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Article ; Online: Severe traumatic tricuspid regurgitation detected 8 years after chest trauma.

Nishihara, Takahiro / Takaya, Yoichi / Toh, Norihisa / Yuasa, Shinsuke

Journal of medical ultrasonics (2001)

2024

Language	English
Publishing date	2024-04-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-024-01452-w
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Article ; Online: Utility of angiopoietin-2 measured early after the Fontan operation.

Toh, Norihisa / Akagi, Teiji / Nakamura, Kazufumi / Kasahara, Shingo

The American journal of cardiology

2023 Volume 205, Page(s) 516

MeSH term(s)	Humans ; Angiopoietin-2 ; Fontan Procedure
Chemical Substances	Angiopoietin-2
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Editorial
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.07.125
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Article ; Online: Long-term outcome and cardiac function after anatomic repair of congenitally corrected transposition.

Yokohama, Fumi / Toh, Norihisa / Kotani, Yasuhiro / Takaya, Yoichi / Kuroko, Yosuke / Baba, Kenji / Akagi, Teiji / Kasahara, Shingo / Ito, Hiroshi

Interdisciplinary cardiovascular and thoracic surgery

2024 Volume 38, Issue 3

Abstract: Objectives: There is limited information on long-term outcomes and trajectories of ventricular and valvular functions in patients with congenitally corrected transposition of the great arteries after anatomic repair according to the operative strategy ... ...

Abstract	Objectives: There is limited information on long-term outcomes and trajectories of ventricular and valvular functions in patients with congenitally corrected transposition of the great arteries after anatomic repair according to the operative strategy with a median follow-up period of more than 10 years. Methods: Twenty-nine patients who underwent anatomic repair in Okayama University Hospital between January 1994 and December 2020 were reviewed. Outcomes were compared between patients who underwent a double switch operation (DS group) and patients with an atrial switch with a Rastelli operation (Rastelli-Senning/Mustard group). Results: Fifteen (52%) were in the DS group and 14 (48%) were in the Rastelli-Senning/Mustard group. The median follow-up period after anatomic repair was 12.7 (interquartile range 4.2-18.8) years. There were 3 (10%) early deaths and 3 (10%) late deaths. Survival rates for the entire cohort at 10 and 20 years were 86% and 71%, respectively, and were not different between the 2 groups. Using competing risk analysis, risks of heart failure, cardiac rhythm device implantation and atrial arrhythmia showed no significant differences between the 2 groups, whereas risk of reoperation was higher in the Rastelli-Senning/Mustard group than that in the DS group. Four patients after a DS operation and 1 patient after a Rastelli technique developed more than moderate aortic regurgitation. Conclusions: During a median follow-up period of more than 10 years, mortality rate and ventricular and valvular functions after anatomic repair were acceptable, though the incidences of late complications were relatively high, especially in the Rastelli-Senning/Mustard group.
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ISSN	2753-670X
ISSN (online)	2753-670X
DOI	10.1093/icvts/ivae033
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Article ; Online: Evolution of echocardiography in adult congenital heart disease: from pulsed-wave Doppler to fusion imaging.

Toh, Norihisa / Akagi, Teiji / Kasahara, Shingo / Ito, Hiroshi

Journal of echocardiography

2021 Volume 19, Issue 4, Page(s) 205–211

Abstract: The number of patients with adult congenital heart disease (ACHD) has been dramatically increasing and adults with congenital heart disease now outnumber children with congenital heart disease. However, patients with ACHD are still at increased risk of ... ...

