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  1. AU="Tissera, Hasitha A"
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  1. Artikel ; Online: Severe Dengue Epidemic, Sri Lanka, 2017.

    Tissera, Hasitha A / Jayamanne, Bernard D W / Raut, Rajendra / Janaki, Sakunthala M D / Tozan, Yesim / Samaraweera, Preshila C / Liyanage, Prasad / Ghouse, Azhar / Rodrigo, Chaturaka / de Silva, Aravinda M / Fernando, Sumadhya D

    Emerging infectious diseases

    2020  Band 26, Heft 4, Seite(n) 682–691

    Abstract: In 2017, a dengue epidemic of unexpected magnitude occurred in Sri Lanka. A total of 186,101 suspected cases and 440 dengue-related deaths occurred. We conducted a comprehensive analysis of this epidemic by comparing national surveillance data for 2017 ... ...

    Abstract In 2017, a dengue epidemic of unexpected magnitude occurred in Sri Lanka. A total of 186,101 suspected cases and 440 dengue-related deaths occurred. We conducted a comprehensive analysis of this epidemic by comparing national surveillance data for 2017 with data from the preceding 5 years. In all Sri Lanka districts, dengue incidence in 2017 increased significantly over incidence during the previous 5 years. Older schoolchildren and young adults were more clinically symptomatic than those at extremes of age. Limited virologic surveillance showed the dominant circulating variant was dengue virus type 2 cosmopolitan genotype in the most affected district. One quarter of total annual cases were reported 5 weeks after the southwest monsoon started. Changes in vector abundance were not predictive of the increased incidence. Direct government expenditures on dengue control activities in 2017 were US $12.7 million. The lessons learned from this outbreak are useful for other tropical nations facing increasing dengue incidence.
    Mesh-Begriff(e) Child ; Dengue/epidemiology ; Dengue Virus/genetics ; Epidemics ; Humans ; Severe Dengue/diagnosis ; Severe Dengue/epidemiology ; Sri Lanka/epidemiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-03-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2604.190435
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Risk prediction for severe disease and better diagnostic accuracy in early dengue infection; the Colombo dengue study.

    Sigera, Ponsuge Chathurani / Amarasekara, Ranmalee / Rodrigo, Chaturaka / Rajapakse, Senaka / Weeratunga, Praveen / De Silva, Nipun Lakshita / Huang, Chun Hong / Sahoo, Malaya K / Pinsky, Benjamin A / Pillai, Dylan R / Tissera, Hasitha A / Jayasinghe, Saroj / Handunnetti, Shiroma / Fernando, Sumadhya D

    BMC infectious diseases

    2019  Band 19, Heft 1, Seite(n) 680

    Abstract: Background: A major challenge in dengue management in resource limited settings is the confirmation of diagnosis. Clinical features of dengue often overlap with other infections and molecular diagnostic tools are not readily accessible to clinicians at ... ...

