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  1. Article ; Online: Evaluation of Applicability of Novel Markers of Metabolic Syndrome in Adult Men.

    Tomasiuk, Ryszard

    American journal of men's health

    2022  Volume 16, Issue 4, Page(s) 15579883221108895

    Abstract: There is a continuous worldwide increase in incidences of metabolic syndrome (MetS) reaching about a quarter of the world's population. Thus, studies that allow for a robust diagnosis of MetS are of paramount importance from an economic and medical point ...

    Abstract There is a continuous worldwide increase in incidences of metabolic syndrome (MetS) reaching about a quarter of the world's population. Thus, studies that allow for a robust diagnosis of MetS are of paramount importance from an economic and medical point of view. This study was carried out in a group of men diagnosed with MetS using consensus definition criteria that included the definitions of the International Diabetes Foundation and Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute. The control group consisted of men for whom the parameters that define the MetS were in the norm. This study analyzed statistical differences between MetS and healthy men and the correlations between the set of 14 potential markers of MetS, that is, between body mass index, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein, triglycerides, cortisol, adiponectin, monocyte chemotactic protein-1 (MCP-1), C-reactive protein (CRP), adipsin, leptin, resistin, and plasminogen activator inhibitor-1 (PAI)-1. This report revealed a significant difference between MetS and healthy men in most of the parameters studied. Furthermore, a strong positive correlation between cortisol levels and body mass index was demonstrated. Furthermore, MCP-1 levels in men with MetS were significantly higher than their levels in healthy men. Finally, a strong positive correlation was also observed between adiponectin and adipsin in Mets men. Thus, this study reveals the potential usefulness of adiponectin, MCP-1, adipsin, leptin, resistin, and PAI-1 as markers of MetS in adult men.
    MeSH term(s) Adiponectin ; Adult ; Biomarkers ; Cholesterol, HDL ; Complement Factor D ; Humans ; Hydrocortisone ; Leptin ; Male ; Metabolic Syndrome/epidemiology ; Resistin
    Chemical Substances Adiponectin ; Biomarkers ; Cholesterol, HDL ; Leptin ; Resistin ; Complement Factor D (EC 3.4.21.46) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2275106-3
    ISSN 1557-9891 ; 1557-9883
    ISSN (online) 1557-9891
    ISSN 1557-9883
    DOI 10.1177/15579883221108895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: N-Terminal Pro-C-Type Natriuretic Peptide: The Novel Marker in Selected Disease Units.

    Tomasiuk, Ryszard

    Protein and peptide letters

    2021  Volume 29, Issue 2, Page(s) 125–132

    Abstract: Amino-terminal pro-C-type natriuretic peptide (NT-proCNP) is the N-terminal fragment of the CNP precursor. NT-proCNP occurs in an equimolar concentration with CNP in human plasma and is considered to be a marker of the extent of CNP biosynthesis. A ... ...

    Abstract Amino-terminal pro-C-type natriuretic peptide (NT-proCNP) is the N-terminal fragment of the CNP precursor. NT-proCNP occurs in an equimolar concentration with CNP in human plasma and is considered to be a marker of the extent of CNP biosynthesis. A recent study has shown associations between plasma NT-proCNP and blood pressure; it is also an independent predictor of death and cardiac readmission in people with unstable angina. Beyond that, recent studies have focused on the applicability of assessing NT-proCNP peptide levels in the diagnosis of diseases with different etiologies but the same denominator, i.e., inflammation. This study reviewed recent results on the usability of NT-proCNP peptide levels in the diagnosis of diseases accompanied by statistical analysis of previously reported results. The data obtained confirmed the applicability of the assessment of NT-proCNP levels in biological fluids in diseases, such as Parkinson's disease, sepsis, meningitis, and asthenozoospermia. The reported results demonstrated that NT-proCNP is helpful in a variety of diseases. Furthermore, changes in serum or CSF levels of NT-proCNP reflect only inflammatory states related to general inflammation. Local inflammation does not trigger an increase in NT-proCNP level.
    MeSH term(s) Biomarkers ; Humans ; Inflammation ; Natriuretic Peptide, C-Type ; Peptides ; Vasodilator Agents
    Chemical Substances Biomarkers ; Peptides ; Vasodilator Agents ; Natriuretic Peptide, C-Type (127869-51-6)
    Language English
    Publishing date 2021-11-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1280776-x
    ISSN 1875-5305 ; 0929-8665
    ISSN (online) 1875-5305
    ISSN 0929-8665
    DOI 10.2174/0929866528666211125104944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cardiac Troponin T in Neonates from Normal and Gestational Diabetes Mellitus Pregnancy.