Abstract	The number of patients with adult congenital heart disease (ACHD) has been dramatically increasing and adults with congenital heart disease now outnumber children with congenital heart disease. However, patients with ACHD are still at increased risk of morbidity and mortality due to residua and sequelae. Although echocardiography is an indispensable imaging modality in the comprehensive assessment of ACHD, accurate echocardiographic assessment of ACHD is challenging especially for physicians or sonographers who are not familiar with ACHD because of its complex morphology, physiology, and hemodynamics. A recently developed fusion imaging technology can provide synchronized display of real-time echocardiographic images and multiplanar reconstruction images of computed tomography or magnetic resonance imaging corresponding to the image plane of real-time echocardiography. We have reported the clinical utility of this fusion imaging technology for the precise evaluation of complex ACHD. On the other hand, conventional echocardiographic technology also plays an important role in assessing unique ACHD pathophysiology. For example, restrictive right ventricular physiology is a common finding after tetralogy of Fallot or pulmonary stenosis repair and can be evaluated by conventional pulsed-wave Doppler. In this review, we discuss the clinical usefulness of modern and conventional echocardiographic technologies for the evaluation of ACHD by presenting a case series.
MeSH term(s)	Adult ; Child ; Echocardiography ; Heart Defects, Congenital/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed ; Ventricular Function, Right
Language	English
Publishing date	2021-05-28
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2209473-8
ISSN	1880-344X ; 1349-0222
ISSN (online)	1880-344X
ISSN	1349-0222
DOI	10.1007/s12574-021-00533-w
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Article ; Online: Relationship between patent foramen ovale anatomical features and residual shunt after patent foramen ovale closure.

Nakayama, Rie / Takaya, Yoichi / Akagi, Teiji / Takemoto, Rika / Haruna, Madoka / Nakashima, Mitsutaka / Miki, Takashi / Nakagawa, Koji / Toh, Norihisa / Nakamura, Kazufumi

Cardiovascular intervention and therapeutics

2024 Volume 39, Issue 2, Page(s) 200–206

Abstract: Transcatheter closure of patent foramen ovale (PFO) is an effective strategy for preventing recurrence of paradoxical embolism. However, PFO closure is often associated with residual shunt, which is a risk of recurrent stroke. This study aimed to ... ...

Abstract	Transcatheter closure of patent foramen ovale (PFO) is an effective strategy for preventing recurrence of paradoxical embolism. However, PFO closure is often associated with residual shunt, which is a risk of recurrent stroke. This study aimed to evaluate the relationship between the anatomical features of PFO and residual shunt. The degree of residual shunt and its relationship with the anatomical features of PFO were evaluated in 106 patients who underwent PFO closure at our institution between March 2011 and January 2022 and in whom contrast transthoracic echocardiography was performed 1 year later. The mean PFO tunnel length was 9.3 ± 3.6 mm and the mean PFO height was 3.2 ± 2.2 mm. Atrial septal aneurysm (ASA) was found in 37 patients. After PFO closure, residual shunt was observed in 28 patients (grade 1, n = 8; grade 2, n = 16; grade 3, n = 3; grade 4, n = 1). Univariate logistic analysis identified ASA to be associated with residual shunt (odds ratio 2.78, 95% confidence interval 1.14 to 6.79; p = 0.024). There was no association of residual shunt with the size of the PFO, the length of PFO tunnel, or the size of the device used for closure. Two of four patients with a large residual shunt of grade 3 or grade 4 were found to have device size mismatch. Residual shunt after PFO closure was observed in a quarter of patients and was related to the presence of ASA. A few patients had a large residual shunt due to the device size mismatch.
MeSH term(s)	Humans ; Foramen Ovale, Patent/surgery ; Foramen Ovale, Patent/complications ; Echocardiography ; Septal Occluder Device ; Treatment Outcome ; Cardiac Catheterization ; Stroke
Language	English
Publishing date	2024-01-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2581654-8
ISSN	1868-4297 ; 1868-4300
ISSN (online)	1868-4297
ISSN	1868-4300
DOI	10.1007/s12928-023-00979-y
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Article ; Online: Efficacy of shear wave elastography for assessment of liver function in patients with heart failure.

