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Article: Lemierre's Syndrome in the 21st Century: A Literature Review.

Tiwari, Abhinav

2023 Volume 15, Issue 8, Page(s) e43685

Abstract: Lemierre's syndrome is a rare, life-threatening complication of an acute oropharyngeal infection. It is generally characterised by pharyngitis secondary ... ...

Abstract	Lemierre's syndrome is a rare, life-threatening complication of an acute oropharyngeal infection. It is generally characterised by pharyngitis secondary to
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.43685
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Desorption and Sorption Isotherms of Different Varieties of Hemp Seeds with Different Percentages of Dockage under Different Temperatures and Different Relative Humidities

Tiwari, Abhinav / Jian, Fuji

Agriculture. 2023 Oct. 08, v. 13, no. 10

2023

Abstract: Hemp cultivation faces challenges due to the adoption of dioecious cultivars, which suffer from biomass loss and fibre heterogeneity. In contrast, monoecious cultivars offer simultaneous fibre and seed production, albeit with lower fibre quality. ... ...

Abstract	Hemp cultivation faces challenges due to the adoption of dioecious cultivars, which suffer from biomass loss and fibre heterogeneity. In contrast, monoecious cultivars offer simultaneous fibre and seed production, albeit with lower fibre quality. Understanding the drying characteristics and storage requirements of hemp seeds is crucial for effective post-harvest management. This study explored the moisture sorption and desorption isotherms of two common Canadian hemp seed varieties, Altair (dioecious) and CanMa (monoecious), by using both saturated salt solution (SSS) and thin-layer drying methods. Their isotherms were also compared with the published isotherm of Finola—a common dioecious variety in Europe. The thin-layer drying method yielded higher EMC values than the SSS method due to incomplete equilibrium attainment. Larger EMC differences existed between different seed types (dioecious vs. monoecious), and this difference was small between the same seed types (dioecious vs. dioecious). The GAB equation provided the most accurate prediction of equilibrium moisture contents for both varieties.
Keywords	agriculture ; biomass ; cultivars ; desorption ; dioecy ; equations ; fiber quality ; hemp ; monoecy ; postharvest technology ; prediction ; sorption ; Europe
Language	English
Dates of publication	2023-1008
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture13101959
Database	NAL-Catalogue (AGRICOLA)

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Article: Role of Positron Emission Tomography/Computed Tomography in Epithelial Ovarian Cancer.

Chandra, Rudrika / Kumari, Sarita / Bhatla, Neerja / Kumar, Rakesh / Tiwari, Abhinav / Sachani, Hemant / Kumar, Lalit

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

2023 Volume 38, Issue 4, Page(s) 366–375

Abstract: Ovarian cancer (OC) is the most lethal gynecological malignancy with majority of cases diagnosed in advanced stages and associated with high morbidity and mortality. Positron emission tomography/computed tomography (PET/CT) has emerged as an integral ... ...

Abstract	Ovarian cancer (OC) is the most lethal gynecological malignancy with majority of cases diagnosed in advanced stages and associated with high morbidity and mortality. Positron emission tomography/computed tomography (PET/CT) has emerged as an integral part of the management of several nongynecological cancers. We used PubMed search engine using MeSH words "ovarian cancer" and "PET/CT" and reviewed the current status of PET/CT in epithelial OC. Its application related to ovarian tumor including adnexal mass evaluation, baseline staging, as a triaging tool for upfront surgery or neoadjuvant chemotherapy, for response assessment and prognostication, and for relapse detection and treatment planning has been highlighted. we highlight the current guidelines and newer upcoming PET modalities and radiotracers.
Language	English
Publishing date	2023-12-20
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2181722-4
ISSN	0974-0244 ; 0972-3919
ISSN (online)	0974-0244
ISSN	0972-3919
DOI	10.4103/ijnm.ijnm_42_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of PD1 and PDL1 immunotherapy on non-small cell lung cancer outcomes: a systematic review.

Kanabar, Shivani Setur / Tiwari, Abhinav / Soran, Vina / Balendran, Prashanthan / Price, Malcolm / Turner, Alice Margaret

Thorax

2022 Volume 77, Issue 12, Page(s) 1163–1174

Abstract: Introduction: Despite comprising many cancer diagnoses, few treatments are suitable for patients with advanced non-small cell lung cancer (aNSCLC). Trials suggest blockade of programmed death 1 (PD1) or its ligand (PDL1) may be effective for these ... ...