    Abstract Background: A major challenge in dengue management in resource limited settings is the confirmation of diagnosis. Clinical features of dengue often overlap with other infections and molecular diagnostic tools are not readily accessible to clinicians at hospitals. In addition, the prediction of plasma leakage in dengue is also difficult. Hematocrit level and ultrasound scans (combined with clinical parameters) are helpful to detect plasma leakage once it has happened, not before.
    Methods: Colombo Dengue Study (CDS) is a prospective cohort study of clinically suspected adult dengue patients recruited from the National hospital of Sri Lanka (within the first 3 days of fever) that aimed to a) identify clinical and basic laboratory test parameters to differentiate dengue from non-dengue fever, b) evaluate the comparative efficacy of loop-mediated isothermal amplification (LAMP) for dengue diagnosis (vs. NS1 antigen test and RT-qPCR) and c) identify early associations that are predictive of plasma leakage or severe dengue. The basic laboratory tests considered here included hematological parameters, serum biochemistry and inflammatory markers.
    Results: Only 70% of clinically suspected patients were confirmed as having dengue by either the NS1 antigen test or RT-qPCR. On a Bayesian latent class model which assumes no "gold standard", LAMP performed equally or better than RT-qPCR and NS1 antigen test respectively. When confirmed dengue patients were compared with others, the earlier group had significantly lower lymphocyte counts and higher aspartate aminotransferase levels (AST) within the first 3 days of fever. Confirmed dengue patients with plasma leakage had a lower mean age and a higher median baseline AST level compared to those without plasma leakage (p < 0.05).
    Conclusion: Clinical suspicion overestimates the true number of dengue patients. RT-LAMP is a potentially useful low-cost diagnostic tool for dengue diagnosis. Confirmed dengue patients had significantly higher AST levels and lower lymphocyte counts in early disease compared to others. In confirmed dengue patients, younger age and a higher AST level in early infection were associated with subsequent plasma leakage.
    Mesh-Begriff(e) Adult ; Aspartate Aminotransferases/blood ; Bayes Theorem ; Biomarkers/blood ; Cohort Studies ; Dengue/diagnosis ; Dengue Virus/genetics ; Female ; Fever/virology ; Humans ; Immunologic Tests ; Lymphocyte Count ; Male ; Middle Aged ; Nucleic Acid Amplification Techniques/methods ; Prospective Studies ; Real-Time Polymerase Chain Reaction/methods ; Risk Assessment ; Sensitivity and Specificity ; Severe Dengue/blood ; Severe Dengue/diagnosis ; Severe Dengue/etiology ; Sri Lanka
    Chemische Substanzen Biomarkers ; Aspartate Aminotransferases (EC 2.6.1.1)
    Sprache Englisch
    Erscheinungsdatum 2019-08-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Observational Study
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-019-4304-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Characteristics of and factors associated with dengue vector breeding sites in the City of Colombo, Sri Lanka.

    Louis, Valérie R / Montenegro Quiñonez, Carlos Alberto / Kusumawathie, Pad / Palihawadana, Paba / Janaki, Sakoo / Tozan, Yesim / Wijemuni, Ruwan / Wilder-Smith, Annelies / Tissera, Hasitha A

    Pathogens and global health

    2016  Band 110, Heft 2, Seite(n) 79–86

    Abstract: Introduction: Dengue has emerged as a major public health problem in Sri Lanka. Vector control at community level is a frequent and widespread strategy for dengue control. The aim of the study was to assess Aedes mosquito breeding sites and the ... ...

    Abstract Introduction: Dengue has emerged as a major public health problem in Sri Lanka. Vector control at community level is a frequent and widespread strategy for dengue control. The aim of the study was to assess Aedes mosquito breeding sites and the prevention practices of community members in a heavily urbanized part of Colombo.
    Methods: A cross-sectional entomological survey was conducted from April to June 2013 in 1469 premises located in a subdistrict of the City of Colombo. Types of breeding sites and, where found, their infestation with larvae or pupae were recorded. Furthermore, a questionnaire was administered to the occupants of these premises to record current practices of dengue vector control.
    Results: The surveyed premises consisted of 1341 residential premises and 110 non-residential premises (11 schools, 99 work or public sites), 5 open lands, and 13 non-specified. In these 1469 premises, 15447 potential breeding sites suitable to host larvae of pupae were found; of these sites18.0% contained water. Among the 2775 potential breeding sites that contained water, 452 (16.3%) were positive for larvae and/or pupae. Schools were associated with the proportionally highest number of breeding sites; 85 out of 133 (63.9%) breeding sites were positive for larvae and/or pupae in schools compared with 338 out of 2288 (14.8%) in residential premises. The odds ratio (OR) for schools and work or public sites for being infested with larvae and/or pupae was 2.77 (95% CI 1.58, 4.86), when compared to residential premises. Occupants of 80.8% of the residential premises, 54.5% of the schools and 67.7% of the work or public sites reported using preventive measures. The main prevention practices were coverage of containers and elimination of mosquito breeding places. Occupants of residential premises were much more likely to practice preventive measures than were those of non-residential premises (OR 2.23; 1.49, 3.36).
    Conclusion: Schools and working sites were associated with the highest numbers of breeding sites and lacked preventive measures for vector control. In addition to pursuing vector control measures at residential level, public health strategies should be expanded in schools and work places.
    Mesh-Begriff(e) Adult ; Aedes/physiology ; Aedes/virology ; Animals ; Breeding ; Child ; Cross-Sectional Studies ; Dengue/epidemiology ; Dengue/prevention & control ; Dengue/transmission ; Dengue Virus/immunology ; Female ; Housing ; Humans ; Insect Vectors/physiology ; Insect Vectors/virology ; Larva ; Male ; Mosquito Control/methods ; Public Health ; Pupa ; Sri Lanka/epidemiology ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2016-05-31
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2625162-0
    ISSN 2047-7732 ; 2047-7724
    ISSN (online) 2047-7732
    ISSN 2047-7724
    DOI 10.1080/20477724.2016.1175158
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Emergence and diversification of dengue 2 cosmopolitan genotype in Pakistan, 2011.

