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Article ; Online: EVALUATING LACTOFERRIN AND CALPROTECTIN AS MARKERS OF INTESTINAL INFLAMMATION INCHRONIC PANCREATITIS.

Carvente, Claudia Teresa / Ferraz, Maria Lúcia Cardoso Gomes / Toledo, Carlos Fischer de

2024 Volume 61, Page(s) e24003

Abstract: Background: The treatment of chronic pancreatitis does not consistently solve intestinal abnormalities, and despite the implementation of various therapeutic measures, patients often continue to experience persistent diarrhea. Therefore, it is ... ...

Abstract	Background: The treatment of chronic pancreatitis does not consistently solve intestinal abnormalities, and despite the implementation of various therapeutic measures, patients often continue to experience persistent diarrhea. Therefore, it is imperative to recognize that diarrhea may stem from factors beyond pancreatic insufficiency, and intestinal inflammation emerges as a potential contributing factor. Objective: The aim of this study was to assess fecal lactoferrin and calprotectin levels as indicators of intestinal inflammation in patients with chronic pancreatitis experiencing persistent diarrhea. Methods: In this study, 23 male patients with chronic pancreatitis primarily attributed to alcohol consumption and presenting with diarrhea (classified as Bristol stool scale type 6 or 7), underwent a comprehensive evaluation of their clinical and nutritional status. Fecal lactoferrin and calprotectin levels were mea-sured utilizing immunoassay techniques. Results: The average age of the participants was 54.8 years, 43.5% had diabetes, and 73.9% were smokers. Despite receiving enzyme replacement therapy and refraining from alcohol for over 4 years, all participants exhibited persistent diarrhea, accompanied by elevated calprotectin and lactoferrin levels indicative of ongoing intestinal inflammation. Conclusion: The findings of this study underscore that intestinal inflammation, as evidenced by elevated fecal biomarkers calprotectin and lactoferrin, may contribute to explaining the persistence of diarrhea in patients with chronic pancreatitis. Background: • Exploration of intestinal inflammation in chronic pancreatitis patients with altered bowel habits. Background: • Assessment of 23 patients using lactoferrin and calprotectin as intestinal inflammation biomarkers. Background: • Intestinal inflammation was detected in all patients; positive correlation between both biomarkers. Background: • Established connection between altered bowel habits and intestinal inflammation in chronic pancreatitis.
MeSH term(s)	Humans ; Male ; Middle Aged ; Lactoferrin ; Pancreatitis, Chronic/complications ; Diarrhea/etiology ; Leukocyte L1 Antigen Complex ; Biomarkers ; Inflammation
Chemical Substances	Lactoferrin (EC 3.4.21.-) ; Leukocyte L1 Antigen Complex ; Biomarkers
Language	English
Publishing date	2024-03-04
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	137743-7
ISSN	1678-4219 ; 0004-2803
ISSN (online)	1678-4219
ISSN	0004-2803
DOI	10.1590/S0004-2803.246102024-03
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Article ; Online: Is impaired coordination related to match physical load in footballers with cerebral palsy of different sport classes?

Reina, Raúl / Iturricastillo, Aitor / Castillo, Daniel / Roldan, Alba / Toledo, Carlos / Yanci, Javier

Journal of sports sciences

2021 Volume 39, Issue sup1, Page(s) 140–149

Abstract: Impaired coordination is a characteristic feature in cerebral palsy (CP) football players. This study aimed to determine the relationships of three coordination tests with match physical load during competition of para-footballers from different sport ... ...

Abstract	Impaired coordination is a characteristic feature in cerebral palsy (CP) football players. This study aimed to determine the relationships of three coordination tests with match physical load during competition of para-footballers from different sport classes. Records from 259 para-footballers from 25 national teams were obtained in four international competitions held in 2018 and 2019. The three coordination tests were conducted prior to competition (i.e., rapid heel-toe, side-stepping, and split jumps), and physical match load was recorded by GPS devices during the real game: i.e., maximum/mean, total distance, distance covered at different speed zones, number of accelerations/decelerations at different intensities, and player load. FT1 and FT3 players have the lowest and highest performance in all the coordination tests, respectively, but inconclusive between-groups differences were obtained (p=0.022‒0.238). Split jumps and side-stepping tests are associated with the performance of moderate and high accelerations during competition (r = -0.20‒0.71; p<0.01). Significant correlations (r = 0.36‒0.71; p<0.01) were obtained between all the coordination measures. Coordination tests better discriminate those with more severe impairments and some evidence for the validity of the new CP football sport classes is provided. Further research is necessary to identify the portion of the variance in sports performance that coordination explains.
MeSH term(s)	Acceleration ; Adult ; Analysis of Variance ; Ataxia/classification ; Ataxia/physiopathology ; Athletic Performance/classification ; Athletic Performance/physiology ; Cerebral Palsy/classification ; Cerebral Palsy/physiopathology ; Cross-Sectional Studies ; Deceleration ; Geographic Information Systems ; Humans ; Internationality ; Lower Extremity/physiopathology ; Movement/physiology ; Para-Athletes ; Soccer/classification ; Soccer/physiology ; Soccer/statistics & numerical data ; Sports for Persons with Disabilities/classification ; Sports for Persons with Disabilities/physiology ; Young Adult
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	995528-8
ISSN	1466-447X ; 0264-0414
ISSN (online)	1466-447X
ISSN	0264-0414
DOI	10.1080/02640414.2021.1880740
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Article ; Online: Consolidated Overview of Notifiable Adverse Events in the U.S. President's Emergency Plan for AIDS Relief's Voluntary Medical Male Circumcision Program Through 2020.

