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Article ; Online: Toxicological impacts of microplastics on human health: a bibliometric analysis.

Mittal, Nishu / Tiwari, Neeraj / Singh, Dhananjay / Tripathi, Prabhanshu / Sharma, Sapna

Environmental science and pollution research international

2023

Abstract: Plastic has been known as an artificial polymer whereas environmental microplastics become a global concern. Microplastics are reported to cause immunotoxicity in humans through gut deposition and entering the bloodstream. This study is a comprehensive ... ...

Abstract	Plastic has been known as an artificial polymer whereas environmental microplastics become a global concern. Microplastics are reported to cause immunotoxicity in humans through gut deposition and entering the bloodstream. This study is a comprehensive indication of the recent research on microplastic toxicity in the gastrointestinal system. We performed bibliographic analysis using VOS viewer software and analyzed the data received on microplastics and their impact on gut health which has grown exponentially since 2016. Recent findings also support microplastic toxicity in combination with heavy metals. The smaller particle size and other factors enhanced the adsorption ability of environmental contamination such as heavy metals on microplastic which increased their bioaccumulation. Such toxic complexes of heavy metals and microplastics are a concern to natural ecosystems and environmental biologists. Few reports also demonstrated the biofilm formation on microplastic surfaces which might cause greater environmental as well as human health risks. Notably, terms of determining the microplastics in human tissues through several analytical techniques are still limited to some extent. Future research should be focused on the quantification of microplastics in human tissues, the combined effect of microplastics with other contaminants, and their effects on pre-existing diseases. This study boosts understanding of the potential impacts of microplastic and nanoplastic toxicity in the human gastrointestinal system.
Language	English
Publishing date	2023-11-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-30801-4
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Article: In Vitro Analysis of Outcome Differences Between Repairing and Replacing Broken Dental Restorations.

Sachan, Saraswati / De, Raktim / Balivada, Akshita / Pandey, Soni / Tiwari, Neeraj K / Franklin, Supurna / Ganiga Channaiah, Shivakumar / Siddiqui, Shazia

Cureus

2024 Volume 16, Issue 3, Page(s) e56071

Abstract: Objective In light of several advancements and considerations in endodontic dentistry, there still remains a need to comprehensively evaluate the outcome disparities between repairing and replacing broken dental restorations. This study aims to compare ... ...

Abstract	Objective In light of several advancements and considerations in endodontic dentistry, there still remains a need to comprehensively evaluate the outcome disparities between repairing and replacing broken dental restorations. This study aims to compare the effectiveness of repairing dental restorations versus replacing them, focusing on how each method affects the structural strength and longevity of the restorations. Methods The study included 60 freshly removed human maxillary premolars. Initial processing involved rigorous washing, descaling, and polishing of the teeth. To ensure preservation, the specimens were stored in sterile, distilled water. To occlude the root canals, a self-hardening composite resin was used, and the roots were coated with two coats of clear nail polish to prevent moisture penetration. A 245 carbide bur attached to a high-speed dental handpiece with air and water spray cooling produced standardized Class II cavities on the occluso-proximal surfaces. Each cavity had a buccolingual breadth of 2 mm, an occluso-cervical length of 4 mm, and a gingival boundary that was 1 mm coronal to the cement-enamel junction. Following this preparation, the teeth were randomly separated into three groups (Group A, Group B, and Group C), each containing 20 teeth. Results Our analysis showed that teeth with entirely replaced restorations had a higher average fracture resistance than those with repaired restorations. However, the difference in fracture resistance between the repair and replacement groups for each type of material was not statistically significant. Conclusion Based on the findings, repairing a dental restoration can be a conservative and less invasive alternative to a full replacement without a significant compromise in the restoration's ability to withstand fracture. Therefore, dental professionals might consider full restoration as a viable option, taking into account the need to preserve dental tissue as well as the restoration's durability and structural integrity.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56071
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Article ; Online: SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress.