Abstract	Introduction: Despite comprising many cancer diagnoses, few treatments are suitable for patients with advanced non-small cell lung cancer (aNSCLC). Trials suggest blockade of programmed death 1 (PD1) or its ligand (PDL1) may be effective for these patients. However, this therapy's impact on outcomes other than survival, and outcomes of patients not in trials, remains largely unknown. Therefore, we compared the effectiveness of PD1 and PDL1 immunotherapy to chemotherapy and placebo across multiple clinical outcomes. Methods: Six databases were searched on 12-13 October 2019 for randomised controlled trials (RCTs) and observational studies investigating nivolumab, pembrolizumab, atezolizumab or durvalumab. Study selection was performed independently by two reviewers. Data for overall survival, progression-free survival, adverse effects (AEs) and quality of life (QoL) were descriptively and meta-analysed. Factors impacting treatment outcomes, including PDL1 expression, were explored. The similarity between RCT and observational data was assessed. Results: From 5423 search results, 139 full texts and abstracts were included. Immunotherapy was associated with a lower risk of death than both comparators. In RCTs, the incidence of treatment-related AEs was approximately 20% lower among patients using immunotherapy compared with chemotherapy. However, no other consistent benefits were observed. Progression-free survival results were inconsistent. Improvements to QoL varied according to the instrument used; however, QoL was not recorded widely. Survival results were similar between study designs; however, AEs incidence was lower in observational studies. Discussion: Among patients with aNSCLC, immunotherapy improved overall survival and incidence of treatment-related AEs compared with chemotherapy. Benefits to progression-free survival and QoL were less consistent. Prospero registration number: CRD42019153345.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Immunotherapy/adverse effects ; Nivolumab/therapeutic use ; Lung Neoplasms/drug therapy
Chemical Substances	Nivolumab (31YO63LBSN)
Language	English
Publishing date	2022-06-10
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thoraxjnl-2020-215614
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Respiratory T-Wave Inversion in a Patient With Chest Pain.

Sharma, Himani / Tiwari, Abhinav

Clinical medicine insights. Case reports

2017 Volume 10, Page(s) 1179547617723309

Abstract: T-wave inversion on electrocardiogram (ECG) is always a concerning finding as it is often associated with myocardial ischemia or ventricular strain. Respiratory variation in the T-wave morphology has been reported in the literature; however, the ... ...

Abstract	T-wave inversion on electrocardiogram (ECG) is always a concerning finding as it is often associated with myocardial ischemia or ventricular strain. Respiratory variation in the T-wave morphology has been reported in the literature; however, the frequency of this observation remains unknown as this is not routinely evaluated. Although the exact physiological mechanisms underlying this ECG change are unclear, it is proposed to be due to the respiratory variation of the heart position resulting in an alteration in T-wave polarity. We describe a case of a patient who presented with chest pain with T-wave inversions in inferior and lateral ECG leads. On repeating ECG with breath held in end inspiration, the T waves became positive. The pain was found to be musculoskeletal in origin. This case is a reminder of an under-recognized physiological phenomenon involving the cardiac conduction. Variation of T-wave morphology with respiration may suggest a noncardiac cause of chest pain.
Language	English
Publishing date	2017-08-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	2580498-4
ISSN	1179-5476
ISSN	1179-5476
DOI	10.1177/1179547617723309
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Combinatorial encoding of odors in the mosquito antennal lobe.

Singh, Pranjul / Goyal, Shefali / Gupta, Smith / Garg, Sanket / Tiwari, Abhinav / Rajput, Varad / Bates, Alexander Shakeel / Gupta, Arjit Kant / Gupta, Nitin

Nature communications

2023 Volume 14, Issue 1, Page(s) 3539

Abstract: Among the cues that a mosquito uses to find a host for blood-feeding, the smell of the host plays an important role. Previous studies have shown that host odors contain hundreds of chemical odorants, which are detected by different receptors on the ... ...

