LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 25

Search options

  1. Article: Targeting cyclin-dependent kinases in sarcoma treatment: Current perspectives and future directions.

    Merlini, Alessandra / Pavese, Valeria / Manessi, Giulia / Rabino, Martina / Tolomeo, Francesco / Aliberti, Sandra / D'Ambrosio, Lorenzo / Grignani, Giovanni

    Frontiers in oncology

    2023  Volume 13, Page(s) 1095219

    Abstract: Effective treatment of advanced/metastatic bone and soft tissue sarcomas still represents an unmet medical need. Recent advances in targeted therapies have highlighted the potential of cyclin-dependent kinases (CDK) inhibitors in several cancer types, ... ...

    Abstract Effective treatment of advanced/metastatic bone and soft tissue sarcomas still represents an unmet medical need. Recent advances in targeted therapies have highlighted the potential of cyclin-dependent kinases (CDK) inhibitors in several cancer types, including sarcomas. CDKs are master regulators of the cell cycle; their dysregulation is listed among the "hallmarks of cancer" and sarcomas are no exception to the rule. In this review, we report both the molecular basis, and the potential therapeutic implications for the use of CDK inhibitors in sarcoma treatment. What is more, we describe and discuss the possibility and biological rationale for combination therapies with conventional treatments, target therapy and immunotherapy, highlighting potential avenues for future research to integrate CDK inhibition in sarcoma treatment.
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1095219
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Response to eribulin in a patient with metastatic uterine leiomyosarcoma: a case report.

    Aliberti, Sandra / Miano, Sara / Tolomeo, Francesco / Merlini, Alessandra / Aglietta, Massimo / Grignani, Giovanni

    Future oncology (London, England)

    2020  Volume 16, Issue 1s, Page(s) 15–19

    Abstract: We report the case of a 51 year-old patient affected by an advanced uterine leiomyosarcoma treated with eribulin as fourth-line therapy. The patient, with a previous history of leiomyomas of the myometrium, had undergone total hysterectomy for repeated ... ...

    Abstract We report the case of a 51 year-old patient affected by an advanced uterine leiomyosarcoma treated with eribulin as fourth-line therapy. The patient, with a previous history of leiomyomas of the myometrium, had undergone total hysterectomy for repeated metrorrhagias. After 7 years, metastases in the liver, bone and lung were documented. A fine needle liver biopsy demonstrated leiomyosarcoma metastasis. The patient was treated with first-line doxorubicin chemotherapy; after six cycles, disease progression was observed. A second-line trabectedin chemotherapy and a third-line gemcitabine chemotherapy were performed; no objective responses were seen after two cycles. The patient was then treated with eribulin on the basis of an EORTC Phase II trial showing preliminary activity in uterine leiomyosarcoma. After six cycles, CT scan showed partial remission of liver lesion. Disease progression was observed after nine cycles with eribulin, without severe side effects and preserving a good quality of life.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Biopsy ; Bone Marrow/pathology ; Female ; Furans/administration & dosage ; Furans/adverse effects ; Furans/therapeutic use ; Humans ; Ketones/administration & dosage ; Ketones/adverse effects ; Ketones/therapeutic use ; Leiomyosarcoma/diagnosis ; Leiomyosarcoma/drug therapy ; Magnetic Resonance Imaging ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Tomography, X-Ray Computed ; Treatment Outcome
    Chemical Substances Antineoplastic Agents ; Furans ; Ketones ; eribulin (LR24G6354G)
    Language English
    Publishing date 2020-01-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2019-0597
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Enantioseparation of chiral phytocannabinoids in medicinal cannabis.

    Russo, Fabiana / Tolomeo, Francesco / Angela Vandelli, Maria / Biagini, Giuseppe / Laganà, Aldo / Laura Capriotti, Anna / Cerrato, Andrea / Carbone, Luigi / Perrone, Elisabetta / Cavazzini, Alberto / Maiorano, Vincenzo / Gigli, Giuseppe / Cannazza, Giuseppe / Citti, Cinzia

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2023  Volume 1221, Page(s) 123682

    Abstract: The evaluation of the chiral composition of phytocannabinoids in the cannabis plant is particularly important as the pharmacological effects of the (+) and (-) enantiomers of these compounds are completely different. Chromatographic attempts to assess ... ...