Jing, Shuaiyang / Gao, Jingkai / Tiwari, Neeraj / Du, Yulei / Zhu, Lianhui / Gim, Bopil / Qian, Yi / Yue, Xihua / Lee, Intaek

Communications biology

2024 Volume 7, Issue 1, Page(s) 532

Abstract: Golgin tethers are known to mediate vesicular transport in the secretory pathway, whereas it is relatively unknown whether they may mediate cellular stress response within the cell. Here, we describe a cellular stress response during heat shock stress ... ...

Abstract	Golgin tethers are known to mediate vesicular transport in the secretory pathway, whereas it is relatively unknown whether they may mediate cellular stress response within the cell. Here, we describe a cellular stress response during heat shock stress via SUMOylation of a Golgin tether, Golgin45. We found that Golgin45 is a SUMOylated Golgin via SUMO1 under steady state condition. Upon heat shock stress, the Golgin enters the nucleus by interacting with Importin-β2 and gets further modified by SUMO3. Importantly, SUMOylated Golgin45 appears to interact with PML and SUMO-deficient Golgin45 mutant functions as a dominant negative for PML-NB formation during heat shock stress, suppressing transcription of lipid metabolism genes. These results indicate that Golgin45 may play a role in heat stress response by transcriptional regulation of lipid metabolism genes in SUMOylation-dependent fashion.
MeSH term(s)	Sumoylation ; Humans ; Lipid Metabolism/genetics ; Heat-Shock Response/genetics ; Gene Expression Regulation ; Promyelocytic Leukemia Protein/metabolism ; Promyelocytic Leukemia Protein/genetics ; HeLa Cells ; SUMO-1 Protein/metabolism ; SUMO-1 Protein/genetics ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Small Ubiquitin-Related Modifier Proteins/genetics ; HEK293 Cells ; Transcription, Genetic ; beta Karyopherins/metabolism ; beta Karyopherins/genetics ; Ubiquitins
Chemical Substances	Promyelocytic Leukemia Protein ; SUMO-1 Protein ; Small Ubiquitin-Related Modifier Proteins ; SUMO3 protein, human ; SUMO1 protein, human ; PML protein, human (143220-95-5) ; beta Karyopherins ; Ubiquitins
Language	English
Publishing date	2024-05-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-06232-3
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Article ; Online: Carbamoylated Erythropoietin-Induced Cerebral Blood Perfusion and Vascular Gene Regulation.

Sadanandan, Jayanarayanan / Sathyanesan, Monica / Liu, Yutong / Tiwari, Neeraj K / Newton, Samuel S

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: Cerebral hypoperfusion is associated with enhanced cognitive decline and increased risk of neuropsychiatric disorders. Erythropoietin (EPO) is a neurotrophic factor known to improve cognitive function in preclinical and clinical studies of ... ...

Abstract	Cerebral hypoperfusion is associated with enhanced cognitive decline and increased risk of neuropsychiatric disorders. Erythropoietin (EPO) is a neurotrophic factor known to improve cognitive function in preclinical and clinical studies of neurodegenerative and psychiatric disorders. However, the clinical application of EPO is limited due to its erythropoietic activity that can adversely elevate hematocrit in non-anemic populations. Carbamoylated erythropoietin (CEPO), a chemically engineered non-erythropoietic derivative of EPO, does not alter hematocrit and maintains neurotrophic and behavioral effects comparable to EPO. Our study aimed to investigate the role of CEPO in cerebral hemodynamics. Magnetic resonance imaging (MRI) analysis indicated increased blood perfusion in the hippocampal and striatal region without altering tight junction integrity. In vitro and in vivo analyses indicated that hippocampal neurotransmission was unaltered and increased cerebral perfusion was likely due to EDRF, CGRP, and NOS-mediated vasodilation. In vitro analysis using human umbilical vein endothelial cells (HUVEC) and hippocampal vascular gene expression analysis showed CEPO to be a non-angiogenic agent which regulates the MEOX2 gene expression. The results from our study demonstrate a novel role of CEPO in modulating cerebral vasodilation and blood perfusion.
MeSH term(s)	Humans ; Endothelial Cells ; Erythropoietin/genetics ; Erythropoietin/pharmacology ; Epoetin Alfa ; Gene Expression Regulation ; Perfusion
Chemical Substances	Erythropoietin (11096-26-7) ; Epoetin Alfa (64FS3BFH5W)
Language	English
Publishing date	2023-07-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411507
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Article ; Online: Ariadne's Thread in the Developing Cerebral Cortex: Mechanisms Enabling the Guiding Role of the Radial Glia Basal Process during Neuron Migration.

