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  1. Article: Radio-Guided Lung Surgery: A Feasible Approach for a Cancer Precision Medicine.

    Conte, Miriam / De Feo, Maria Silvia / Frantellizzi, Viviana / Tomaciello, Miriam / Marampon, Francesco / Evangelista, Laura / Filippi, Luca / De Vincentis, Giuseppe

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 16

    Abstract: Background: Radio-guided surgery is a reliable approach used for localizing ground-glass opacities, lung nodules, and metastatic lymph nodes. Lung nodules, lymph node metastatic involvement, and ground-glass opacities often represent a challenge for ... ...

    Abstract Background: Radio-guided surgery is a reliable approach used for localizing ground-glass opacities, lung nodules, and metastatic lymph nodes. Lung nodules, lymph node metastatic involvement, and ground-glass opacities often represent a challenge for surgical management and clinical work-up.
    Methods: PubMed research was conducted from January 1997 to June 2023 using the keywords "radioguided surgery and lung cancer".
    Results: Different studies were conducted with different tracers: technetium-99m-albumin macroaggregates, cyanoacrylate combined to technetium-99m-sulfur colloid, indium-111-pentetreotide, and fluorine-18-deoxyglucose. A study proposed naphthalocyanine radio-labeled with copper-64. Radio-guided surgery has been demonstrated to be a reliable approach in localizing a lesion, and has a low radiological burden for personnel exposure and low morbidity. The lack of necessity to conduct radio-guided surgery under fluoroscopy or echography makes this radio-guided surgery an easy way of performing precise surgical procedures.
    Conclusions: Radio-guided surgery is a feasible approach useful for the intraoperative localization of ground-glass opacities, lung nodules, and metastatic lymph nodes. It is a valid alternative to the existing approaches due to its low cost, associated low morbidity, the possibility to perform the procedure after several hours, the low radiation dose applied, and the small amount of time that is required to perform it.
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13162628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Skin metastases from prostate cancer successfully treated with radiation therapy.

    Marampon, Francesco / Parisi, Martina / Cicco, Piero Rodolfo / Serpone, Maria / Tomaciello, Miriam / Musio, Daniela / De Felice, Francesca / Tombolini, Vincenzo

    BJR case reports

    2023  Volume 9, Issue 4, Page(s) 20200142

    Abstract: Skin metastases from prostate cancer (PCa) are rare, cause considerable discomfort, and usually indicate advanced disease and a poor prognosis. To date, literature accounts for no more than 88 cases of skin metastasis from PCa, and radiation therapy (RT) ...

    Abstract Skin metastases from prostate cancer (PCa) are rare, cause considerable discomfort, and usually indicate advanced disease and a poor prognosis. To date, literature accounts for no more than 88 cases of skin metastasis from PCa, and radiation therapy (RT) is not considered a standard treatment option. Here, we have described a rare case of skin localization of castration-resistant metastatic PCa, which occurred in a 75-year-old male previously treated with RT for PCa, 11 years earlier. The skin lesions, which progressively appeared in different areas of the chest wall, were successfully treated with electron beam RT (900 cGy, for 3 consecutive days). Five months after irradiating skin metastases, the patient showed general fair conditions and no longer developed other skin lesions in the areas already treated or elsewhere. This report describes a scarce case of cutaneous metastases from PCa, underlying the crucial role of RT as a definitive palliative treatment that should be used to limit systemic chemotherapy-related toxicity.
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Case Reports
    ISSN 2055-7159
    ISSN (online) 2055-7159
    DOI 10.1259/bjrcr.20200142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Low expression of Ki-67/MIB-1 labeling index in IDH wild type glioblastoma predicts prolonged survival independently by MGMT methylation status.

