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  1. AU="Tomassoni, Daniele"
  2. AU="Minji Kang"
  3. AU="Maarten Jacquemyn"
  4. AU="Gilboa, Eli"
  5. AU="Matthew Collins"
  6. AU="Buttar, Irvind"
  7. AU="F Leslie, Katie"
  8. AU="Zafar, Mohammad A"
  9. AU=Owens Michael D
  10. AU="Kuveždić, D."
  11. AU="John, Shannon"
  12. AU="O'Shaughnessy, R F L"
  13. AU="AlHarfoush, Enmar"
  14. AU="Savill, Edward"
  15. AU="Pavel P. Polyakov"
  16. AU="Robert Haennel"
  17. AU="Robert W. Crawford"
  18. AU="Figueroa, Andres V"
  19. AU="Racca, C."
  20. AU="Slavu, Diana-Maria"
  21. AU="Talbert, Emily"
  22. AU=Abdelnour Loay H
  23. AU=Meisburger Steve P.
  24. AU="Silveira, Fernando A. O."
  25. AU="Toru Nabika"
  26. AU="Vojkovic, Marina"
  27. AU="Gaier, Eric D"
  28. AU="Chandler Crews"
  29. AU="Comte, Marie-Hélène"
  30. AU="Cohen, Or"
  31. AU="Abdellatifi, Mohamed"
  32. AU="Luebbe, Elizabeth"
  33. AU="Emidio, Adriana"
  34. AU=Masmejan Sophie
  35. AU="Samantha Ridley"
  36. AU="Moghaddam-Alvandi, Arash"
  37. AU="Khanolkar, Amey R."
  38. AU="Vasquez Martinez, Rodolfo"
  39. AU="Morgan, E"

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  1. Artikel: Effects of choline containing phospholipids on the neurovascular unit: A review.

    Roy, Proshanta / Tomassoni, Daniele / Nittari, Giulio / Traini, Enea / Amenta, Francesco

    Frontiers in cellular neuroscience

    2022  Band 16, Seite(n) 988759

    Abstract: The roles of choline and of choline-containing phospholipids (CCPLs) on the maintenance and progress of neurovascular unit (NVU) integrity are analyzed. NVU is composed of neurons, glial and vascular cells ensuring the correct homeostasis of the blood- ... ...

    Abstract The roles of choline and of choline-containing phospholipids (CCPLs) on the maintenance and progress of neurovascular unit (NVU) integrity are analyzed. NVU is composed of neurons, glial and vascular cells ensuring the correct homeostasis of the blood-brain barrier (BBB) and indirectly the function of the central nervous system. The CCPLs phosphatidylcholine (lecithin), cytidine 5'-diphosphocholine (CDP-choline), choline alphoscerate or α-glyceryl-phosphorylcholine (α-GPC) contribute to the modulation of the physiology of the NVU cells. A loss of CCPLs contributes to the development of neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis, Parkinson's disease. Our study has characterized the cellular components of the NVU and has reviewed the effect of lecithin, of CDP-choline and α-GPC documented in preclinical studies and in limited clinical trials on these compounds. The interesting results obtained with some CCPLs, in particular with α-GPC, probably would justify reconsideration of the most promising molecules in larger attentively controlled studies. This can also contribute to better define the role of the NVU in the pathophysiology of brain disorders characterized by vascular impairment.
    Sprache Englisch
    Erscheinungsdatum 2022-09-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.988759
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Brain and Retinal Organoids for Disease Modeling: The Importance of In Vitro Blood-Brain and Retinal Barriers Studies.

    Martinelli, Ilenia / Tayebati, Seyed Khosrow / Tomassoni, Daniele / Nittari, Giulio / Roy, Proshanta / Amenta, Francesco

    Cells

    2022  Band 11, Heft 7

    Abstract: Brain and retinal organoids are functional and dynamic in vitro three-dimensional (3D) structures derived from pluripotent stem cells that spontaneously organize themselves to their in vivo counterparts. Here, we review the main literature data of how ... ...

