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  1. Book ; Online ; E-Book: Pan-genomics

    Barh, Debmalya / Soares, Siomar C. / Tiwari, Sandeep / Azevedo, Vasco

    applications, challenges, and future prospects

    2020  

    Author's details edited by Debmalya Barh, Siomar C. Soares, Sandeep Tiwari, Vasco Azevedo
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxiv, 450 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020440616
    ISBN 978-0-12-817077-9 ; 9780128170762 ; 0-12-817077-8 ; 012817076X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Consolidative radiation in partial responders/unresectable/recurrent disease after first-line/salvage chemotherapy in poor-risk nonseminomatous germ cell tumor prolongs survival: A new paradigm?

    Tiwari, Sandeep / Agrawal, Sushma

    Journal of cancer research and therapeutics

    2023  Volume 19, Issue 2, Page(s) 457–460

    Abstract: The role of radiotherapy (RT) in partial radiographic response (PR)/unresectable has not been evaluated earlier in nonseminomatous germ cell tumor (NSGCT). Can the PR/unresectable be treated with consolidation RT instead of surgery? This approach will ... ...

    Abstract The role of radiotherapy (RT) in partial radiographic response (PR)/unresectable has not been evaluated earlier in nonseminomatous germ cell tumor (NSGCT). Can the PR/unresectable be treated with consolidation RT instead of surgery? This approach will allow avoidance of surgical morbidity and be an additional tool for treatment. We report a series of five cases with poor prognosis NSGCT, who were treated with consolidation RT after PR/un-resectable disease and complete serum marker decline. The median survival of these patients was 52 months (range 21-112 months).
    MeSH term(s) Humans ; Male ; Neoplasms, Germ Cell and Embryonal/drug therapy ; Neoplasms, Germ Cell and Embryonal/radiotherapy ; Testicular Neoplasms/drug therapy ; Testicular Neoplasms/radiotherapy ; Chronic Disease ; Radiation Oncology
    Language English
    Publishing date 2023-06-14
    Publishing country India
    Document type Case Reports
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.jcrt_1859_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Revisiting extracranial cysticercosis: A rare case series of mycoparasitism affecting the cervicofacial region from an endemic zone.

    Singh, Saumya / Jaiswal, Vaibhav / Tiwari, Sandeep / Yadav, Shailendra

    National journal of maxillofacial surgery

    2023  Volume 14, Issue 2, Page(s) 317–320

    Abstract: A systemic parasitic infestation caused by the larval stages of the pork tapeworm, Taenia solium is known as Cysticercosis. While encysted form of the larval stage is attributed to rare variant of Cysticercosis of soft tissues. Muscle infestation by this ...

    Abstract A systemic parasitic infestation caused by the larval stages of the pork tapeworm, Taenia solium is known as Cysticercosis. While encysted form of the larval stage is attributed to rare variant of Cysticercosis of soft tissues. Muscle infestation by this parasite can lead to vague clinical presentation. We are presenting a series of 4 rare cases of extracranial, cervicofacial cysticercosis their clinical attributes and imaging characteristics leading to diagnosis of cysticercosis and approach to successful outcome with pharmacotherapy alone that spared the need of surgical management.
    Language English
    Publishing date 2023-07-13
    Publishing country India
    Document type Case Reports
    ZDB-ID 2653583-X
    ISSN 2229-3418 ; 0975-5950
    ISSN (online) 2229-3418
    ISSN 0975-5950
    DOI 10.4103/njms.njms_141_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Eigenfrequency Behavior of Banana/Glass/Epoxy Hybrid Composite-A Numerical and Experimental Investigation

    Tiwari, Sandeep / Hirwani, Chetan Kumar / Barman, Asim Gopal

    Journal of Natural Fibers. 2022 Oct. 28, v. 19, no. 14 p.9514-9530

    2022  

    Abstract: In the present work, a finite element model in conjunction with higher-order shear deformation theory was developed to investigate the eigenfrequency responses of hybrid composite (banana-glass-epoxy) flat-panel structures. First of all, five different ... ...