Abstract	Among the cues that a mosquito uses to find a host for blood-feeding, the smell of the host plays an important role. Previous studies have shown that host odors contain hundreds of chemical odorants, which are detected by different receptors on the peripheral sensory organs of mosquitoes. But how individual odorants are encoded by downstream neurons in the mosquito brain is not known. We developed an in vivo preparation for patch-clamp electrophysiology to record from projection neurons and local neurons in the antennal lobe of Aedes aegypti. Combining intracellular recordings with dye-fills, morphological reconstructions, and immunohistochemistry, we identify different sub-classes of antennal lobe neurons and their putative interactions. Our recordings show that an odorant can activate multiple neurons innervating different glomeruli, and that the stimulus identity and its behavioral preference are represented in the population activity of the projection neurons. Our results provide a detailed description of the second-order olfactory neurons in the central nervous system of mosquitoes and lay a foundation for understanding the neural basis of their olfactory behaviors.
MeSH term(s)	Animals ; Odorants ; Olfactory Receptor Neurons/physiology ; Olfactory Pathways/physiology ; Smell/physiology ; Aedes/physiology
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39303-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recurrent Upper Extremity Thrombosis Associated with Overactivity: A Case of Delayed Diagnosis of Paget-Schroetter Syndrome.

Sharma, Himani / Tiwari, Abhinav

Case reports in vascular medicine

2017 Volume 2017, Page(s) 8764903

Abstract: Paget-Schroetter syndrome is thrombosis of the axillary-subclavian vein that is associated with strenuous and repetitive activity of the upper extremities. Overuse of the arm coupled with external compression results in microtrauma in the intima of the ... ...

Abstract	Paget-Schroetter syndrome is thrombosis of the axillary-subclavian vein that is associated with strenuous and repetitive activity of the upper extremities. Overuse of the arm coupled with external compression results in microtrauma in the intima of the subclavian vein, resulting in the activation of the coagulation cascade. Diagnosis is usually made by Doppler ultrasound and the treatment involves thrombolysis, while routine surgical decompression of the thoracic outlet is controversial. In this report, we present a case of a patient who presented with a second episode of spontaneous right upper extremity deep venous thrombosis. The first episode was inadequately treated with oral anticoagulation alone. During the second episode, Paget-Schroetter syndrome was diagnosed, after careful review of his occupational history. He subsequently underwent angioplasty and decompression of thoracic outlet with no recurrence of thrombosis in a 12-month follow-up period.
Language	English
Publishing date	2017-07-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2629916-1
ISSN	2090-6994 ; 2090-6986
ISSN (online)	2090-6994
ISSN	2090-6986
DOI	10.1155/2017/8764903
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Importance of Feedback and Feedforward Loops to Adaptive Immune Response Modeling.

Rahman, Anisur / Tiwari, Abhinav / Narula, Jatin / Hickling, Timothy

CPT: pharmacometrics & systems pharmacology

2018 Volume 7, Issue 10, Page(s) 621–628

Abstract: The human adaptive immune system is a very complex network of different types of cells, cytokines, and signaling molecules. This complex network makes it difficult to understand the system level regulations. To properly explain the immune system, it is ... ...

Abstract	The human adaptive immune system is a very complex network of different types of cells, cytokines, and signaling molecules. This complex network makes it difficult to understand the system level regulations. To properly explain the immune system, it is necessary to explicitly investigate the presence of different feedback and feedforward loops (FFLs) and their crosstalks. Considering that these loops increase the complexity of the system, the mathematical modeling has been proved to be an important tool to explain such complex biological systems. This review focuses on these regulatory loops and discusses their importance on systems modeling of the immune system.
MeSH term(s)	Adaptive Immunity ; Feedback ; Humans ; Models, Biological ; T-Lymphocytes, Regulatory/immunology
Language	English
Publishing date	2018-09-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2697010-7
ISSN	2163-8306 ; 2163-8306
ISSN (online)	2163-8306
ISSN	2163-8306
DOI	10.1002/psp4.12352
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Intractable Seizures and Limbic Encephalitis, Unaccounted Complications of Type 1 Diabetes Autoimmunity.

Madkhali, Mohammed A / Hao, Jenifer-Kris / Khan, Mohammad Saud / Himani, Sharma / Jaume, Alexa / Tiwari, Abhinav / Imam, Shahnawaz / Jaume, Juan Carlos

Journal of the Endocrine Society

2022 Volume 6, Issue 2, Page(s) bvab188

Abstract: Glutamic acid decarboxylase 65kD autoantibody (GAD65Ab) is frequently detected in patients with refractory epilepsy and stiff person syndrome. In contrast to T1D, the pathological role of GAD65Ab in neurological disorders is still debatable. As a result, ...

