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  1. Article ; Online: Present status of support for adolescent and young adult cancer patients in member hospitals of Japanese Association of Clinical Cancer Centers.

    Nakayama, Hideki / Toh, Yasushi / Fujishita, Manami / Nakagama, Hitoshi

    Japanese journal of clinical oncology

    2020  Volume 50, Issue 11, Page(s) 1282–1289

    Abstract: Background: the proportion of adolescent and young adult cancer patients is relatively small, but they require age-specific support. We conducted a survey on the present status of support for adolescent and young adult cancer patients in the Japanese ... ...

    Abstract Background: the proportion of adolescent and young adult cancer patients is relatively small, but they require age-specific support. We conducted a survey on the present status of support for adolescent and young adult cancer patients in the Japanese Association of Clinical Cancer Centers.
    Methods: in December 2018, the primary questionnaires were sent to 32 hospitals of Japanese Association of Clinical Cancer Centers regarding support for adolescent and young adult cancer patients. Secondary questionnaires were sent to doctors, nurses and medical social workers in 24 hospitals for the implementation rates of information provision and consultation on 17 unmet needs identified in the study by the Ministry of Health, Labour and Welfare, Japan.
    Results: there were marked differences in support for adolescent and young adult cancer patients among hospitals. Only one hospital facilitated an adolescent and young adult department and ward. Thirteen hospitals cooperated with the paediatric cancer designated hospitals. A learning support for high school-aged patients was provided in 15 hospitals. Adolescent and young adult support teams were active in seven hospitals and staff training sessions were held in eight hospitals. Many hospitals had referrals for fertility preservation. The rates of information provision and consultation for more than 70% of adolescent and young adult patients showed statistically significant differences among the medical professions in most of the 17 items.
    Conclusions: support systems and activities for adolescent and young adult cancer patients vary extremely across hospitals. Information provision and consultation for unmet needs are still insufficient. Therefore, sharing information and experiences is required to enhance the support for adolescent and young adult cancer patients.
    MeSH term(s) Adolescent ; Child ; Female ; Fertility Preservation ; Hospitals ; Humans ; Interdisciplinary Research ; Japan ; Male ; Neoplasms/psychology ; Social Support ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2020-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyaa141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Geriatric Screening for Hospitalized Older Adults with Cancer: A Survey of the Japanese Association of Clinical Cancer Centers.

    Nishijima, Tomohiro F / Toh, Yasushi / Tanimizu, Masahito / Nakagama, Hitoshi

    Internal medicine (Tokyo, Japan)

    2021  Volume 60, Issue 18, Page(s) 2927–2932

    Abstract: Objective Geriatric screening followed by a more detailed assessment and intervention is recommended for older adults with cancer. However, little is known regarding how the geriatric screening covered by Japanese health insurance is used for ... ...

    Abstract Objective Geriatric screening followed by a more detailed assessment and intervention is recommended for older adults with cancer. However, little is known regarding how the geriatric screening covered by Japanese health insurance is used for hospitalized older cancer patients. We surveyed all hospitals in Japanese Association of Clinical Cancer Centers (JACCC) to explore the current use of this approach. Methods The JACCC member hospitals specialize in cancer care from prevention, through diagnosis and treatment, to palliative care. We mailed paper questionnaires to the presidents of the hospitals in December 2019 and collected them by February 2020. The survey requested general hospital information and asked whether (and how) such geriatric screening for hospitalized older adults with cancer was conducted. Results Twenty-six of 32 hospitals completed the survey (81%). Fourteen hospitals are cancer centers, while the remaining 12 hospitals are general hospitals which care of both cancer and non-cancer patients. Eleven hospitals (42%) performed geriatric screening and the most common use of the results was for "early discharge planning" and for "applying for long-term care insurance." Most clinicians rated the screening "somewhat" or "a little" helpful and found it most helpful for "meeting patient-post discharge needs". The most frequently reported barrier to implementation was a "lack of leadership to improve the care of older adults." Conclusion Geriatric screening was used at less than half of the major cancer centers and hospitals in Japan. One feasible solution to this problem is to establish an interprofessional workgroup at each hospital with the shared goal of providing high-quality care for this population.
    MeSH term(s) Aftercare ; Aged ; Early Detection of Cancer ; Geriatric Assessment ; Humans ; Japan/epidemiology ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/therapy ; Patient Discharge ; Surveys and Questionnaires
    Language English
    Publishing date 2021-03-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.6760-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comprehensive geriatric assessment: Valuation and patient preferences in older Japanese adults with cancer.