    Khan, Mohammad A / Ellis, Esther M / Tissera, Hasitha A / Alvi, Mohammad Y / Rahman, Fatima F / Masud, Faisal / Chow, Angelia / Howe, Shiqin / Dhanasekaran, Vijaykrishna / Ellis, Brett R / Gubler, Duane J

    PloS one

    2013  Band 8, Heft 3, Seite(n) e56391

    Abstract: Major dengue epidemics have been observed in the Indian subcontinent since the 1980s and have occurred with increased hospitalizations and mortality. In 2011, the first major epidemic of dengue occurred in Lahore, the second largest city in Pakistan, and ...

    Abstract Major dengue epidemics have been observed in the Indian subcontinent since the 1980s and have occurred with increased hospitalizations and mortality. In 2011, the first major epidemic of dengue occurred in Lahore, the second largest city in Pakistan, and resulted in 21,685 confirmed cases and 350 deaths. To investigate the possible viral causes for the increased epidemic activity, we determined the predominant serotype and characterized the viruses genetically. Of 50 patients carefully selected as probable dengue fever or dengue hemorrhagic fever, 34 were positive by virologic testing (i.e. PCR and/or virus isolation). DENV-2 was detected in 32 patients and DENV-1 in two. A total of 24 partial and three full DENV genomes were sequenced. Phylogenetic analyses of the capsid (C), pre-membrane (prM), and envelope genes comprising 2500 nucleotides in length indicated that all DENV-2 isolates in Pakistan since 2007 form a monophyletic lineage that is endemic in the country. These viruses were all of the cosmopolitan genotype (IV) and most closely related to viruses isolated in India and Sri Lanka in the past two decades. Phylogenetic analyses of data currently available in GenBank suggest that the Cosmopolitan genotype has diverged into two geographically distinct sub-lineages: sub-lineage IV-a has only been observed in Southeast Asia, China and Oceania, while IV-b is prevalent in the Indian subcontinent. These results highlight the increased diversity of dengue viruses as they spread geographically within the region.
    Mesh-Begriff(e) Adult ; Capsid Proteins/genetics ; DNA, Viral/genetics ; Dengue/epidemiology ; Dengue/genetics ; Dengue/virology ; Dengue Virus/genetics ; Dengue Virus/isolation & purification ; Female ; Genotype ; Humans ; Male ; Pakistan/epidemiology ; Phylogeny ; Polymerase Chain Reaction/methods ; Urban Population
    Chemische Substanzen Capsid Proteins ; DNA, Viral
    Sprache Englisch
    Erscheinungsdatum 2013-03-08
    Erscheinungsland United States
    Dokumenttyp Clinical Trial ; Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0056391
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Severe dengue epidemics in Sri Lanka, 2003-2006.

    Kanakaratne, Nalaka / Wahala, Wahala M P B / Messer, William B / Tissera, Hasitha A / Shahani, Aruna / Abeysinghe, Nihal / de-Silva, Aravinda M / Gunasekera, Maya

    Emerging infectious diseases

    2008  Band 15, Heft 2, Seite(n) 192–199

    Abstract: Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003-2006) and past (1980-1997) dengue surveillance data for Sri Lanka. The 4 dengue virus (DENV) serotypes have been ... ...

