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  1. Article ; Online: Software that combines deep learning, 3D reconstruction and CFD to analyze the state of carotid arteries from ultrasound imaging.

    Tomasevic, Smiljana / Anic, Milos / Arsic, Branko / Gakovic, Branko / Filipovic, Nenad / Djukic, Tijana

    Technology and health care : official journal of the European Society for Engineering and Medicine

    2024  

    Abstract: Background: Ultrasound is one of the non-invasive techniques that are used in clinical diagnostics of carotid artery disease.: Objective: This paper presents software methodology that can be used in combination with this imaging technique to provide ... ...

    Abstract Background: Ultrasound is one of the non-invasive techniques that are used in clinical diagnostics of carotid artery disease.
    Objective: This paper presents software methodology that can be used in combination with this imaging technique to provide additional information about the state of patient-specific artery.
    Methods: Overall three modules are combined within the proposed methodology. A clinical dataset is used within the deep learning module to extract the contours of the carotid artery. This data is then used within the second module to perform the three-dimensional reconstruction of the geometry of the carotid bifurcation and ultimately this geometry is used within the third module, where the hemodynamic analysis is performed. The obtained distributions of hemodynamic quantities enable a more detailed analysis of the blood flow and state of the arterial wall and could be useful to predict further progress of present abnormalities in the carotid bifurcation.
    Results: The performance of the deep learning module was demonstrated through the high values of relevant common classification metric parameters. Also, the accuracy of the proposed methodology was shown through the validation of results for the reconstructed parameters against the clinically measured values.
    Conclusion: The presented methodology could be used in combination with standard clinical ultrasound examination to quickly provide additional quantitative and qualitative information about the state of the patient's carotid bifurcation and thus ensure a treatment that is more adapted to the specific patient.
    Language English
    Publishing date 2024-02-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1159961-3
    ISSN 1878-7401 ; 0928-7329
    ISSN (online) 1878-7401
    ISSN 0928-7329
    DOI 10.3233/THC-231306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Computational Modeling on Drugs Effects for Left Ventricle in Cardiomyopathy Disease.

    Tomasevic, Smiljana / Milosevic, Miljan / Milicevic, Bogdan / Simic, Vladimir / Prodanovic, Momcilo / Mijailovich, Srboljub M / Filipovic, Nenad

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: Cardiomyopathy is associated with structural and functional abnormalities of the ventricular myocardium and can be classified in two major groups: hypertrophic (HCM) and dilated (DCM) cardiomyopathy. Computational modeling and drug design approaches can ... ...

    Abstract Cardiomyopathy is associated with structural and functional abnormalities of the ventricular myocardium and can be classified in two major groups: hypertrophic (HCM) and dilated (DCM) cardiomyopathy. Computational modeling and drug design approaches can speed up the drug discovery and significantly reduce expenses aiming to improve the treatment of cardiomyopathy. In the SILICOFCM project, a multiscale platform is developed using coupled macro- and microsimulation through finite element (FE) modeling of fluid-structure interactions (FSI) and molecular drug interactions with the cardiac cells. FSI was used for modeling the left ventricle (LV) with a nonlinear material model of the heart wall. Simulations of the drugs' influence on the electro-mechanics LV coupling were separated in two scenarios, defined by the principal action of specific drugs. We examined the effects of Disopyramide and Dygoxin which modulate Ca
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15030793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Conference proceedings: Agent Based and Finite Element Method for Plaque Development in the Carotid Artery

    Filipovic, Nenad / Blagojevic, Andjela / Tomasevic, Smiljana / Arsic, Branko / Djukic, Tijana

    AORTA

    2022  Volume 10, Issue S 01

    Event/congress 70th International Congress of the European Society for Cardiovascular and Endovascular Surgery and 7th International Meeting on Aortic Diseases, Leige, Belgium, 2022-06-20
    Language English
    Publishing date 2022-06-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2325-4637
    ISSN (online) 2325-4637
    DOI 10.1055/s-0042-1750984
    Database Thieme publisher's database

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  4. Article ; Conference proceedings: Atherosclerotic Plaque Characterization Using Deep Learning Methods

    Arsic, Branko / Tomasevic, Smiljana / Anic, Milos / Gakovic, Branko / Koncar, Igor / Filipovic, Nenad

    AORTA

    2022  Volume 10, Issue S 01

    Event/congress 70th International Congress of the European Society for Cardiovascular and Endovascular Surgery and 7th International Meeting on Aortic Diseases, Leige, Belgium, 2022-06-20
    Language English
    Publishing date 2022-06-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2325-4637
    ISSN (online) 2325-4637
    DOI 10.1055/s-0042-1750994
    Database Thieme publisher's database

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