Meyerink, Brandon L / Tiwari, Neeraj K / Pilaz, Louis-Jan

Cells

2020 Volume 10, Issue 1

Abstract: Radial neuron migration in the developing cerebral cortex is a complex journey, starting in the germinal zones and ending in the cortical plate. In mice, migratory distances can reach several hundreds of microns, or millimeters in humans. Along the ... ...

Abstract	Radial neuron migration in the developing cerebral cortex is a complex journey, starting in the germinal zones and ending in the cortical plate. In mice, migratory distances can reach several hundreds of microns, or millimeters in humans. Along the migratory path, radially migrating neurons slither through cellularly dense and complex territories before they reach their final destination in the cortical plate. This task is facilitated by radial glia, the neural stem cells of the developing cortex. Indeed, radial glia have a unique bipolar morphology, enabling them to serve as guides for neuronal migration. The key guiding structure of radial glia is the basal process, which traverses the entire thickness of the developing cortex. Neurons recognize the basal process as their guide and maintain physical interactions with this structure until the end of migration. Thus, the radial glia basal process plays a key role during radial migration. In this review, we highlight the pathways enabling neuron-basal process interactions during migration, as well as the known mechanisms regulating the morphology of the radial glia basal process. Throughout, we describe how dysregulation of these interactions and of basal process morphology can have profound effects on cortical development, and therefore lead to neurodevelopmental diseases.
MeSH term(s)	Animals ; Cell Movement ; Cerebral Cortex/cytology ; Cerebral Cortex/growth & development ; Humans ; Neural Stem Cells/cytology ; Neurogenesis ; Neuroglia/cytology ; Neurons/cytology
Language	English
Publishing date	2020-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10010003
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Article: A Comparative Analysis of Erythropoietin and Carbamoylated Erythropoietin Proteome Profiles.

Tiwari, Neeraj K / Sathyanesan, Monica / Kumar, Vikas / Newton, Samuel S

Life (Basel, Switzerland)

2021 Volume 11, Issue 4

Abstract: In recent years, erythropoietin (EPO) has emerged as a useful neuroprotective and neurotrophic molecule that produces antidepressant and cognitive-enhancing effects in psychiatric disorders. However, EPO robustly induces erythropoiesis and elevates red ... ...

Abstract	In recent years, erythropoietin (EPO) has emerged as a useful neuroprotective and neurotrophic molecule that produces antidepressant and cognitive-enhancing effects in psychiatric disorders. However, EPO robustly induces erythropoiesis and elevates red blood cell counts. Chronic administration is therefore likely to increase blood viscosity and produce adverse effects in non-anemic populations. Carbamoylated erythropoietin (CEPO), a chemically engineered modification of EPO, is non-erythropoietic but retains the neurotrophic and neurotrophic activity of EPO. Blood profile analysis after EPO and CEPO administration showed that CEPO has no effect on red blood cell or platelet counts. We conducted an unbiased, quantitative, mass spectrometry-based proteomics study to comparatively investigate EPO and CEPO-induced protein profiles in neuronal phenotype PC12 cells. Bioinformatics enrichment analysis of the protein expression profiles revealed the upregulation of protein functions related to memory formation such as synaptic plasticity, long term potentiation (LTP), neurotransmitter transport, synaptic vesicle priming, and dendritic spine development. The regulated proteins, with roles in LTP and synaptic plasticity, include calcium/calmodulin-dependent protein kinase type 1 (Camk1), Synaptosomal-Associated Protein, 25 kDa (SNAP-25), Sectretogranin-1 (Chgb), Cortactin (Cttn), Elongation initiation factor 3a (Eif3a) and 60S acidic ribosomal protein P2 (Rplp2). We examined the expression of a subset of regulated proteins, Cortactin, Grb2 and Pleiotrophin, by immunofluorescence analysis in the rat brain. Grb2 was increased in the dentate gyrus by EPO and CEPO. Cortactin was induced by CEPO in the molecular layer, and pleiotrophin was increased in the vasculature by EPO. The results of our study shed light on potential mechanisms whereby EPO and CEPO produce cognitive-enhancing effects in clinical and preclinical studies.
Language	English
Publishing date	2021-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life11040359
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Article ; Online: Differential Expression of Non-Coding RNAs in Stem Cell Development and Therapeutics of Bone Disorders.

