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  1. Article ; Online: Future perspectives of radiation therapy for Hodgkin Lymphoma: Risk-adapted, response-adapted, and safer than before.

    Saddi, Jessica / Barcellini, Amelia / Gotti, Manuel / Mazzacane, Alessandro / Tolva, Alessandra / Lazic, Tanja / Arcaini, Luca / Zecca, Marco / Orlandi, Ester / Filippi, Andrea Riccardo

    Hematological oncology

    2024  Volume 42, Issue 3, Page(s) e3269

    Abstract: Classical Hodgkin lymphoma is a lymphoproliferative disease with a good prognosis mainly seen in young people. Nevertheless secondary malignancy, cardiac disease and infertility may affect the long survivors with significant impact on quality of life, ... ...

    Abstract Classical Hodgkin lymphoma is a lymphoproliferative disease with a good prognosis mainly seen in young people. Nevertheless secondary malignancy, cardiac disease and infertility may affect the long survivors with significant impact on quality of life, morbidity and overall survival. In the last decades several treatment strategies were evaluated to reduce the toxicity of first line treatment such as avoiding radiotherapy or its reduction in terms of dosage and extension. Many trials including interim Positron Emission Tomography evaluation fail to compare efficacy between combined modality treatment versus chemotherapy alone in particular in early stage disease. In this review we analyze which subset of patients could take advantage from proton therapy in terms of toxicity and cost effectiveness.
    MeSH term(s) Humans ; Hodgkin Disease/radiotherapy ; Proton Therapy/adverse effects ; Proton Therapy/methods
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1816: Show issues Location:
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  2. Article ; Online: Recommendations for the management of acute immune thrombocytopenia in children. A Consensus Conference from the Italian Association of Pediatric Hematology and Oncology.

    Russo, Giovanna / Parodi, Emilia / Farruggia, Piero / Notarangelo, Lucia D / Perrotta, Silverio / Casale, Maddalena / Cesaro, Simone / Del Borrello, Giovanni / Del Vecchio, Giovanni C / Giona, Fiorina / Gorio, Chiara / Ladogana, Saverio / Lassandro, Giuseppe / Marzollo, Antonio / Maslak, Karolina / Miano, Maurizio / Nardi, Margherita / Palumbo, Giuseppe / Rossi, Francesca /
    Spinelli, Marco / Tolva, Alessandra / Saracco, Paola / Ramenghi, Ugo / Giordano, Paola

    Blood transfusion = Trasfusione del sangue

    2024  Volume 22, Issue 3, Page(s) 253–265

    Abstract: Background: Immune thrombocytopenia (ITP) is an acquired immune-mediated bleeding disorder characterized by isolated thrombocytopenia. Its estimated yearly incidence in the pediatric population is 1.9-6.4/100,000. ITP in children is usually a self- ... ...

    Abstract Background: Immune thrombocytopenia (ITP) is an acquired immune-mediated bleeding disorder characterized by isolated thrombocytopenia. Its estimated yearly incidence in the pediatric population is 1.9-6.4/100,000. ITP in children is usually a self-limiting and benign disorder. The clinical management of children with ITP often remains controversial, as robust randomized trials on the management of this disorder are lacking. Treatments vary widely in clinical practice and existing guidelines from hematology societies on clinical management offer indications based largely on expert opinion rather than strong evidence.
    Materials and methods: The Coagulative Disorder Working Group of the Italian Association of Pediatric Hematology and Oncology (AIEOP) developed this document to collect shared expert opinions on the management of newly diagnosed ITP, updating previous guidelines and providing recommendations to pediatricians. Each statement has been given a score expressing the strength of evidence, appropriateness and agreement among participants.
    Results: Clear-cut definitions of the clinical phases of the disease and clinical response are stated. Recommendations are given regarding the classification of bleeding symptoms, evaluation of bleeding risk, diagnosis, and prognostic factors. Specific recommendations for treatment include indications for first-line (intravenous immunoglobulins, steroids) and second-line (combined therapy, thrombopoietin receptor agonists, immunosuppressive drugs, rituximab) therapeutic agents, as well as hemorrhagic emergency and supportive treatment, including emergency splenectomy. The optimal follow-up schedule, the relation between ITP and vaccines and health-related quality-of-life issues are also discussed.
    Discussion: The panel achieved broad consensus on issues related to how to treat children with newly diagnosed ITP, providing a comprehensive review of all relevant clinical aspects.
    MeSH term(s) Humans ; Child ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/epidemiology ; Italy ; Hemorrhage/therapy ; Hemorrhage/etiology ; Immunoglobulins, Intravenous/therapeutic use ; Child, Preschool ; Female ; Male ; Acute Disease ; Hematology
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2024-01-29
    Publishing country Italy
    Document type Journal Article ; Consensus Development Conference
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/BloodTransfus.501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 798: Show issues Location:
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  3. Article: Long term use of eltrombopag in children with chronic immune thrombocytopenia: extended real life retrospective multicenter experience of the Italian Association of Pediatric Hematology and Oncology.

