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Book ; Conference proceedings: Proceedings of the First International Transplant Network

Tokat, Yaman

October 17-21, 2018, Antalya Turkey

(Transplantation proceedings ; vol. 51, no. 7 (September 2019))

2019

Event/congress	International Transplant Network (1., 2018, Antalya, Congress)
Author's details	guest editor Yaman Tokat, MD
Series title	Transplantation proceedings ; vol. 51, no. 7 (September 2019)
Collection
Language	English
Size	Diagramme
Publisher	Elsevier
Publishing place	New York, NY
Publishing country	United States
Document type	Book ; Conference proceedings
HBZ-ID	HT020277870
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Factor 5 and Factor 2 heterozygous positivity and complications in living donor liver transplant donors.

Anilir, Ender / Oral, Alihan / Sahin, Tolga / Turker, Fatih / Yuzer, Yildiray / Tokat, Yaman

Northern clinics of Istanbul

2023 Volume 10, Issue 5, Page(s) 550–555

Abstract: Objective: Factor 2 and Factor 5 mutations are among the most common procoagulant genetic disorders and are routinely evaluated in donor preparation. Homozygous mutations are contraindicated for surgery, but heterozygous mutations cannot be said to be ... ...

Abstract	Objective: Factor 2 and Factor 5 mutations are among the most common procoagulant genetic disorders and are routinely evaluated in donor preparation. Homozygous mutations are contraindicated for surgery, but heterozygous mutations cannot be said to be an impediment. We aimed to investigate the effect of heterozygous gene mutation of F2 and/or F5 on complications. Methods: In our study, 210 living liver donors were examined. The available data of Factor 2 and 5 heterozygous positive donors were evaluated in terms of 21 donor patients and 30 liver recipients. The heterozygous positive group and the control group were statistically compared in terms of age, gender, length of hospital stay, post-operative deep vein thrombosis, pulmonary embolism, portal vein thrombosis, bile duct stenosis and bile leakage complications, lung infection and atelectasis, and wound infection. In addition, these patients were statistically compared in terms of laboratory tests. In addition, complications in recipients implanted with mutant grafts were evaluated statistically and numerically. Results: Hospital staying was longer statistically in the donor group with heterozygous mutations than in the control group. Hemoglobin and albumin blood levels were lower (p=0.031, p=0.016); INR and ALT levels were higher (p=0.005, p=0.047) statistically in the control group than in the donor group with heterozygous mutations. There was no statistically significant difference between heterozygous mutant groups in terms of biliary tract complications and hepatic vessel thrombosis in recipients. Conclusion: Considering the longer hospital stay in the presence of these mutations, the increased need for treatment in this process and the close follow-up of liver functions should be considered.
Language	English
Publishing date	2023-09-26
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3031921-3
ISSN	2536-4553 ; 2148-4902
ISSN (online)	2536-4553
ISSN	2148-4902
DOI	10.14744/nci.2023.49354
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Article ; Online: Incidental combined hepatocellular-cholangiocarcinoma in liver transplant patients: Does it have a worse prognosis?

Anilir, Ender / Oral, Alihan / Sahin, Tolga / Turker, Fatih / Yuzer, Yildiray / Tokat, Yaman

Hepatology forum

2023 Volume 4, Issue 3, Page(s) 97–102

Abstract: Background and aim: Combined hepatocellular-cholangiocarcinoma (CHC) requires attention clinically and pathologically after liver transplantation (LT) because of its unique biology, difficulties in diagnosis, and being rare. We aimed to present our ... ...

Abstract	Background and aim: Combined hepatocellular-cholangiocarcinoma (CHC) requires attention clinically and pathologically after liver transplantation (LT) because of its unique biology, difficulties in diagnosis, and being rare. We aimed to present our single-center experience for this incidental combined tumor. It is aimed to present our single-center experience for this incidental combined tumor. Materials and methods: Seventeen patients with CHC were included in the study. There were 260 hepatocellular carcinoma (HCC) patients determined as the control group. Patients were evaluated for demographic, etiological, pathological features, and survival. Results: Macrovascular and microvascular invasion levels were significantly higher in the CHC group (p<0.05). P53, CK19, and CK7 levels were significantly higher in the CHC group (p<0.05). Hepatocyte-specific antigen level was significantly higher in the HCC group. The mean overall survival was significantly higher in the HCC group (p<0.05). Conclusion: Even though CHC is a rare liver tumor, it has features that need to be clarified regarding both survival and tumor biology. İnvestigating prognostic factors, especially in terms of survival and recurrence, will be very beneficial to identify candidates who will benefit from LT and be included in the indications for LT for CHC. This study evaluated the outcomes of patients showing combined HCC-intrahepatic cholangiocarcinoma in explant pathology.
Language	English
Publishing date	2023-09-20
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-7392
ISSN (online)	2757-7392
DOI	10.14744/hf.2022.2022.0037
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Article ; Online: First International Transplant Network Congress.

