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  1. Book ; Online: Trabajo y crisis de los modelos productivos en América Latina

    Neffa, Julio César / Garza Toledo, Enrique de la

    (Grupos de Trabajo de CLACSO. Trabajo y relaciones laborales)

    2020  

    Series title Grupos de Trabajo de CLACSO. Trabajo y relaciones laborales
    Keywords Labour economics ; Labor & Employment Relations
    Language Spanish
    Size 1 Online-Ressource
    Publisher CLACSO
    Document type Book ; Online
    Note Spanish
    HBZ-ID HT030611917
    ISBN 9789877225983 ; 9877225980
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Comparison of abdominal adipose tissue versus Body Mass Index (BMI) as a predictor of complications and survival in liver transplantation.

    Toledo, Enrique / Canal, Gema / Sánchez, Sara / Echeverri, Juan / Fernández, Roberto / Del Mar Achalandabaso, Mª / Anderson, Edward J / Castillo, Federico / Rodríguez, Juan Carlos

    Cirugia espanola

    2024  

    Abstract: Introduction: Because of the obesity epidemic, more obese patients are on liver transplant (LT) waiting lists. The diseases associated with obesity may increase complications and limit survival after LT. However, there is no established measure or cut- ... ...

    Abstract Introduction: Because of the obesity epidemic, more obese patients are on liver transplant (LT) waiting lists. The diseases associated with obesity may increase complications and limit survival after LT. However, there is no established measure or cut-off point to determine this impact and aid decision making. The aim of the present study is to evaluate obesity in patients undergoing LT via BMI and CT-based measurement of adipose tissue (AAT). These parameters will be used to predict the risk of postoperative complications and 5-year survival.
    Methods: A retrospective, single-center study was carried out at a tertiary Spanish hospital, including all patients who received LT between January 2012 and July 2019 (n = 164). The patients were adults who underwent LT using the 'piggyback' technique, preserving the recipient vena cava. Visceral adipose tissue (VAT) and BMI were calculated to examine correlations with postoperative complications and 5-year survival.
    Results: No significant association was found between postoperative complications by Comprehensive Complication Index, BMI, AAT/height, subcutaneous fat/height and VAT/height. Kaplan-Meier curves for 5-year survival compared LT recipients with BMI < 30.45 vs ≥30.45, with an estimated survival of 58.97 months versus 43.11 months, respectively (P < .001) (Fig. 3) and for LT recipients with an AAT/height <27.35 mm versus ≥27.35 mm, with an estimated survival of 57.69 months versus 46.34 months (P = .001).
    Conclusions: This study does not show a higher rate of postoperative complications in obese patients. There is a significantly lower long-term survival in patients with AAT/height ≥27.35 mm and BMI ≥ 30.45. BMI is a valid estimate of obesity and is predictive of survival.
    Language English
    Publishing date 2024-03-18
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2024.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Incidental mesonephric remnant hyperplasia of the jejunal mesentery: A diagnostic challenge.

    Val-Bernal, José-Fernando / Mayorga, Marta M / Calapaquí-Terán, Adriana K / Toledo, Enrique

    Pathology, research and practice

    2021  Volume 220, Page(s) 153388

    Abstract: Mesonephric remnants are embryonic vestiges of the mesonephric (Wolffian) ducts which regress during normal development. These remnants have been uncommonly reported in the female and male reproductive tract as a spectrum of morphologic lesions that can ... ...

    Abstract Mesonephric remnants are embryonic vestiges of the mesonephric (Wolffian) ducts which regress during normal development. These remnants have been uncommonly reported in the female and male reproductive tract as a spectrum of morphologic lesions that can be misdiagnosed as carcinoma. One case of mesonephric remnant hyperplasia of the jejunal mesentery incidentally found in a 47-year-old man is herein reported. This is the first description of mesonephric hyperplasia arisen in the mesentery. The presence of ducts, tubules, and cysts lined by bland, epithelial, cuboidal cells with scant cytoplasm, and diffuse pseudoinfiltrative growth pattern can raise the possibility of neoplasia. Immunohistochemically, mesonephric epithelia have a characteristic staining. CD10 highlights the apical-luminal aspect of the cells. Besides, intense reactivity is showed for high-molecular-weight cytokeratin (CK), CK7, bcl2, and vimentin. The main differential diagnosis includes mesothelial hyperplasia, epithelial mesothelioma, well-differentiated neuroendocrine tumor, and infiltration due to acinar adenocarcinoma of the prostate. However, a detailed microscopic study with the aid of immunohistochemistry helps separate mesonephric remnants from malignant processes. The mesonephric hyperplasia of the mesentery we have reported adds to the spectrum of mesonephric remnants a new location. Familiarity with this lesion is indispensable to avoid overdiagnosis.
    MeSH term(s) Biomarkers/analysis ; Biopsy ; Diagnosis, Differential ; Humans ; Hyperplasia ; Immunohistochemistry ; Incidental Findings ; Jejunum/chemistry ; Jejunum/pathology ; Jejunum/surgery ; Male ; Mesentery/chemistry ; Mesentery/pathology ; Mesentery/surgery ; Mesonephros/chemistry ; Mesonephros/metabolism ; Mesonephros/surgery ; Middle Aged ; Predictive Value of Tests ; Wolffian Ducts/chemistry ; Wolffian Ducts/pathology ; Wolffian Ducts/surgery
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-02-18
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2021.153388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: NMDA Receptor Antagonists Increase the Release of GLP-1 From Gut Endocrine Cells.