Lucas, Todd / Cooney, Caroline / Prainito, Amber / Godfrey, Catherine / Kiggundu, Valerian / Thomas, Anne Goldzier / Ridzon, Renee / Toledo, Carlos

Current HIV/AIDS reports

2022 Volume 19, Issue 6, Page(s) 508–515

Abstract: Purpose of review: Through December 2020, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) supported more than 25 million voluntary medical male circumcisions (VMMC) as part of the combined HIV prevention strategy in 15 African countries. ... ...

Abstract	Purpose of review: Through December 2020, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) supported more than 25 million voluntary medical male circumcisions (VMMC) as part of the combined HIV prevention strategy in 15 African countries. PEPFAR monitors defined adverse events (AEs) occurring within 30 days of VMMC through its notifiable adverse event reporting system (NAERS). All NAERS reports through December 2020 were reviewed to quantify AE type, severity, and relation to the VMMC procedure. Interventions to improve client safety based on NAERS findings are described. Recent findings: Fourteen countries reported 446 clients with notifiable adverse events (NAEs); 394/446 (88%) were determined VMMC-related, representing approximately 18 NAE reports per million circumcisions. Fatalities comprised 56/446 (13%) with 24/56 (43%) of fatalities determined VMMC-related, representing 0.96 VMMC-related fatalities per million circumcisions. The remaining 390 NAEs were non-fatal with 370/390 (95%) VMMC-related. Multiple programmatic changes have been made based on NAERS data to improve client safety. Client safety is paramount in this surgical program designed for individual and population-level benefit. Surveillance of rare but severe complications following circumcision has identified pre-existing or new safety concerns and guided continuous programmatic improvement.
MeSH term(s)	Male ; Humans ; Circumcision, Male/adverse effects ; Acquired Immunodeficiency Syndrome ; HIV Infections/epidemiology ; Voluntary Programs ; Africa
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2151206-1
ISSN	1548-3576 ; 1548-3568
ISSN (online)	1548-3576
ISSN	1548-3568
DOI	10.1007/s11904-022-00636-8
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Article ; Online: Factors Beyond Compensation Associated with Uptake of Voluntary Medical Male Circumcision in Zambia.

Ong, Katherine S / Laube, Catharine / Mohan, Diwakar / Iverson, Lara / Kaonga, Albert / Chituwo, Omega / Kamboyi, Royd / Kabila, Makando / Toledo, Carlos

AIDS and behavior

2022 Volume 27, Issue 6, Page(s) 1836–1848

Abstract: Voluntary medical male circumcision (VMMC) provides partial protection against female-to-male transmission of HIV. The Maximizing the Impact of Voluntary Medical Male Circumcision in Zambia (MAXZAM) project was a phased implementation of a demand ... ...

Abstract	Voluntary medical male circumcision (VMMC) provides partial protection against female-to-male transmission of HIV. The Maximizing the Impact of Voluntary Medical Male Circumcision in Zambia (MAXZAM) project was a phased implementation of a demand generation strategy for VMMC through economic compensation. Previously published findings showed increased uptake of VMMC when compensation was provided. This paper is a follow-up evaluation of the MAXZAM project exploring additional factors associated with uptake of VMMC. Factors found associated include the outreach setting in which men were approached, number of information sources seen, heard, or read about VMMC, their self-reported HIV risk behaviors, their self-reported intention to go through the procedure, and their behavioral-psychographic profile. The findings highlight the importance of considering general (e.g., intensifying mass communications and targeting specific settings) and person-centered demand generation approaches (e.g., considering the client's psychographic profile and HIV risk level) to maximize effect on VMMC uptake.
MeSH term(s)	Humans ; Male ; Female ; Circumcision, Male ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Zambia/epidemiology ; Sexual Behavior ; Intention
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-022-03915-y
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Article: At 100 years of Gaceta Médica de México resumption.

