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Article: Gut microbiota across early stages of synucleinopathy: abridged secondary publication.

Wing, Y K / Zhang, J / To, K F / Mok, C T V / Ng, S M S / Wong, H S / Li, X S

Hong Kong medical journal = Xianggang yi xue za zhi

2023 Volume 29 Suppl 7, Issue 6, Page(s) 24–30

MeSH term(s)	Humans ; Synucleinopathies ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-12-27
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
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Article ; Online: Spindle cell/sclerosing rhabdomyosarcoma with DCTN1::ALK fusion: broadening the molecular spectrum with potential therapeutic implications.

Fung, C K / Chow, Chit / Chan, W K / Choi, Eric W K / To, K F / Chan, John K C / Cheuk, Wah

Virchows Archiv : an international journal of pathology

2022 Volume 480, Issue 4, Page(s) 927–932

Abstract: Spindle cell/sclerosing rbabdomyosarcoma (RMS) is a recently characterized variant of RMS with several distinct molecular subtypes. We describe an example occurring in the tongue of a 10-year-old boy with a novel DCTN1::ALK fusion. The tumor exhibited ... ...

Abstract	Spindle cell/sclerosing rbabdomyosarcoma (RMS) is a recently characterized variant of RMS with several distinct molecular subtypes. We describe an example occurring in the tongue of a 10-year-old boy with a novel DCTN1::ALK fusion. The tumor exhibited infiltrative growth and was comprised of fascicles and focally whorls of spindle cells with eosinophilic cytoplasm, in a collagenous or myxoid stroma. Moderate cytologic atypia, mitotic activity (2/10 HPFs), and perineural invasion were identified. The tumor cells expressed actin, desmin, MyoD1, myogenin, and ALK. An in-frame fusion between DCTN1 exon 26 and ALK exon 20 was detected by RNA sequencing, which was confirmed by split reads and supported by FISH studies. The tumor showed an indolent behavior with local recurrence 3 years after excision. This study broadens the molecular spectrum of spindle cell/sclerosing RMS and this molecular aberration may represent a potential therapeutic target for unresectable or disseminated disease.
MeSH term(s)	Actins ; Biomarkers, Tumor/genetics ; Child ; Dynactin Complex ; Humans ; Male ; Receptor Protein-Tyrosine Kinases ; Rhabdomyosarcoma/genetics ; Rhabdomyosarcoma/pathology ; Rhabdomyosarcoma/therapy
Chemical Substances	Actins ; Biomarkers, Tumor ; DCTN1 protein, human ; Dynactin Complex ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2022-03-01
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-022-03305-8
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Article ; Online: Durable disease control with apatinib, irinotecan and temozolomide in a case of metastatic primitive myxoid mesenchymal tumour of infancy.

Yu, S H / Kan, Amanda N C / To, K F / Lam, Y L / Yan, Carol L S / Liu, Anthony P Y / Ku, Dennis T L

Pediatric blood & cancer

2022 Volume 70, Issue 3, Page(s) e30026

MeSH term(s)	Humans ; Infant ; Irinotecan ; Temozolomide ; Neoplasms ; Pyridines
Chemical Substances	Irinotecan (7673326042) ; apatinib (5S371K6132) ; Temozolomide (YF1K15M17Y) ; Pyridines
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30026
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Zs.A 1131: Show issues

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Article: Epstein-Barr virus-driven promoter hypermethylated genes in gastric cancer.

Yu, J / To, K F / Liang, Q Y

Hong Kong medical journal = Xianggang yi xue za zhi

2017 Volume 23 Suppl 5, Issue 4, Page(s) 17–22

MeSH term(s)	Cell Cycle Proteins/genetics ; DNA Methylation ; Epstein-Barr Virus Infections/complications ; Humans ; Promoter Regions, Genetic ; Receptors, Somatostatin/genetics ; Stomach Neoplasms/genetics
Chemical Substances	Cell Cycle Proteins ; REC8 protein, human ; Receptors, Somatostatin ; somatostatin receptor type 1
Language	English
Publishing date	2017-09-25
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
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Article: Targeting H3K27 trimethylation epigenome for liver cancer prevention: abridged secondary publication.

Cheng, A S L / Wang, H T / Tsang, D P F / Lee, Y Y / Kang, W / To, K F

Hong Kong medical journal = Xianggang yi xue za zhi

2021 Volume 26 Suppl 8, Issue 6, Page(s) 10–15

Language	English
Publishing date	2021-01-27
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
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Article ; Online: PRAME immunostain expression in sebaceous lesions, cutaneous carcinomas and adnexal structures.

Ng, Joanna K M / Choi, Paul C L / Chow, Chit / Li, Joshua J X / Chan, Agnes W S / Cheung, Christina M T / Ip, Edric C C / Ng, H K / To, K F

Pathology

2022 Volume 54, Issue 6, Page(s) 721–728

Abstract: The use of immunostain for PRAME antigen is well established for cutaneous melanolocytic lesions. However, its staining in other cutaneous structures and lesions is under reported. This study assessed PRAME staining in a large cohort of normal skin ... ...