    Cyranka, Malgorzata / Monfeuga, Thomas / Vedovato, Natascia / Larabee, Chelsea M / Chandran, Anandhakumar / Toledo, Enrique M / de Wet, Heidi

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 861311

    Abstract: Type 2 diabetes mellitus (T2DM) remains one of the most pressing health issues facing modern society. Several antidiabetic drugs are currently in clinical use to treat hyperglycaemia, but there is a need for new treatments that effectively restore ... ...

    Abstract Type 2 diabetes mellitus (T2DM) remains one of the most pressing health issues facing modern society. Several antidiabetic drugs are currently in clinical use to treat hyperglycaemia, but there is a need for new treatments that effectively restore pancreatic islet function in patients. Recent studies reported that both murine and human pancreatic islets exhibit enhanced insulin release and β-cell viability in response to N-methyl-D-aspartate (NMDA) receptor antagonists. Furthermore, oral administration of dextromethorphan, an over-the-counter NMDA receptor antagonist, to diabetic patients in a small clinical trial showed improved glucose tolerance and increased insulin release. However, the effects of NMDA receptor antagonists on the secretion of the incretin hormone GLP-1 was not tested, and nothing is known regarding how NMDA receptor antagonists may alter the secretion of gut hormones. This study demonstrates for the first time that, similar to β-cells, the NMDA receptor antagonist MK-801 increases the release of GLP-1 from a murine L-cell enteroendocrine model cell line, GLUTag cells. Furthermore, we report the 3' mRNA expression profiling of GLUTag cells, with a specific focus on glutamate-activated receptors. We conclude that if NMDA receptor antagonists are to be pursued as an alternative, orally administered treatment for T2DM, it is essential that the effects of these drugs on the release of gut hormones, and specifically the incretin hormones, are fully investigated.
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.861311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Physical activity-related indicators in children and adolescents in Uruguay: A scoping review based on the Global Matrix initiative.

    Bizzozero-Peroni, Bruno / Fernández-Giménez, Sofía / Pintos-Toledo, Enrique / Corvos, César Augusto / Díaz-Goñi, Valentina / Brazo-Sayavera, Javier

    Frontiers in public health

    2022  Volume 10, Page(s) 954621

    Abstract: Background: The first Uruguay's Report Card in 2018 based on the Global Matrix initiative showed the lack of information on physical activity in children and adolescents. This study mapped and examined the available evidence on physical activity-related ...

    Abstract Background: The first Uruguay's Report Card in 2018 based on the Global Matrix initiative showed the lack of information on physical activity in children and adolescents. This study mapped and examined the available evidence on physical activity-related indicators based on Uruguay's 2022 Report Card.
    Methods: The scoping review was reported using the Joanna Briggs Institute and the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews guidelines. A comprehensive literature search was performed for the period between 2018 and 2021, including electronic databases (PubMed, Web of Science, LILACS, Scielo, and Latindex), gray literature (Google Scholar, open access thesis, relevant websites of State-agencies and International Organizations), national and regional relevant journals, and reference lists of key texts. Two researchers independently conducted both the selection and data-charting process. Data items from each paper were charted based on the Population, Concept, and Context elements reflected in the objective of the review. A narrative synthesis and network plots were conducted to summarize the evidence.
    Results: A total of 20 papers were included in this review, consisting of four peer-reviewed scientific papers, three bachelor's theses, four official documents of State-agencies, four Government reports, of which three included national surveys, and five laws. Strengths, weaknesses, and knowledge gaps were identified from the available evidence. We synthesized main challenges such as publishing scientific studies, establishing cross-national and cross-sectoral collaborations in research projects, generating high-quality data, reporting information on social inequality indicators that influence equitable distribution, or increasing access to public information. Our results support early emerging and growth research on this topic. However, despite existing papers on physical activity-related indicators in Uruguayan youths, the lack of high-quality evidence remains clear.
    Conclusion: The findings of this scoping review provide the best available evidence for identifying and overcoming the challenges of physical activity-related indicators research in Uruguay. The methodological framework used could be useful for countries involved in future editions of the Global Matrix initiative.
    Systematic review registration: Open Science Framework, https://osf.io/hstbd/.
    MeSH term(s) Adolescent ; Child ; Exercise ; Humans ; Uruguay
    Language English
    Publishing date 2022-09-07
    Publishing country Switzerland
    Document type Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.954621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Results from the Uruguay's 2022 report card on physical activity for children and adolescents.

