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  1. Article ; Online: Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population

    Tomasz Olesiński / Anna Lutkowska / Adam Balcerek / Anna Sowińska / P Piotrowski / Tomasz Trzeciak / Tomasz Maj / Piotr Hevelke / Pawel P. Jagodziński

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Abstract The role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated ...

    Abstract Abstract The role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated the effect of rs67085638 on B-cell-specific Moloney leukaemia virus insertion site 1 (BMI1) transcripts in primary GC and counterpart histopathologically confirmed disease-free margin tissue. Using high-resolution melting analysis, we evaluated rs67085638 frequency in patients with the GC genotype (n = 214) and controls (n = 502) in a Polish Caucasian population. qRT-PCR was used to determine BMI1 transcripts. We observed the trend of rs67085638 association in all patients with GC (p trend = 0.028), a strong risk of the GC genotype in male (p trend = 0.035) but not female (p trend = 0.747) patients, and the association with non-cardia GC (p trend = 0.041), tumour stages T3 (p trend = 0.014) and T4 (p trend = 0.032), differentiation grading G3 (p trend = 0.009), lymph node metastasis stage N3 (p trend = 0.0005) and metastasis stage M0 (p trend = 0.027). We found that significantly increased BMI1 transcripts were associated with the primary GC genotype classified as grade G3 (p = 0.011) and as lymph node metastasis N3 (p = 0.010) and counterpart marginal tissues (p = 0.026, p = 0.040, respectively) from carriers of the T/T versus C/C genotypes. rs67085638 may contribute to increased BMI1 transcripts and the progression and rapid growth of GC.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: CD80 and CD86 Costimulatory Molecules Differentially Regulate OT-II CD4+ T Lymphocyte Proliferation and Cytokine Response in Cocultures with Antigen-Presenting Cells Derived from Pregnant and Pseudopregnant Mice

    Tomasz Maj / Anna Slawek / Anna Chelmonska-Soyta

    Mediators of Inflammation, Vol

    2014  Volume 2014

    Keywords Pathology ; RB1-214 ; Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: CD80 and CD86 Costimulatory Molecules Differentially Regulate OT-II CD4+ T Lymphocyte Proliferation and Cytokine Response in Cocultures with Antigen-Presenting Cells Derived from Pregnant and Pseudopregnant Mice

    Tomasz Maj / Anna Slawek / Anna Chelmonska-Soyta

    Mediators of Inflammation, Vol

    2014  Volume 2014

    Keywords Pathology ; RB1-214 ; Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: CD80 and CD86 Costimulatory Molecules Differentially Regulate OT-II CD4+ T Lymphocyte Proliferation and Cytokine Response in Cocultures with Antigen-Presenting Cells Derived from Pregnant and Pseudopregnant Mice

    Tomasz Maj / Anna Slawek / Anna Chelmonska-Soyta

    Mediators of Inflammation, Vol

    2014  Volume 2014

    Keywords Pathology ; RB1-214 ; Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Antigen presenting cells costimulatory signaling during pre-implantation pregnancy

    Anna Sławek / Tomasz Maj / Anna Chełmonska-Soyta

    Postępy Higieny i Medycyny Doświadczalnej, Vol 66, Iss 855199, Pp 674-

    2012  Volume 682

    Abstract: Success of pregnancy depends on many factors. Three phenomena inducing immune tolerance against semi-allogeneic conceptus may play a crucial role in the pre-implantation period of pregnancy: influence of sex hormones in sex cycle, presence of oocyte or ... ...

    Abstract Success of pregnancy depends on many factors. Three phenomena inducing immune tolerance against semi-allogeneic conceptus may play a crucial role in the pre-implantation period of pregnancy: influence of sex hormones in sex cycle, presence of oocyte or embryo and the presence of semen in the female reproductive tract. On the other hand dendritic cells are the most effective antigen-presenting cells in regulation of immune phenomena and also are considered as potent participants in inducing immune tolerance in the pregnancy. They communicate with T cells in cell contact-dependent manner or via cytokines. During cell-cell contacts, costimulatory molecules play a key role and their expression is often dependent on cytokines milieu. Both costimulatory molecules and cytokines influence generation of T regulatory cells. Interactions of these molecules are closely related. In this paper we would like to pay attention to the importance of antigen presenting cells costimulatory potency in immune regulation during a pre-implantation period of pregnancy.
    Keywords costimulatory molecules ; antigen presenting cells ; preimplantation pregnancy ; cząsteczki kostymulacyjne ; komórki prezentujące antygen ; ciąża ; Medicine ; R
    Language English
    Publishing date 2012-09-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

    Wang, Weimin / Ilona Kryczek / Lubomír Dostál / Heng Lin / Lijun Tan / Lili Zhao / Fujia Lu / Shuang Wei / Tomasz Maj / Dongjun Peng / Gong He / Linda Vatan / Wojciech Szeliga / Rork Kuick / Jan Kotarski / Rafał Tarkowski / Yali Dou / Ramandeep Rattan / Adnan Munkarah /
    J. Rebecca Liu / Weiping Zou

    Cell. 2016 May 19, v. 165

    2016  

    Abstract: Effector T cells and fibroblasts are major components in the tumor microenvironment. The means through which these cellular interactions affect chemoresistance is unclear. Here, we show that fibroblasts diminish nuclear accumulation of platinum in ... ...

    Abstract Effector T cells and fibroblasts are major components in the tumor microenvironment. The means through which these cellular interactions affect chemoresistance is unclear. Here, we show that fibroblasts diminish nuclear accumulation of platinum in ovarian cancer cells, resulting in resistance to platinum-based chemotherapy. We demonstrate that glutathione and cysteine released by fibroblasts contribute to this resistance. CD8+ T cells abolish the resistance by altering glutathione and cystine metabolism in fibroblasts. CD8+ T-cell-derived interferon (IFN)γ controls fibroblast glutathione and cysteine through upregulation of gamma-glutamyltransferases and transcriptional repression of system xc− cystine and glutamate antiporter via the JAK/STAT1 pathway. The presence of stromal fibroblasts and CD8+ T cells is negatively and positively associated with ovarian cancer patient survival, respectively. Thus, our work uncovers a mode of action for effector T cells: they abrogate stromal-mediated chemoresistance. Capitalizing upon the interplay between chemotherapy and immunotherapy holds high potential for cancer treatment.
    Keywords CD8-positive T-lymphocytes ; animal ovaries ; antiporters ; cysteine ; cystine ; drug therapy ; fibroblasts ; glutamic acid ; glutathione ; immunotherapy ; interferons ; mechanism of action ; metabolism ; neoplasm cells ; ovarian neoplasms ; patients ; platinum ; transcription (genetics)
    Language English
    Dates of publication 2016-0519
    Size p. 1092-1105.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2016.04.009
    Database NAL-Catalogue (AGRICOLA)

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