    Nishijima, Tomohiro F / Shimokawa, Mototsugu / Esaki, Taito / Morita, Masaru / Toh, Yasushi / Muss, Hyman B

    Journal of the American Geriatrics Society

    2022  Volume 71, Issue 1, Page(s) 259–267

    Abstract: Background: Current guidelines recommend a comprehensive geriatric assessment (CGA) for the management of older adults with cancer. We evaluated the effect of CGA conducted by a geriatric oncology service (GOS) on the management of older adults with ... ...

    Abstract Background: Current guidelines recommend a comprehensive geriatric assessment (CGA) for the management of older adults with cancer. We evaluated the effect of CGA conducted by a geriatric oncology service (GOS) on the management of older adults with cancer. We also queried patients about their perceptions of the value of this process.
    Methods: This was a prospective quality assessment study of 498 consecutive older adults with cancer who were referred to the GOS from May 2020 through December 2021. Treating physicians requested a consultation and the GOS conducted a CGA and assessed patient preferences. The GOS provided recommendations on cancer treatment and geriatric interventions. Patient perspectives on the consultation were evaluated using collaboRATE and modified Patient Assessment of Care for Chronic Conditions (PACIC) subscales.
    Results: A 10-item frailty index based on a CGA (FI-CGA-10) [Oncologist, 26, e1751 (2021)] in the 498 patients showed that 19% of patients were fit, 40% pre-frail, and 41% frail. Prior to CGA the intent of the proposed cancer treatment was curative in 56% (n = 280), life-extending in 40% (n = 201), and palliative in 3.4% (n = 17). After a CGA consultation, a cancer treatment decision was changed in 45% of patients. The intent of treatment after the CGA consultation was curative in 45%, life-extending in 34%, and palliative in 21%. At least one referral to relevant disciplines was recommended for 88% of patients and was implemented in 43%. As part of the GOS consultation educational support was provided to 97% of patients. Based on the collaboRATE and PACIC tools, patients perceived the GOS consultation positively and helpful for facilitating shared decision-making and patient-centered care.
    Conclusion: Our institutional experience demonstrated the valuable effect of the CGA consultation on oncologic decision-making and geriatric interventions in a patient-centered manner.
    MeSH term(s) Humans ; Aged ; Prospective Studies ; East Asian People ; Patient Preference ; Neoplasms/therapy ; Medical Oncology ; Geriatric Assessment
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18023
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  4. Article ; Online: Survival in Older Japanese Adults With Advanced Cancer Before and After Implementation of a Geriatric Oncology Service.

    Nishijima, Tomohiro F / Shimokawa, Mototsugu / Komoda, Masato / Hanamura, Fumiyasu / Okumura, Yuta / Morita, Masaru / Toh, Yasushi / Esaki, Taito / Muss, Hyman B

    JCO oncology practice

    2023  Volume 19, Issue 12, Page(s) 1125–1132

    Abstract: Purpose: Research studies have demonstrated that comprehensive geriatric assessment (CGA) improves outcomes in older adults with cancer treated with chemotherapy. We compared survival outcomes on older adults with advanced cancer before and after the ... ...

    Abstract Purpose: Research studies have demonstrated that comprehensive geriatric assessment (CGA) improves outcomes in older adults with cancer treated with chemotherapy. We compared survival outcomes on older adults with advanced cancer before and after the initiation of a geriatric oncology service (GOS) in a single Japanese cancer center.
    Methods: This was a comparative study of two groups of consecutive patients 70 years and older with advanced cancer who were referred to medical oncology for first-line chemotherapy before (controls; n = 151, September 2015-August 2018) and after (GOS; n = 191, September 2018-March 2021) implementation of the GOS. When the treating physician requested a consultation from the GOS, a geriatrician and an oncologist performed CGA and provided recommendations for cancer treatment and geriatric interventions. Time to treatment failure (TTF) and overall survival (OS) were compared between the two groups.
    Results: The median age for all patients was 75 (range, 70-95) years, and 85% had GI cancers. In the GOS group, 82 patients received the CGA before a treatment decision and oncologic treatment plans were changed in 49 patients (60%). The overall implementation rate of the CGA-based geriatric interventions was 45%. Two hundred and eighty-two patients received chemotherapy (controls; n = 128 and GOS; n = 154), and 60 patients were treated with best supportive care only (controls; n = 23 and GOS; n = 37). Among patients receiving chemotherapy, TTF event rates for the GOS group compared with the control group were 5.7% versus 14% at 30 days (
    Conclusion: In this study, older adults with advanced cancer managed after the implementation of a GOS had improved survival outcomes compared with a historical control of patients.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Japan/epidemiology ; Neoplasms/drug therapy ; Medical Oncology ; Geriatric Assessment ; Patient Care Planning
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.22.00842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma.