    Abstract Brain and retinal organoids are functional and dynamic in vitro three-dimensional (3D) structures derived from pluripotent stem cells that spontaneously organize themselves to their in vivo counterparts. Here, we review the main literature data of how these organoids have been developed through different protocols and how they have been technically analyzed. Moreover, this paper reviews recent advances in using organoids to model neurological and retinal diseases, considering their potential for translational applications but also pointing out their limitations. Since the blood-brain barrier (BBB) and blood-retinal barrier (BRB) are understood to play a fundamental role respectively in brain and eye functions, both in health and in disease, we provide an overview of the progress in the development techniques of in vitro models as reliable and predictive screening tools for BBB and BRB-penetrating compounds. Furthermore, we propose potential future directions for brain and retinal organoids, in which dedicated biobanks will represent a novel tool for neuroscience and ophthalmology research.
    Mesh-Begriff(e) Blood-Brain Barrier ; Brain ; Organoids ; Pluripotent Stem Cells ; Retina
    Sprache Englisch
    Erscheinungsdatum 2022-03-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11071120
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Telemedicine in the COVID-19 Era: A Narrative Review Based on Current Evidence.

    Nittari, Giulio / Savva, Demetris / Tomassoni, Daniele / Tayebati, Seyed Khosrow / Amenta, Francesco

    International journal of environmental research and public health

    2022  Band 19, Heft 9

    Abstract: During the recent COVID-19 pandemic, healthcare providers have been encouraged to increase their use of telemedicine and to adopt telemedicine platforms for the majority of their clients who have chronic illnesses. Due to the outbreak itself, almost all ... ...

    Abstract During the recent COVID-19 pandemic, healthcare providers have been encouraged to increase their use of telemedicine and to adopt telemedicine platforms for the majority of their clients who have chronic illnesses. Due to the outbreak itself, almost all countries worldwide were placed under emergency lockdowns. In this paper, we reviewed the literature regarding the use of telemedicine during the COVID-19 pandemic. Consequentially, we identified the adoption of telemedicine in various countries worldwide and evaluated their future steps in order to increase the adoption of e-health technologies. As a result of COVID-19, the e-health agenda, especially telemedicine, has been accelerated in several countries. COVID-19 is affecting individuals' daily lives and has created major difficulties in the management of healthcare facilities for both infected and non-infected patients. A large portion of the rapid increase in the use of telemedicine can be attributed to evidence from previous pandemics as well as progress made by the field in response to COVID-19, especially in industrialized countries. A lack of effective treatment, large numbers of unvaccinated individuals, as well as social distancing and lockdown measures suggest telemedicine is the safest and most appropriate way of working with patients and doctors. In spite of this willingness, a large number of barriers need to be overcome in order for the telemedicine system to function properly and effectively throughout countries. In order for telemedicine to be sustainable and beneficial beyond the pandemic, several technical, educational, infrastructure, legal, and economic issues must be addressed and solved.
    Mesh-Begriff(e) COVID-19/epidemiology ; Communicable Disease Control ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; Telemedicine
    Sprache Englisch
    Erscheinungsdatum 2022-04-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19095101
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Batten disease through different in vivo and in vitro models: A review.

    Nittari, Giulio / Tomassoni, Daniele / Roy, Proshanta / Martinelli, Ilenia / Tayebati, Seyed Khosrow / Amenta, Francesco

    Journal of neuroscience research

    2022  Band 101, Heft 3, Seite(n) 298–315

    Abstract: Batten disease consists of a family of primarily autosomal recessive, progressive neuropediatric disorders, also known as neuronal ceroid lipofuscinoses (NCLs). These pathologies are characterized by seizures and visual, cognitive and motor decline, and ... ...

    Abstract Batten disease consists of a family of primarily autosomal recessive, progressive neuropediatric disorders, also known as neuronal ceroid lipofuscinoses (NCLs). These pathologies are characterized by seizures and visual, cognitive and motor decline, and premature death. The pathophysiology of this rare disease is still unclear despite the years of trials and financial aids. This paper has reviewed advantages and limits of in vivo and in vitro models of Batten disease from murine and larger animal models to primitive unicellular models, until the most recently developed patient-derived induced pluripotent stem cells. For each model advantages, limits and applications were analyzed. The first prototypes investigated were murine models that due to their limits were replaced by larger animals. In vitro models gradually replaced animal models for practical, cost, and ethical reasons. Using induced pluripotent stem cells to study neurodegeneration is a new way of studying the disease, since they can be distinguished into differentiating elements like neurons, which are susceptible to neurodegeneration. In vivo and in vitro models have contributed to clarifying to some extent the pathophysiology of the disease. The collection and sharing of suitable human bio samples likely through biobanks can contribute to a better understanding, prevention, and to identify possible treatment strategies of Batten disease.
    Mesh-Begriff(e) Humans ; Animals ; Mice ; Neuronal Ceroid-Lipofuscinoses/pathology ; Neuronal Ceroid-Lipofuscinoses/therapy ; Disease Models, Animal ; Seizures ; Rare Diseases
    Sprache Englisch
    Erscheinungsdatum 2022-11-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.25147
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1232: Hefte anzeigen Standort:
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  5. Artikel: Rodent Models of Huntington's Disease: An Overview.

