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  1. Article ; Online: Rothmund-Thomson syndrome: a case series from a tertiary pediatric hospital in Mexico.

    Sánchez-Padilla, Alicia P / Valencia-Herrera, Adriana M / Toledo-Bahena, Mirna E / Mena-Cedillos, Carlos A / Toussaint-Caire, Sonia

    Boletin medico del Hospital Infantil de Mexico

    2022  Volume 79, Issue 1, Page(s) 56–61

    Abstract: Background: Rothmund-Thomson syndrome, also known as congenital poikiloderma, is a rare autosomal recessive genodermatosis with onset in early childhood that affects at a multisystem level.: Case reports: Case 1. A 4-year-old male patient, ... ...

    Title translation Síndrome de Rothmund-Thomson: serie de casos de un hospital pediátrico de tercer nivel en México.
    Abstract Background: Rothmund-Thomson syndrome, also known as congenital poikiloderma, is a rare autosomal recessive genodermatosis with onset in early childhood that affects at a multisystem level.
    Case reports: Case 1. A 4-year-old male patient, consanguineous parents, 26-year-old brother with a probable diagnosis of Rothmund-Thompson syndrome. He presented with adactyly of the right thumb, hypoplasia of the left thumb, delayed growth and psychomotor development. At 3 months, he presented rough, dry, sparse hair and erythematous lesions on the face, leaving hyperpigmented and hypopigmented spots with a reticulated pattern. We detected hypoacusis, skeletal alterations, narrow chin, short stature, severe malnutrition, and chronic and asymptomatic hypodontia. Genetic sequencing showed a mutation for the RECQL4 gene, for which a multidisciplinary follow-up was provided by the genetics, gastroenterology, nutrition, endocrinology, stomatology, audiology, orthopedics, rehabilitation, ophthalmology and oncology services. Case 2. A 2-year-old female patient presented facial erythema that spread to the arms and legs at 3 months; skin biopsy showed poikiloderma. She was evaluated by the endocrinology service and followed up for short stature and hypogonadism. A genetic study was not performed.
    Conclusions: Rothmund-Thomson syndrome is characterized by atrophy. Only a few cases are reported in the literature. We present two cases of Rothmund-Thomson syndrome, emphasizing its clinical and dermatological characteristics.
    MeSH term(s) Adult ; Child ; Child, Preschool ; Female ; Hospitals, Pediatric ; Humans ; Male ; Mexico ; Mutation ; Rothmund-Thomson Syndrome/diagnosis ; Rothmund-Thomson Syndrome/genetics ; Rothmund-Thomson Syndrome/pathology
    Language English
    Publishing date 2022-01-25
    Publishing country Mexico
    Document type Case Reports ; Journal Article
    ZDB-ID 730519-9
    ISSN 1665-1146 ; 1665-1146 ; 0539-6115 ; 0539-6123
    ISSN (online) 1665-1146
    ISSN 1665-1146 ; 0539-6115 ; 0539-6123
    DOI 10.24875/BMHIM.21000013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 258: Show issues Location:
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  2. Article ; Online: Pigmented neurofibroma with hypertrichosis.

    Godínez-Chaparro, Juan A / Valencia-Herrera, Adriana M / Mena-Cedillos, Carlos A / Toussaint-Caire, Sonia / Duarte-Abdala, Mario R / Loza-Escutia, Omar / Toledo-Bahena, Mirna E

    Boletin medico del Hospital Infantil de Mexico

    2023  Volume 80, Issue 1, Page(s) 57–62

    Abstract: Background: Pigmented (or melanocytic) neurofibroma (PN) constitutes only 1% of cases and is considered a rare variant of neurofibroma containing melanin-producing cells. In addition, the association of PN with hypertrichosis is infrequent.: Case ... ...

    Title translation Neurofibroma pigmentado con hipertricosis.
    Abstract Background: Pigmented (or melanocytic) neurofibroma (PN) constitutes only 1% of cases and is considered a rare variant of neurofibroma containing melanin-producing cells. In addition, the association of PN with hypertrichosis is infrequent.
    Case report: We describe the case of an 8-year-old male with a neurofibromatosis type 1 (NF1) diagnosis, who presented a light brown hyperpigmented plaque, smooth and well-demarcated, and hypertrichosis on the left thigh. The skin biopsy showed characteristics of neurofibroma; however, in the deep portion of the lesion, melanin deposits positive for S100, Melan-A, and HMB45 were observed, thus establishing the diagnosis of pigmented neurofibroma.
    Conclusions: Although PN is a rare subtype of neurofibroma, it is considered a chronically progressive benign tumor containing melanin-producing cells. These lesions can appear alone or in association with neurofibromatosis. Since this is a tumor that can be confused with other skin lesions, biopsy analysis is essential to differentiate it from other pigmented skin tumors, such as melanocytic schwannoma, dermatofibrosarcoma protuberans, neurocristic hamartoma, or neuronevus. Surveillance is part of the treatment, and surgical resection is sometimes performed.
    MeSH term(s) Male ; Humans ; Child ; Hypertrichosis ; Melanins ; Neurofibroma ; Neurofibromatosis 1 ; Biopsy
    Chemical Substances Melanins
    Language English
    Publishing date 2023-03-03
    Publishing country Mexico
    Document type Case Reports ; Journal Article
    ZDB-ID 730519-9
    ISSN 1665-1146 ; 1665-1146 ; 0539-6115 ; 0539-6123
    ISSN (online) 1665-1146
    ISSN 1665-1146 ; 0539-6115 ; 0539-6123
    DOI 10.24875/BMHIM.21000197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 258: Show issues Location:
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  3. Article ; Online: Leukemia cutis and other dermatological findings in pediatric patients with acute myeloid leukemia.