    Shimagaki, Tomonari / Sugimachi, Keishi / Mano, Yohei / Onishi, Emi / Iguchi, Tomohiro / Nakashima, Yuichiro / Sugiyama, Masahiko / Yamamoto, Manabu / Morita, Masaru / Toh, Yasushi

    Annals of gastroenterological surgery

    2023  Volume 7, Issue 6, Page(s) 977–986

    Abstract: Aim: This study was performed to investigate the relationship between the preoperative cachexia index (CXI) and long-term outcomes in patients who have undergone radical resection of pancreatic ductal adenocarcinoma (PDAC).: Methods: In total, 144 ... ...

    Abstract Aim: This study was performed to investigate the relationship between the preoperative cachexia index (CXI) and long-term outcomes in patients who have undergone radical resection of pancreatic ductal adenocarcinoma (PDAC).
    Methods: In total, 144 patients who underwent pancreatic resection for treatment of PDAC were retrospectively analyzed. The relationship between the CXI and the patients' long-term outcomes after PDAC resection was investigated. The CXI was calculated based on the preoperative skeletal muscle index, serum albumin level, and neutrophil-to-lymphocyte ratio. After propensity-score matching, we compared clinicopathological features and outcomes.
    Results: The multivariate analysis showed that lymph node metastasis (hazard ratio [HR], 1.93; 95% confidence interval [CI], 1.16-3.23;
    Conclusion: The CXI can be a useful prognostic factor for DFS and OS after pancreatic resection for treatment of PDAC.
    Language English
    Publishing date 2023-04-24
    Publishing country Japan
    Document type Journal Article
    ISSN 2475-0328
    ISSN (online) 2475-0328
    DOI 10.1002/ags3.12686
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  6. Article ; Online: Prognosis of Patients with Esophageal Carcinoma After Routine Thoracic Duct Resection: A Propensity-matched Analysis of 12,237 Patients Based on the Comprehensive Registry of Esophageal Cancer in Japan.

    Oshikiri, Taro / Numasaki, Hodaka / Oguma, Junya / Toh, Yasushi / Watanabe, Masayuki / Muto, Manabu / Kakeji, Yoshihiro / Doki, Yuichiro

    Annals of surgery

    2023  Volume 277, Issue 5, Page(s) e1018–e1025

    Abstract: Objective: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy.: Summary of background data: Although TD resection can cause nutritional disadvantage and immune ...

    Abstract Objective: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy.
    Summary of background data: Although TD resection can cause nutritional disadvantage and immune suppression, it has been performed for the resection of surrounding lymph nodes.
    Methods: We analyzed 12,237 patients from the Comprehensive Registry of Esophageal Cancer in Japan who underwent esophagectomy between 2007 and 2012. TD resection and preservation groups were compared in terms of prognosis, perioperative outcomes, and initial recurrent patterns using strict propensity score matching. Particularly, the year of esophagectomy and history of primary cancer of other organs were added as covariates.
    Results: After propensity score matching, 1638 c-Stage I-IV patients participated in each group. The 5 year overall survival and cause-specific survival rates were 57.5% and 65.6% in the TD-resected group and 55.2% and 63.4% in the TD-preserved group, respectively, without significant differences. The TD-resected group had significantly more retrieved mediastinal nodes (30 vs 21, P < 0.0001) and significantly fewer lymph node recurrence (376 vs 450, P = 0.0029) compared with the TD-preserved group. However, the total number of distant metastatic organs was significantly greater in TD-resected group than in the TD-preserved group (499 vs 421, P = 0.0024).
    Conclusions: TD resection did not improve survival in patients with esoph-ageal cancer. Despite having retrieved more lymph nodes, TD resection caused distant metastases in more organs compared to TD preservation. Hence, prophylactic TD resection should not be recommended in patients with esophageal cancer.
    MeSH term(s) Humans ; Thoracic Duct/surgery ; Thoracic Duct/pathology ; Lymph Node Excision ; Japan/epidemiology ; Retrospective Studies ; Follow-Up Studies ; Esophageal Neoplasms ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Prognosis ; Esophagectomy ; Neoplasm Staging
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000005340
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  7. Article ; Online: Chronic expanding hematoma of the liver: a case report and review of the literature.