Abstract	Glutamic acid decarboxylase 65kD autoantibody (GAD65Ab) is frequently detected in patients with refractory epilepsy and stiff person syndrome. In contrast to T1D, the pathological role of GAD65Ab in neurological disorders is still debatable. As a result, the implementation of possible immunotherapy is usually delayed. This report presents 2 cases of GAD65Ab-associated brain autoimmunity and their different management. We present clinical data and discuss management based on available evidence in the reviewed literature. Both cases presented with acute on chronic neurological symptoms and were GAD65Ab positive. Case 1, a 30-year-old man with a history of early-onset type 1 diabetes mellitus at 14 months, followed by cryptogenic temporal epilepsy at 11 years of age, presented with intractable seizures. Case 2, a 48-year-old woman, presented with a history of recurrent severe headaches, cognitive impairment, decreased memory, and behavioral symptoms. GAD65Ab was detected in both patients' sera. Cerebrospinal fluid GAD65Ab was only checked and positive in case 1. Case 2 was diagnosed with limbic encephalitis, treated with immunotherapy, and showed a remarkable clinical improvement. Case 1 with refractory epilepsy failed multiple antiepileptic drugs and responsive-stimulator system treatments. He was finally diagnosed with autoimmune epilepsy. The delay in diagnosis resulted in a lost opportunity for early immunotherapy. In conclusion, autoantibody screening and early initiation of immunotherapy should be considered to manage GAD65Ab-associated neurological disorders.
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Case Reports
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvab188
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparative laboratory efficacy of novel botanical extracts against Tribolium castaneum

Mangang, Irengbam Barun / Tiwari, Abhinav / Rajamani, Meenatchi / Manickam, Loganathan

Journal of the science of food and agriculture. 2020 Mar. 15, v. 100, no. 4

2020

Abstract: BACKGROUND: Citrus sinensis, Allium sativum, Ocimum basilicum, Mentha spicata, Curcuma longa, Carica papaya, Andrographis paniculata, Azadirachta indica, Cymbopogon citratus and Acorus calamus were compared in the form of extracts of chloroform, hexane ... ...

Abstract	BACKGROUND: Citrus sinensis, Allium sativum, Ocimum basilicum, Mentha spicata, Curcuma longa, Carica papaya, Andrographis paniculata, Azadirachta indica, Cymbopogon citratus and Acorus calamus were compared in the form of extracts of chloroform, hexane and aqueous media for their effectiveness in repelling Tribolium castaneum. Filter paper of 9 cm in diameter was cut into halves. Using a micro‐pipette, each extract was applied to one half of the filter paper. The volume applied was kept constant at 0.6 mL per 30 cm2. The filter paper was dried and reattached leaving a 0.5 cm gap between, in a Petri‐plate. Ten adults of T. castaneum were introduced and the repellency was observed after 30, 60 and 180 min. RESULTS: The aqueous extract of C. papaya exhibited the highest repellency (82–97%) followed by that of garlic bulbs (aqueous extract) with 86.67% repellency. Further, gunny bags were sprayed separately using bottle sprayers with the two most effective extracts at a constant volume of 42 mL per 575 cm2. These treated gunny bags were compared with malathion‐treated gunny bags in the insect management unit. The observations were taken after 2, 8 and 24 h. Papaya leaf extract‐treated gunny bags showed relative repellent activity similar to that of malathion‐treated gunny bags after 24 h of treatment. Thus, gas chromatography–mass spectrometry analysis of aqueous extract of papaya leaves was performed. CONCLUSIONS: It can be concluded that extract of papaya leaves containing 2‐methoxy‐4‐vinylphenol (8.47% peak area) can be used as a repellent biopesticide. © 2019 Society of Chemical Industry
Keywords	Acorus calamus ; Allium sativum ; Andrographis paniculata ; Azadirachta indica ; Carica papaya ; Citrus sinensis ; Curcuma longa ; Cymbopogon citratus ; Mentha spicata ; Ocimum basilicum ; Tribolium castaneum ; bags ; biopesticides ; bulbs ; chloroform ; garlic ; gas chromatography-mass spectrometry ; hexane ; imagos ; insect control ; leaves ; papayas ; plant extracts ; sprayers
Language	English
Dates of publication	2020-0315
Size	p. 1541-1546.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.10162
Database	NAL-Catalogue (AGRICOLA)

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