    Abstract The evaluation of the chiral composition of phytocannabinoids in the cannabis plant is particularly important as the pharmacological effects of the (+) and (-) enantiomers of these compounds are completely different. Chromatographic attempts to assess the presence of the minor (+) enantiomers of the main phytocannabinoids, cannabidiolic acid (CBDA) and trans-Δ
    MeSH term(s) Medical Marijuana ; Dronabinol/analysis ; Cannabinoids/analysis ; Cannabis/chemistry ; Cannabidiol/analysis
    Chemical Substances Medical Marijuana ; Dronabinol (7J8897W37S) ; cannabidiolic acid (FJX8O3OJCD) ; Cannabinoids ; Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2023-03-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2023.123682
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Origin of Δ

    Citti, Cinzia / Russo, Fabiana / Linciano, Pasquale / Strallhofer, Sarah Sylvana / Tolomeo, Francesco / Forni, Flavio / Vandelli, Maria Angela / Gigli, Giuseppe / Cannazza, Giuseppe

    Cannabis and cannabinoid research

    2021  Volume 6, Issue 1, Page(s) 28–39

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Cannabidiol/chemical synthesis ; Cannabidiol/chemistry ; Cannabidiol/isolation & purification ; Chromatography, High Pressure Liquid ; Dronabinol/analogs & derivatives ; Dronabinol/analysis ; Dronabinol/chemistry ; Drug Contamination ; Mass Spectrometry ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification
    Chemical Substances Plant Extracts ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2021-02-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2867624-5
    ISSN 2378-8763 ; 2578-5125
    ISSN (online) 2378-8763
    ISSN 2578-5125
    DOI 10.1089/can.2020.0021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Overlapping Infection by

    Lupia, Tommaso / Crisà, Elena / Gaviraghi, Alberto / Rizzello, Barbara / Di Vincenzo, Alessia / Carnevale-Schianca, Fabrizio / Caravelli, Daniela / Fizzotti, Marco / Tolomeo, Francesco / Vitolo, Umberto / De Benedetto, Ilaria / Shbaklo, Nour / Cerutti, Alessandro / Fenu, Piero / Gregorc, Vanesa / Corcione, Silvia / Ghisetti, Valeria / De Rosa, Francesco Giuseppe

    Tropical medicine and infectious disease

    2023  Volume 8, Issue 7

    Abstract: ... ...

    Abstract Strongyloides
    Language English
    Publishing date 2023-07-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8070358
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Strongyloides

    Lupia, Tommaso / Crisà, Elena / Gaviraghi, Alberto / Rizzello, Barbara / Di Vincenzo, Alessia / Carnevale-Schianca, Fabrizio / Caravelli, Daniela / Fizzotti, Marco / Tolomeo, Francesco / Vitolo, Umberto / De Benedetto, Ilaria / Shbaklo, Nour / Cerutti, Alessandro / Fenu, Piero / Gregorc, Vanesa / Corcione, Silvia / Ghisetti, Valeria / De Rosa, Francesco Giuseppe

    Tropical medicine and infectious disease

    2023  Volume 8, Issue 6

    Abstract: To our knowledge, we have described the first case ... ...

    Abstract To our knowledge, we have described the first case of
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8060331
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Cis-Δ

    Tolomeo, Francesco / Russo, Fabiana / Kaczorova, Dominika / Vandelli, Maria Angela / Biagini, Giuseppe / Laganà, Aldo / Capriotti, Anna Laura / Paris, Roberta / Fulvio, Flavia / Carbone, Luigi / Perrone, Elisabetta / Gigli, Giuseppe / Cannazza, Giuseppe / Citti, Cinzia

    Journal of pharmaceutical and biomedical analysis

    2022  Volume 219, Page(s) 114958

    Abstract: Cannabidiolic acid (CBDA) and trans- ... ...