    Brazo-Sayavera, Javier / Fernandez-Gimenez, Sofia / Pintos-Toledo, Enrique / Corvos, Cesar / Souza-Marabotto, Franco / Bizzozero-Peroni, Bruno

    Journal of exercise science and fitness

    2022  Volume 21, Issue 1, Page(s) 104–110

    Abstract: Background/objective: Uruguay was enrolled in the fourth edition of the Global Matrix on physical activity-related indicators in children and adolescents with the aim of producing its second Report Card and analyses on the ten core indicators.: ... ...

    Abstract Background/objective: Uruguay was enrolled in the fourth edition of the Global Matrix on physical activity-related indicators in children and adolescents with the aim of producing its second Report Card and analyses on the ten core indicators.
    Methods: A harmonized development process proposed by the Active Healthy Kids Global Alliance was followed. The best available scientific and grey literature was systematically searched for all the indicators included in the Report Card (Overall Physical Activity, Organized Sport Participation, Active Play, Active Transportation, Sedentary Behavior, Physical Fitness, Family and Peers, School, Community and Environment, and Government). A grading scale ranging from A to F was used. A new approach was used to grade the Government indicator according to the Active Healthy Kids Global Alliance guidance.
    Results: New information was identified and 7 out of 10 indicators were graded, while there were 3 out of 10 indicators with incomplete information to be graded. An gender-based analysis was included in this second Report Card, providing separate grades for 5 of the indicators [girls/boys]: Overall Physical Activity [F/F], Organized Sport Participation [F/D], Active Transportation [C/C], Sedentary Behavior [D+/D+], and Community and Environment [D+/C-]. The comparison between 2018 and 2022 analysis showed a decrease in Overall Physical Activity and Organized Sport Participation, while the sources of influence School and Government obtained a higher grade in comparison with the previous Report Card.
    Conclusion: Uruguay has developed its second version of the Report Card on physical activity-related indicators in children and adolescents. The gender analysis showed inequalities between girls and boys. In summary, behavioral indicators have decreased while sources of influence have risen along the time.
    Language English
    Publishing date 2022-11-14
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2205204-5
    ISSN 1728-869X
    ISSN 1728-869X
    DOI 10.1016/j.jesf.2022.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Functional module detection through integration of single-cell RNA sequencing data with protein-protein interaction networks.

    Klimm, Florian / Toledo, Enrique M / Monfeuga, Thomas / Zhang, Fang / Deane, Charlotte M / Reinert, Gesine

    BMC genomics

    2020  Volume 21, Issue 1, Page(s) 756

    Abstract: Background: Recent advances in single-cell RNA sequencing have allowed researchers to explore transcriptional function at a cellular level. In particular, single-cell RNA sequencing reveals that there exist clusters of cells with similar gene expression ...

    Abstract Background: Recent advances in single-cell RNA sequencing have allowed researchers to explore transcriptional function at a cellular level. In particular, single-cell RNA sequencing reveals that there exist clusters of cells with similar gene expression profiles, representing different transcriptional states.
    Results: In this study, we present SCPPIN, a method for integrating single-cell RNA sequencing data with protein-protein interaction networks that detects active modules in cells of different transcriptional states. We achieve this by clustering RNA-sequencing data, identifying differentially expressed genes, constructing node-weighted protein-protein interaction networks, and finding the maximum-weight connected subgraphs with an exact Steiner-tree approach. As case studies, we investigate two RNA-sequencing data sets from human liver spheroids and human adipose tissue, respectively. With SCPPIN we expand the output of differential expressed genes analysis with information from protein interactions. We find that different transcriptional states have different subnetworks of the protein-protein interaction networks significantly enriched which represent biological pathways. In these pathways, SCPPIN identifies proteins that are not differentially expressed but have a crucial biological function (e.g., as receptors) and therefore reveals biology beyond a standard differential expressed gene analysis.
    Conclusions: The introduced SCPPIN method can be used to systematically analyse differentially expressed genes in single-cell RNA sequencing data by integrating it with protein interaction data. The detected modules that characterise each cluster help to identify and hypothesise a biological function associated to those cells. Our analysis suggests the participation of unexpected proteins in these pathways that are undetectable from the single-cell RNA sequencing data alone. The techniques described here are applicable to other organisms and tissues.
    MeSH term(s) Cluster Analysis ; Gene Expression Profiling ; Gene Regulatory Networks ; Humans ; Protein Interaction Maps ; RNA/genetics ; Sequence Analysis, RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2020-11-02
    Publishing country England
    Document type Journal Article
    ISSN 1471-2164
    ISSN (online) 1471-2164
    DOI 10.1186/s12864-020-07144-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Translation of WNT developmental programs into stem cell replacement strategies for the treatment of Parkinson's disease.