Mishra, Anurag / Kumar, Rishabh / Mishra, Satya Narayan / Vijayaraghavalu, Sivakumar / Tiwari, Neeraj Kumar / Shukla, Girish C / Gurusamy, Narasimman / Kumar, Munish

Cells

2023 Volume 12, Issue 8

Abstract: Stem cells' self-renewal and multi-lineage differentiation are regulated by a complex network consisting of signaling factors, chromatin regulators, transcription factors, and non-coding RNAs (ncRNAs). Diverse role of ncRNAs in stem cell development and ... ...

Abstract	Stem cells' self-renewal and multi-lineage differentiation are regulated by a complex network consisting of signaling factors, chromatin regulators, transcription factors, and non-coding RNAs (ncRNAs). Diverse role of ncRNAs in stem cell development and maintenance of bone homeostasis have been discovered recently. The ncRNAs, such as long non-coding RNAs, micro RNAs, circular RNAs, small interfering RNA, Piwi-interacting RNAs, etc., are not translated into proteins but act as essential epigenetic regulators in stem cells' self-renewal and differentiation. Different signaling pathways are monitored efficiently by the differential expression of ncRNAs, which function as regulatory elements in determining the fate of stem cells. In addition, several species of ncRNAs could serve as potential molecular biomarkers in early diagnosis of bone diseases, including osteoporosis, osteoarthritis, and bone cancers, ultimately leading to the development of new therapeutic strategies. This review aims to explore the specific roles of ncRNAs and their effective molecular mechanisms in the growth and development of stem cells, and in the regulation of osteoblast and osteoclast activities. Furthermore, we focus on and explore the association of altered ncRNA expression with stem cells and bone turnover.
MeSH term(s)	Humans ; RNA, Untranslated/genetics ; RNA, Untranslated/metabolism ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Cell Differentiation/genetics ; Bone Diseases/genetics ; Bone Diseases/therapy
Chemical Substances	RNA, Untranslated ; MicroRNAs ; RNA, Long Noncoding
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12081159
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Article ; Online: A genetic programming-based approach to identify potential inhibitors of serine protease of

Kumari, Madhulata / Tiwari, Neeraj / Subbarao, Naidu

Future medicinal chemistry

2019 Volume 12, Issue 2, Page(s) 147–159

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Machine Learning ; Models, Molecular ; Mycobacterium tuberculosis/enzymology ; Serine Proteases/genetics ; Serine Proteases/metabolism ; Serine Proteinase Inhibitors/chemistry ; Serine Proteinase Inhibitors/pharmacology
Chemical Substances	Serine Proteinase Inhibitors ; Serine Proteases (EC 3.4.-)
Language	English
Publishing date	2019-11-15
Publishing country	England
Document type	Journal Article
ISSN	1756-8927
ISSN (online)	1756-8927
DOI	10.4155/fmc-2018-0560
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Article ; Online: Breasi-CRISPR: an efficient genome-editing method to interrogate protein localization and protein-protein interactions in the embryonic mouse cortex.

Meyerink, Brandon L / Kc, Pratiksha / Tiwari, Neeraj K / Kittock, Claire M / Klein, Abigail / Evans, Claire M / Pilaz, Louis-Jan

Development (Cambridge, England)

2022 Volume 149, Issue 18

Abstract: In developing tissues, knowing the localization and interactors of proteins of interest is key to understanding their function. Here, we describe the Breasi-CRISPR approach (Brain Easi-CRISPR), combining Easi-CRISPR with in utero electroporation to tag ... ...