    Abstract Cannabidiolic acid (CBDA) and trans-Δ
    MeSH term(s) Cannabidiol/analysis ; Cannabis/chemistry ; Chromatography, High Pressure Liquid/methods ; Dronabinol/analogs & derivatives ; Dronabinol/analysis
    Chemical Substances Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S) ; delta(9)-tetrahydrocannabinolic acid (EJ6CZV0K5Y)
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2022.114958
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1850: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Kynurenine and kynurenic acid: Two human neuromodulators found in Cannabis sativa L.

    Russo, Fabiana / Tolomeo, Francesco / Vandelli, Maria Angela / Biagini, Giuseppe / Paris, Roberta / Fulvio, Flavia / Laganà, Aldo / Capriotti, Anna Laura / Carbone, Luigi / Gigli, Giuseppe / Cannazza, Giuseppe / Citti, Cinzia

    Journal of pharmaceutical and biomedical analysis

    2022  Volume 211, Page(s) 114636

    Abstract: L-Kynurenine (KYN) and kynurenic acid (KYNA) are products of the metabolism of L-tryptophan (TRP) in the central nervous system of animals, but they are not commonly found in plants. In particular, KYNA is known for its interesting pharmacological ... ...

    Abstract L-Kynurenine (KYN) and kynurenic acid (KYNA) are products of the metabolism of L-tryptophan (TRP) in the central nervous system of animals, but they are not commonly found in plants. In particular, KYNA is known for its interesting pharmacological properties (anti-oxidative, anti-inflammatory, hypolipidemic, and neuroprotective), which suggest a potential functional food ingredient role. The three compounds were identified in samples of Cannabis sativa L. by means of high-performance liquid chromatography coupled to high-resolution mass spectrometry using an untargeted metabolomics approach. Their concentrations were evaluated using a targeted metabolomics method in three organs of the plant (roots, stem, and leaves) in soil at two different growth stages and in hydroponics conditions. The distribution of TRP, KYN and KYNA was found tendentially higher in leaves compared to stem and roots and changed over time. Moreover, the levels of KYNA found in this study are unprecedentedly high compared to those found so far in other plant species, suggesting that Cannabis sativa L. could be a promising alternative source of this metabolite.
    MeSH term(s) Animals ; Cannabis ; Humans ; Kynurenic Acid ; Kynurenine/metabolism ; Neurotransmitter Agents ; Tryptophan/metabolism
    Chemical Substances Neurotransmitter Agents ; Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX) ; Kynurenic Acid (H030S2S85J)
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2022.114636
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1850: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: A Prospective Observational Study of Active Surveillance in Primary Desmoid Fibromatosis.

    Colombo, Chiara / Fiore, Marco / Grignani, Giovanni / Tolomeo, Francesco / Merlini, Alessandra / Palassini, Elena / Collini, Paola / Stacchiotti, Silvia / Casali, Paolo Giovanni / Perrone, Federica / Mariani, Luigi / Gronchi, Alessandro

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 18, Page(s) 4027–4032

    MeSH term(s) Adult ; Female ; Fibromatosis, Aggressive/genetics ; Fibromatosis, Aggressive/mortality ; Fibromatosis, Aggressive/therapy ; Humans ; Male ; Prognosis ; Prospective Studies ; Watchful Waiting ; beta Catenin/genetics
    Chemical Substances beta Catenin
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-21-4205
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Towards a sustainable synthesis of amides: chemoselective palladium-catalysed aminocarbonylation of aryl iodides in deep eutectic solvents.

    Messa, Francesco / Perrone, Serena / Capua, Martina / Tolomeo, Francesco / Troisi, Luigino / Capriati, Vito / Salomone, Antonio

    Chemical communications (Cambridge, England)

    2018  Volume 54, Issue 58, Page(s) 8100–8103

    Abstract: A palladium-catalysed aminocarbonylation of (hetero)aryl iodides has, for the first time, been accomplished in deep eutectic solvents as environmentally benign and recyclable media, under mild conditions. The reactions proceeded with a good substrate ... ...

    Abstract A palladium-catalysed aminocarbonylation of (hetero)aryl iodides has, for the first time, been accomplished in deep eutectic solvents as environmentally benign and recyclable media, under mild conditions. The reactions proceeded with a good substrate scope, and a variety of amides have been synthesized in yields up to 98%.
    Language English
    Publishing date 2018-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c8cc03858a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top