    Giordano, Paola / Lassandro, Giuseppe / Barone, Angelica / Cesaro, Simone / Fotzi, Ilaria / Giona, Fiorina / Gorio, Chiara / Maggio, Angela / Miano, Maurizio / Marzollo, Antonio / Nardi, Margherita / Pession, Andrea / Ruggiero, Antonio / Russo, Giovanna / Saracco, Paola / Spinelli, Marco / Tolva, Alessandra / Tornesello, Assunta / Palladino, Valentina /
    Del Vecchio, Giovanni Carlo

    Frontiers in medicine

    2023  Volume 10, Page(s) 1214308

    Abstract: Background: The present multicenter retrospective study on eltrombopag administration in Italian children with chronic ITP aims to extend follow-up of our previous study.: Materials and methods: This retrospective multicenter study was conducted in ... ...

    Abstract Background: The present multicenter retrospective study on eltrombopag administration in Italian children with chronic ITP aims to extend follow-up of our previous study.
    Materials and methods: This retrospective multicenter study was conducted in 17 centers affiliated to the Italian Association of Pediatric Hematology and Oncology (AIEOP). Patients were classified into three subgroups: group 1 included patients who discontinued treatment due to a stable platelet count; group 2 included patients who discontinued treatment due to ineffectiveness; group 3 included patients who did not permanently discontinue treatment.
    Results: 56 patients were eligible for analysis. The median duration of eltrombopag treatment was 40 months (7-71 months). Twenty patients (36%) discontinued permanently eltrombopag. The reasons of permanent discontinuation were adverse effects (
    Conclusion: Our study found that the benefits of eltrombopag treatment, in terms of platelet count improvement and use of additional therapies, are identifiable from the first 6 months of treatment.
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1214308
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  4. Article ; Online: Brain Imaging Findings and Neurologic Complications after Allogenic Hematopoietic Stem Cell Transplantation in Children.

    Bonardi, Mara / Turpini, Elena / Sanfilippo, Giuseppina / Mina, Tommaso / Tolva, Alessandra / Zappoli Thyrion, Federico

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2018  Volume 38, Issue 4, Page(s) 1223–1238

    Abstract: Hematopoietic stem cell transplantation (HSCT) is the only therapy for a subset of patients with malignant and nonmalignant diseases. Central nervous system (CNS) complications continue to be an important cause of morbidity and significantly contribute ... ...

