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  1. Article ; Online: Purkinje Cardiomyocytes of the Adult Ventricular Conduction System Are Highly Diploid but Not Uniquely Regenerative.

    Watanabe, Hirofumi / Tao, Ge / Gan, Peiheng / Westbury, Baylee C / Cox, Kristie D / Tjen, Kelsey / Song, Ruolan / Fishman, Glenn I / Makita, Takako / Sucov, Henry M

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 4

    Abstract: Adult hearts are characterized by inefficient regeneration after injury, thus, the features that support or prevent cardiomyocyte (CM) proliferation are important to clarify. Diploid CMs are a candidate cell type that may have unique proliferative and ... ...

    Abstract Adult hearts are characterized by inefficient regeneration after injury, thus, the features that support or prevent cardiomyocyte (CM) proliferation are important to clarify. Diploid CMs are a candidate cell type that may have unique proliferative and regenerative competence, but no molecular markers are yet known that selectively identify all or subpopulations of diploid CMs. Here, using the conduction system expression marker Cntn2-GFP and the conduction system lineage marker Etv1Cre
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10040161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries.

    Arhontoulis, Dimitrios C / Kerr, Charles / Richards, Dylan / Tjen, Kelsey / Hyams, Nathaniel / Jones, Jefferey A / Deleon-Pennell, Kristine / Menick, Donald / Lindner, Diana / Westermann, Dirk / Mei, Ying

    bioRxiv : the preprint server for biology

    2022  

    Abstract: Acute cardiac injuries occur in 20-25% of hospitalized COVID-19 patients. Despite urgent needs, there is a lack of 3D organotypic models of COVID-19 hearts for mechanistic studies and drug testing. Herein, we demonstrate that human cardiac organoids ( ... ...

    Abstract Acute cardiac injuries occur in 20-25% of hospitalized COVID-19 patients. Despite urgent needs, there is a lack of 3D organotypic models of COVID-19 hearts for mechanistic studies and drug testing. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1βis an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1 β treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1β treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1β treated hCOs also provide a viable model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions.
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2022.01.31.478497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries.

    Arhontoulis, Dimitrios C / Kerr, Charles M / Richards, Dylan / Tjen, Kelsey / Hyams, Nathaniel / Jones, Jefferey A / Deleon-Pennell, Kristine / Menick, Donald / Bräuninger, Hanna / Lindner, Diana / Westermann, Dirk / Mei, Ying

    Journal of tissue engineering and regenerative medicine

    2022  Volume 16, Issue 9, Page(s) 799–811

    Abstract: Acute cardiac injuries occur in 20%-25% of hospitalized COVID-19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1β is an upstream ... ...

    Abstract Acute cardiac injuries occur in 20%-25% of hospitalized COVID-19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1β is an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1β treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1β treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1β treated hCOs thus provide a defined and robust model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions.
    MeSH term(s) COVID-19/complications ; Cytokine Release Syndrome/virology ; Cytokines/metabolism ; Heart Diseases/virology ; Humans ; Models, Biological ; Organoids
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-06-11
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2316155-3
    ISSN 1932-7005 ; 1932-6254
    ISSN (online) 1932-7005
    ISSN 1932-6254
    DOI 10.1002/term.3327
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  4. Article ; Online: Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries

    Arhontoulis, Dimitrios C / Kerr, Charles / Richards, Dylan / Tjen, Kelsey / Hyams, Nathaniel / Jones, Jefferey A / Deleon-Pennell, Kristine / Menick, Donald R / Lindner, Diana / Westermann, Dirk / Mei, Ying

    bioRxiv

    Abstract: Acute cardiac injuries occur in 20-25% of hospitalized COVID-19 patients. Despite urgent needs, there is a lack of 3D organotypic models of COVID-19 hearts for mechanistic studies and drug testing. Herein, we demonstrate that human cardiac organoids ( ... ...

    Abstract Acute cardiac injuries occur in 20-25% of hospitalized COVID-19 patients. Despite urgent needs, there is a lack of 3D organotypic models of COVID-19 hearts for mechanistic studies and drug testing. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1β is an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1β treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1β treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1β treated hCOs also provide a viable model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions.
    Keywords covid19
    Language English
    Publishing date 2022-02-01
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2022.01.31.478497
    Database COVID19

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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