    Nittari, Giulio / Roy, Proshanta / Martinelli, Ilenia / Bellitto, Vincenzo / Tomassoni, Daniele / Traini, Enea / Tayebati, Seyed Khosrow / Amenta, Francesco

    Biomedicines

    2023  Band 11, Heft 12

    Abstract: Huntington's disease (HD) is an autosomal-dominant inherited neurological disorder caused by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a polyglutamine repeat expansion mutation in the widely expressed huntingtin ( ... ...

    Abstract Huntington's disease (HD) is an autosomal-dominant inherited neurological disorder caused by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a polyglutamine repeat expansion mutation in the widely expressed huntingtin (HTT) protein. HD is characterized by the degeneration of basal ganglia neurons and progressive cell death in intrinsic neurons of the striatum, accompanied by dementia and involuntary abnormal choreiform movements. Animal models have been extensively studied and have proven to be extremely valuable for therapeutic target evaluations. They reveal the hallmark of the age-dependent formation of aggregates or inclusions consisting of misfolded proteins. Animal models of HD have provided a therapeutic strategy to treat HD by suppressing mutant HTT (mHTT). Transgenic animal models have significantly increased our understanding of the molecular processes and pathophysiological mechanisms underlying the HD behavioral phenotype. Since effective therapies to cure or interrupt the course of the disease are not yet available, clinical research will have to make use of reliable animal models. This paper reviews the main studies of rodents as HD animal models, highlighting the neurological and behavioral differences between them. The choice of an animal model depends on the specific aspect of the disease to be investigated. Toxin-based models can still be useful, but most experimental hypotheses depend on success in a genetic model, whose choice is determined by the experimental question. There are many animal models showing similar HD symptoms or pathologies. They include chemical-induced HDs and genetic HDs, where cell-free and cell culture, lower organisms (such as yeast,
    Sprache Englisch
    Erscheinungsdatum 2023-12-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11123331
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  6. Artikel ; Online: Starch-enriched diet modulates the glucidic profile in the rat colonic mucosa.

    Gabrielli, Maria Gabriella / Tomassoni, Daniele

    European journal of nutrition

    2017  Band 57, Heft 3, Seite(n) 1109–1121

    Abstract: Purpose: The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins. Modifications of their expression can be induced ...

    Abstract Purpose: The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins. Modifications of their expression can be induced by an altered intestinal microenvironment and have been associated with inflammatory disorders and colorectal cancer. Given the influence of dietary factors on the gut ecosystem, here we have investigated whether a long term feeding on a starch-rich diet can modulate the glucidic profile in the colonic mucosa of rats.
    Methods: Animals were divided into two groups and maintained for 9 months at different diets: one group was fed a standard diet, the second was fed a starch-enriched diet. Samples of colonic mucosa, divided in proximal and distal portions, were processed for microscopic analysis. Conventional stainings and lectin histochemistry were applied to identify acidic glycoconjugates and specific sugar residues in oligosaccharide chains, respectively. Some lectins were applied on adjacent sections after sialidase/fucosidase digestion, deacetylation, and oxidation to characterize either terminal dimers or sialic acid acetylation.
    Results: An increase in sulfomucins was found to be associated with the starch-enriched diet that affected also the expression of several sugar residues as well as fucosylated and sialylated sequences in both proximal and distal colon.
    Conclusions: Although the mechanisms leading to such a modulation are at present unknown, either an altered intestinal microbiota or a dysregulation of glycosylation patterns might be responsible for the types and distribution of changes in the glucidic profile here observed.
    Mesh-Begriff(e) Animals ; Carbohydrate Sequence ; Colon/cytology ; Colon/metabolism ; Diet, Carbohydrate Loading/adverse effects ; Enterocytes/cytology ; Enterocytes/metabolism ; Female ; Fucose/metabolism ; Glycolipids/chemistry ; Glycolipids/metabolism ; Glycoproteins/chemistry ; Glycoproteins/metabolism ; Glycosylation ; Goblet Cells/cytology ; Goblet Cells/metabolism ; Indicators and Reagents/analysis ; Indicators and Reagents/metabolism ; Intestinal Mucosa/cytology ; Intestinal Mucosa/metabolism ; Lectins/analysis ; Lectins/metabolism ; Microvilli/metabolism ; Mucins/chemistry ; Mucins/metabolism ; N-Acetylneuraminic Acid/metabolism ; Rats, Sprague-Dawley ; Starch/adverse effects ; Starch/metabolism
    Chemische Substanzen Glycolipids ; Glycoproteins ; Indicators and Reagents ; Lectins ; Mucins ; sulfomucin ; Fucose (28RYY2IV3F) ; Starch (9005-25-8) ; N-Acetylneuraminic Acid (GZP2782OP0)
    Sprache Englisch
    Erscheinungsdatum 2017-04-09
    Erscheinungsland Germany
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-017-1393-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.262: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Artikel: Dysfunction of the Brown Adipose Organ in HFD-Obese Rats and Effect of Tart Cherry Supplementation.

