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  1. Book ; Online ; E-Book: Medical product regulatory affairs

    Tobin, John J. / Walsh, Gary

    pharmaceuticals, diagnostics, medical devices

    2024  

    Author's details John J. Tobin, Gary Walsh
    Keywords Drugs-Law and legislation ; Pharmacy-Law and legislation
    Subject code 344.0416
    Language English
    Size 1 Online-Ressource (xiii, 316 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030596445f
    ISBN 978-3-527-68897-5 ; 978-3-527-68898-2 ; 9783527333264 ; 3-527-68897-8 ; 3-527-68898-6 ; 3527333266
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Medical product regulatory affairs

    Tobin, John J. / Walsh, Gary

    pharmaceuticals, diagnostics, medical devices

    2008  

    Author's details John J. Tobin and Gary Walsh
    Keywords Europäische Union ; Arzneimittelrecht ; USA
    Subject Arzneimittel
    Language English
    Size XIII, 283 S. : Ill., graph. Darst.
    Publisher WILEY-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT015608596
    ISBN 978-3-527-31877-3 ; 3-527-31877-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 3782 order for loan Magazin

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  3. Article ; Online: Deuterium-enriched water ties planet-forming disks to comets and protostars.

    Tobin, John J / van 't Hoff, Merel L R / Leemker, Margot / van Dishoeck, Ewine F / Paneque-Carreño, Teresa / Furuya, Kenji / Harsono, Daniel / Persson, Magnus V / Cleeves, L Ilsedore / Sheehan, Patrick D / Cieza, Lucas

    Nature

    2023  Volume 615, Issue 7951, Page(s) 227–230

    Abstract: Water is a fundamental molecule in the star and planet formation process, essential for catalysing the growth of solid material and the formation of planetesimals within ... ...

    Abstract Water is a fundamental molecule in the star and planet formation process, essential for catalysing the growth of solid material and the formation of planetesimals within disks
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-05676-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
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  4. Book ; Online: Medical Product Regulatory Affairs

    Tobin, John J / Walsh, Gary

    Pharmaceuticals, Diagnostics, Medical Devices

    2008  

    Abstract: This book is an excellent reference for people starting out in regulatory affairs, as well as those working within the area whose product portfolio is adapting and changing."-Microbiology Today, May 2009 Written in a clear and concise style by ... ...

    Abstract "This book is an excellent reference for people starting out in regulatory affairs, as well as those working within the area whose product portfolio is adapting and changing."-Microbiology Today, May 2009 Written in a clear and concise style by experienced authors, this book covers regulatory affairs in all major global markets for pharmaceuticals and medical devices. Following a look at drug development, complete sections are devoted to national and EU regulatory issues, manufacturing license application and retention, and regulation in the USA. Other topics include CDER, CBER and marketing a
    MeSH term(s) Device Approval ; Equipment and Supplies ; Legislation, Drug ; Legislation, Pharmacy
    Keywords Technik / Wissen # Biologie
    Language English
    Size Online-Ressource (299 p.)
    Publisher Wiley-VCH
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 3527318771 ; 3527623035 ; 9783527318773 ; 9783527318773 ; 9783527623037
    DOI 10.1002/9783527623037
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article: Formation and Evolution of Disks Around Young Stellar Objects.

    Zhao, Bo / Tomida, Kengo / Hennebelle, Patrick / Tobin, John J / Maury, Anaëlle / Hirota, Tomoya / Sánchez-Monge, Álvaro / Kuiper, Rolf / Rosen, Anna / Bhandare, Asmita / Padovani, Marco / Lee, Yueh-Ning

    Space science reviews

    2020  Volume 216, Issue 3, Page(s) 43

    Abstract: Recent observations have suggested that circumstellar disks may commonly form around young stellar objects. Although the formation of circumstellar disks can be a natural result of the conservation of angular momentum in the parent cloud, theoretical ... ...

    Abstract Recent observations have suggested that circumstellar disks may commonly form around young stellar objects. Although the formation of circumstellar disks can be a natural result of the conservation of angular momentum in the parent cloud, theoretical studies instead show disk formation to be difficult from dense molecular cores magnetized to a realistic level, owing to efficient magnetic braking that transports a large fraction of the angular momentum away from the circumstellar region. We review recent progress in the formation and early evolution of disks around young stellar objects of both low-mass and high-mass, with an emphasis on mechanisms that may bridge the gap between observation and theory, including non-ideal MHD effects and asymmetric perturbations in the collapsing core (e.g., magnetic field misalignment and turbulence). We also address the associated processes of outflow launching and the formation of multiple systems, and discuss possible implications in properties of protoplanetary disks.
    Language English
    Publishing date 2020-04-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2017804-9
    ISSN 1572-9672 ; 0038-6308
    ISSN (online) 1572-9672
    ISSN 0038-6308
    DOI 10.1007/s11214-020-00664-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article ; Online: A triple protostar system formed via fragmentation of a gravitationally unstable disk.

