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Article ; Online: Man with abdominal pain.

Saito, Yasutaka / Tomatsu, Makoto / Nakamura, Toru

Journal of the American College of Emergency Physicians open

2024 Volume 5, Issue 2, Page(s) e13155

Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ISSN	2688-1152
ISSN (online)	2688-1152
DOI	10.1002/emp2.13155
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Article: Mediastinal hematoma as an unusual intrathoracic manifestation of Boerhaave Syndrome: A case report.

Nakano, Yusuke / Nakamura, Toru / Tomatsu, Makoto / Miyaki, Yuichiro / Suzuki, Kazufumi

International journal of surgery case reports

2024 Volume 116, Page(s) 109366

Abstract: Introduction: Boerhaave Syndrome (BS) is rare but life-threatening condition caused by a sudden increase in the intraluminal pressure due to vomiting. We present a case of BS manifesting as a posterior mediastinal hematoma, indicative of a potentially ... ...

Abstract	Introduction: Boerhaave Syndrome (BS) is rare but life-threatening condition caused by a sudden increase in the intraluminal pressure due to vomiting. We present a case of BS manifesting as a posterior mediastinal hematoma, indicative of a potentially fatal condition. Presentation of case: A 51-year-old man presented with acute chest pain after vomiting. Enhanced Computed Tomography revealed mediastinal fluid with a left pleural effusion, leading to a diagnosis of BS. Emergency surgery revealed a posterior mediastinal hematoma with active bleeding due to a torn proper esophageal artery. Hemostasis and a wall repair were performed, and the patient was discharged uneventfully. Discussion: This case highlights two important aspects. Firstly, a spontaneous esophageal perforation can manifest as a mediastinal hematoma due to the subpleural arterial injury, delaying bacterial spillage. While preoperative thoracentesis may not always diagnose BS accurately, bloody thoracic drainage can serve as an alternative diagnostic sign. Secondly, the mediastinal hematoma itself poses a serious risk, as it can lead to a catastrophic outcome even before bacterial contamination occurs, emphasizing the necessity of a timely surgical intervention in BS cases. Conclusion: BS can manifest as a mediastinal hematoma, and the absence of gastrointestinal content in the thoracic drainage does not rule out the possibility of BS. Prompt surgical intervention remains essential, as a mediastinal hematoma alone can result in a catastrophic outcome. This case highlights the significance of a comprehensive diagnostic assessment for BS.
Language	English
Publishing date	2024-02-12
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2024.109366
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Article ; Online: Evaluation of the widths of the mucosal strips in pathological examination of specimens of endoscopic submucosal dissection for early gastric cancer.

Katsuragi, Shin-Ya / Otsuki, Yoshiro / Unno, Shuhei / Kimata, Masaharu / Yoshizawa, Yashiro / Tomatsu, Makoto / Shinmura, Kazuya / Suzuki, Kazufumi / Sugimura, Haruhiko

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

2023 Volume 26, Issue 5, Page(s) 755–762

Abstract: Background: Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric cancer in Japan. Pathological evaluation of ESD specimens is considered essential to determine if additional gastrectomy is necessary. Usually, specimens ... ...

Abstract	Background: Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric cancer in Japan. Pathological evaluation of ESD specimens is considered essential to determine if additional gastrectomy is necessary. Usually, specimens resected by ESD are sliced into 2-3 mm wide sections, and each section is examined for depth of tumor and lymphovascular invasion. Nevertheless, in most cases of additional gastrectomy, lymph node metastasis is not present. Given that there are few-studies on how clinical-decisions based on the pathologic-evaluation-method, in particular the specimen cut-width, influence patient outcomes, we retrospectively evaluated whether reducing the number of cuts to one-half or one-third would result in underestimation of the real need for additional surgery. The effect of the actual cut-width on recommended treatment (referral to operation) and patient-outcomes was also assessed. Methods: Pathological records of 498 lesions from 439 patients were reviewed and re-evaluated. All pathological descriptions are based on the gastric cancer classification system of the Japanese Gastric Cancer Association, 15th edition. Results: In 5.8% and 8.5% of the total specimens, underdiagnosis of tumor-depth and lymphovascular invasion occurred when the number of sections was reduced to one-half and one-third, respectively. Significantly more submucosal invasions were found in the group in which the cut-with was between 3 and 4 mm than in the group in which the cut width was less than 3 mm. Conclusion: Evaluation of the appropriate cut-width is important and should be discussed from the standpoint of labor costs and lost opportunities to search for molecular markers in ESD materials.
MeSH term(s)	Humans ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Retrospective Studies ; Endoscopic Mucosal Resection/methods ; Gastric Mucosa/surgery ; Gastric Mucosa/pathology ; Gastroscopy/methods ; Gastrectomy/methods ; Treatment Outcome
Language	English
Publishing date	2023-05-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1463526-4
ISSN	1436-3305 ; 1436-3291
ISSN (online)	1436-3305
ISSN	1436-3291
DOI	10.1007/s10120-023-01396-z
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Article: Novel angiotensin I-converting enzyme inhibitory peptides derived from soya milk.