Rodríguez-Pérez, Martha Eugenia / Rodríguez-Toledo, Carlos Andrés / Cruz-Gaytán, Eduardo Iván

Gaceta medica de Mexico

2020 Volume 155, Issue 5, Page(s) 511–515

Abstract: Gaceta Médica de México, official journal of the National Academy of Medicine of Mexico, began its circulation on September 15, 1864, and continues to be positioned as the oldest medical periodical publication. However, its publication was temporarily ... ...

Abstract	Gaceta Médica de México, official journal of the National Academy of Medicine of Mexico, began its circulation on September 15, 1864, and continues to be positioned as the oldest medical periodical publication. However, its publication was temporarily interrupted. The present study analyzes the interruption suffered by Gaceta in 1916, its resumption in 1919, and the causes that originated that discontinuity. The consequences of the so-called Mexican revolution and the enthusiasm and commitment of the academy and its editors to continue working for the progress of national medicine are discussed.
MeSH term(s)	Academies and Institutes/history ; Advertising/history ; Civil Disorders/history ; History, 19th Century ; History, 20th Century ; Mexico ; Periodicals as Topic/history
Language	English
Publishing date	2020-02-24
Publishing country	Mexico
Document type	Historical Article ; Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.M20000341
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Article ; Online: Change-of-Direction Ability of Para-Footballers With Cerebral Palsy Under a New Evidence-Based and Sport-Specific Classification System.

Peña-González, Iván / Roldan, Alba / Toledo, Carlos / Urbán, Tomás / Reina, Raúl

International journal of sports physiology and performance

2020 Volume 16, Issue 2, Page(s) 267–272

Abstract: Purpose: This study aimed (1) to explore the validity and reliability of a new and specific change-of-direction (COD) test that requires dribbling skills to classify international footballers with cerebral palsy (CP) and compare it with another valid ... ...

Abstract	Purpose: This study aimed (1) to explore the validity and reliability of a new and specific change-of-direction (COD) test that requires dribbling skills to classify international footballers with cerebral palsy (CP) and compare it with another valid and reliable COD test without ball dribbling and (2) to probe whether both tests can discriminate between the new CP football classes (ie, FT1, FT2, and FT3) established worldwide in 2018. Methods: This study involved 180 international para-footballers with CP from 23 national teams at the 3 regional competitions held in 2018. They performed 2 COD tests, the modified agility test (no dribbling skills) and the dribbling speed test (DST). Results: Reliability was excellent for both the modified agility test (intraclass correlation coefficient [ICC]2,1 = .91, SEM = 5.75%) and the DST (ICC2,1 = .92, SEM = 4.66%). The modified agility test and DST results were highly to very highly correlated to one another for the whole group and considering the sport classes (r = .60-.80; P < .001). A 1-way analysis of variance showed significant differences between sport classes in both tests (P < .001). However, among classes, there were significant differences between FT1 and FT2 and FT3 (P < .01, effect size = large) and low to moderate effect sizes between FT2 and FT3 for either test. Conclusion: The DST appears to be valid and reliable to classify CP football players within the new classification system. Regression analysis revealed that 18.2% of the variance in the new sport classes could be explained by the 2 examined tests.
MeSH term(s)	Athletic Performance ; Cerebral Palsy ; Exercise Test/standards ; Humans ; Reproducibility of Results ; Soccer ; Sports for Persons with Disabilities
Language	English
Publishing date	2020-11-20
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2019-0656
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Article ; Online: The impact of different prophylactic anticoagulation doses on the outcomes of patients with COVID-19.

Jiménez-Soto, Rodolfo / Aguilar-Soto, Mercedes / Rodríguez-Toledo, Carlos Andrés / Camiro-Zúñiga, Antonio / Demichelis, Roberta

Thrombosis research

2021 Volume 202, Page(s) 14–16

MeSH term(s)	Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Blood Coagulation ; COVID-19 ; Enoxaparin/pharmacology ; Humans ; SARS-CoV-2
Chemical Substances	Anticoagulants ; Enoxaparin
Language	English
Publishing date	2021-03-06
Publishing country	United States
Document type	Letter
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2021.02.031
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Article: El Dr. Levi B. Salmans, fundador del sanatorio "El Buen Samaritano" en Guanajuato.