Abstract	The use of immunostain for PRAME antigen is well established for cutaneous melanolocytic lesions. However, its staining in other cutaneous structures and lesions is under reported. This study assessed PRAME staining in a large cohort of normal skin tissue, sebaceous lesions, and cutaneous carcinomas to better delineate patterns of PRAME immunoreactivity. PRAME immunostaining was performed on sections of sebaceous lesions and tissue microarrays of basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs). Normal cutaneous adnexal structures were assessed on the sections of sebaceous lesions. For sebaceous lesions and non-lesional sebaceous glands, PRAME immunostaining was assessed for mature, germinative and sebocytes independently. A total of 193 sebaceous lesions, 64 BCCs and 35 SCCs were stained for PRAME immunostain. Staining pattern was predominantly cytoplasmic in normal apocrine glands, germinative sebocytes of sebaceous glands, and hair germs (p<0.001). Lesional sebocytes did not show different staining compared to normal sebaceous glands (p>0.05). Rare nuclear staining was observed in the normal epidermis (0.6%) and junctional melanocytes (4.1%). BCC, SCC and sebaceous carcinoma all showed low levels of PRAME immunoreactivity with variable proportions of cases demonstrating nuclear staining (BCC 59.4%, SCC 37.1%, sebaceous carcinoma 5.3%). PRAME immunostaining is positive in germinative sebocytes, various cutaneous structures and carcinomas. Nuclear staining, identical to melanoma, was observed in normal epidermis, junctional melanocytes, BCCs, SCCs, and sebaceous carcinomas. The pattern of PRAME staining in the skin must be recognised to avoid pitfalls in interpretating PRAME immunostain.
MeSH term(s)	Antigens, Neoplasm ; Carcinoma, Basal Cell/diagnosis ; Carcinoma, Basal Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Humans ; Neoplasms, Adnexal and Skin Appendage/diagnosis ; Neoplasms, Adnexal and Skin Appendage/pathology ; Sebaceous Gland Neoplasms/diagnosis ; Sebaceous Glands/pathology ; Skin/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/metabolism
Chemical Substances	Antigens, Neoplasm ; PRAME protein, human
Language	English
Publishing date	2022-05-26
Publishing country	England
Document type	Journal Article
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2022.03.003
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Zs.A 723: Show issues

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Article: Avian influenza A H5N1 infection on human cellular microRNA profile: identification of gene regulatory pathway.

Chan, P K S / To, K F / Lam, W Y

Hong Kong medical journal = Xianggang yi xue za zhi

2014 Volume 20 Suppl 6, Page(s) 7–10

MeSH term(s)	Animals ; Birds ; Gene Expression Profiling ; Host-Pathogen Interactions ; Humans ; Influenza A Virus, H1N1 Subtype/pathogenicity ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza in Birds/virology ; Influenza, Human/virology ; MicroRNAs/biosynthesis
Chemical Substances	MicroRNAs
Language	English
Publishing date	2014-12
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
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Article ; Online: Ocular PEComas are frequently melanotic and TFE3-translocated: report of two cases including the first description of PRCC-TFE3 fusion in PEComa.

Gao, Y / Chen, G / Chow, C / Io, I / Wong, E W N / Tsui, W M S / Lam, W Y / To, K F / Chan, J K C / Cheuk, Wah

Virchows Archiv : an international journal of pathology

2020 Volume 478, Issue 5, Page(s) 1025–1031

Abstract: Ocular perivascular epithelioid cell tumor (PEComa) is exceedingly rare. We reported two examples involving the choroid and subconjunctival tissue, respectively, in patients aged 17 and 20 years. Both tumors comprised packets and sheets of large ... ...