Nakayama, Rie / Takaya, Yoichi / Nakamura, Kazufumi / Toh, Norihisa / Ito, Hiroshi

ESC heart failure

2021 Volume 8, Issue 3, Page(s) 1751–1758

Abstract: Aims: Liver dysfunction is important for prognosis in heart failure (HF). Shear wave elastography (SWE), which is a novel ultrasound technique for charactering tissues, has been used in liver diseases. However, clinical implication of SWE, including ... ...

Abstract	Aims: Liver dysfunction is important for prognosis in heart failure (HF). Shear wave elastography (SWE), which is a novel ultrasound technique for charactering tissues, has been used in liver diseases. However, clinical implication of SWE, including dispersion slope, remains unknown in heart diseases. This study aimed to evaluate the efficacy of SWE assessing liver function in the severity of HF. Methods and results: We enrolled 316 consecutive patients with or suspected heart diseases, who were classified according to the American College of Cardiology Foundation/American Heart Association stage of HF, including 37 with Stage A, 139 with Stage B, 114 with Stage C, and 26 with Stage D, and 45 normal subjects. Elasticity and dispersion slope of shear wave were assessed according to the HF stage. Elasticity and dispersion slope were not elevated in normal subjects and patients with Stage A. Elasticity was slightly increased from Stage A to Stage C and was remarkably elevated in Stage D (normal: 5.2 ± 1.1 kPa, Stage A: 5.4 ± 1.2 kPa, Stage B: 6.4 ± 1.8 kPa, Stage C: 7.8 ± 3.5 kPa, and Stage D: 17.7 ± 12.7 kPa), whereas dispersion slope was gradually increased from Stage A to Stage D (normal: 9.7 ± 1.7m/s/kHz, Stage A: 10.4 ± 1.6m/s/kHz, Stage B: 11.7 ± 2.4m/s/kHz, Stage C: 13.2 ± 3.4m/s/kHz, and Stage D: 17.6 ± 5.6 m/s/kHz). In the early HF stage, dispersion slope was elevated. In the advanced HF stage, both elasticity and dispersion slope were elevated. Liver function test abnormalities were observed only from Stage C or Stage D. Conclusions: Dispersion slope could detect early liver damage, and the combination of elasticity and dispersion slope could clarify the progression of liver dysfunction in HF. SWE may be valuable to manage therapeutic strategies in patients with HF.
MeSH term(s)	Elasticity Imaging Techniques ; Heart Failure/diagnosis ; Humans ; Liver Diseases/diagnostic imaging ; Ultrasonography ; United States
Language	English
Publishing date	2021-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13318
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Article ; Online: Assessment of congestion and clinical outcomes in patients with chronic heart failure using shear wave elasticity.

Nakayama, Rie / Takaya, Yoichi / Nakamura, Kazufumi / Takemoto, Rika / Toh, Norihisa / Ito, Hiroshi

ESC heart failure

2022 Volume 9, Issue 2, Page(s) 1279–1286

Abstract: Aims: The relief of congestion is essential for the prevention of worsening heart failure (HF) resulting in hospitalizations. Assessment of the degree of organ congestion in the chronic phase of HF is important for determining therapeutic strategies. ... ...