Tokat, Yaman / Balci, Deniz

Transplantation proceedings

2019 Volume 51, Issue 7, Page(s) 2153

Language	English
Publishing date	2019-08-31
Publishing country	United States
Document type	Editorial
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2019.07.002
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Article ; Online: Recurrence of Hepatitis D Virus in Liver Transplant Recipients With Hepatitis B and D Virus-Related Chronic Liver Disease.

Serin, Ayfer / Tokat, Yaman

Transplantation proceedings

2019 Volume 51, Issue 7, Page(s) 2457–2460

Abstract: Purpose: Data on recurrence of hepatitis D virus (HDV) and its long-term impact on liver transplant (LT) are limited. In this study, we investigated the incidence of hepatitis B virus (HBV) and the long-term effect of postoperative HDV recurrence HDV ... ...

Abstract	Purpose: Data on recurrence of hepatitis D virus (HDV) and its long-term impact on liver transplant (LT) are limited. In this study, we investigated the incidence of hepatitis B virus (HBV) and the long-term effect of postoperative HDV recurrence HDV coinfection in our liver transplant patients. Patients and methods: Between 2004 and 2018, all patients with LT because of HBV (n = 361; 37.3%) were reviewed, and those with HBV and HDV coinfection (n = 104; 30% of all HBV patients) were enrolled in our study. All patients received post-transplant combination therapy with nucleos(t)ide analogue and antihepatitis B immunoglobulins. Breakthrough infection was defined as reemergence of HBV DNA or hepatitis B surface antigen during postoperative treatment. In case of recurrence, another oral nucleos(t)ide analogue was added and antihepatitis B immunoglobulins were stopped. Results: During the study period, the frequency of HDV (+) was decreased (41% to 14%). Median follow-up time was 82 months (range, 1-274 months). Post LT survival and HBV recurrence were 97% (n = 15) and 13.4%, respectively. Only 15 patients (14%) developed breakthrough infection. There was no predictive factor for recurrent HDV infection, including demographics data and concomitant hepatocellular carcinoma (P = .73). Mortality was similar between patients with and without recurrence (2.2% vs 7.1%, P = .35) CONCLUSIONS: Patients who received transplants for hepatitis B and D virus cirrhosis had favorable prognosis and good long-term results despite recurrent infection. Close follow-up of patients and effective postoperative viral suppression with appropriate medications seems to be favorable for both prevention and management of recurrence and provides comparable outcome with patients without recurrence.
MeSH term(s)	Adult ; Coinfection/complications ; Coinfection/epidemiology ; Female ; Graft Survival ; Hepatitis B/complications ; Hepatitis B virus ; Hepatitis D/complications ; Hepatitis D/epidemiology ; Hepatitis Delta Virus ; Humans ; Incidence ; Liver Transplantation ; Male ; Middle Aged ; Recurrence ; Treatment Outcome
Language	English
Publishing date	2019-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2019.01.163
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Article ; Online: Predictive Value of Preoperative 18 Fludeoxyglucose Positron Emission Tomography-Computed Tomography for Survival in Liver Transplantation Due to Hepatocellular Cancer.

Anılır, Ender / Oral, Alihan / Turker, Fatih / Şahin, Tolga / Topçu, Feyza Sönmez / Yuzer, Yıldıray / Tokat, Yaman

Transplantation proceedings

2024 Volume 56, Issue 1, Page(s) 111–115

Abstract: Background: We aimed to study the predictive value of preoperative perform [18F] Fludeoxyglucose positron emission tomography-computed tomography ([18] FDG PET-CT) for survival in liver transplantation due to hepatocellular cancer.: Methods: Ninety- ... ...

