Protease inhibitors from the Kunitz superfamily have a low molecular weight (18-24 kDa) and are characterized by the presence of one or more Kunitz motifs consisting of α-helices and antiparallel β-sheets stabilized by three disulfide bonds. Kunitz-type inhibitors are an important fraction of the protease inhibitors found in tick saliva. Their roles in inhibiting and/or suppressing host homeostatic responses continue to be shown to be additive or synergistic with other protease inhibitors such as cystatins or serpins, ultimately mediating successful blood feeding for the tick. In this review, we discuss the biochemical features of tick salivary Kunitz-type protease inhibitors. We focus on their various effects on host hemostasis and immunity at the molecular and cellular level and their potential therapeutic applications. In doing so, we highlight that their pharmacological properties can be exploited for the development of novel therapies and vaccines.
    MeSH term(s) Animals ; Ticks ; Serine Proteinase Inhibitors/pharmacology ; Serine Proteinase Inhibitors/therapeutic use ; Serine Proteinase Inhibitors/metabolism ; Serpins/metabolism ; Saliva/metabolism ; Cystatins/metabolism
    Chemical Substances Serine Proteinase Inhibitors ; Serpins ; Cystatins
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021556
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  3. Article ; Online: A longitudinal transcriptomic analysis from unfed to post-engorgement midguts of adult female Ixodes scapularis.

    Lu, Stephen / Martins, Larissa A / Kotál, Jan / Ribeiro, José M C / Tirloni, Lucas

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11360

    Abstract: The hematophagy behavior has evolved independently several times within the Arthropoda phylum. Interestingly, the process of acquiring a blood meal in ticks is considerably distinct from that observed in other blood-feeding arthropods. Instead of taking ... ...

    Abstract The hematophagy behavior has evolved independently several times within the Arthropoda phylum. Interestingly, the process of acquiring a blood meal in ticks is considerably distinct from that observed in other blood-feeding arthropods. Instead of taking seconds to minutes to complete a blood meal, an adult female Ixodes scapularis tick can remain attached to its host for numerous days. During this extended feeding period, the tick undergoes drastic morphological changes. It is well established that the tick midgut plays a pivotal role not only in blood meal digestion but also in pathogen acquisition and transmission. However, our understanding of the underlying molecular mechanisms involved in these events remains limited. To expedite tick research, we conducted a comprehensive longitudinal RNA-sequencing of the tick midgut before, during, and after feeding. By collecting ticks in different feeding stages (unfed, slow feeding, rapid feeding, and early post-detached), we obtained a comprehensive overview of the transcripts present in each stage and the dynamic transcriptional changes that occur between them. This provides valuable insights into tick physiology. Additionally, through unsupervised clustering, we identified transcripts with similar patterns and stage-specific sequences. These findings serve as a foundation for selecting targets in the development of anti-tick control strategies and facilitate a better understanding of how blood feeding and pathogen infection impact tick physiology.
    MeSH term(s) Animals ; Female ; Ixodes/genetics ; Transcriptome ; Digestive System ; Gene Expression Profiling ; Feeding Behavior
    Language English
    Publishing date 2023-07-13
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38207-5
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  4. Article ; Online: A longitudinal transcriptomic analysis of Rhipicephalus microplus midgut upon feeding.

    Lu, Stephen / Waldman, Jéssica / Parizi, Luís Fernando / Junior, Itabajara da Silva Vaz / Tirloni, Lucas

    Ticks and tick-borne diseases

    2023  Volume 15, Issue 2, Page(s) 102304

    Abstract: Rhipicephalus microplus, a highly host-specific tick that primarily feeds on cattle, posing a significant threat to livestock production. The investigation of tick physiology is crucial for identifying potential targets in tick control. Of particular ... ...