    Tini, Paolo / Yavoroska, Mariya / Mazzei, Maria Antonietta / Miracco, Clelia / Pirtoli, Luigi / Tomaciello, Miriam / Marampon, Francesco / Minniti, Giuseppe

    Journal of neuro-oncology

    2023  Volume 163, Issue 2, Page(s) 339–344

    Abstract: Purpose: The Ki-67/MIB-1 labeling index (LI) is clinically used to differentiate between high and low-grade gliomas, while its prognostic value remains questionable. Glioblastoma (GBM) expressing wild-type isocitrate dehydrogenase IDH: Methods: One ... ...

    Abstract Purpose: The Ki-67/MIB-1 labeling index (LI) is clinically used to differentiate between high and low-grade gliomas, while its prognostic value remains questionable. Glioblastoma (GBM) expressing wild-type isocitrate dehydrogenase IDH
    Methods: One hundred nineteen IDH
    Results: A multivariate analysis showed that Ki-67/MIB-1-LI expression < 15% significantly correlated with a longer overall survival (OS), independently from the age of the patients, Karnofsky performance status scale, extent of surgery and O
    Conclusions: Among other studies focused on Ki-67/MIB-1-LI, this is the first observational study showing a positive correlation between OS of IDH
    MeSH term(s) Adult ; Humans ; Glioblastoma ; Ki-67 Antigen/metabolism ; Retrospective Studies ; Methylation ; Glioma/pathology ; Prognosis ; Brain Neoplasms/pathology ; O(6)-Methylguanine-DNA Methyltransferase/genetics ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; DNA Methylation ; DNA Modification Methylases/genetics ; DNA Modification Methylases/metabolism ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
    Chemical Substances Ki-67 Antigen ; O(6)-Methylguanine-DNA Methyltransferase (EC 2.1.1.63) ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; DNA Modification Methylases (EC 2.1.1.-) ; DNA Repair Enzymes (EC 6.5.1.-) ; MGMT protein, human (EC 2.1.1.63) ; Tumor Suppressor Proteins
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-023-04342-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1825: Show issues Location:
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  4. Article: Abscopal Effect on Bone Metastases from Solid Tumors: A Systematic Review and Retrospective Analysis of Challenge within a Challenge.

    Tomaciello, Miriam / Conte, Miriam / Montinaro, Francesca Romana / Sabatini, Arianna / Cunicella, Giorgia / Di Giammarco, Federico / Tini, Paolo / Gravina, Giovanni Luca / Cortesi, Enrico / Minniti, Giuseppe / De Vincentis, Giuseppe / Frantellizzi, Viviana / Marampon, Francesco

    Biomedicines

    2023  Volume 11, Issue 4

    Abstract: Background: Abscopal effect (AE) describes the ability of radiotherapy (RT) to induce immune-mediated responses in nonirradiated distant metastasis. Bone represents the third most frequent site of metastasis and an immunologically favorable environment ... ...

    Abstract Background: Abscopal effect (AE) describes the ability of radiotherapy (RT) to induce immune-mediated responses in nonirradiated distant metastasis. Bone represents the third most frequent site of metastasis and an immunologically favorable environment for the proliferation of cancer cells. We revised the literature, searching documented cases of AE involving bone metastases (BMs) and evaluated the incidence of AE involving BMs in patients requiring palliative RT on BMs or non-BMs treated at our department.
    Methods: Articles published in the PubMed/MEDLINE database were selected using the following search criteria: ((abscopal effect)) AND ((metastases)). Patients with BMs, who underwent performed bone scintigraphy before and at least 2-3 months after RT, were selected and screened between January 2015 and July 2022. AE was defined as an objective response according to the scan bone index for at least one nonirradiated metastasis at a distance > 10 cm from the irradiated lesion. The primary endpoint was the rate of AE on BMs.
    Results: Ten cases experiencing AE of BMs were identified from the literature and eight among our patients.
    Conclusions: The analysis performed here suggests the use of hypofractionated radiotherapy as the only triggering factor for AE of BMs through the activation of the immune response.
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11041157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Radioresistance in rhabdomyosarcomas: Much more than a question of dose.