Abstract	Ocular perivascular epithelioid cell tumor (PEComa) is exceedingly rare. We reported two examples involving the choroid and subconjunctival tissue, respectively, in patients aged 17 and 20 years. Both tumors comprised packets and sheets of large polygonal cells with moderately pleomorphic nuclei and prominent nucleoli, traversed by delicate fibrovascular septa. Melanin pigmentation was present in one case. The tumors showed HMB45 and TFE3 immunoreactivity. TFE3 gene translocation was confirmed by FISH break-apart probes. RNA seq revealed PRCC-TFE3 and NONO-TFE3 fusions, with the former representing the first description of PRCC-TFE3 in PEComa. Critical reappraisal of the reported cases showed that ocular PEComa frequently affected young patents with melanin pigmentation, frequent TFE3 protein expression, and/or TFE3 gene translocation. No recurrence or metastasis was reported after complete excision despite the presence of cytologic atypia.
MeSH term(s)	Adolescent ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Cell Cycle Proteins/genetics ; Choroid Neoplasms/chemistry ; Choroid Neoplasms/genetics ; Choroid Neoplasms/pathology ; Choroid Neoplasms/surgery ; Eye Neoplasms/chemistry ; Eye Neoplasms/genetics ; Eye Neoplasms/pathology ; Eye Neoplasms/surgery ; Female ; Gene Fusion ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lacrimal Apparatus Diseases/genetics ; Lacrimal Apparatus Diseases/metabolism ; Lacrimal Apparatus Diseases/pathology ; Lacrimal Apparatus Diseases/surgery ; Male ; Melanins/analysis ; Neoplasm Proteins/genetics ; Perivascular Epithelioid Cell Neoplasms/chemistry ; Perivascular Epithelioid Cell Neoplasms/genetics ; Perivascular Epithelioid Cell Neoplasms/pathology ; Perivascular Epithelioid Cell Neoplasms/surgery ; RNA-Seq ; Young Adult
Chemical Substances	Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Biomarkers, Tumor ; Cell Cycle Proteins ; Melanins ; Neoplasm Proteins ; PRCC protein, human ; TFE3 protein, human
Language	English
Publishing date	2020-07-16
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-020-02890-w
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Article: Prognostic implication of the neoadjuvant rectal score and other biomarkers of clinical outcome in Hong Kong Chinese patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiotherapy.

Ho, S S K / Hon, S S F / Hung, E / Lee, J F Y / Mo, F / Tong, M / So, C / Chu, S / Ng, D C K / Lam, D / Cho, C / Mak, T W C / Ng, S S M / Futaba, K / Suen, J / To, K F / Chan, A W H / Yeung, W W K / Ma, B B Y

Hong Kong medical journal = Xianggang yi xue za zhi

2022 Volume 28, Issue 3, Page(s) 230–238

Abstract: Background: Neoadjuvant chemoradiotherapy is a standard treatment for locally advanced rectal cancer, for which pathological complete response is typically used as a surrogate survival endpoint. Neoadjuvant rectal score is a new biomarker that has been ... ...

Abstract	Background: Neoadjuvant chemoradiotherapy is a standard treatment for locally advanced rectal cancer, for which pathological complete response is typically used as a surrogate survival endpoint. Neoadjuvant rectal score is a new biomarker that has been shown to correlate with survival. The main objectives of this study were to investigate factors contributing to pathological complete response, to validate the prognostic significance of neoadjuvant rectal score, and to investigate factors associated with a lower neoadjuvant rectal score in a cohort of Hong Kong Chinese. Methods: Data of patients with locally advanced rectal cancer who received neoadjuvant chemoradiotherapy from August 2006 to October 2018 were retrieved from hospital records and retrospectively analysed. Results: Of 193 patients who had optimal response to neoadjuvant chemoradiotherapy and surgery, tumour down-staging was the only independent prognostic factor that predicted pathological complete response (P<0.0001). Neoadjuvant rectal score was associated with overall survival (hazard ratio [HR]=1.042, 95% confidence interval [CI]=1.021-1.064; P<0.0001), disease-free survival (HR=1.042, 95% CI=1.022-1.062; P<0.0001), locoregional recurrence-free survival (HR=1.070, 95% CI=1.039-1.102; P<0.0001) and distant recurrence-free survival (HR=1.034, 95% CI=1.012-1.056; P=0.002). Patients who had pathological complete response were associated with a lower neoadjuvant rectal score (P<0.0001), but pathological complete response was not associated with survival. For patients with intermediate neoadjuvant rectal scores, late recurrences beyond 72 months from diagnosis were observed. Conclusion: Neoadjuvant rectal score is an independent prognostic marker of survival and disease recurrence in a cohort of Hong Kong Chinese patients who received neoadjuvant chemoradiotherapy for locally advanced rectal cancer.
MeSH term(s)	Biomarkers ; Chemoradiotherapy ; Disease-Free Survival ; Hong Kong ; Humans ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Prognosis ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-06-07
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj208969
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Article: Human papillomavirus infection and squamous cell carcinoma in Hong Kong: a case-control study.

Chan, P Ks / To, K F / Tsang, S H / Lau, C H / Kwong, W H / Chan, Y Hy

Hong Kong medical journal = Xianggang yi xue za zhi

2017 Volume 23 Suppl 5, Issue 4, Page(s) 8–11

MeSH term(s)	Carcinoma, Squamous Cell/etiology ; Case-Control Studies ; Cross-Sectional Studies ; DNA, Viral/analysis ; Esophageal Neoplasms/etiology ; Female ; Genes, p53 ; Humans ; Male ; Middle Aged ; Papillomavirus Infections/complications ; Smoking/adverse effects
Chemical Substances	DNA, Viral
Language	English
Publishing date	2017-09-25
Publishing country	China
Document type	Journal Article ; Multicenter Study
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
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