    Abstract Rhipicephalus microplus, a highly host-specific tick that primarily feeds on cattle, posing a significant threat to livestock production. The investigation of tick physiology is crucial for identifying potential targets in tick control. Of particular interest adult female ticks undergo a significant expansion of the midgut during feeding, leading to an over 100-fold increase in body weight. Beyond the functions of storing and digesting blood meals, the tick midgut plays a crucial role in acquiring and transmitting pathogens. However, our understanding of tick midgut physiology remains limited. In this study we conducted a comprehensive longitudinal transcriptome analysis of the midgut from adult female R. microplus ticks collected at various feeding stages, providing an overview of the transcriptional modulation in this organ as feeding progress. By employing a de novo assembly approach followed by coding-sequences (CDS) extraction, 60,599 potential CDS were identified. In preparation for functional annotation and differential expression analysis, transcripts that showed an average transcript per million (TPM) ≥ 3 in at least one of the biological conditions were extracted. This selection process resulted in a total of 10,994 CDS, which were categorized into 24 functional classes. Notably, our differential expression analysis revealed three main transcriptional profiles. In the first one, representing the slow-feeding stage, the most abundant functional classes were the "protein synthesis" and "secreted" groups, reflecting the highly active state of the tick midgut. The second profile partially accounts for the rapid-feeding stage, in which a high number of differentially expressed transcripts was observed. Lastly, the third transcriptional profile represents post-detached ticks. Notably the highest number of modulated transcripts was observed up to 48 h post-detachment (hpd), however no major differences was observed up to 168 hpd. Overall, the data presented here offers a temporal insight into tick midgut physiology, contributing to the identification of potential targets for the development of anti-tick control strategies.
    MeSH term(s) Female ; Animals ; Cattle ; Rhipicephalus/genetics ; Gene Expression Profiling ; Digestive System/metabolism
    Language English
    Publishing date 2023-12-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Putative target sites in synganglion for novel ixodid tick control strategies.

    Waldman, Jéssica / Klafke, Guilherme Marcondes / Tirloni, Lucas / Logullo, Carlos / da Silva Vaz, Itabajara

    Ticks and tick-borne diseases

    2023  Volume 14, Issue 3, Page(s) 102123

    Abstract: Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to ... ...

    Abstract Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control.
    MeSH term(s) Animals ; Humans ; Cattle ; Acaricides/pharmacology ; Rhipicephalus ; Tick Control ; Ixodidae ; Vaccines ; Tick Infestations/prevention & control ; Tick Infestations/veterinary ; Cattle Diseases/prevention & control
    Chemical Substances Acaricides ; Vaccines
    Language English
    Publishing date 2023-01-19
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102123
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  6. Article ; Online: Use of a novel chyme reinfusion device during damage control surgery to improve nutritional status in a patient with a proximal ileostomy: A video vignette.

    Alemanno, Giovanni / Tirloni, Luca / Morabito, Antonino / Coletta, Riccardo / Prosperi, Paolo

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2022  Volume 24, Issue 10, Page(s) 1255–1256

    MeSH term(s) Humans ; Ileostomy ; Nutritional Status ; Gastrointestinal Contents
    Language English
    Publishing date 2022-06-03
    Publishing country England
    Document type Video-Audio Media ; Letter
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16166
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5799: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Iripin 1, a new anti inflammatory tick serpin, inhibits leukocyte recruitment in vivo while altering the levels of chemokines and adhesion molecules

    Chlastakova, A. / Kascakova, B. / Kotal, J. / Langhansova, H. / Kotsyfakis, M. / Kuta Smatanova, I. / Tirloni, L. / Chmelar, J.

    2023  

    Abstract: Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti coagulation, anti inflammatory, and immunomodulatory activities via their saliva into the feeding cavity to modulate host s hemostatic ...