    Abstract Hematopoietic stem cell transplantation (HSCT) is the only therapy for a subset of patients with malignant and nonmalignant diseases. Central nervous system (CNS) complications continue to be an important cause of morbidity and significantly contribute to mortality after HSCT. These complications include infections, cerebrovascular lesions, therapy-induced diseases, metabolic disturbances, and post-HSCT carcinogenesis. Following HSCT, three phases can be identified on the basis of the patient's immune status: the pre-engraftment period (<30 days after HSCT), the early postengraftment period (30-100 days after HSCT), and the late postengraftment period (>100 days after HSCT). There is a distinct relationship between the patient's degree of immunodeficiency after HSCT and the incidence of various complications that may occur. Early diagnosis of CNS complications is crucial for successful management and a good prognosis, and computed tomography and magnetic resonance imaging play an important role in achieving these goals. The global increase in the use of HSCT requires radiologists to be familiar with CNS complications, their relationship to the patient's immune status, and their imaging appearances. This article describes the clinical background of HSCT; reviews the incidence, causes, and timeline of brain complications in children who underwent allogenic HSCT; and identifies the characteristic imaging findings of these disorders.
    MeSH term(s) Central Nervous System Diseases/diagnostic imaging ; Central Nervous System Diseases/etiology ; Child ; Early Diagnosis ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Neuroimaging/methods
    Language English
    Publishing date 2018-08-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.2018170139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1751: Show issues Location:
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  5. Article ; Online: Fatigue perception in a cohort of children with chronic immune thrombocytopenia and their caregivers using the PedsQL MFS: Real-life multicenter experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP).

    Lassandro, Giuseppe / Palmieri, Viviana Valeria / Barone, Angelica / Farruggia, Piero / Giona, Fiorina / Licciardello, Maria / Marinoni, Maddalena / Marzollo, Antonio / Notarangelo, Lucia Dora / Palumbo, Giuseppe / Ramenghi, Ugo / Russo, Giovanna / Saracco, Paola / Spinelli, Marco / Tolva, Alessandra / Tornesello, Assunta / Palladino, Valentina / Noviello, Domenico / Giordano, Paola

    Pediatric blood & cancer

    2020  Volume 68, Issue 3, Page(s) e28840

    Abstract: Background: Fatigue is an important clinical and psychological aspect for a significant number of children affected by immune thrombocytopenia (ITP). To date, few studies have explored fatigue and its relationship with chronic ITP in pediatric age. The ... ...

    Abstract Background: Fatigue is an important clinical and psychological aspect for a significant number of children affected by immune thrombocytopenia (ITP). To date, few studies have explored fatigue and its relationship with chronic ITP in pediatric age. The aim of the present multicentric pilot study is to determine fatigue perception in a large group of children with chronic ITP and their caregivers using the PedsQL Multidimensional Fatigue Scale (PedsQL MFS), and to compare the results with those of healthy control subjects.
    Procedure: Children with chronic ITP aged 5-18 years and/or caregivers of children aged 2-18 years were enrolled. Child/adolescent self-report was used for patients aged 5-18 years, and parent proxy-report for patients aged 2-18 years. The questionnaire was offered as online survey. PedsQL MFS is composed of 18 items covering three dimensions: General Fatigue Scale, Sleep/Rest Fatigue Scale, and Cognitive Fatigue Scale.
    Results: One hundred ninety-one patients affected by chronic ITP and 248 caregivers answered the PedsQL MFS. We have highlighted that lower values of PedsQL MFS scores are obtained in the 13-18 age group. Moreover, sleep/rest fatigue domain appears to be more compromised in all age groups. For all PedsQL MFS scores, pediatric patients with chronic ITP and their caregivers reported statistically significant worse fatigue than healthy children.
    Conclusions: This study suggests that fatigue is relevant among children and adolescents affected by chronic ITP. The PedsQL MFS represents an adequate instrument for measuring fatigue in patients with chronic ITP. Therefore, symptoms of fatigue should be routinely assessed in clinical practice.
    MeSH term(s) Adolescent ; Adult ; Caregivers/psychology ; Child ; Child, Preschool ; Fatigue/diagnosis ; Fatigue/etiology ; Fatigue/psychology ; Female ; Follow-Up Studies ; Humans ; Male ; Perception ; Pilot Projects ; Prognosis ; Purpura, Thrombocytopenic, Idiopathic/complications ; Quality of Life ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2020-12-04
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28840
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1131: Show issues Location:
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  6. Article ; Online: Role of antithyroid autoimmunity as a predictive biomarker of chronic immune thrombocytopenia.