    Godínez-Chaparro, Juan A / Valencia-Herrera, Adriana M / Duarte-Abdala, Mario R / Mena-Cedillos, Carlos A / Toledo-Bahena, Mirna E

    Boletin medico del Hospital Infantil de Mexico

    2021  Volume 78, Issue 5, Page(s) 411–417

    Abstract: Background: Leukemia cutis (LC) is the infiltration of neoplastic leukocytes into the skin, causing skin lesions. In children, it appears more frequently in patients with acute myeloblastic leukemia (AML), particularly in subtypes with a monocytic ... ...

    Title translation Leucemia cutis y otras manifestaciones dermatológicas en pacientes pediátricos con leucemia mieloide aguda.
    Abstract Background: Leukemia cutis (LC) is the infiltration of neoplastic leukocytes into the skin, causing skin lesions. In children, it appears more frequently in patients with acute myeloblastic leukemia (AML), particularly in subtypes with a monocytic component.
    Methods: We studied a retrospective cohort including all AML cases from the Hospital Infantil de México Federico Gómez between January 2009 to December 2019 and described the clinical characteristics of those who presented LC and other mucocutaneous manifestations. The information was collected from clinical records and analyzed using SPSS software (version 17).
    Results: We identified 54 AML cases: 53.7% were males, and 75.9% of the patients presented at least one dermatosis in the course of the disease. LC was clinically present in 14.8% of patients and was histologically confirmed in 9.2% of them; two congenital leukemia cases were identified. Among these patients, LC was more frequent in males. LC patients were younger than those without LC, the most frequent AML subtype was M2 (37.5%), and the most frequent clinical manifestations were plaques, chloromas, and gingival hyperplasia. None of the patients presented LC before AML diagnosis.
    Conclusions: Currently, only a few studies about LC on pediatric populations have been reported, and the existing ones have small sample sizes. We found clinical and epidemiological similarities with other populations in the studied sample.
    MeSH term(s) Child ; Cohort Studies ; Humans ; Leukemia, Myeloid, Acute/epidemiology ; Male ; Retrospective Studies ; Skin ; Skin Neoplasms
    Language English
    Publishing date 2021-10-27
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 730519-9
    ISSN 1665-1146 ; 1665-1146 ; 0539-6115 ; 0539-6123
    ISSN (online) 1665-1146
    ISSN 1665-1146 ; 0539-6115 ; 0539-6123
    DOI 10.24875/BMHIM.20000370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 258: Show issues Location:
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  4. Article: Guía de dermatitis atópica para México (GUIDAMEX): lineamientos usando metodología ADAPTE.

    Larenas-Linnemann, Désirée / Rincón-Pérez, Catalina / Luna-Pech, Jorge A / Macías-Weinmann, Alejandra / Vidaurri-de la Cruz, Helena / Navarrete-Rodríguez, Elsy M / Del Río-Navarro, Blanca E / Godínez-Alderete, Liliana / Guevara-Sanginés, Esther / Ortega-Martell, José A / Toledo-Bahena, Mirna E / Elizondo-Villareal, Bárbara / Madrigal-Beas, Ileana M / Amaya-Guerra, Mario / Barreras-Salcedo, José I / Boeta-Ángeles, Leticia / Campos-Rivera, Armando / Casillas-Guzmán, Martha E / Duarte-Abdala, Mario R /
    Espinosa-Padilla, Sara E / García-Rodríguez, Juan C / Gómez-Flores, Minerva / Gómez-Mendoza, Rubén A / Del C Lacy-Niebla, Rosa Ma / Miranda-Aguirre, Alessandra I / Olivares-Nolasco, Claudia / Onuma-Takane, Ernesto / Pérez-Luna, Mariana / Pliego-Reyes, Carlos L / Rodríguez-Aguilera, Ma de Lourdes / Sáez-de Ocariz-Gutiérrez, María Del Mar / Saucedo-Sánchez, Arturo / Sotelo-Ocampo, Ana B / Valencia-Herrera, Adriana Ma / Vázquez-García, Jorge / Wakida-Kuzunoki, Guillermo H / Camarillo-Saavedra, Jacqueline / Rodríguez Monroy, Fernanda A

    Gaceta medica de Mexico

    2023  Volume 158, Issue Suplement 2, Page(s) 1–116

    Abstract: With the advancement of knowledge in relation to the physiopathogenesis of atopic dermatitis (AD), several new therapeutic forms have been developed. There are also new guidelines for self-care. On the other hand, there is still an underdiagnosis of AD ... ...