Abstract	Aims: The relief of congestion is essential for the prevention of worsening heart failure (HF) resulting in hospitalizations. Assessment of the degree of organ congestion in the chronic phase of HF is important for determining therapeutic strategies. The aim of this study was to evaluate the efficacy of shear wave (SW) elasticity for assessing congestion and clinical outcomes in patients with chronic HF. Methods and results: We prospectively enrolled 345 consecutive patients with chronic HF who underwent SW elastography at outpatient clinic. Patients were divided into two groups according to the median value of SW elasticity: low group (SW elasticity <6.4 kPa, n = 176) and high group (SW elasticity ≥6.4 kPa, n = 169). The endpoint was cardiovascular death or hospitalization for HF. During the median follow-up period of 19 months (range: 7-36 months), cardiovascular death or hospitalization for HF occurred in 4 patients of low group and 27 patients of high group. In high group, 8 patients died, and 19 patients were hospitalized for HF. In low group, 3 patients died, and 1 patient was hospitalized. Kaplan-Meier analysis showed that the event-free survival rate was worse in high group than in low group (log-rank test, P = 0.004). After adjusting for variables, high SW elasticity was independently related to cardiac events. In multivariate regression analysis, SW elasticity was correlated with left atrial volume index, early diastolic mitral inflow velocity to mitral annular velocity ratio, and inferior vena cava diameter. Conclusions: The SW elasticity reflected haemodynamic congestion in patients with chronic HF, which was related to cardiac events.
MeSH term(s)	Elasticity ; Elasticity Imaging Techniques/methods ; Heart Failure/complications ; Heart Failure/diagnosis ; Hospitalization ; Humans ; Prognosis
Language	English
Publishing date	2022-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13809
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Article ; Online: Left atrial appendage morphology with the progression of atrial fibrillation.

Takaya, Yoichi / Nakayama, Rie / Yokohama, Fumi / Toh, Norihisa / Nakagawa, Koji / Miyamoto, Masakazu / Ito, Hiroshi

PloS one

2022 Volume 17, Issue 11, Page(s) e0278172

Abstract: Left atrial appendage (LAA) size is crucial for determining the indication of transcatheter LAA closure. The aim of this study was to evaluate the differences in LAA morphology according to the types of atrial fibrillation (AF). A total of 299 patients ( ... ...

Abstract	Left atrial appendage (LAA) size is crucial for determining the indication of transcatheter LAA closure. The aim of this study was to evaluate the differences in LAA morphology according to the types of atrial fibrillation (AF). A total of 299 patients (mean age: 67 ± 13 years) who underwent transesophageal echocardiography (TEE) were included. Patients were classified into non-AF (n = 64), paroxysmal AF (n = 86), persistent AF (n = 87), or long-standing persistent AF (n = 62). LAA morphology, including LAA ostial diameter and depth, was assessed using TEE. Patients with long-standing persistent AF had larger LAA ostial diameter and depth and lower LAA flow velocity. The maximum LAA ostial diameter was 19 ± 4 mm in patients with non-AF, 21 ± 4 mm in patients with paroxysmal AF, 23 ± 5 mm in patients with persistent AF, and 26 ± 5 mm in patients with long-standing persistent AF. LAA ostial diameter was increased by 2 or 3 mm with the progression of AF. LAA ostial diameter was correlated with LA volume index (R = 0.37, P < 0.01) and the duration of continuous AF (R = 0.30, P < 0.01), but not with age or the period from the onset of AF. In conclusion, LAA size was increased with the progression of AF.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Atrial Appendage/diagnostic imaging ; Echocardiography, Transesophageal
Language	English
Publishing date	2022-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0278172
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Article ; Online: Efficacy of shear wave elasticity for predicting clinical outcomes in patients with significant tricuspid regurgitation.

Nakayama, Rie / Takaya, Yoichi / Nakamura, Kazufumi / Takemoto, Rika / Toh, Norihisa / Ito, Hiroshi

Heart and vessels

2022 Volume 37, Issue 11, Page(s) 1866–1872

Abstract: This study aimed to evaluate the efficacy of shear wave (SW) elasticity for assessing clinical outcomes in patients with significant tricuspid regurgitation (TR). Significant TR develops right heart failure (HF) with organ congestion, resulting in ... ...