    Giordano, Paola / Urbano, Flavia / Lassandro, Giuseppe / Bianchi, Francesco Paolo / Tolva, Alessandra / Saracco, Paola / Russo, Giovanna / Notarangelo, Lucia Dora / Gabelli, Maria / Cesaro, Simone / Wasniewska, Malgorzata / Faienza, Maria Felicia

    Pediatric blood & cancer

    2018  Volume 66, Issue 1, Page(s) e27452

    Abstract: Background: Immune thrombocytopenia (ITP) is an acquired immune-mediated disorder characterized by isolated thrombocytopenia. Pediatric ITP patients are prone to develop autoantibodies such as antithyroglobulin (TG) and antithyroperoxidase (TPO), even ... ...

    Abstract Background: Immune thrombocytopenia (ITP) is an acquired immune-mediated disorder characterized by isolated thrombocytopenia. Pediatric ITP patients are prone to develop autoantibodies such as antithyroglobulin (TG) and antithyroperoxidase (TPO), even in the absence of clinical signs of autoimmune disease. The aim of this multicenter retrospective study was to evaluate (1) the prevalence of positivity of antithyroid antibodies (TPO and TG) in a large cohort of pediatric patients with chronic ITP; (2) the role of autoimmune thyroiditis as a prognostic factor for chronicity of ITP.
    Procedure: For this retrospective study, we collected data from patients diagnosed as affected by chronic ITP between 2011 and 2014 in six centers belonging to the Italian Association of Pediatric Haematology and Oncology (AIEOP).
    Results: From the analysis of data, we found a significantly higher prevalence of antithyroid antibodies in children with chronic ITP (11.6%) than in the pediatric population (1.2%-1.3%). No correlation has been found between the platelet count and the prevalence of positive antithyroid antibodies at any detection time of the study.
    Conclusions: The results of our study demonstrated that (1) the prevalence of positivity for antithyroid antibodies (anti-TPO and anti-TG) in pediatric patients with chronic ITP results is significantly higher than in the pediatric population; (2) autoimmune thyroiditis does not seem to play a role as a prognostic factor for chronicity of ITP in pediatric patients.
    MeSH term(s) Adolescent ; Autoantibodies/blood ; Autoantibodies/immunology ; Biomarkers/blood ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Infant ; Iodide Peroxidase/immunology ; Italy/epidemiology ; Male ; Prevalence ; Prognosis ; Purpura, Thrombocytopenic, Idiopathic/blood ; Purpura, Thrombocytopenic, Idiopathic/epidemiology ; Purpura, Thrombocytopenic, Idiopathic/immunology ; Retrospective Studies ; Thyroiditis, Autoimmune/immunology ; Thyroiditis, Autoimmune/physiopathology
    Chemical Substances Autoantibodies ; Biomarkers ; anti-thyroglobulin ; Iodide Peroxidase (EC 1.11.1.8)
    Language English
    Publishing date 2018-09-30
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.27452
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  7. Article: Use of Eltrombopag in Children With Chronic Immune Thrombocytopenia (ITP): A Real Life Retrospective Multicenter Experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP).

    Giordano, Paola / Lassandro, Giuseppe / Barone, Angelica / Cesaro, Simone / Fotzi, Ilaria / Giona, Fiorina / Ladogana, Saverio / Miano, Maurizio / Marzollo, Antonio / Nardi, Margherita / Notarangelo, Lucia Dora / Pession, Andrea / Ruggiero, Antonio / Russo, Giovanna / Saracco, Paola / Spinelli, Marco / Tolva, Alessandra / Tornesello, Assunta / Palladino, Valentina /
    Del Vecchio, Giovanni Carlo

    Frontiers in medicine

    2020  Volume 7, Page(s) 66

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00066
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