    Bellitto, Vincenzo / Gabrielli, Maria Gabriella / Martinelli, Ilenia / Roy, Proshanta / Nittari, Giulio / Cocci, Paolo / Palermo, Francesco Alessandro / Amenta, Francesco / Micioni Di Bonaventura, Maria Vittoria / Cifani, Carlo / Tomassoni, Daniele / Tayebati, Seyed Khosrow

    Antioxidants (Basel, Switzerland)

    2024  Band 13, Heft 4

    Abstract: Obesity has a great impact on adipose tissue biology, based on its function as a master regulator of energy balance. Brown adipose tissue (BAT) undergoes remodeling, and its activity declines in obese subjects due to a whitening process. The anti-obesity ...

    Abstract Obesity has a great impact on adipose tissue biology, based on its function as a master regulator of energy balance. Brown adipose tissue (BAT) undergoes remodeling, and its activity declines in obese subjects due to a whitening process. The anti-obesity properties of fruit extracts have been reported. The effects of tart cherry against oxidative stress, inflammation, and the whitening process in the BAT of obese rats were investigated. Intrascapular BAT (iBAT) alterations and effects of
    Sprache Englisch
    Erscheinungsdatum 2024-03-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13040388
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD).

    Battineni, Gopi / Sagaro, Getu Gamo / Chintalapudi, Nalini / Amenta, Francesco / Tomassoni, Daniele / Tayebati, Seyed Khosrow

    International journal of molecular sciences

    2021  Band 22, Heft 9

    Abstract: Overweight and obesity are key risk factors of cardiovascular disease (CVD). Obesity is currently presented as a pro-inflammatory state with an expansion in the outflow of inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor- ... ...

    Abstract Overweight and obesity are key risk factors of cardiovascular disease (CVD). Obesity is currently presented as a pro-inflammatory state with an expansion in the outflow of inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), alongside the expanded emission of leptin. The present review aimed to evaluate the relationship between obesity and inflammation and their impacts on the development of cardiovascular disease. A literature search was conducted by employing three academic databases, namely PubMed (Medline), Scopus (EMBASE), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL). The search presented 786 items, and by inclusion and exclusion filterers, 59 works were considered for final review. The Newcastle-Ottawa Scale (NOS) method was adopted to conduct quality assessment; 19 papers were further selected based on the quality score. Obesity-related inflammation leads to a low-grade inflammatory state in organisms by upregulating pro-inflammatory markers and downregulating anti-inflammatory cytokines, thereby contributing to cardiovascular disease pathogenesis. Because of inflammatory and infectious symptoms, adipocytes appear to instigate articulation and discharge a few intense stage reactants and carriers of inflammation. Obesity and inflammatory markers are strongly associated, and are important factors in the development of CVD. Hence, weight management can help prevent cardiovascular risks and poor outcomes by inhibiting inflammatory mechanisms.
    Mesh-Begriff(e) Adipocytes/metabolism ; Adipocytes/pathology ; Animals ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Cytokines/analysis ; Cytokines/metabolism ; Humans ; Inflammation/complications ; Inflammation/metabolism ; Inflammation/pathology ; Obesity/complications ; Obesity/metabolism ; Obesity/pathology
    Chemische Substanzen Cytokines
    Sprache Englisch
    Erscheinungsdatum 2021-04-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22094798
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Altered Brain Cholinergic and Synaptic Markers in Obese Zucker Rats.