    Shimagaki, Tomonari / Sugimachi, Keishi / Mano, Yohei / Tomino, Takahiro / Onishi, Emi / Taguchi, Kenichi / Morita, Masaru / Toh, Yasushi

    Clinical journal of gastroenterology

    2023  Volume 17, Issue 1, Page(s) 93–99

    Abstract: Chronic expanding hematoma (CEH) is defined as a hematoma that grows slowly over a month or longer. CEH with a primary hepatic origin is extremely rare. An 85-year-old man presented with general malaise and low-grade fever. His medical history included ... ...

    Abstract Chronic expanding hematoma (CEH) is defined as a hematoma that grows slowly over a month or longer. CEH with a primary hepatic origin is extremely rare. An 85-year-old man presented with general malaise and low-grade fever. His medical history included hypertension and postoperative appendicitis, and he was taking oral aspirin. Computed tomography showed a 7-cm mass in liver S7 with calcification at the margin. On contrast-enhanced magnetic resonance imaging, the inside of the mass showed heterogeneous hyperintensity on T1-weighted images, mainly low intensity on T2-weighted images, and mild hyperintensity in some areas. Under the preoperative diagnosis of suspected CEH, hemorrhagic cyst, or hepatocellular carcinoma, S7 partial liver resection and cholecystectomy were performed. Histopathological findings showed that the mass was continuous with the liver and protruded extrahepatically, and was covered with a hard fibrous capsule. The capsule contained hematomas ranging from obsolete to relatively fresh, with no neoplastic lesions. He was diagnosed with CEH in the liver. This subcapsular hepatic hematoma was pathologically shown to be a CEH. Complete surgical resection was effective in treating this CEH in the liver.
    MeSH term(s) Male ; Humans ; Aged, 80 and over ; Chronic Disease ; Hematoma/diagnostic imaging ; Hematoma/etiology ; Hematoma/surgery ; Tomography, X-Ray Computed ; Magnetic Resonance Imaging ; Liver/diagnostic imaging ; Liver/pathology
    Language English
    Publishing date 2023-09-26
    Publishing country Japan
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-023-01864-0
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  8. Article ; Online: ASO Author Reflections: Preservation of the Thoracic Duct is Feasible for Esophageal Squamous Cell Carcinoma Patients Treated with Esophagectomy After Neoadjuvant Chemoradiotherapy.

    Oshikiri, Taro / Numasaki, Hodaka / Oguma, Junya / Toh, Yasushi / Watanabe, Masayuki / Muto, Manabu / Kakeji, Yoshihiro / Doki, Yuichiro

    Annals of surgical oncology

    2023  Volume 30, Issue 5, Page(s) 2699–2700

    MeSH term(s) Humans ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Neoplasms/pathology ; Neoadjuvant Therapy ; Esophagectomy ; Thoracic Duct/pathology ; Chemoradiotherapy
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12892-4
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  9. Article ; Online: Impact of a board certification system and adherence to the clinical practice guidelines for gastric cancer on risk-adjusted surgical mortality after distal and total gastrectomy in Japan: a questionnaire survey of departments registered in the National Clinical Database.

    Yamamoto, Hiroyuki / Nashimoto, Atsushi / Miyashiro, Isao / Miyata, Hiroaki / Toh, Yasushi / Gotoh, Mitsukazu / Kodera, Yasuhiro / Kakeji, Yoshihiro / Seto, Yasuyuki

    Surgery today

    2023  Volume 54, Issue 5, Page(s) 459–470

    Abstract: Purpose: The relationship between board certification, clinical guideline implementation, and quality of gastric cancer surgery remains unclear.: Methods: A web-based questionnaire survey was administered to departments registered in the National ... ...