    Abstract Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti coagulation, anti inflammatory, and immunomodulatory activities via their saliva into the feeding cavity to modulate host s hemostatic and immune reaction initiated by the insertion of tick s mouthparts into skin. The suppression of the host s immune response not only allows ticks to feed on a host for several days but also creates favorable conditions for the transmission of tick borne pathogens. Herein we present the functional and structural characterization of Iripin 1 Ixodes ricinus serpin 1 , whose expression was detected in the salivary glands of the tick Ixodes ricinus, a European vector of tick borne encephalitis and Lyme disease. Of 16 selected serine proteases, Iripin 1 inhibited primarily trypsin and further exhibited weaker inhibitory activity against kallikrein, matriptase, and plasmin. In the mouse model of acute peritonitis, Iripin 1 enhanced the production of the anti inflammatory cytokine IL 10 and chemokines involved in neutrophil and monocyte recruitment, including MCP 1 CCL2, a potent histamine releasing factor. Despite increased chemokine levels, the migration of neutrophils and monocytes to inflamed peritoneal cavities was significantly attenuated following Iripin 1 administration. Based on the results of in vitro experiments, immune cell recruitment might be inhibited due to Iripin 1 mediated reduction of the expression of chemokine receptors in neutrophils and adhesion molecules in endothelial cells. Decreased activity of serine proteases in the presence of Iripin 1 could further impede cell migration to the site of inflammation. Finally, we determined the tertiary structure of native Iripin 1 at 2.10 resolution by employing the X ray crystallography technique. In conclusion, our data indicate that Iripin 1 facilitates I. ricinus feeding by attenuating the host s inflammatory response at the tick attachment site
    Keywords serpin ; iripin ; ticks ; ixodes ricinus ; tick saliva ; tick host interaction ; anti inflammatory protein ; cell migration
    Subject code 572
    Language Undetermined
    Publishing date 2023-01-01
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Editorial: The Role of Saliva in Arthropod-Host-Pathogen Relationships.

    Tirloni, Lucas / Calvo, Eric / Konnai, Satoru / da Silva Vaz, Itabajara

    Frontiers in cellular and infection microbiology

    2021  Volume 10, Page(s) 630626

    MeSH term(s) Animals ; Arthropod Vectors ; Arthropods ; Saliva ; Ticks
    Language English
    Publishing date 2021-01-28
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.630626
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  9. Article: Complications in Post-Liver Transplant Patients.

    Agostini, Carlotta / Buccianti, Simone / Risaliti, Matteo / Fortuna, Laura / Tirloni, Luca / Tucci, Rosaria / Bartolini, Ilenia / Grazi, Gian Luca

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: Liver transplantation (LT) is the treatment of choice for liver failure and selected cases of malignancies. Transplantation activity has increased over the years, and indications for LT have been widened, leading to organ shortage. To face this condition, ...

    Abstract Liver transplantation (LT) is the treatment of choice for liver failure and selected cases of malignancies. Transplantation activity has increased over the years, and indications for LT have been widened, leading to organ shortage. To face this condition, a high selection of recipients with prioritizing systems and an enlargement of the donor pool were necessary. Several authors published their case series reporting the results obtained with the use of marginal donors, which seem to have progressively improved over the years. The introduction of in situ and ex situ machine perfusion, although still strongly debated, and better knowledge and treatment of the complications may have a role in achieving better results. With longer survival rates, a significant number of patients will suffer from long-term complications. An extensive review of the literature concerning short- and long-term outcomes is reported trying to highlight the most recent findings. The heterogeneity of the behaviors within the different centers is evident, leading to a difficult comparison of the results and making explicit the need to obtain more consent from experts.
    Language English
    Publishing date 2023-09-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196173
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  10. Article ; Online: Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment

    Chlastáková, Adéla / Kaščáková, Barbora / Kotál, Jan / Langhansová, Helena / Kotsyfakis, Michail / Kutá Smatanová, Ivana / Tirloni, Lucas / Chmelař, Jindřich

    Frontiers in immunology

    2023  Volume 14, Page(s) 1116324

    Abstract: Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory ... ...

    Abstract Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities
    MeSH term(s) Mice ; Animals ; Serpins/metabolism ; Endothelial Cells/metabolism ; Ixodes/metabolism ; Chemokines ; Monocytes/metabolism ; Trypsin ; Anti-Inflammatory Agents/pharmacology
    Chemical Substances Serpins ; Chemokines ; Trypsin (EC 3.4.21.4) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1116324
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