    Martinelli, Ilenia / Tomassoni, Daniele / Roy, Proshanta / Amenta, Francesco / Tayebati, Seyed Khosrow

    Cells

    2021  Band 10, Heft 10

    Abstract: The association between obesity and loss of cognitive performance has been recognized. Although there are data regarding the metabolic alterations in obese conditions and the development of neuroinflammation, no clear evidence concerning obesity-related ... ...

    Abstract The association between obesity and loss of cognitive performance has been recognized. Although there are data regarding the metabolic alterations in obese conditions and the development of neuroinflammation, no clear evidence concerning obesity-related cholinergic and synaptic impairments in the frontal cortex and hippocampus has been reported yet. Here, we investigate different cholinergic and synaptic markers in 12-, 16-, and 20-week-old obese Zucker rats (OZRs) compared with lean littermate rats (LZRs), using immunochemical and immunohistochemical analysis. Consequently, OZRs showed body weight gain, hypertension, and dysmetabolism. In 20-week-old OZRs, the reduction of vesicular acetylcholine transporter (VAChT) and alpha7 nicotinic acetylcholine receptors (α7nAChR) occurred both in the frontal cortex and in the hippocampus, suggesting a cognitive dysfunction due to obesity and aging. Among the muscarinic receptors analyzed, the level of expression of type 1 (mAChR1) was lower in the hippocampus of the older OZRs. Finally, we showed synaptic dysfunctions in OZRs, with a reduction of synaptophysin (SYP) and synaptic vesicle glycoprotein 2B (SV2B) in 20-week-old OZRs, both in the frontal cortex and in the hippocampus. Taken together, our data suggest specific alterations of cholinergic and synaptic markers that can be targeted to prevent cognitive deficits related to obesity and aging.
    Mesh-Begriff(e) Aging/physiology ; Animals ; Blood Glucose/metabolism ; Brain/metabolism ; Disease Models, Animal ; Hypertension/metabolism ; Neuroinflammatory Diseases/metabolism ; Obesity/complications ; Obesity/metabolism ; Rats ; Synapses/metabolism
    Chemische Substanzen Blood Glucose
    Sprache Englisch
    Erscheinungsdatum 2021-09-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10102528
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Antioxidant Properties of Alpha-Lipoic (Thioctic) Acid Treatment on Renal and Heart Parenchyma in a Rat Model of Hypertension

    Martinelli, Ilenia / Tomassoni, Daniele / Roy, Proshanta / Di Cesare Mannelli, Lorenzo / Amenta, Francesco / Tayebati, Seyed Khosrow

    Antioxidants. 2021 June 23, v. 10, no. 7

    2021  

    Abstract: Renal and cardiac impairments are frequent events in the presence of hypertension. Organ damage is mainly linked to oxidative stress due to high blood pressure and may be reduced by antioxidant supplementation. Alpha-lipoic acid (ALA) is one of most ... ...

    Abstract Renal and cardiac impairments are frequent events in the presence of hypertension. Organ damage is mainly linked to oxidative stress due to high blood pressure and may be reduced by antioxidant supplementation. Alpha-lipoic acid (ALA) is one of most effective antioxidants. It is widely used as a nutritional supplement in a racemic mixture (+/–), even though the (+)-enantiomer is biologically active. This study was designed to investigate the effect of treatment with (+/–)-ALA and its enantiomers on renal and heart parenchyma in spontaneously hypertensive rats (SHR), using immunochemical and immunohistochemical techniques. The results confirmed that the oxidative mechanisms of organ alterations, due to hypertension, and characterized by glomerular and tubular lesions, left ventricular hypertrophy, and fibrosis but not by apoptosis were accompanied by proteins’ and nucleic acids’ oxidation. We found greater effectiveness of (+)-ALA compared to (+/−)-ALA in reducing oxidative stress, cardiac and renal damages in SHR. To conclude, these data propose (+)-ALA as one of the more appropriate antioxidant molecules to prevent renal and cardiac alterations associated with hypertension.
    Schlagwörter acid treatment ; antioxidants ; apoptosis ; enantiomers ; fibrosis ; hypertension ; hypertrophy ; immunohistochemistry ; lipoic acid ; oxidation ; oxidative stress ; parenchyma (animal tissue)
    Sprache Englisch
    Erscheinungsverlauf 2021-0623
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10071006
    Datenquelle NAL Katalog (AGRICOLA)

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