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Article: Access to new direct-acting antiviral agents against HCV infection: A view from Spain.

Tomé, Santiago / Otero, Esteban

2015 Volume 5, Issue 1, Page(s) 22–23

Language	English
Publishing date	2015-03-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2657644-2
ISSN	2046-2484
ISSN	2046-2484
DOI	10.1002/cld.444
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Article: [No title information]

Tome, Santiago / Otero, Esteban

Clinical liver disease

2015 Volume 5, Issue 1, Page(s) 24–25

Title translation	Accesibilidad a los nuevos agentes antivirales directos contra la infeccion por VHC. Un punto de vista desde España.
Language	Spanish
Publishing date	2015-03-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2657644-2
ISSN	2046-2484
ISSN	2046-2484
DOI	10.1002/cld.467
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Article ; Online: Clinical and capillaroscopic findings in patients with liver disease and proximal apparent leukonychia (Terry nails and its variants).

Fernandez-Somoza, Juan-Manuel / Ginarte, Manuel / Otero, Esteban / Tomé, Santiago / Soutullo, Carlos / Martínez-Ulloa, Aarón / Gonzalez-Quintela, Arturo

Medicine

2021 Volume 100, Issue 22, Page(s) e26207

Abstract: Abstract: Terry nails and Lindsay nails are similar forms of proximal apparent leukonychia (PAL). A change in nail bed vascularity is thought to be responsible for PAL. The study was aimed at investigating the frequency of PAL in patients attending a ... ...

Abstract	Abstract: Terry nails and Lindsay nails are similar forms of proximal apparent leukonychia (PAL). A change in nail bed vascularity is thought to be responsible for PAL. The study was aimed at investigating the frequency of PAL in patients attending a liver disease clinic, the factors associated with its presence, its value for detecting cirrhosis, its prognostic value for mortality, and associated capillaroscopic findings.A total of 521 patients were included (age range, 18-94 years; 69% men). Systematic nail photographs were evaluated by 2 independent investigators. Disease-related data were obtained from the medical records. Mortality was evaluated after 7 years of follow-up. Nailfold capillaroscopy was performed on a subset of 80 patients.PAL was present in 228 patients (43.8%; Terry nails in 205, Lindsay nails in 20, and both in 3). The kappa-coefficient of interobserver agreement was 0.82. The presence of PAL was associated with cirrhosis and, accordingly, with portal hypertension and hepatocellular dysfunction. The positive likelihood ratio of PAL for the diagnosis of cirrhosis was 1.6 (95% CI 1.3-1.92). PAL was independently associated with chronic alcohol abuse and was not a significant predictor of mortality. Venous loop dilatation and prominence of the venous plexus were observed on capillaroscopy in patients with cirrhosis but were not significantly associated with PAL.In summary, PAL is a common finding in patients from a liver clinic; it is associated with liver cirrhosis and with alcohol abuse. PAL is not associated with specific capillaroscopic findings. We propose the generic term proximal apparent leukonychia instead of classic eponymous titles to avoid confusion in the literature.
MeSH term(s)	Adult ; Aged ; Alcoholism/complications ; Capillaries/pathology ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Hypopigmentation/diagnosis ; Hypopigmentation/etiology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/mortality ; Liver Diseases/complications ; Liver Diseases/pathology ; Male ; Microscopic Angioscopy/methods ; Microscopic Angioscopy/statistics & numerical data ; Middle Aged ; Nail Diseases/congenital ; Nail Diseases/diagnosis ; Nail Diseases/etiology ; Nails/blood supply ; Nails, Malformed/diagnosis ; Nails, Malformed/pathology ; Photography/methods ; Prognosis
Language	English
Publishing date	2021-06-04
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026207
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Article: Time-Course Changes of Serum Keratin Concentrations after Liver Transplantation: Contrasting Results of Keratin-18 and Keratin-19 Fragments.