Abstract	Background: We aimed to study the predictive value of preoperative perform [18F] Fludeoxyglucose positron emission tomography-computed tomography ([18] FDG PET-CT) for survival in liver transplantation due to hepatocellular cancer. Methods: Ninety-six patients who underwent liver transplantation for hepatocellular cancer (HCC) after preoperative PET-CT evaluation were examined for the study. All patients' ages, genders, body mass index, blood groups, Child-Pugh and Model for End-Stage Liver Disease scores, etiologies, median Alpha Fetoprotein values, Milan Criteria and T stages, grades, macrovascular and microvascular invasions, multicentricities, maximum and total tumor sizes, tumor number findings in explant specimens, and recurrence rates were analyzed statistically. Results: Statistically, microvascular (P = .002) and macrovascular invasions (P = .034) were observed more frequently in patients who are PET-CT (+) compared with patients who are PET-CT (-). PET-CT positivity was associated with shortened disease-free survival (DFS) statistically (P = .004). Conclusion: Positron emission tomography-CT positivity may be important for predicting prognostic markers such as DFS and vascular invasion in the preoperative evaluation. Before transplantation, PET-CT should be applied to all patients with HCC.
MeSH term(s)	Humans ; Female ; Male ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Positron Emission Tomography Computed Tomography/methods ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/surgery ; Liver Transplantation/methods ; End Stage Liver Disease ; Fluorodeoxyglucose F18 ; Radiopharmaceuticals ; Severity of Illness Index ; Positron-Emission Tomography ; Prognosis ; Retrospective Studies
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2023.12.007
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Article ; Online: Multi-center living liver donor quality of life survey up to 20 years after donor hepatectomy and association with surgical outcomes.

Andacoglu, Oya / Sabisch, Eva / Malamutmann, Eugen / Ozbek, Umut / Emre, Anilalp / Tokat, Yaman / Oezcelik, Arzu

HPB : the official journal of the International Hepato Pancreato Biliary Association

2022 Volume 24, Issue 11, Page(s) 1975–1979

Abstract: Background: We implemented a multicenter interview with the donors to investigate Quality of Life (QoL) up to 20 years following donation.: Methods: Data were collected retrospectively. Complications were graded by Dindo-Clavien classification.: ... ...

Abstract	Background: We implemented a multicenter interview with the donors to investigate Quality of Life (QoL) up to 20 years following donation. Methods: Data were collected retrospectively. Complications were graded by Dindo-Clavien classification. Results: Median follow-up was 16.1 years. Out of 485 donors, 272 responded (56.1%). The majority (>90%) reported they are in excellent/good overall health and positive or no impact of donation on professional life. Length of stay (LOS) was associated with impact on professional life and return to baseline functionality (both p = 0.046). Major complication was not associated with current physical condition or return to baseline normalcy (p = 0.06). Seventy-five (27.5%) reported unsure or no to donate again. None of the parameters were associated with donation again response. Faster return to baseline functionality, and more positive impact on professional life were reported in the last decade, likely secondary to less complication rates (all p < 0.001). Conclusion: This the longest follow up reports after living liver donation among German and Turkish populations. Although subject to recall bias, LOS was associated with negative impact on professional life and return to baseline functionality. Regret feelings were higher than literature. These long-term effects should be incorporated into donor discussions.
MeSH term(s)	Humans ; Quality of Life ; Hepatectomy/adverse effects ; Retrospective Studies ; Living Donors ; Liver ; Treatment Outcome
Language	English
Publishing date	2022-06-24
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2022.06.007
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Article ; Online: Comparison of intraoperative biliary anastomosis stenting technique in living-donor liver transplantation: Review of 41 patients.

Dönmez, Ramazan / Balas, Şener / Göktuğ, Ufuk Utku / Emek, Ertan / Tokat, Yaman

Turkish journal of medical sciences

2022 Volume 52, Issue 4, Page(s) 942–947

Abstract: Background: Biliary fistula is one of the most important complications in liver transplantation. Complications can vary from simple local peritonitis to death, and various techniques have been described to prevent them. In this study, we compared two ... ...