Abstract	This study aimed to evaluate the efficacy of shear wave (SW) elasticity for assessing clinical outcomes in patients with significant tricuspid regurgitation (TR). Significant TR develops right heart failure (HF) with organ congestion, resulting in adverse outcomes, but appropriate therapeutic strategies remain unclear. The assessment of the degree of hepatic congestion using SW elasticity may be effective for determining therapeutic strategies. We prospectively enrolled 77 patients with moderate or severe TR who underwent SW elastography. Patients were divided into three groups according to the value of SW elasticity: low group (SW elasticity < 6.4 kPa, n = 26), medium group (6.4 ≤ SW elasticity < 9.5 kPa, n = 26), and high group (SW elasticity ≥ 9.5 kPa, n = 25). The endpoint was cardiovascular death or hospitalization for HF. During the median follow-up period of 17 months (range 7-39 months), cardiovascular death or hospitalization for HF occurred in seven patients of high group, in three patients of medium group, and in no patients of low group. In high group, three patients died and seven patients were hospitalized for HF. In medium group, two patients died and one patient was hospitalized. Kaplan-Meier analysis showed that the event-free survival rate was worse in high group than in other groups (log-rank test, p = 0.02). High SW elasticity was independently related to cardiac events as well as right ventricular and left ventricular dysfunction. SW elasticity was a predictor of cardiac events in patients with significant TR by assessing hepatic congestion. SW elasticity can be valuable for determining therapeutic strategies for TR.
MeSH term(s)	Elasticity ; Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Prognosis ; Retrospective Studies ; Tricuspid Valve Insufficiency/diagnostic imaging ; Ventricular Dysfunction, Left
Language	English
Publishing date	2022-05-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	89678-0
ISSN	1615-2573 ; 0910-8327 ; 0935-736X
ISSN (online)	1615-2573
ISSN	0910-8327 ; 0935-736X
DOI	10.1007/s00380-022-02084-1
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Zs.A 2049: Show issues

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Article ; Online: Association Between Aortic Valve Calcification and Severity of Concomitant Aortic Regurgitation in Patients With Severe Aortic Stenosis.

Yokohama, Fumi / Takaya, Yoichi / Ichikawa, Keishi / Nakayama, Rie / Miki, Takashi / Toda, Hironobu / Toh, Norihisa / Miyoshi, Toru / Nakamura, Kazufumi / Ito, Hiroshi

Circulation journal : official journal of the Japanese Circulation Society

2023 Volume 88, Issue 4, Page(s) 606–611

Abstract: Background: Patients with severe aortic stenosis (AS) frequently have concomitant aortic regurgitation (AR), but the association between aortic valvular calcification (AVC) and the severity of AR remains unclear.Methods and Results: We retrospectively ... ...

Abstract	Background: Patients with severe aortic stenosis (AS) frequently have concomitant aortic regurgitation (AR), but the association between aortic valvular calcification (AVC) and the severity of AR remains unclear.Methods and Results: We retrospectively reviewed patients with severe AS who underwent transthoracic echocardiography and multidetector computed tomography (MDCT) within 1 month. The patients were divided into 3 groups according to the degree of concomitant AR. The association between AVC and the severity of concomitant AR was assessed in patients with severe AS. The study population consisted of 95 patients: 43 men and 52 women with a mean age of 82±7 years. Of the 95 patients with severe AS, 27 had no or trivial AR, 53 had mild AR, and 15 had moderate AR. The AVC score (AVCS) and AVC volume (AVCV) significantly increased as the severity of concomitant AR increased (P=0.014 for both), and similar findings were obtained for the AVCS and AVCV indexes (P=0.004 for both). Conclusions: The severity of AR correlated with AVCS and AVCV measured by MDCT in patients with severe AS. AVC may cause concomitant AR, leading to worsening of disease condition.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Aged, 80 and over ; Aortic Valve/diagnostic imaging ; Aortic Valve/pathology ; Aortic Valve Insufficiency/complications ; Aortic Valve Insufficiency/diagnostic imaging ; Retrospective Studies ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/diagnostic imaging ; Multidetector Computed Tomography/methods ; Severity of Illness Index ; Calcinosis
Language	English
Publishing date	2023-04-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-22-0746
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