    Abstract Purpose: The relationship between board certification, clinical guideline implementation, and quality of gastric cancer surgery remains unclear.
    Methods: A web-based questionnaire survey was administered to departments registered in the National Clinical Database (NCD) of Japan between October 2014 and January 2015. Quality indicators (QIs) based on the Donabedian model were evaluated. Structural QIs (e.g., affiliations with academic societies and board certifications) and process QIs (adherence to clinical practice guidelines for gastric cancer) were assessed using risk-adjusted odds ratios (AORs) for surgical mortality. Multivariable logistic regression models with a generalized estimating equation were used.
    Results: A total of 835 departments performing 40,992 distal gastrectomies and 806 departments performing 19,618 total gastrectomies responded. Some certified institutions and physicians showed significant associations, with lower AORs for surgical mortality. Important process QIs included pre- and postoperative abdominal CT scanning, endoscopic resection based on progression, curative resection with D2 dissection for advanced gastric cancer, laparoscopic surgery, and HER2 testing for patients with unresectable recurrent gastric cancer.
    Conclusions: Multiple structural and process QIs are associated with surgical mortality after gastrectomy in Japan. Measuring and visualizing QIs may enhance healthcare improvements.
    MeSH term(s) Humans ; Stomach Neoplasms/surgery ; Japan ; Neoplasm Recurrence, Local/surgery ; Certification ; Gastrectomy ; Surveys and Questionnaires
    Language English
    Publishing date 2023-11-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1115435-4
    ISSN 1436-2813 ; 0941-1291
    ISSN (online) 1436-2813
    ISSN 0941-1291
    DOI 10.1007/s00595-023-02753-2
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  10. Article ; Online: A Multicenter Analysis of Short-term and Long-term Outcomes Following Laparoscopic Multivisceral Resection for Advanced Colorectal Cancer.

    Nambara, Sho / Nakanishi, Ryota / Nonaka, Kentaro / Fujimoto, Yoshiaki / Hu, Qingjiang / Nakanoko, Tomonori / Sugiyama, Masahiko / Ota, Mitsuhiko / Kimura, Yasue / Oki, Eiji / Toh, Yasushi / Yoshizumi, Tomoharu

    Cancer diagnosis & prognosis

    2024  Volume 4, Issue 2, Page(s) 157–164

    Abstract: Background/aim: Recent research has demonstrated that laparoscopic multivisceral resection (MVR) for advanced colorectal cancer is safe, practicable, and yields satisfactory oncological results, which is in line with the growing usage of laparoscopic ... ...

    Abstract Background/aim: Recent research has demonstrated that laparoscopic multivisceral resection (MVR) for advanced colorectal cancer is safe, practicable, and yields satisfactory oncological results, which is in line with the growing usage of laparoscopic surgery. The effectiveness of laparoscopic MVR is still debatable, though. The goal of this study was to compare the short- and long-term results of patients with advanced colorectal cancer treated with open MVR with laparoscopic procedures.
    Patients and methods: Data on 3,571 consecutive patients hospitalized at the Kyushu University National Kyushu Cancer Center for colorectal cancer surgery between 2004 and 2020 were gathered retrospectively. In the end, 84 individuals with advanced colorectal cancer who had a colectomy with MVR were examined. We evaluated invasiveness in terms of complications, blood loss, and operating time. Recurrence-free survival rates and overall 5-year survival were among the oncological outcomes.
    Results: Of the 84 patients examined, 29 underwent laparoscopic treatment, and 55 underwent open treatment. The laparoscopic surgery group experienced shorter hospital stays (15 vs. 18 days, p<0.05) and much less blood loss (median volume: 167 vs. 1,058 g, p<0.005) than the open surgery group. Following the exclusion of patients with stage IV colorectal cancer from the study (groups undergoing laparoscopic surgery, n=25; open surgery, n=38), the groups displayed comparable pathologic results and no discernible variations in either the 5-year overall survival (p=0.87) or recurrence-free survival (p=0.86).
    Conclusion: In certain individuals with advanced colorectal cancer, a laparoscopic method of manipulation with MVR may be less invasive than an open method without compromising the prognosis.
    Language English
    Publishing date 2024-03-03
    Publishing country Greece
    Document type Journal Article
    ISSN 2732-7787
    ISSN (online) 2732-7787
    DOI 10.21873/cdp.10302
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