    Toledo, Enrique M / Gyllborg, Daniel / Arenas, Ernest

    British journal of pharmacology

    2017  Volume 174, Issue 24, Page(s) 4716–4724

    Abstract: Wnt signalling is a highly conserved pathway across species that is critical for normal development and is deregulated in multiple disorders including cancer and neurodegenerative diseases. Wnt signalling is critically required for midbrain dopaminergic ( ...

    Abstract Wnt signalling is a highly conserved pathway across species that is critical for normal development and is deregulated in multiple disorders including cancer and neurodegenerative diseases. Wnt signalling is critically required for midbrain dopaminergic (mDA) neuron development and maintenance. Understanding the molecular processes controlled by Wnt signalling may thus hold the key to understand the physiopathology and to develop novel therapies aimed at preventing the loss of mDA neurons in Parkinson's disease (PD). Pharmacological tools to activate Wnt signalling have been used to translate in vivo developmental processes into protocols for the generation of bona fide mDA neurons from human pluripotent stem cells. Moreover, these protocols are currently being fine-tuned to generate mDA neurons for clinical trials in PD. At the same time, a vast amount of molecular details of Wnt signalling continues to emerge and remains to be implemented into new protocols. We hereby review novel pharmacological tools to activate Wnt signalling and how single-cell RNA-sequencing is contributing to unravel the complexity of this pathway in the developing human ventral midbrain, generating novel hypotheses and identifying new players and opportunities to further improve cell replacement therapy for PD.
    Linked articles: This article is part of a themed section on WNT Signalling: Mechanisms and Therapeutic Opportunities. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.24/issuetoc.
    MeSH term(s) Animals ; Humans ; Parkinson Disease/metabolism ; Parkinson Disease/therapy ; Pluripotent Stem Cells ; Stem Cell Transplantation ; Wnt Signaling Pathway
    Language English
    Publishing date 2017-07-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.13871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Configuraciones productivas y relaciones laborales en empresas multinacionales en América Latina

    Garza Toledo, Enrique de la / Hernández-Romo, Marcela

    (Biblioteca Iberoamericana de pensamiento)

    2017  

    Abstract: La quatrième de couverture indique : "Las multinacionales se han convertido en los actores centrales de las economías globalizadas. En este texto se analizan las políticas de relaciones laborales y sindicales de multinacionales norteamericanas y ... ...

    Author's details Enrique de la Garza Toledo, Marcela Hernández Romo, coordinadores
    Series title Biblioteca Iberoamericana de pensamiento
    Abstract La quatrième de couverture indique : "Las multinacionales se han convertido en los actores centrales de las economías globalizadas. En este texto se analizan las políticas de relaciones laborales y sindicales de multinacionales norteamericanas y latinoamericanas en cinco países de América latina: México, Colombia, Venezuela, Brasil y argentina. Dentro de la polémica entre convergencia y divergencia, esta obra explora tendencias en el siglo xxi. Para esto se puso a prueba el método configuracionista por el cual no se parte de hipótesis ni de marcos teóricos rígidos, sino de problemas y con una perspectiva de reconstrucción de la teoría para el caso concreto. De esta forma, concluimos que las multinacionales pueden tener estrategias globales, que tienden a la convergencia. Aunque, estas tendencias al situarse en países concretos sufren de otras mediaciones, que las llevan a la coexistencia de lo genérico con lo específico [divergiendo convergencias]. Estas especificidades están presionadas por los contextos locales y especialmente, por el comportamiento y concepciones de los actores involucrados (gerencias, sindicatos, trabajadores, estados)
    Language Spanish
    Size 510 Seiten, Illustrationen, Diagramme, 23 cm
    Edition Primera edición
    Document type Book
    Note Bobliogr. en fin de chapitre. Notes bibliogr
    ISBN 6072810578 ; 8416919453 ; 9786072810570 ; 9788416919451
    Database ECONomics Information System

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  10. Book: La situación del trabajo en México, 2012

    Garza Toledo, Enrique de la

    el trabajo en la crisis

    2012  

    Author's details Enrique de la Garza Toledo (coordinador)
    Keywords Labor ; Labor supply ; Labor unions ; Working class
    Language Spanish ; English
    Size 769 S., graph. Darst., 23 cm
    Edition 1. ed
    Publisher Univ. Autónoma Metropolitiana, Unidad Itzapalapa
    Publishing place México, D.F
    Document type Book
    Note Spanish, with 1 contribution in English ; Includes bibliographical references
    ISBN 9786074025439 ; 6074025436
    Database Former special subject collection: coastal and deep sea fishing

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