    Kłaczewska, Joanna / Tomasiuk, Ryszard

    BioMed research international

    2022  Volume 2022, Page(s) 6171687

    Abstract: This study is aimed at testing the hypothesis that serum analysis of high-sensitivity troponin T in neonates may serve as a diagnostic tool to predict the risk of gestational diabetes mellitus (GDM). 86 newborns were studied and stratified into two ... ...

    Abstract This study is aimed at testing the hypothesis that serum analysis of high-sensitivity troponin T in neonates may serve as a diagnostic tool to predict the risk of gestational diabetes mellitus (GDM). 86 newborns were studied and stratified into two groups: healthy group; newborns with body weight ≥ 10th percentile, born in good condition (APG 8-10pts) of pregnancy not complicated by diabetes, and the GDM group; neonates born to mothers with type 1 or type 2 diabetes.
    MeSH term(s) Pregnancy ; Child ; Female ; Infant, Newborn ; Humans ; Diabetes, Gestational ; Troponin T ; Diabetes Mellitus, Type 2/complications ; Mothers
    Chemical Substances Troponin T
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/6171687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Physiological Responses Associated with Nordic-Walking and Walking in Middle-age Women.

    Wiacek, Magdalena / Natora, Justyna / Zubrzycki, Igor Z / Tomasiuk, Ryszard

    International journal of sports medicine

    2023  Volume 44, Issue 12, Page(s) 865–870

    Abstract: This study aimed to analyze the influence of supervised 12-week walking (W) and Nordic-walking (NW) programs on changes in specific physiological parameters in middle-aged women 55.40±7.87 and 52.58±6.91 years of age, respectively. Body mass, fat tissue ... ...

    Abstract This study aimed to analyze the influence of supervised 12-week walking (W) and Nordic-walking (NW) programs on changes in specific physiological parameters in middle-aged women 55.40±7.87 and 52.58±6.91 years of age, respectively. Body mass, fat tissue percentage, muscle tissue percentage, systolic blood pressure, diastolic blood pressure, resting pulse, and maximum oxygen uptake were measured at the beginning and end of the exercise program. Intra- and intergroup differences in physiological parameters as a function of the preparation period were analyzed using bootstrap analysis. Clinically reliable changes for a specific subject in the W and NW programs were analyzed using the Reliable Change Index (RCI). The results of this study indicate that more distinct differences were observed in the NW group. However, both programs improved the parameters studied. Nevertheless, an analysis of the RCI indicates that the W provides results similar to, if not better than, NW for increasing neuromuscular, cardiovascular, and cardiorespiratory fitness. This study leads us to the conclusion that the W is not less efficient than the NW for middle-aged women.
    MeSH term(s) Middle Aged ; Humans ; Female ; Oxygen Consumption/physiology ; Oxygen ; Walking/physiology ; Exercise/physiology ; Exercise Test
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-09-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/a-2134-3769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prognostic properties of the association between the S-100B protein levels and the mean cerebral blood flow velocity in patients diagnosed with severe traumatic brain injury.

    Dzierzęcki, Sebastian / Ząbek, Mirosław / Zaczyński, Artur / Tomasiuk, Ryszard

    Biomedical reports

    2022  Volume 17, Issue 1, Page(s) 58

    Abstract: Craniocerebral injury (CBI) is tissue damage caused by a sudden mechanical force. CBI can result in neurological, neuropsychological and psychiatric dysfunctions. Currently, the severity of CBI is assessed using the Glasgow Coma Scale, brain perfusion ... ...

    Abstract Craniocerebral injury (CBI) is tissue damage caused by a sudden mechanical force. CBI can result in neurological, neuropsychological and psychiatric dysfunctions. Currently, the severity of CBI is assessed using the Glasgow Coma Scale, brain perfusion pressure measurements, transcranial Doppler tests and biochemical markers. This study aimed to determine the applicability of the S-100B protein levels and the time-averaged mean maximum cerebral blood flow velocity (V
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2022.1541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The S-100B level, intracranial pressure, body temperature, and transcranial blood flow velocities predict the outcome of the treatment of severe brain injury.

    Dzierzęcki, Sebastian / Ząbek, Mirosław / Zapolska, Gabriela / Tomasiuk, Ryszard

    Medicine

    2022  Volume 101, Issue 38, Page(s) e30348

    Abstract: This study evaluates the applicability of S100B levels, mean maximum velocity (Vmean) over time, pulsatility index (PI), intracranial pressure (ICP), and body temperature (T) for the prediction of the treatment of patients with traumatic brain injury ( ... ...