Tomatsu, Makoto / Shimakage, Atsushi / Shinbo, Mamoru / Yamada, Seihan / Takahashi, Saori

Food chemistry

2013 Volume 136, Issue 2, Page(s) 612–616

Abstract: Inhibitors of angiotensin I-converting enzyme (ACE) are useful in treating hypertension, and many have been derived from food products, including soybeans. Using the industrial protease PROTIN SD-NY10, we developed a processed soya milk (PSM) with ... ...

Abstract	Inhibitors of angiotensin I-converting enzyme (ACE) are useful in treating hypertension, and many have been derived from food products, including soybeans. Using the industrial protease PROTIN SD-NY10, we developed a processed soya milk (PSM) with enhanced ACE inhibitory activity. The ACE inhibitory activity of PSM (IC(50)=0.26 μg/ml) was greater than that of regular soya milk (IC(50)=8.75 μg/ml). Eight novel ACE inhibitory peptides were purified from PSM by reversed-phase chromatography: FFYY (IC(50),1.9 μM), WHP (4.8 μM), FVP (10.1 μM), LHPGDAQR (10.3 μM), IAV (27.0 μM), VNP (32.5 μM), LEPP (100.1 μM), and WNPR (880.0 μM). The IC(50) values of these peptides are comparable to those reported for other ACE inhibitory peptides derived from wheat, chicken, bonito, wine, etc. Due to the relatively low IC(50) values of several peptides identified in this study, they may serve as ideal base components of food supplements for patients with hypertension.
MeSH term(s)	Angiotensin-Converting Enzyme Inhibitors/chemistry ; Angiotensin-Converting Enzyme Inhibitors/isolation & purification ; Kinetics ; Peptide Mapping ; Peptides/chemistry ; Peptides/isolation & purification ; Soy Milk/chemistry
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Peptides
Language	English
Publishing date	2013-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2012.08.080
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Article: Novel angiotensin I-converting enzyme inhibitory peptides derived from soya milk

Tomatsu, Makoto / Shimakage, Atsushi / Shinbo, Mamoru / Yamada, Seihan / Takahashi, Saori

Food chemistry. 2013 Jan. 15, v. 136, no. 2

2013

Abstract	Inhibitors of angiotensin I-converting enzyme (ACE) are useful in treating hypertension, and many have been derived from food products, including soybeans. Using the industrial protease PROTIN SD-NY10, we developed a processed soya milk (PSM) with enhanced ACE inhibitory activity. The ACE inhibitory activity of PSM (IC₅₀=0.26μg/ml) was greater than that of regular soya milk (IC₅₀=8.75μg/ml). Eight novel ACE inhibitory peptides were purified from PSM by reversed-phase chromatography: FFYY (IC₅₀,1.9μM), WHP (4.8μM), FVP (10.1μM), LHPGDAQR (10.3μM), IAV (27.0μM), VNP (32.5μM), LEPP (100.1μM), and WNPR (880.0μM). The IC₅₀ values of these peptides are comparable to those reported for other ACE inhibitory peptides derived from wheat, chicken, bonito, wine, etc. Due to the relatively low IC₅₀ values of several peptides identified in this study, they may serve as ideal base components of food supplements for patients with hypertension.
Keywords	bonito ; chickens ; dietary supplements ; hypertension ; patients ; peptides ; peptidyl-dipeptidase A ; reversed-phase chromatography ; soybeans ; soymilk ; wheat ; wines
Language	English
Dates of publication	2013-0115
Size	p. 612-616.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2012.08.080
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Article: [A Case of Duodenal Gastrointestinal Stromal Tumor Resection with Preservation of the Pancreatic Head Following Chemotherapy with Imatinib].

Inoue, Seiji / Nakauchi, Masaya / Matsuo, Kazuhiro / Amano, Sayaka / Goto, Ai / Tomatsu, Makoto / Nakamura, Kenichi / Shibasaki, Susumu / Kikuchi, Kenji / Kadoya, Shinichi / Inaba, Kazuki / Kato, Yutaro / Hanai, Tsunekazu / Sugioka, Atsushi / Uyama, Ichiro

Gan to kagaku ryoho. Cancer & chemotherapy

2019 Volume 45, Issue 13, Page(s) 2238–2240

Abstract: A 60-year-old male was admitted to our hospital on account of a duodenal submucosal tumor on the opposite side of Vater's papilla identified on a screening gastroduodenoscopy. The tumor was diagnosed as a duodenal gastrointestinal stromal tumor(GIST)due ... ...