Macía, Cristina / Loureiro, Jose / Campos-Varela, Isabel / Abdulkader, Ihab / Otero, Esteban / Varo, Evaristo / Tomé, Santiago / Gonzalez-Quintela, Arturo

Case reports in hepatology

2020 Volume 2020, Page(s) 8895435

Abstract: Objective: Under normal conditions, adult hepatocytes express only keratin-8 (K8) and keratin-18 (K18), whereas cholangiocytes also express K19. In this study, we delineate the pattern of normal time-course changes in serum K19 and K18 levels after ... ...

Abstract	Objective: Under normal conditions, adult hepatocytes express only keratin-8 (K8) and keratin-18 (K18), whereas cholangiocytes also express K19. In this study, we delineate the pattern of normal time-course changes in serum K19 and K18 levels after liver transplantation. Results: There was a gradual decrease in serum K19 concentrations from baseline values after transplantation, following a time-course pattern similar to that of serum bilirubin. In contrast, serum concentrations of K18 fragments increased markedly shortly after transplantation and gradually decreased thereafter, following a time-course pattern similar to that of serum transaminases. The increase in TPS tended to occur earlier than that in M30, suggesting an initial predominance of hepatocyte necrosis followed by a predominance of apoptosis in the first days after transplantation. Five patients presented posttransplant complications (acute rejection in three cases and HCV recurrence in two cases). An early increase in serum K19 concentrations was observed in all cases. An increase in serum concentrations of K18 fragments (M30 and TPS) was observed in the two cases with HCV recurrence and was more variable in the three cases with acute rejection. Conclusions: Serum concentrations of K19 and K18 fragments follow a dissimilar pattern of time-course changes after liver transplantation. The diagnostic value of variations in these normal patterns should be addressed in future studies.
Language	English
Publishing date	2020-11-30
Publishing country	United States
Document type	Case Reports
ISSN	2090-6587
ISSN	2090-6587
DOI	10.1155/2020/8895435
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Article: Trasplante hepático en hepatitis alcohólica.

Herrero, José Ignacio / Tomé, Santiago / González-Pinto, Ignacio

Gastroenterologia y hepatologia

2013 Volume 36, Issue 4, Page(s) 297–298

Title translation	Liver transplantation in alcoholic hepatitis.
MeSH term(s)	Female ; Hepatitis, Alcoholic/surgery ; Humans ; Liver Transplantation ; Male
Language	Spanish
Publishing date	2013-04
Publishing country	Spain
Document type	Comment ; Letter
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2012.11.007
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Article: Post-operative stress hyperglycemia is a predictor of mortality in liver transplantation.

Giráldez, Elena / Varo, Evaristo / Guler, Ipek / Cadarso-Suarez, Carmen / Tomé, Santiago / Barral, Patricia / Garrote, Antonio / Gude, Francisco

Diabetology & metabolic syndrome

2018 Volume 10, Page(s) 35

Abstract: Background: A significant association is known between increased glycaemic variability and mortality in critical patients. To ascertain whether glycaemic profiles during the first week after liver transplantation might be associated with long-term ... ...

Abstract	Background: A significant association is known between increased glycaemic variability and mortality in critical patients. To ascertain whether glycaemic profiles during the first week after liver transplantation might be associated with long-term mortality in these patients, by analysing whether diabetic status modified this relationship. Method: Observational long-term survival study includes 642 subjects undergoing liver transplantation from July 1994 to July 2011. Glucose profiles, units of insulin and all variables with influence on mortality are analysed using joint modelling techniques. Results: Patients registered a survival rate of 85% at 1 year and 65% at 10 years, without differences in mortality between patients with and without diabetes. In glucose profiles, however, differences were observed between patients with and without diabetes: patients with diabetes registered lower baseline glucose values, which gradually rose until reaching a peak on days 2-3 and then subsequently declined, diabetic subjects started from higher values which gradually decreased across the first week. Patients with diabetes showed an association between mortality and age, Model for End-Stage Liver Disease score (MELD) score and hepatitis C virus; among non-diabetic patients, mortality was associated with age, body mass index, malignant aetiology, red blood cell requirements and parenteral nutrition. Glucose profiles were observed to be statistically associated with mortality among patients without diabetes ( Conclusions: Glucose profiles during the first week after liver transplantation are different in patients with and without diabetes. While glucose profiles are associated with long-term mortality in patients without diabetes, after adjusting for potential confounding variables such as age, cause of transplantation, MELD, nutrition, immunosuppressive drugs, and units of insulin administered, this does not occur among patients with diabetes.
Language	English
Publishing date	2018-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-018-0334-5
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Article ; Online: Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach.