    Abstract Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003-2006) and past (1980-1997) dengue surveillance data for Sri Lanka. The 4 dengue virus (DENV) serotypes have been cocirculating in Sri Lanka for >30 years. Over this period, a new genotype of DENV-1 has replaced an old genotype. Moreover, new clades of DENV-3 genotype III viruses have replaced older clades. Emergence of new clades of DENV-3 in 1989 and 2000 coincided with abrupt increases in the number of reported dengue cases, implicating this serotype in severe epidemics. In 1980-1997, most reported dengue cases were in children. Recent epidemics have been characterized by many cases in children and adults. Changes in local transmission dynamics and genetic changes in DENV-3 are likely increasing emergence of severe dengue epidemics in Sri Lanka.
    Mesh-Begriff(e) Adolescent ; Adult ; Age Distribution ; Animals ; Child ; Child, Preschool ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/physiopathology ; Communicable Diseases, Emerging/virology ; Dengue Virus/classification ; Dengue Virus/genetics ; Dengue Virus/isolation & purification ; Disease Outbreaks ; Genotype ; Humans ; Infant ; Infant, Newborn ; Middle Aged ; Phylogeny ; Sequence Analysis, DNA ; Serotyping ; Severe Dengue/epidemiology ; Severe Dengue/physiopathology ; Severe Dengue/virology ; Severity of Illness Index ; Sri Lanka/epidemiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2008-12-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid1502.080926
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Severe Dengue Epidemics in Sri Lanka, 2003–2006.

    Kanakaratne, Nalaka / Wahala, Wahala MPB / Messer, William B / Tissera, Hasitha A / Shahani, Aruna / Abeysinghe, Nihal / de Silva, Aravinda M / Gunasekera, Maya

    2009  

    Abstract: Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003–2006) and past (1980–1997) dengue surveillance data for Sri Lanka. The 4 dengue virus (DENV) serotypes have been ... ...

    Abstract Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003–2006) and past (1980–1997) dengue surveillance data for Sri Lanka. The 4 dengue virus (DENV) serotypes have been cocirculating in Sri Lanka for >30 years. Over this period, a new genotype of DENV-1 has replaced an old genotype. Moreover, new clades of DENV-3 genotype III viruses have replaced older clades. Emergence of new clades of DENV-3 in 1989 and 2000 coincided with abrupt increases in the number of reported dengue cases, implicating this serotype in severe epidemics. In 1980–1997, most reported dengue cases were in children. Recent epidemics have been characterized by many cases in children and adults. Changes in local transmission dynamics and genetic changes in DENV-3 are likely increasing emergence of severe dengue epidemics in Sri Lanka.
    Sprache Englisch
    Erscheinungsdatum 2009-02-04
    Erscheinungsland th
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  7. Artikel ; Online: New dengue virus type 1 genotype in Colombo, Sri Lanka.

    Tissera, Hasitha A / Ooi, Eng Eong / Gubler, Duane J / Tan, Ying / Logendra, Barathy / Wahala, Wahala M P B / de Silva, Aravinda M / Abeysinghe, M R Nihal / Palihawadana, Paba / Gunasena, Sunethra / Tam, Clarence C / Amarasinghe, Ananda / Letson, G William / Margolis, Harold S / De Silva, Aruna Dharshan

    Emerging infectious diseases

    2011  Band 17, Heft 11, Seite(n) 2053–2055

    Abstract: The number of cases and severity of disease associated with dengue infection in Sri Lanka has been increasing since 1989, when the first epidemic of dengue hemorrhagic fever was recorded. We identified a new dengue virus 1 strain circulating in Sri Lanka ...

    Abstract The number of cases and severity of disease associated with dengue infection in Sri Lanka has been increasing since 1989, when the first epidemic of dengue hemorrhagic fever was recorded. We identified a new dengue virus 1 strain circulating in Sri Lanka that coincided with the 2009 dengue epidemic.
    Mesh-Begriff(e) Dengue/epidemiology ; Dengue/virology ; Dengue Virus/classification ; Dengue Virus/genetics ; Dengue Virus/isolation & purification ; Genes, Viral ; Genotype ; Humans ; Phylogeny ; RNA, Viral/chemistry ; Severe Dengue/epidemiology ; Severe Dengue/virology ; Sri Lanka/epidemiology
    Chemische Substanzen RNA, Viral
    Sprache Englisch
    Erscheinungsdatum 2011-11-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid1711.101893
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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