    Abstract This study evaluates the applicability of S100B levels, mean maximum velocity (Vmean) over time, pulsatility index (PI), intracranial pressure (ICP), and body temperature (T) for the prediction of the treatment of patients with traumatic brain injury (TBI). Sixty patients defined by the Glasgow Coma Scale score ≤ 8 were stratified using the Glasgow Coma Scale into 2 groups: favorable (FG: Glasgow Outcome Scale ≥ 4) and unfavorable (UG: Glasgow Outcome Scale < 4). The S100B concentration was at the time of hospital admission. Vmean was measured using transcranial Doppler. PI was derived from a transcranial Doppler examination. T was measured in the temporal artery. The differences in mean between FG and UG were tested using a bootstrap test of 10,000 repetitions with replacement. Changes in S100B, Vmean, PI, ICP, and T levels stratified by the group were calculated using the one-way aligned rank transform for nonparametric factorial analysis of variance. The reference ranges for the levels of S100B, Vmean, and PI were 0.05 to 0.23 µg/L, 30.8 to 73.17 cm/s, and 0.62 to 1.13, respectively. Both groups were defined by an increase in Vmean, a decrease in S100B, PI, and ICP levels; and a virtually constant T. The unfavorable outcome is defined by significantly higher levels of all parameters, except T. A favorable outcome is defined by S100B < 3 mg/L, PI < 2.86, ICP > 25 mm Hg, and Vmean > 40 cm/s. The relationships provided may serve as indicators of the results of the TBI treatment.
    MeSH term(s) Blood Flow Velocity ; Body Temperature ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/therapy ; Cerebrovascular Circulation/physiology ; Glasgow Coma Scale ; Humans ; Intracranial Pressure ; Theophylline ; Ultrasonography, Doppler, Transcranial
    Chemical Substances Theophylline (C137DTR5RG)
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000030348
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  7. Article: Age-dependent changes in fat- and water-soluble vitamins-National Health and Nutrition Examination Surveys study.

    Tomasiuk, Ryszard / Zubrzycki, Igor Z / Wiacek, Magdalena

    Frontiers in medicine

    2022  Volume 9, Page(s) 907067

    Abstract: Aging is an independent risk factor for the development of various diseases associated, among others, with detrimental blood levels of fat- and water-soluble vitamins. Thus, the objective of this study is to investigate age-related changes in blood ... ...

    Abstract Aging is an independent risk factor for the development of various diseases associated, among others, with detrimental blood levels of fat- and water-soluble vitamins. Thus, the objective of this study is to investigate age-related changes in blood levels of vitamin A, B12, C, D, and E. Subject serum vitamin levels were obtained from the combined National Health and Nutrition Examination Surveys (NHANES). NHANESIII and NHANES 1999-2000, 2001-2002, 2003-2004, and 2005-2006. The raw data set was stratified into five age groups G1- G5: 20 ≤ G1 < 30, 30 ≤ G2 < 40, 40 ≤ G3 < 50, 50 ≤ G4 < 60, and 60 ≤ G5 < 70 years of age. Age stratified data was cleaned using the modified Horn algorithm. The reference range for the vitamin level of a specific age group was defined as data between the first and third quartile of the subject defined by normal blood pressure and normal bone density. Age-dependent changes in serum/plasma vitamin levels were assessed using the bootstrap technique with 10,000 repeats and Bonferroni adjustment. There was a continuous increase in vitamin A, B12, D, and E levels in the blood. However, the vitamin C concentration remained virtually constant in all age groups. There was a lack of cross-correlations between lipid and water-soluble vitamin levels and blood pressure and bone health. The following reference levels for vitamin A, B12, C, D, and E in subjects older than 20 years of age were established: vitamin A: 1.32-2.8 mmol/L, vitamin B12: 257.94-498.33 pmol/L, vitamin C: 38.18-79.2 mmol/L, vitamin D: 76.33-199.36 nmol/L and vitamin E: 3.65-41.12 μmol/L.
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.907067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Predictors of COVID-19 Hospital Treatment Outcome.

    Tomasiuk, Ryszard / Dabrowski, Jan / Smykiewicz, Jolanta / Wiacek, Magdalena

    International journal of general medicine

    2021  Volume 14, Page(s) 10247–10256

    Abstract: Background: There are more than 228,394,572 confirmed cases and 4,690,186 confirmed deaths caused by COVID-19 worldwide. The magnitude of the COOVID-19 pandemic has stimulated research on the treatment and diagnosis of COVID-19 patients.: Objective: ... ...