    Title translation Guidelines on atopic dermatitis for Mexico (GUIDAMEX): using the ADAPTE methodology.
    Abstract With the advancement of knowledge in relation to the physiopathogenesis of atopic dermatitis (AD), several new therapeutic forms have been developed. There are also new guidelines for self-care. On the other hand, there is still an underdiagnosis of AD in Mexico. Thus, the need was seen to develop a national guide, with a broad base among the different medical groups that care for patients with AD. The Atopic Dermatitis Guidelines for Mexico (GUIDAMEX) was developed with the ADAPTE methodology, with the endorsement and participation of ten national medical societies, from physicians in Primary Healthcare to allergists and dermatologists. Throughout the manuscript, key clinical questions are answered that lead to recommendations and suggestions for the diagnosis of AD (including differential diagnosis with immunodeficiency syndromes), the recognition of comorbidities and complications, non-pharmacological treatment including therapeutic education, treatment of flares and maintenance therapy. The latter encompasses general measures to avoid triggering factors, first-line treatment focussed on repair of the skin barrier, second-line treatment (topical proactive therapy), and third-line phototherapy or systemic treatment, including dupilumab and JAK inhibitors.
    MeSH term(s) Humans ; Dermatitis, Atopic/therapy ; Dermatitis, Atopic/drug therapy ; Mexico ; Comorbidity ; Diagnosis, Differential ; Phototherapy/methods
    Language Spanish
    Publishing date 2023-01-20
    Publishing country Mexico
    Document type English Abstract ; Journal Article
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.M22000690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.

    Toledo-Bahena, Mirna E / Bucko, Alicia / Ocampo-Candiani, Jorge / Herz-Ruelas, Maira E / Jones, Terry M / Jarratt, Michael T / Pollak, Richard A / Zane, Lee T

    Journal of drugs in dermatology : JDD

    2014  Volume 13, Issue 9, Page(s) 1124–1132

    Abstract: Objective: To assess the potential efficacy, safety, and optimal dosing concentration of tavaborole, a novel, boron-based pharmaceutical agent with broad-spectrum antifungal activity, for the treatment of onychomycosis of the toenail due to ... ...

    Abstract Objective: To assess the potential efficacy, safety, and optimal dosing concentration of tavaborole, a novel, boron-based pharmaceutical agent with broad-spectrum antifungal activity, for the treatment of onychomycosis of the toenail due to dermatophytes.
    Methods: One double-blind, randomized, vehicle-controlled study (study 1) and two open-label studies (studies 2 and 3) examined the efficacy, safety, and optimal dosing concentration of tavaborole topical solution applied once daily or three times weekly for 180 days at concentrations of 1.0%, 2.5%, 5.0%, or 7.5%. Patient cohort 3 of study 2 received open-label tavaborole 5.0% once daily for 360 days. All three studies assessed day 180 treatment success, defined as complete or partial clinical evidence of clear nail growth plus negative fungal culture.
    Results: A total of 336 patients were included in the intent-to-treat (ITT) or modified ITT populations and efficacy analyses across the 3 studies. In study 1, treatment success rates at day 180 were higher with tavaborole 2.5%, 5.0%, and 7.5% vs vehicle (27%, 26%, and 32% vs 14%, respectively; slope P=0.030). In cohort 3 of study 2, 7% of patients achieved treatment success with tavaborole 5.0% at day 360. Negative culture rates at day 180 in study 1 were numerically higher for tavaborole 2.5%, 5.0%, and 7.5% vs vehicle (slope P=0.046). Application-site reactions of general irritation, erythema, scaling, and stinging/burning were most common with tavaborole 7.5%, were generally mild to moderate, and resolved with treatment discontinuation and/or a reduction in dosing frequency. No systemic safety concerns were observed.
    Conclusion: Tavaborole solution demonstrated favorable efficacy and safety in phase 2 clinical studies. Based on these findings, tavaborole topical solution, 5% was further investigated in larger, more definitive phase 3 studies. Results from these completed phase 3 studies will provide additional evidence regarding the safety and efficacy of tavaborole in the treatment of toenail onychomycosis.
    MeSH term(s) Administration, Topical ; Adolescent ; Adult ; Aged ; Antifungal Agents/administration & dosage ; Antifungal Agents/adverse effects ; Boron/administration & dosage ; Boron/adverse effects ; Boron Compounds/administration & dosage ; Boron Compounds/adverse effects ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Bridged Bicyclo Compounds, Heterocyclic/adverse effects ; Cohort Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Erythema/chemically induced ; Female ; Foot Dermatoses/diagnosis ; Foot Dermatoses/drug therapy ; Humans ; Male ; Middle Aged ; Onychomycosis/diagnosis ; Onychomycosis/drug therapy ; Treatment Outcome ; Young Adult
    Chemical Substances Antifungal Agents ; Boron Compounds ; Bridged Bicyclo Compounds, Heterocyclic ; tavaborole (K124A4EUQ3) ; Boron (N9E3X5056Q)
    Language English
    Publishing date 2014-09
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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