Abstract	In developing tissues, knowing the localization and interactors of proteins of interest is key to understanding their function. Here, we describe the Breasi-CRISPR approach (Brain Easi-CRISPR), combining Easi-CRISPR with in utero electroporation to tag endogenous proteins within embryonic mouse brains. Breasi-CRISPR enables knock-in of both short and long epitope tag sequences with high efficiency. We visualized epitope-tagged proteins with varied expression levels, such as ACTB, LMNB1, EMD, FMRP, NOTCH1 and RPL22. Detection was possible by immunohistochemistry as soon as 1 day after electroporation and we observed efficient gene editing in up to 50% of electroporated cells. Moreover, tagged proteins could be detected by immunoblotting in lysates from individual cortices. Next, we demonstrated that Breasi-CRISPR enables the tagging of proteins with fluorophores, allowing visualization of endogenous proteins by live imaging in organotypic brain slices. Finally, we used Breasi-CRISPR to perform co-immunoprecipitation mass-spectrometry analyses of the autism-related protein FMRP to discover its interactome in the embryonic cortex. Together, these data demonstrate that Breasi-CRISPR is a powerful tool with diverse applications that will propel the understanding of protein function in neurodevelopment.
MeSH term(s)	Animals ; CRISPR-Cas Systems/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Electroporation/methods ; Epitopes ; Gene Editing/methods ; Mice
Chemical Substances	Epitopes
Language	English
Publishing date	2022-09-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.200616
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Article: Routine and efficient in vitro regeneration system amenable to biolistic particle delivery in chickpea (Cicer arietinum L.)

Singh, Prateek / Shukla, Alok / Tiwari, Neeraj Nath / Ansari, Jamal / Thakur, Shallu / Patil, Prakash G. / Rathore, Meenal / Verma, O. P. / Singh, Narendra Pratap / Das, Alok

Plant cell, tissue, and organ culture. 2022 Mar., v. 148, no. 3

2022

Abstract: Genetic engineering can add new capabilities or traits and direct method using biolistic particle delivery holds key for rapid, routine and efficient transformation of chickpea. Regeneration efficiencies of five different explants derived from BAP pre- ... ...

Abstract	Genetic engineering can add new capabilities or traits and direct method using biolistic particle delivery holds key for rapid, routine and efficient transformation of chickpea. Regeneration efficiencies of five different explants derived from BAP pre-treated breeders’ chickpea seeds (cv. DCP 92-2) raised in phytohormones combinations (BAP and KIN for shoot primordia induction; GA₃ for shoot elongation and NAA for rooting) were compared. Best response was obtained using the embryonic axis (EAX) explants with 86.69% regeneration efficiency followed by epicotyl (EPI) explants (78.69%). Direct genetic transformation were demonstrated in two responding explants by bombarding with pre-treated tungsten, coated with plant expression cassette (harboring Bt and nptII gene) from a distance of 4 cm with 1100 psi helium pressure. Transgenic chickpea lines with multiple and single copy integrations were obtained with transformation frequency of 0.72% for EPI explants and 1.21% for EAX explants, significantly higher than Agrobacterium tumefaciens mediated transformation of same genotype (0.076%). Southern blot based analyses of seven single copy transgenic chickpea lines exhibited presence and transmission to subsequent generations (T₁ and T₂). Presence of Bt protein were detected in the leaves of transgenic chickpea lines at pre-flowering (6.63–11.95 ng/mg TSP) and post flowering stages (4.85–8.93 ng/mg TSP). Genetic fidelity analysis using genome wide SSR markers of ten independent transgenic lines indicated true to type with original genotype. Taken together, this study describes a protocol that can be adapted for direct genetic transformation of chickpea with high efficiency.
Keywords	Agrobacterium radiobacter ; Cicer arietinum ; Southern blotting ; biolistics ; chickpeas ; genes ; genetic transformation ; genotype ; helium ; organ culture ; shoot primordia ; tungsten
Language	English
Dates of publication	2022-03
Size	p. 699-711.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	406394-6
ISSN	1573-5044 ; 0167-6857
ISSN (online)	1573-5044
ISSN	0167-6857
DOI	10.1007/s11240-022-02230-7
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