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  1. Article ; Online: WITHDRAWN: The Ascension of Nanosponges as a Drug Delivery Carrier: Preparation, Characterization and Applications

    Tiwari, Kartik / Bhattacharya, Sankha

    Current drug delivery

    2022  

    Language English
    Publishing date 2022-06-16
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2185284-4
    ISSN 1875-5704 ; 1567-2018
    ISSN (online) 1875-5704
    ISSN 1567-2018
    DOI 10.2174/1567201819666220616120828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6415: Show issues Location:
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  2. Article ; Online: The ascension of nanosponges as a drug delivery carrier: preparation, characterization, and applications.

    Tiwari, Kartik / Bhattacharya, Sankha

    Journal of materials science. Materials in medicine

    2022  Volume 33, Issue 3, Page(s) 28

    Abstract: Nanosponges are nanosized drug carriers with a three-dimensional structure created by crosslinking polymers. They have the advantage of being able to hold a wide range of drugs of various sizes. Nanosponges come in a variety of shapes and sizes. They are ...

    Abstract Nanosponges are nanosized drug carriers with a three-dimensional structure created by crosslinking polymers. They have the advantage of being able to hold a wide range of drugs of various sizes. Nanosponges come in a variety of shapes and sizes. They are distinguished by the research method used, the type of polymer used, and the type of drug they may contain. Nanosponges are superior to other delivery systems because they can provide a controlled drug release pattern with targeted drug delivery. The period of action, as well as the drug's residence time, may be regulated. Since it is made of biodegradable materials, it has a low toxicity and is safe to use. The efficiency of drug encapsulation is determined by the size of the drug molecule and the amount of void space available. Cancer, enzyme and biocatalyst carrier, oxygen delivery, solubility enhancement, enzyme immobilization, and poison absorbent are some of the applications for nanosponges. The method of preparation, characterization, factors affecting nanosponge development, drug loading and release mechanism, recent developments in this area, and patents filed in the area of nanosponges are all highlighted in this study. Graphical abstract.
    MeSH term(s) Cyclodextrins/chemistry ; Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Drug Liberation ; Solubility
    Chemical Substances Cyclodextrins ; Drug Carriers
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1031752-1
    ISSN 1573-4838 ; 0957-4530
    ISSN (online) 1573-4838
    ISSN 0957-4530
    DOI 10.1007/s10856-022-06652-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3040: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Soot Morphology and Nanostructure in Complex Flame Flow Patterns via Secondary Particle Surface Growth.

    Davis, Justin / Tiwari, Kartik / Novosselov, Igor

    Fuel (London, England)

    2019  Volume 245, Page(s) 447–457

    Abstract: While the majority of studies explore soot formation in relatively simple, one-dimensional flames, most real-world flames consist of complex flows defined by large-scale turbulent eddies, recirculating flow patterns, and buoyancy effects. The effects of ... ...

    Abstract While the majority of studies explore soot formation in relatively simple, one-dimensional flames, most real-world flames consist of complex flows defined by large-scale turbulent eddies, recirculating flow patterns, and buoyancy effects. The effects of complex flow on soot physicochemical properties are poorly understood. This work employs an inverted gravity flame reactor (IGFR) to compare differences in soot growth between a one-dimensional laminar diffusion flame and a recirculating flame. Computational fluid dynamics (CFD) and experimental observations show particle oscillations between (i) a rich region with a high concentration of surface growth species, and (ii) a high-temperature oxidation region. Transmission electron microscopy (TEM) shows a significant difference in final primary particle diameter, where the one-dimensional flame produces primary particles 10 to 25 nm in diameter and the recirculating flame produces primary particles 25 to 75 nm in diameter. Additionally, larger primary particles from the recirculating flame contain both single and multiple cores. We propose that due to the spheroidal shape of the large primary particles, the secondary surface growth is primarily a result of polyaromatic hydrocarbon (PAH) condensation during re-entrainment of mature soot into the fuel-rich region followed by subsequent liquid layer carbonization in the high-temperature environment of the flame front. The recirculating flow patterns in the IGFR and repeated particle growth/oxidation cycle can serve as a model for soot formation in the large-scale flames with complex flow patterns, such as forest fires, coal fire plants, and other sources.
    Language English
    Publishing date 2019-02-22
    Publishing country England
    Document type Journal Article
    ISSN 0016-2361
    ISSN 0016-2361
    DOI 10.1016/j.fuel.2019.02.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Supercritical water gasification: practical design strategies and operational challenges for lab-scale, continuous flow reactors.

    Pinkard, Brian R / Gorman, David J / Tiwari, Kartik / Rasmussen, Elizabeth G / Kramlich, John C / Reinhall, Per G / Novosselov, Igor V

    Heliyon

    2019  Volume 5, Issue 2, Page(s) e01269

    Abstract: Optimizing an industrial-scale supercritical water gasification process requires detailed knowledge of chemical reaction pathways, rates, and product yields. Laboratory-scale reactors are employed to develop this knowledge base. The rationale behind ... ...