    Abstract Background: There are more than 228,394,572 confirmed cases and 4,690,186 confirmed deaths caused by COVID-19 worldwide. The magnitude of the COOVID-19 pandemic has stimulated research on the treatment and diagnosis of COVID-19 patients.
    Objective: In this report, a battery of specific parameters was used to develop a model that allows prediction of the outcome of the COVID-19 treatment. These parameters are C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6.
    Methods: The study was carried out on a sample of N = 49 survivors (22 men, 27 women) and 83 deceased patients (62 men, 21 women). The distribution of means and differences in means of the parameters studied between survivors and deceased patients were evaluated using the bootstrap method.
    Results: A mathematical model that allows for the prediction of hospitalization outcome was obtained using the Naive Bayes model. The results demonstrated a statistically significant difference between survivors and deceased patients in all parameters studied. A mathematical model employing a battery of parameters provided a 97% precision in predicting the outcome of hospitalization.
    Conclusion: This study showed that the cross-correlation of survivability with absolute levels of C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6 could be used successfully in the hospital setting as a diagnostic tool.
    Language English
    Publishing date 2021-12-22
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S334544
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  9. Article ; Online: Usability of the Level of the S100B Protein, the Gosling Pulsatility Index, and the Jugular Venous Oxygen Saturation for the Prediction of Mortality and Morbidity in Patients with Severe Traumatic Brain Injury.

    Tomasiuk, Ryszard / Dzierzęcki, Sebastian / Zaczyński, Artur / Ząbek, Mirosław

    BioMed research international

    2021  Volume 2021, Page(s) 2398488

    Abstract: The high frequency of traumatic brain injury imposes severe economic stress on health and insurance services. The objective of this study was to analyze the association between the serum S100B protein, the Gosling pulsatility index (PI), and the level of ...

    Abstract The high frequency of traumatic brain injury imposes severe economic stress on health and insurance services. The objective of this study was to analyze the association between the serum S100B protein, the Gosling pulsatility index (PI), and the level of oxygen saturation at the tip of the internal jugular vein (SjVO2%) in patients diagnosed with severe TBI. The severity of TBI was assessed by a GCS score ≤ 8 stratified by Glasgow outcome scale (GOS) measured on the day of discharge from the hospital. Two groups were included: GOS < 4 (unfavorable group (UG)) and GOS ≥ 4 (favorable group (UG)). S100B levels were higher in the UG than in the FG. PI levels in the UG were also substantially higher than in the FG. There were similar levels of SjVO2 in the two groups. This study confirmed that serum S100B levels were higher in patients with unfavorable outcomes than in those with favorable outcomes. Moreover, a clear demarcation in PI between unfavorable and FGs was observed. This report shows that mortality and morbidity rates in patients with traumatic brain injury can be assessed within the first 4 days of hospitalization using the S100B protein, PI values, and SjVO2.
    MeSH term(s) Adolescent ; Adult ; Aged ; Brain Injuries, Traumatic/classification ; Brain Injuries, Traumatic/mortality ; Female ; Glasgow Coma Scale ; Humans ; Jugular Veins/physiology ; Length of Stay/trends ; Male ; Middle Aged ; Morbidity ; Oximetry ; Oxygen Saturation/physiology ; Prognosis ; Pulsatile Flow/physiology ; S100 Calcium Binding Protein beta Subunit/analysis ; S100 Calcium Binding Protein beta Subunit/blood
    Chemical Substances S100 Calcium Binding Protein beta Subunit ; S100B protein, human
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2021/2398488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Changes in Health-related Parameters Associated with Sports Performance Enhancement Drugs.

    Wiacek, Magdalena / Trąbka, Bartosza / Tomasiuk, Ryszard / Zubrzycki, Igor Z

    International journal of sports medicine

    2022  Volume 44, Issue 3, Page(s) 206–214

    Abstract: The purpose of this study was to evaluate changes in health-related parameters caused by the administration of anabolic-androgenic steroids and "fat-burning drugs" during a 6-month competition preparation period. The physiological, biochemical, and ... ...

    Abstract The purpose of this study was to evaluate changes in health-related parameters caused by the administration of anabolic-androgenic steroids and "fat-burning drugs" during a 6-month competition preparation period. The physiological, biochemical, and anthropometric parameters studied included serum cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, aspartate aminotransferase, alanine transaminase, bilirubin, body mass, and percentage of total body fat. Changes in the parameters studied were analyzed at monthly intervals during six months of preparation for competition. The study revealed a continuous increase in body mass, accompanied by a decrease in body fat percentage to the physiologically essential level. Total cholesterol levels remined in the
    MeSH term(s) Humans ; Alanine Transaminase ; Triglycerides ; Cholesterol, HDL ; Cholesterol, LDL ; Bilirubin ; Aspartate Aminotransferases ; Athletic Performance
    Chemical Substances Alanine Transaminase (EC 2.6.1.2) ; Triglycerides ; Cholesterol, HDL ; Cholesterol, LDL ; Bilirubin (RFM9X3LJ49) ; Aspartate Aminotransferases (EC 2.6.1.1)
    Language English
    Publishing date 2022-12-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/a-1960-2543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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