    Tobin, John J / Kratter, Kaitlin M / Persson, Magnus V / Looney, Leslie W / Dunham, Michael M / Segura-Cox, Dominique / Li, Zhi-Yun / Chandler, Claire J / Sadavoy, Sarah I / Harris, Robert J / Melis, Carl / Pérez, Laura M

    Nature

    2016  Volume 538, Issue 7626, Page(s) 483–486

    Abstract: Binary and multiple star systems are a frequent outcome of the star formation process and as a result almost half of all stars with masses similar to that of the Sun have at least one companion star. Theoretical studies indicate that there are two main ... ...

    Abstract Binary and multiple star systems are a frequent outcome of the star formation process and as a result almost half of all stars with masses similar to that of the Sun have at least one companion star. Theoretical studies indicate that there are two main pathways that can operate concurrently to form binary/multiple star systems: large-scale fragmentation of turbulent gas cores and filaments or smaller-scale fragmentation of a massive protostellar disk due to gravitational instability. Observational evidence for turbulent fragmentation on scales of more than 1,000 astronomical units has recently emerged. Previous evidence for disk fragmentation was limited to inferences based on the separations of more-evolved pre-main sequence and protostellar multiple systems. The triple protostar system L1448 IRS3B is an ideal system with which to search for evidence of disk fragmentation as it is in an early phase of the star formation process, it is likely to be less than 150,000 years old and all of the protostars in the system are separated by less than 200 astronomical units. Here we report observations of dust and molecular gas emission that reveal a disk with a spiral structure surrounding the three protostars. Two protostars near the centre of the disk are separated by 61 astronomical units and a tertiary protostar is coincident with a spiral arm in the outer disk at a separation of 183 astronomical units. The inferred mass of the central pair of protostellar objects is approximately one solar mass, while the disk surrounding the three protostars has a total mass of around 0.30 solar masses. The tertiary protostar itself has a minimum mass of about 0.085 solar masses. We demonstrate that the disk around L1448 IRS3B appears susceptible to disk fragmentation at radii between 150 and 320 astronomical units, overlapping with the location of the tertiary protostar. This is consistent with models for a protostellar disk that has recently undergone gravitational instability, spawning one or two companion stars.
    Language English
    Publishing date 2016--27
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature20094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A ∼0.2-solar-mass protostar with a Keplerian disk in the very young L1527 IRS system.

    Tobin, John J / Hartmann, Lee / Chiang, Hsin-Fang / Wilner, David J / Looney, Leslie W / Loinard, Laurent / Calvet, Nuria / D'Alessio, Paola

    Nature

    2012  Volume 492, Issue 7427, Page(s) 83–85

    Abstract: In their earliest stages, protostars accrete mass from their surrounding envelopes through circumstellar disks. Until now, the smallest observed protostar-to-envelope mass ratio was about 2.1 (ref. 1). The protostar L1527 IRS is thought to be in the ... ...

    Abstract In their earliest stages, protostars accrete mass from their surrounding envelopes through circumstellar disks. Until now, the smallest observed protostar-to-envelope mass ratio was about 2.1 (ref. 1). The protostar L1527 IRS is thought to be in the earliest stages of star formation. Its envelope contains about one solar mass of material within a radius of about 0.05 parsecs (refs 3, 4), and earlier observations suggested the presence of an edge-on disk. Here we report observations of dust continuum emission and (13)CO (rotational quantum number J = 2 → 1) line emission from the disk around L1527 IRS, from which we determine a protostellar mass of 0.19 ± 0.04 solar masses and a protostar-to-envelope mass ratio of about 0.2. We conclude that most of the luminosity is generated through the accretion process, with an accretion rate of about 6.6 × 10(-7) solar masses per year. If it has been accreting at that rate through much of its life, its age is approximately 300,000 years, although theory suggests larger accretion rates earlier, so it may be younger. The presence of a rotationally supported disk is confirmed, and significantly more mass may be added to its planet-forming region as well as to the protostar itself in the future.
    Language English
    Publishing date 2012-12-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature11610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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