Abstract	Background: Biliary fistula is one of the most important complications in liver transplantation. Complications can vary from simple local peritonitis to death, and various techniques have been described to prevent them. In this study, we compared two different stenting methods used in biliary tract anastomosis in living-donor liver transplantation. Methods: We retrospectively analyzed data from 41 living-donor liver transplantations that were performed due to endstage liver failure between August 2019 and November 2020. Patients were grouped according to the stenting technique used in biliary anastomosis. Postoperative biliary tract complications were investigated. Results: Biliary fistulas were observed in 2 (7.4%) patients in the internal stent group, while 4 (28.5) fistulas were observed in the external stent group. Biliary tract stricture was observed in 2 (7.4%) patients in the internal stent group, but there was no statistical difference in complications. The preoperative MELD score (p = 0.038) was found to be statistically significant in regard to developing complications. Discussion:* Our study did not show the effect of stenting methods used during biliary anastomosis on the development of complications. However, larger randomized controlled studies are needed.
MeSH term(s)	Humans ; Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Bile Ducts/surgery ; Liver Transplantation/adverse effects ; Living Donors ; Postoperative Complications/prevention & control ; Retrospective Studies ; Stents/adverse effects
Language	English
Publishing date	2022-08-10
Publishing country	Turkey
Document type	Journal Article ; Review
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.55730/1300-0144.5394
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Article ; Online: The value of 18F-FDG PET/MRI in prediction of microvascular invasion in hepatocellular carcinoma.

Çelebi, Filiz / Görmez, Aysegül / Ilgun, Ahmet Serkan / Tokat, Yaman / Balcı, Numan Cem

European journal of radiology

2022 Volume 149, Page(s) 110196

Abstract: Rationale and objectives: Investigating the association between maximum standardized uptake value (SUV: Materials and methods: Forty-four patients [8 women and 36 men, median age of 62 (21-76)] with single HCCs (≥2 cm) who underwent preoperative 18F- ... ...

Abstract	Rationale and objectives: Investigating the association between maximum standardized uptake value (SUV Materials and methods: Forty-four patients [8 women and 36 men, median age of 62 (21-76)] with single HCCs (≥2 cm) who underwent preoperative 18F-FDG PET/MRI were retrospectively evaluated. The peritumoral and intratumoral ADC values were evaluated on diffusion-weighted images using Image J an open software and the intratumoral SUV Results: Univariate analysis showed that the histologic grade, tumor size, maximum peritumoral ADC (PT Conclusion: 18F-FDG PET/MRI is a useful noninvasive imaging tool for predicting the MVI of HCC.
MeSH term(s)	Carcinoma, Hepatocellular/pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Liver Neoplasms/pathology ; Magnetic Resonance Imaging ; Male ; Retrospective Studies
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-02-04
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2022.110196
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Article ; Online: Outcomes of right lobe donors with BMI≥30 for living donor liver transplantation.

Andacoglu, Oya / Tokat, Yaman / Malamutmann, Eugen / Adali, Gupse / Emre, Anilalp / Oezcelik, Arzu

Clinical transplantation

2022 Volume 36, Issue 7, Page(s) e14698

Abstract: Background: Donor BMI above 30 is generally considered contraindication for donor hepatectomy. We compared the donor outcomes based on BMI threshold and weight loss.: Patients and methods: All potential donors were identified and data were collected ... ...

Abstract	Background: Donor BMI above 30 is generally considered contraindication for donor hepatectomy. We compared the donor outcomes based on BMI threshold and weight loss. Patients and methods: All potential donors were identified and data were collected retrospectively. Steatosis was assessed based on liver-spleen Hounsfield unit difference and absolute liver intensity values. We compared BMI≥30 (n = 53) and BMI < 30 (n = 64) donor outcomes. Donors with weight loss (WL) prior to surgery were also analyzed separately. Complications were graded by Clavien-Dindo classification. Results: All donors underwent open right donor hepatectomy. There was no difference between BMI≥30 and < 30 groups except female predominance in BMI≥30 group (P = .006). Both groups had similar rates of complication rates in all categories, similar remnant volume, operative time, length of stay and similar postoperative liver function recovery (all P > .05). On the other hand, donors with WL were more commonly male, had smaller graft size, and higher biliary complications rates compared to no-WL donors (all P < .05). Multivariate binary logistics regression analysis revealed no association between BMI or WL and outcomes. Conclusion: We demonstrate that donors with BMI≥30 have similar outcomes compared to BMI < 30 donors with our defined selection criterion, therefore BMI≥30 is not an absolute contraindication to donate right liver, provided that there is no significant steatosis and remnant liver is satisfactory. For potential overweight donors, WL down to BMI < 30 is a reasonable target. Higher biliary complication rates after WL should be investigated further.
MeSH term(s)	Body Mass Index ; Fatty Liver/surgery ; Female ; Hepatectomy ; Humans ; Liver/surgery ; Liver Transplantation/adverse effects ; Living Donors ; Male ; Postoperative Complications/etiology ; Retrospective Studies ; Weight Loss
Language	English
Publishing date	2022-06-08
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.14698
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