Olivier-Toledo, Carlos / Viesca-Treviño, Carlos

Revista medica del Instituto Mexicano del Seguro Social

2016 Volume 54, Issue 3, Page(s) 380–385

Abstract: In this research we focus on the medical evangelist Levi B. Salmans, and The Good Samaritan sanitarium. Doctor Salmans lived in Mexico for about 50 years (1885-1935). During the first part of his stay, he was devoted to found churches and Methodist ... ...

Title translation	Doctor Levi B. Salmans, founder of The Good Samaritan sanitarium in Guanajuato.
Abstract	In this research we focus on the medical evangelist Levi B. Salmans, and The Good Samaritan sanitarium. Doctor Salmans lived in Mexico for about 50 years (1885-1935). During the first part of his stay, he was devoted to found churches and Methodist schools. However, from 1891 he took a turn in his career by founding dispensaries in different towns of Guanajuato to create, in 1899, the private charity association for the sick and infirm The Good Samaritan. His intense, intellectual, and practical work led him to create health journals, to train nurses, and to promote physiotherapies in accordance with the science advances of that time. By itself, this research shows that the history of medicine in Mexico still has long way to go and that Protestant communities, in favor of modernity and scientific knowledge, took a big part in shaping the history of this discipline in Mexico.
MeSH term(s)	Charities/history ; History, 19th Century ; History, 20th Century ; Hospitals, Religious/history ; Mexico ; Missionaries/history ; Protestantism/history ; Religion and Medicine
Language	Spanish
Publishing date	2016-05
Publishing country	Mexico
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	732133-8
ISSN	0443-5117 ; 0484-7849
ISSN	0443-5117 ; 0484-7849
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Article: Does voluntary medical male circumcision protect against sexually transmitted infections among men and women in real-world scale-up settings? Findings of a household survey in KwaZulu-Natal, South Africa.

Davis, Stephanie / Toledo, Carlos / Lewis, Lara / Maughan-Brown, Brendan / Ayalew, Kassahun / Kharsany, Ayesha B M

BMJ global health

2019 Volume 4, Issue 3, Page(s) e001389

Abstract: Introduction: Male circumcision (MC) confers partial protection to men against HIV and, in research settings, some sexually transmitted infections (STIs). It is also associated with protection from some STIs among female partners. However, real-world ... ...

Abstract	Introduction: Male circumcision (MC) confers partial protection to men against HIV and, in research settings, some sexually transmitted infections (STIs). It is also associated with protection from some STIs among female partners. However, real-world data on changes in STI transmission associated with large-scale public African medical male circumcision (MMC) conducted for HIV prevention are lacking and would improve estimates of the health impact of MMC. Methods: The HIV Incidence Provincial Surveillance System is a community-based surveillance platform for HIV prevalence, incidence and intervention coverage trends in KwaZulu-Natal province, South Africa. HIPPS collected cross-sectional self-reported data on circumcision status (from men), partner circumcision status for past three partners (from women) and demographic characteristics and behavioural risk factors; and tested participants for HIV, herpes simplex virus type 2 (HSV-2), syphilis, hepatitis B, Results: Among men, MMC had a protective association with HSV-2 (OR 0.66, 95% CI 0.50 to 0.86), hepatitis B (OR 0.53, 95% CI 0.30 to 0.95), HIV (OR 0.50, 95% CI 0.38 to 0.65) and Conclusion: These real-world data, supporting protective associations between MMC conducted for HIV prevention and STIs in men and women, can help clarify the full impact of MMC and support a role in broader sexual health programming.
Language	English
Publishing date	2019-05-30
Publishing country	England
Document type	Journal Article
ISSN	2059-7908
ISSN	2059-7908
DOI	10.1136/bmjgh-2019-001389
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Article: A 100 años de la reanudación de Gaceta Médica de México.

Rodríguez-Pérez, Martha Eugenia / Rodríguez-Toledo, Carlos Andrés / Cruz-Gaytán, Eduardo Iván

Gaceta medica de Mexico

2019 Volume 155, Issue 5, Page(s) 554–558

Abstract	Gaceta Médica de México, official journal of the National Academy of Medicine of Mexico, began its circulation on September 15, 1864, and continues to be positioned as the oldest medical periodical publication. However, its publication was temporarily interrupted. The present study analyzes the interruption suffered by Gaceta in 1916, its resumption in 1919, and the causes that originated that discontinuity. The consequences of the so-called Mexican revolution and the enthusiasm and commitment of the academy and its editors to continue working for the progress of national medicine are discussed.
MeSH term(s)	Academies and Institutes/history ; History, 19th Century ; History, 20th Century ; Mexico ; Periodicals as Topic/history ; Time Factors
Language	English
Publishing date	2019-11-06
Publishing country	Mexico
Document type	Historical Article ; Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.19005379
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