Abstract	A 60-year-old male was admitted to our hospital on account of a duodenal submucosal tumor on the opposite side of Vater's papilla identified on a screening gastroduodenoscopy. The tumor was diagnosed as a duodenal gastrointestinal stromal tumor(GIST)due to positive c-kit and DOG1tests. Gastroduodenography and enhanced computed tomography showed a 50mm tumor widely invadingthe descendingportion of the duodenum close to the papilla of Vater and indicated the need for extended resection includingpancreaticoduodenectomy to achieve curation. Preoperative chemotherapy was initiated with imatinib mesylate(imatinib)to preserve the pancreas. A 16 month course of imatinib shrunk the tumor up to 21mm and laparoscopic partial duodenectomy was performed as a curative resection. So far, no local tumor recurrence has been seen for 26 months after the surgery. Herein, we report this case with a review of the literature.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Digestive System Surgical Procedures ; Duodenum ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Imatinib Mesylate/therapeutic use ; Male ; Middle Aged ; Pancreatic Ducts
Chemical Substances	Antineoplastic Agents ; Imatinib Mesylate (8A1O1M485B)
Language	Japanese
Publishing date	2019-04-02
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: Multiple Gastric Gastrointestinal Stromal Tumors in a Patient with Neurofibromatosis Type 1.

Tomatsu, Makoto / Isogaki, Jun / Watanabe, Takahiro / Yajima, Kiyoshige / Okumura, Takuya / Yamashita, Kimihiro / Suzuki, Kenji / Kawabe, Akihiro / Komiyama, Akira / Hirota, Seiichi

Case reports in surgery

2016 Volume 2016, Page(s) 1515202

Abstract: Gastrointestinal stromal tumors (GISTs) are relatively common in neurofibromatosis type 1 (NF 1) patients. Approximately 90% of GISTs associated with NF 1 are located in the small intestine, while sporadic GISTs are most commonly located in the stomach. ... ...

Abstract	Gastrointestinal stromal tumors (GISTs) are relatively common in neurofibromatosis type 1 (NF 1) patients. Approximately 90% of GISTs associated with NF 1 are located in the small intestine, while sporadic GISTs are most commonly located in the stomach. Here we report an extremely rare case of an NF 1 patient with multiple gastric GITs (90 or more) but without multiple small intestinal tumors. A 63-year-old female patient who had a history of NF 1 underwent surgery for a gastric neuroendocrine tumor and gastric submucosal tumor (SMT). During the operation, multiple small nodules were identified on the serosal surface of the upper stomach. SMT and multiple nodules on the serosal surface were diagnosed as GISTs consisting of spindle cells positive for KIT, CD34, and DOG-1. Both GIST and the normal gastric mucosa showed no mutations not only in the c-kit gene (exons 8, 9, 11, 13, and 17) but also in the PDGFRA gene (exons 12, 14, and 18). This patient is being followed up without the administration of a tyrosine kinase inhibitor.
Language	English
Publishing date	2016-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2657697-1
ISSN	2090-6919 ; 2090-6900
ISSN (online)	2090-6919
ISSN	2090-6900
DOI	10.1155/2016/1515202
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Article: Texture of Cooked Rice Prepared from Aged Rice and Its Improvement by Reducing Agents

OHNO, Toshihisa / TOMATSU, Makoto / TOEDA, Kazuki / OHISA, Naganori

Bioscience, biotechnology, and biochemistry. 2007 Dec. 23, v. 71, no. 12

2007

Abstract: The textures of cooked rice prepared from aged rice grains and their improvement by reducing agents were investigated. For aged rice that was stored for 5 months without air by the operation of a vacuum packing machine, the stickiness/hardness ratio of ... ...