    Abstract Optimizing an industrial-scale supercritical water gasification process requires detailed knowledge of chemical reaction pathways, rates, and product yields. Laboratory-scale reactors are employed to develop this knowledge base. The rationale behind designs and component selection of continuous flow, laboratory-scale supercritical water gasification reactors is analyzed. Some design challenges have standard solutions, such as pressurization and preheating, but issues with solid precipitation and feedstock pretreatment still present open questions. Strategies for reactant mixing must be evaluated on a system-by-system basis, depending on feedstock and experimental goals, as mixing can affect product yields, char formation, and reaction pathways.
    Language English
    Publishing date 2019-02-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2019.e01269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Supercritical water gasification: practical design strategies and operational challenges for lab-scale, continuous flow reactors

    Pinkard, Brian R / Gorman, David J / Tiwari, Kartik / Rasmussen, Elizabeth G / Kramlich, John C / Reinhall, Per G / Novosselov, Igor V

    Heliyon. 2019 Feb., v. 5, no. 2

    2019  

    Abstract: Optimizing an industrial-scale supercritical water gasification process requires detailed knowledge of chemical reaction pathways, rates, and product yields. Laboratory-scale reactors are employed to develop this knowledge base. The rationale behind ... ...

    Abstract Optimizing an industrial-scale supercritical water gasification process requires detailed knowledge of chemical reaction pathways, rates, and product yields. Laboratory-scale reactors are employed to develop this knowledge base. The rationale behind designs and component selection of continuous flow, laboratory-scale supercritical water gasification reactors is analyzed. Some design challenges have standard solutions, such as pressurization and preheating, but issues with solid precipitation and feedstock pretreatment still present open questions. Strategies for reactant mixing must be evaluated on a system-by-system basis, depending on feedstock and experimental goals, as mixing can affect product yields, char formation, and reaction pathways. In-situ Raman spectroscopic monitoring of reaction chemistry promises to further fundamental knowledge of gasification and decrease experimentation time. High-temperature, high-pressure spectroscopy in supercritical water conditions is performed, however, long-term operation flow cell operation is challenging. Comparison of Raman spectra for decomposition of formic acid in the supercritical region and cold section of the reactor demonstrates the difficulty in performing quantitative spectroscopy in the hot zone. Future designs and optimization of continuous supercritical water gasification reactors should consider well-established solutions for pressurization, heating, and process monitoring, and effective strategies for mixing and solids handling for long-term reactor operation and data collection.
    Keywords chemical reactions ; cold ; data collection ; feedstocks ; formic acid ; gasification
    Language English
    Dates of publication 2019-02
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2019.e01269
    Database NAL-Catalogue (AGRICOLA)

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  6. Book ; Online: Supercritical Water Gasification

    Pinkard, Brian R. / Gorman, David J. / Tiwari, Kartik / Rasmussen, Elizabeth G. / Kramlich, John C. / Reinhall, Per G. / Novosselov, Igor V.

    Practical Design Strategies and Operational Challenges for Lab-Scale, Continuous Flow Reactors

    2019  

    Abstract: Optimizing an industrial-scale supercritical water gasification process requires detailed knowledge of chemical reaction pathways, rates, and product yields. Laboratory-scale reactors are employed to develop this knowledge base. The rationale behind ... ...

    Abstract Optimizing an industrial-scale supercritical water gasification process requires detailed knowledge of chemical reaction pathways, rates, and product yields. Laboratory-scale reactors are employed to develop this knowledge base. The rationale behind designs and component selection of continuous flow, laboratory-scale supercritical water gasification reactors is analyzed. Some design challenges have standard solutions, such as pressurization and preheating, but issues with solid precipitation and feedstock pretreatment still present open questions. Strategies for reactant mixing must be evaluated on a system-by-system basis, depending on feedstock and experimental goals, as mixing can affect product yields, char formation, and reaction pathways. In-situ Raman spectroscopic monitoring of reaction chemistry promises to further fundamental knowledge of gasification and decrease experimentation time. High-temperature, high-pressure spectroscopy in supercritical water conditions is performed, however, long-term operation flow cell operation is challenging. Comparison of Raman spectra for decomposition of formic acid in the supercritical region and cold section of the reactor demonstrates the difficulty in performing quantitative spectroscopy in the hot zone. Future designs and optimization of SCWG reactors should consider well-established solutions for pressurization, heating, and process monitoring, and effective strategies for mixing and solids handling for long-term reactor operation and data collection.
    Keywords Physics - Applied Physics
    Subject code 660
    Publishing date 2019-01-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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