Diaz-Louzao, Carla / Barrera-Lopez, Lucia / Lopez-Rodriguez, Maria / Casar, Clara / Vazquez-Agra, Nestor / Pernas-Pardavila, Hadrian / Marques-Afonso, Ana / Vidal-Vazquez, Martin / Montoya, Jonathan G / Andrade, Ariadna H / Fernandez-Castro, Ivan / Varela, Pablo / Gonzalez-Quintela, Arturo / Otero, Esteban / Gude, Francisco / Cadarso-Suarez, Carmen / Tome, Santiago

Scientific reports

2022 Volume 12, Issue 1, Page(s) 5547

Abstract: The mechanisms underlying liver disease in patients with COVID-19 are not entirely known. The aim is to investigate, by means of novel statistical techniques, the changes over time in the relationship between inflammation markers and liver damage markers ...

Abstract	The mechanisms underlying liver disease in patients with COVID-19 are not entirely known. The aim is to investigate, by means of novel statistical techniques, the changes over time in the relationship between inflammation markers and liver damage markers in relation to survival in COVID-19. The study included 221 consecutive patients admitted to the hospital during the first COVID-19 wave in Spain. Generalized additive mixed models were used to investigate the influence of time and inflammation markers on liver damage markers in relation to survival. Joint modeling regression was used to evaluate the temporal correlations between inflammation markers (serum C-reactive protein [CRP], interleukin-6, plasma D-dimer, and blood lymphocyte count) and liver damage markers, after adjusting for age, sex, and therapy. The patients who died showed a significant elevation in serum aspartate transaminase (AST) and alkaline phosphatase levels over time. Conversely, a decrease in serum AST levels was observed in the survivors, who showed a negative correlation between inflammation markers and liver damage markers (CRP with serum AST, alanine transaminase [ALT], and gamma-glutamyl transferase [GGT]; and D-dimer with AST and ALT) after a week of hospitalization. Conversely, most correlations were positive in the patients who died, except lymphocyte count, which was negatively correlated with AST, GGT, and alkaline phosphatase. These correlations were attenuated with age. The patients who died during COVID-19 infection displayed a significant elevation of liver damage markers, which is correlated with inflammation markers over time. These results are consistent with the role of systemic inflammation in liver damage during COVID-19.
MeSH term(s)	Aspartate Aminotransferases ; Biomarkers ; COVID-19/complications ; Humans ; Inflammation/metabolism ; Liver/metabolism ; Liver Diseases/etiology
Chemical Substances	Biomarkers ; Aspartate Aminotransferases (EC 2.6.1.1)
Language	English
Publishing date	2022-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-09290-x
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Article ; Online: Recurrent alcohol-associated hepatitis is common and is associated with increased mortality.