Abstract	The textures of cooked rice prepared from aged rice grains and their improvement by reducing agents were investigated. For aged rice that was stored for 5 months without air by the operation of a vacuum packing machine, the stickiness/hardness ratio of cooked rice was as low as that of aged rice stored in air. The results of electrophoresis showed that oxidation of proteins in the former was advanced to the same degree as in the latter. The stickiness/hardness ratios of the aged rice were increased by the addition of sodium sulfite, cysteine, and dithiothreitol to the cooking water. Sodium sulfite, cysteine, and dithiothreitol cleave disulfide bonds to sulfhydryl groups. Therefore, cleaving disulfide bonds to sulfhydryl groups improved the texture. The addition of them to the cooking water also increased the extractable solids at the time of heating. Hence cleaving disulfide bonds to sulfhydryl groups must increase extractable solids. Consequently, the gelatinized paste layer thickened and the thick paste layer softened the cooked rice.
Keywords	air ; biotechnology ; cysteine ; disulfides ; dithiothreitol ; electrophoresis ; gelatinization ; hardness ; oxidation ; rice ; sodium sulfite ; stickiness ; texture
Language	English
Dates of publication	2007-1223
Size	p. 2912-2920.
Publishing place	Japan Society for Bioscience, Biotechnology, and Agrochemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1271/bbb.70279
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Texture of cooked rice prepared from aged rice and its improvement by reducing agents.

Ohno, Toshihisa / Tomatsu, Makoto / Toeda, Kazuki / Ohisa, Naganori

Bioscience, biotechnology, and biochemistry

2007 Volume 71, Issue 12, Page(s) 2912–2920

Abstract	The textures of cooked rice prepared from aged rice grains and their improvement by reducing agents were investigated. For aged rice that was stored for 5 months without air by the operation of a vacuum packing machine, the stickiness/hardness ratio of cooked rice was as low as that of aged rice stored in air. The results of electrophoresis showed that oxidation of proteins in the former was advanced to the same degree as in the latter. The stickiness/hardness ratios of the aged rice were increased by the addition of sodium sulfite, cysteine, and dithiothreitol to the cooking water. Sodium sulfite, cysteine, and dithiothreitol cleave disulfide bonds to sulfhydryl groups. Therefore, cleaving disulfide bonds to sulfhydryl groups improved the texture. The addition of them to the cooking water also increased the extractable solids at the time of heating. Hence cleaving disulfide bonds to sulfhydryl groups must increase extractable solids. Consequently, the gelatinized paste layer thickened and the thick paste layer softened the cooked rice.
MeSH term(s)	Cooking ; Cysteine/chemistry ; Dithiothreitol/chemistry ; Oryza/chemistry ; Reducing Agents/chemistry ; Sulfites/chemistry
Chemical Substances	Reducing Agents ; Sulfites ; Cysteine (K848JZ4886) ; Dithiothreitol (T8ID5YZU6Y) ; sodium sulfite (VTK01UQK3G)
Language	English
Publishing date	2007-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1271/bbb.70279
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Article: [A Case of Robot-Assisted Conversion Surgery for Gastric Cancer with Peritoneal Dissemination That Responded to Intravenous and Intraperitoneal Paclitaxel Combined with S-1 Chemotherapy].

Hattori, Yutaka / Nakauchi, Masaya / Tsuru, Yasuhiro / Amano, Sayaka / Goto, Ai / Tomatsu, Makoto / Nakamura, Kenichi / Kikuchi, Kenji / Kadoya, Shinichi / Inaba, Kazuki / Kato, Yutaro / Hanai, Tsunekazu / Sugioka, Atsushi / Uyama, Ichiro

Gan to kagaku ryoho. Cancer & chemotherapy

2018 Volume 46, Issue 1, Page(s) 112–114

Abstract: This case involved a 69-year-old female patient with peritoneal dissemination of an advanced gastric cancer. She underwent chemotherapy comprisingintravenous and intraperitoneal paclitaxel combined with S-1. After 20 courses, a staging laparoscopy was ... ...

Abstract	This case involved a 69-year-old female patient with peritoneal dissemination of an advanced gastric cancer. She underwent chemotherapy comprisingintravenous and intraperitoneal paclitaxel combined with S-1. After 20 courses, a staging laparoscopy was performed, and pathological analysis of the peritoneal dissemination and cytologic analysis of ascites fluid yielded negative results. A radical robot-assisted total gastrectomy was successfully performed. The pathological stage was determined to be ypT4aN2M0, ypStage ⅢB. We continued to administer the same chemotherapy regimen for 15 courses (total: 35 courses)after surgery. No recurrence has been detected during the 1-year period after surgery.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols ; Drug Combinations ; Female ; Gastrectomy ; Humans ; Oxonic Acid ; Paclitaxel ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/surgery ; Robotic Surgical Procedures ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Tegafur
Chemical Substances	Drug Combinations ; Tegafur (1548R74NSZ) ; Oxonic Acid (5VT6420TIG) ; Paclitaxel (P88XT4IS4D)
Language	Japanese
Publishing date	2018-07-19
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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