    Abstract In the present work, a finite element model in conjunction with higher-order shear deformation theory was developed to investigate the eigenfrequency responses of hybrid composite (banana-glass-epoxy) flat-panel structures. First of all, five different sets of banana-glass-epoxy hybrid composite plates were fabricated using an in-house fabrication facility. The test specimen for elastic property evaluation was prepared according to the ASTM standard. The necessary elastic properties were obtained by tensile test and utilized in numerical analysis. Furthermore, to develop the mathematical model of hybrid laminated composite, higher-order displacement kinematics were used that eliminates the consideration of shear correction factor. The model of plate was divided into several small parts using 2D nine noded elements. The elemental mass and stiffness of the panel were obtained and assembled to get the global mass and stiffness. The global values were substituted further into the governing equation derived from Hamilton principle. Furthermore, constraints conditions were imposed and the governing equation was solved to get the natural frequency. First, the numerical model’s sensitivity and accuracy were checked by stability and validation study. After that new numerical examples were solved and influences of different parameters including hybridization on frequency responses were studied and discussed in detail.
    Keywords bananas ; epoxides ; equations ; finite element analysis ; glass ; hybridization ; hybrids ; kinematics ; mathematical models ; mathematical theory ; Natural fiber ; vibration ; natural frequency ; hybrid composite ; banana/glass fiber ; fem ; higher-order
    Language English
    Dates of publication 2022-1028
    Size p. 9514-9530.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2182715-1
    ISSN 1544-046X ; 1544-0478
    ISSN (online) 1544-046X
    ISSN 1544-0478
    DOI 10.1080/15440478.2021.1982838
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Shared Landscapes: Optimising Conservation Strategies Using Tiger and Elephant Sympatry in India

    Menon, Vivek / Bhattacharyya, Kamalika / Sinha, Samir Kumar / Tiwari, Sandeep Kumar / Kaul, Rahul

    Diversity. 2022 Dec. 01, v. 14, no. 12

    2022  

    Abstract: Asian elephants (Elephas maximus) and tigers (Panthera tigris) share the same landscape in India. Elephants, which range over 239,171 km², occupy 45.5% of the 433,261 km² habitat that tigers inhabit. Equally, at least 40% of elephant corridors are used ... ...

    Abstract Asian elephants (Elephas maximus) and tigers (Panthera tigris) share the same landscape in India. Elephants, which range over 239,171 km², occupy 45.5% of the 433,261 km² habitat that tigers inhabit. Equally, at least 40% of elephant corridors are used by tigers. A shared landscape offers opportunities for careful, integrated management strategies with shared resources. The species are protected differently in India, with tiger reserves being legal entities dedicated to the protection of tigers and their habitats, and Elephant Reserves being management units with no legal standing. With additional disparities in financial supports to tiger reserves—which receive 10 times more money than elephant reserves—it is obvious that the elephant reserves are being treated inequitably. Since the two species coexist in the same landscapes, efforts to protect tigers can help to make up for elephant conservation gaps and optimise the use of conservation resources by tweaking a few management and policy practices. In addition, the overlay of tigers using elephant corridors can efficiently secure habitat linkages for both species.
    Keywords Elephas maximus ; Panthera tigris ; habitats ; issues and policy ; landscapes ; sympatry ; India
    Language English
    Dates of publication 2022-1201
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2518137-3
    ISSN 1424-2818
    ISSN 1424-2818
    DOI 10.3390/d14121055
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Correction to: Life Quality Index Assessment in Breast Cancer Patients.

    Srivastava, Sanjiv / Srivastava, Alpana / Tiwari, Sandeep / Mishra, Anand K

    Indian journal of surgical oncology

    2021  Volume 13, Issue 2, Page(s) 394

    Abstract: This corrects the article DOI: 10.1007/s13193-019-00923-8.]. ...

    Abstract [This corrects the article DOI: 10.1007/s13193-019-00923-8.].
    Language English
    Publishing date 2021-11-23
    Publishing country India
    Document type Published Erratum
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-021-01479-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Formulation of an oxygen policy to ensure adequate supply of oxygen reserves during the second wave of COVID-19 pandemic.

    Tiwari, Tanmay / Upadhyaya, Divya Narain / Dheer, Yadvendra / Singh, Gyan Prakash / Tiwari, Sandeep

    Medical gas research

    2022  Volume 13, Issue 1, Page(s) 39–40

    MeSH term(s) COVID-19/epidemiology ; Humans ; Oxygen ; Pandemics ; Policy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-08-10
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2616230-1
    ISSN 2045-9912 ; 2045-9912
    ISSN (online) 2045-9912
    ISSN 2045-9912
    DOI 10.4103/2045-9912.344975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Prospective Observational Study on the Outcome Assessment of Conservative Management Versus Intercostal Drainage (ICD) in Blunt Chest Injury Patients With ≤3 Rib Fractures in a North Indian Tertiary Care Center.

    Shandilya, Shreedhar / Roy, Shubhajeet / Rai, Anurag / Kumar, Suresh / Kumar, Shailendra / Tiwari, Sandeep / Sonkar, Abhinav A

    Cureus

    2023  Volume 15, Issue 7, Page(s) e42167

    Abstract: Introduction Trauma is the third most common cause of death in all age groups. One out of four trauma patients die due to thoracic injury or its complications. Seventy percent of thoracic traumas are due to blunt injury. This indicates the importance of ... ...