Gratacós-Ginès, Jordi / Ruz-Zafra, Pilar / Celada-Sendino, Miriam / Martí-Carretero, Aina / Pujol, Clàudia / Martín-Mateos, Rosa / Echavarría, Víctor / Frisancho, Luis E / García, Sonia / Barreales, Mónica / Tejedor-Tejada, Javier / Vázquez-Rodríguez, Sergio / Cañete, Nuria / Fernández-Carrillo, Carlos / Valenzuela, María / Martí-Aguado, David / Horta, Diana / Quiñones, Marta / Bernal-Monterde, Vanesa /

Acosta, Silvia / Artaza, Tomás / Pinazo, José / Villar-Lucas, Carmen / Clemente-Sánchez, Ana / Badia-Aranda, Ester / Giráldez-Gallego, Álvaro / Rodríguez, Manuel / Sancho-Bru, Pau / Cabezas, Joaquín / Ventura-Cots, Meritxell / Fernández-Rodríguez, Conrado / Aguilera, Victoria / Tomé, Santiago / Bataller, Ramon / Caballería, Juan / Pose, Elisa

Hepatology (Baltimore, Md.)

2024

Abstract: Background and aims: Alcohol relapse after surviving an episode of alcohol-associated hepatitis (AH) is common. However, the clinical features, risk factors, and prognostic implications of recurrent alcohol-associated hepatitis (RAH) are not well ... ...

Abstract	Background and aims: Alcohol relapse after surviving an episode of alcohol-associated hepatitis (AH) is common. However, the clinical features, risk factors, and prognostic implications of recurrent alcohol-associated hepatitis (RAH) are not well described. Approach and results: A registry-based study was done of patients admitted to 28 Spanish hospitals for an episode of AH between 2014 and 2021. Baseline demographics and laboratory variables were collected. Risk factors for RAH were investigated using Cox regression analysis. We analyzed the severity of the index episodes of AH and compared it to that of RAH. Long-term survival was assessed by Kaplan-Meier curves and log-rank tests. A total of 1118 patients were included in the analysis, 125 (11%) of whom developed RAH during follow-up (median: 17 [7-36] months). The incidence of RAH in patients resuming alcohol use was 22%. The median time to recurrence was 14 (8-29) months. Patients with RAH had more psychiatric comorbidities. Risk factors for developing RAH included age <50 years, alcohol use >10 U/d, and history of liver decompensation. RAH was clinically more severe compared to the first AH (higher MELD, more frequent ACLF, and HE). Moreover, alcohol abstinence during follow-up was less common after RAH (18% vs. 45%, p <0.001). Most importantly, long-term mortality was higher in patients who developed RAH (39% vs. 21%, p = 0.026), and presenting with RAH independently predicted high mortality (HR: 1.55 [1.11-2.18]). Conclusions: RAH is common and has a more aggressive clinical course, including increased mortality. Patients surviving an episode of AH should undergo intense alcohol use disorder therapy to prevent RAH.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1097/HEP.0000000000000825
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Article: Timing of liver transplantation in alcoholic cirrhosis.

Tome, Santiago / Lucey, Michael R

Journal of hepatology

2003 Volume 39, Issue 3, Page(s) 302–307

MeSH term(s)	Alcoholism ; Hepatitis, Alcoholic/surgery ; Humans ; Liver Cirrhosis, Alcoholic/surgery ; Liver Transplantation ; Recurrence ; Time Factors
Language	English
Publishing date	2003-06-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/s0168-8278(03)00290-3
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Article: Addictive behavior after solid organ transplantation: what do we know already and what do we need to know?

Tome, Santiago / Said, Adnan / Lucey, Michael R

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2008 Volume 14, Issue 2, Page(s) 127–129

MeSH term(s)	Alcohol-Related Disorders/epidemiology ; Alcohol-Related Disorders/psychology ; Behavior, Addictive/epidemiology ; Heart Transplantation/statistics & numerical data ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/statistics & numerical data ; Liver Transplantation/statistics & numerical data ; Organ Transplantation/statistics & numerical data ; Patient Compliance ; Patient Selection ; Recurrence ; Risk Assessment ; Risk Factors ; Smoking/epidemiology ; Social Support ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/psychology ; Temperance ; Time Factors
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2008-02
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1002/lt.21311
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