    Camero, Simona / Cassandri, Matteo / Pomella, Silvia / Milazzo, Luisa / Vulcano, Francesca / Porrazzo, Antonella / Barillari, Giovanni / Marchese, Cinzia / Codenotti, Silvia / Tomaciello, Miriam / Rota, Rossella / Fanzani, Alessandro / Megiorni, Francesca / Marampon, Francesco

    Frontiers in oncology

    2022  Volume 12, Page(s) 1016894

    Abstract: Management of rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, frequently accounting the genitourinary tract is complex and requires a multimodal therapy. In particular, as a consequence of the advancement in dose conformity ... ...

    Abstract Management of rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, frequently accounting the genitourinary tract is complex and requires a multimodal therapy. In particular, as a consequence of the advancement in dose conformity technology, radiation therapy (RT) has now become the standard therapeutic option for patients with RMS. In the clinical practice, dose and timing of RT are adjusted on the basis of patients' risk stratification to reduce late toxicity and side effects on normal tissues. However, despite the substantial improvement in cure rates, local failure and recurrence frequently occur. In this review, we summarize the general principles of the treatment of RMS, focusing on RT, and the main molecular pathways and specific proteins involved into radioresistance in RMS tumors. Specifically, we focused on DNA damage/repair, reactive oxygen species, cancer stem cells, and epigenetic modifications that have been reported in the context of RMS neoplasia in both
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1016894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Relationship between Salivary Amylase and Xerostomia in Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Pilot Study.

    De Felice, Francesca / Scarabelli, Maria Giulia / De Pietro, Raffaella / Chiarello, Giuseppina / Di Giammarco, Federico / Cattaneo, Carlo Guglielmo / Lombardo, Giuliana / Montinaro, Francesca Romana / Tomaciello, Miriam / Tombolini, Mario / Messineo, Daniela / Di Paolo, Pier Luigi / Marchetti, Claudia / Musio, Daniela / Tombolini, Vincenzo

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 9, Page(s) 6564–6572

    Abstract: Purpose: A single-institution prospective pilot study was conducted to the assess correlation between salivary amylase and xerostomia in patients with head and neck squamous cell carcinoma (HNSCC) treated with intensity-modulated radiotherapy (IMRT).: ...

    Abstract Purpose: A single-institution prospective pilot study was conducted to the assess correlation between salivary amylase and xerostomia in patients with head and neck squamous cell carcinoma (HNSCC) treated with intensity-modulated radiotherapy (IMRT).
    Methods and materials: Serum saliva amylase, clinician-reported xerostomia (using Common Terminology Criteria for Adverse Events), and patient-reported xerostomia (using 8-item self-reported xerostomia-specific questionnaire) were prospectively collected at baseline, during treatment and thereafter. Correlations between variables were assessed by correlation matrices.
    Results: Twelve patients with locally advanced HNSCC formed the cohort. Eighty-three percent were male, 75% were smokers, 100% had clinical positive lymph nodes at diagnosis, and 42% received induction chemotherapy. All patients received IMRT with concurrent cisplatin-based chemotherapy. No grade ≥4 xerostomia was observed. Severe (G3) acute and late xerostomia occurred in five cases (41.7%) and two cases (16.7%), respectively. Patient-reported xerostomia scores were highly correlated with the clinician-reported scores (ρ = 0.73). A significant correlation was recorded between the concentration of amylase and the acute (ρ = -0.70) and late (ρ = -0.80) xerostomia.
    Conclusion: Preliminary results are encouraging. Prospective clinical trials are needed to define the value of salivary amylase in the management of HNSCC tumors.
    MeSH term(s) Amylases/analysis ; Cisplatin/therapeutic use ; Female ; Head and Neck Neoplasms/radiotherapy ; Humans ; Male ; Parotid Gland ; Pilot Projects ; Prospective Studies ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods ; Saliva/enzymology ; Squamous Cell Carcinoma of Head and Neck/radiotherapy ; Xerostomia/etiology
    Chemical Substances Amylases (EC 3.2.1.-) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29090516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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