    Abstract Introduction Trauma is the third most common cause of death in all age groups. One out of four trauma patients die due to thoracic injury or its complications. Seventy percent of thoracic traumas are due to blunt injury. This indicates the importance of chest trauma among all traumas. Quick and precise assessment bears paramount importance in deciding life-saving and definitive management. Often, the initial management in blunt injury patients is based on subjective assessment by the attending clinician. A scoring system that provides early identification of the patients at the greatest risk for respiratory failure and more likely to require mechanical ventilation and require prolonged care, as well as those with a higher mortality risk, may allow the early institution of intervention to improve outcomes. Thoracic Trauma Severity Score (TTSS) poses to be a precise tool in directing the management modality to be employed. Methodology This was an observational study including 112 patients of age >12 years, with blunt chest injury, sustaining ≤3 rib fractures, and with a stable chest wall. The patients with penetrating injury, those with blunt chest injury having flail segment, patients in the pediatric age group (<12 years), or polytrauma patients were excluded from our study. Of the 112 patients, 56 had been managed by intercostal drainage (ICD), and the rest (56) had been managed conservatively. Result Road traffic accidents (RTA) were the most common mode of injury in both groups. The percentage of the patients with one, two, and three rib fractures was 57.14%, 32.14%, and 10.71%, respectively, in the ICD group and 85.71%, 7.14%, and 7.14%, respectively, in the conservative management group (p = 0.124). The mean TTSS score was significantly more in the ICD group as compared to the conservative management group in the single rib fracture patients (p = 0.001*), as well as all patients of any number of rib fractures (p < 0.01*) (significance was defined as a value of p less than 0.05 {indicated by an asterisk}). The mean hospital stay was significantly lower in the conservative group as compared to the ICD group (p < 0.01*). The mean SF-36 (outcome) was significantly more in the conservative management group as compared to the ICD group (p = 0.020*). The mean cost of treatment was significantly more in the ICD group as compared to the conservative management group (p < 0.001*). Conclusion In our study, a TTSS (as measured by the primary care surgeon) of >7, across any number of rib fractures, was preferably predictive of management by ICD, while a <7 value was favorable for conservative management. TTSS can be used as an important tool to predict the management modality in blunt chest injury patients with ≤3 rib fractures.
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.42167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Design of a Multi-Epitope Vaccine against

    Marques, Pedro Henrique / Tiwari, Sandeep / Felice, Andrei Giacchetto / Jaiswal, Arun Kumar / Aburjaile, Flávia Figueira / Azevedo, Vasco / Silva-Vergara, Mario León / Ferreira-Paim, Kennio / Soares, Siomar de Castro / Fonseca, Fernanda Machado

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 1

    Abstract: Histoplasmosis is a widespread systemic disease caused ... ...

    Abstract Histoplasmosis is a widespread systemic disease caused by
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10010043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir

    Venkatachalam, Sankaran / Murlidharan, Nisha / Krishnan, Sowmya R. / Irāmakiruṣṇan̲, Ci / Setshedi, Mpho / Pandian, Ramesh / Barh, Debmalya / Tiwari, Sandeep / Azevedo, Vasco / Sayed, Yasien / Gromiha, M. Michael

    Genes (Basel). 2023 Feb. 20, v. 14, no. 2

    2023  

    Abstract: Acquired immunodeficiency syndrome (AIDS) is one of the most challenging infectious diseases to treat on a global scale. Understanding the mechanisms underlying the development of drug resistance is necessary for novel therapeutics. HIV subtype C is ... ...

    Abstract Acquired immunodeficiency syndrome (AIDS) is one of the most challenging infectious diseases to treat on a global scale. Understanding the mechanisms underlying the development of drug resistance is necessary for novel therapeutics. HIV subtype C is known to harbor mutations at critical positions of HIV aspartic protease compared to HIV subtype B, which affects the binding affinity. Recently, a novel double-insertion mutation at codon 38 (L38HL) was characterized in HIV subtype C protease, whose effects on the interaction with protease inhibitors are hitherto unknown. In this study, the potential of L38HL double-insertion in HIV subtype C protease to induce a drug resistance phenotype towards the protease inhibitor, Saquinavir (SQV), was probed using various computational techniques, such as molecular dynamics simulations, binding free energy calculations, local conformational changes and principal component analysis. The results indicate that the L38HL mutation exhibits an increase in flexibility at the hinge and flap regions with a decrease in the binding affinity of SQV in comparison with wild-type HIV protease C. Further, we observed a wide opening at the binding site in the L38HL variant due to an alteration in flap dynamics, leading to a decrease in interactions with the binding site of the mutant protease. It is supported by an altered direction of motion of flap residues in the L38HL variant compared with the wild-type. These results provide deep insights into understanding the potential drug resistance phenotype in infected individuals.
    Keywords Gibbs free energy ; acquired immunodeficiency syndrome ; aspartic proteinases ; drug development ; drug resistance ; molecular dynamics ; mutants ; mutation ; phenotype ; principal component analysis ; proteinase inhibitors ; therapeutics
    Language English
    Dates of publication 2023-0220
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14020533
    Database NAL-Catalogue (AGRICOLA)

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