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  1. Article ; Online: "A star is born"-A unique case of an intranasal foreign body.

    Andrianakis, Alexandros / Tomazic, Peter Valentin

    Wiener klinische Wochenschrift

    2024  

    Language English
    Publishing date 2024-01-04
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-023-02320-2
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  2. Article ; Online: Observing the brain pulsating.

    Andrianakis, Alexandros / Tomazic, Peter Valentin

    Wiener klinische Wochenschrift

    2021  Volume 133, Issue 23-24, Page(s) 1328–1329

    MeSH term(s) Brain/diagnostic imaging ; Humans
    Language English
    Publishing date 2021-11-19
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-021-01980-2
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  3. Article: Frontobasischirurgie

    Tomazic, Peter Valentin

    Wiener medizinische Wochenschrift : Skriptum : Kongressjournal

    2019  Volume 16, Issue 7, Page(s) 19

    Language German
    Document type Article
    ZDB-ID 2142526-7
    ISSN 1613-3803 ; 0043-5341
    Database Current Contents Medicine

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  4. Article ; Online: Nasal mucus proteome and its involvement in allergic rhinitis.

    Tomazic, Peter Valentin / Darnhofer, Barbara / Birner-Gruenberger, Ruth

    Expert review of proteomics

    2020  Volume 17, Issue 3, Page(s) 191–199

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Biomarkers/metabolism ; Humans ; Mass Spectrometry ; Nasal Mucosa/metabolism ; Nasal Mucosa/pathology ; Proteome/genetics ; Proteomics ; Rhinitis, Allergic/genetics ; Rhinitis, Allergic/pathology
    Chemical Substances Biomarkers ; Proteome
    Language English
    Publishing date 2020-04-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2299100-1
    ISSN 1744-8387 ; 1478-9450
    ISSN (online) 1744-8387
    ISSN 1478-9450
    DOI 10.1080/14789450.2020.1748502
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  5. Article ; Online: Current and emerging pharmacotherapy for pediatric allergic rhinitis.

    Tomazic, Peter Valentin / Lang-Loidolt, Doris

    Expert opinion on pharmacotherapy

    2020  Volume 22, Issue 7, Page(s) 849–855

    Abstract: Introduction: Allergic rhinitis (AR) is a global health problem in adults as well as the younger population, continuously increasing and posing a significant problem for patients, health care systems and economies. For the younger population, some ... ...

    Abstract Introduction: Allergic rhinitis (AR) is a global health problem in adults as well as the younger population, continuously increasing and posing a significant problem for patients, health care systems and economies. For the younger population, some aspects differ from treatment of adults, namely, prevention, compliance and adherence.
    Areas covered: This narrative review summarizes all the pharmacotherapeutic options with special focus on the pediatric population. Moreover, it elucidates prevention strategies as well as future developments of AR treatment. Currently, symptomatic therapy in the form of steroids and antihistamines is applied topically and systemically where steroids need to be administered with caution and for a very short term. The only disease-modifying and causal treatment is allergen immunotherapy administered sublingually and subcutaneously. Future and current novel therapeutic options are human monoclonal antibodies.
    Expert opinion: The greatest potential for future developments currently lie in allergen immunotherapy and here in different routes of administration and modification of (recombinant) allergens as well as immune-modulating adjuvants and nanoparticles. Secondly, monoclonal antibodies are promising molecules blocking and/or interfering with up- and downstream immune mechanisms. Another important aspect lies in prevention of allergic sensitization and disease progression through both AIT and biologics which is particularly true for the pediatric population.
    MeSH term(s) Adult ; Allergens ; Child ; Desensitization, Immunologic ; Forecasting ; Histamine Antagonists/therapeutic use ; Humans ; Rhinitis, Allergic/drug therapy
    Chemical Substances Allergens ; Histamine Antagonists
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2020.1808622
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  6. Article ; Online: Comparative proteomics of common allergenic tree pollens of birch, alder, and hazel.

    Darnhofer, Barbara / Tomin, Tamara / Liesinger, Laura / Schittmayer, Matthias / Tomazic, Peter Valentin / Birner-Gruenberger, Ruth

    Allergy

    2021  Volume 76, Issue 6, Page(s) 1743–1753

    Abstract: Background: In addition to known allergens, other proteins in pollen can aid the development of an immune response in allergic individuals. The contribution of the "unknown" protein allergens is apparent in phylogenetically related species where, ... ...

    Abstract Background: In addition to known allergens, other proteins in pollen can aid the development of an immune response in allergic individuals. The contribution of the "unknown" protein allergens is apparent in phylogenetically related species where, despite of high homology of the lead allergens, the degree of allergenic potential can vary greatly. The aim of this study was to identify other potentially allergenic proteins in pollen of three common and highly related allergenic tree species: birch (Betula pendula), hazel (Corylus avellana) and alder (Alnus glutinosa).
    Methods: For that purpose, we carried out a comprehensive, comparative proteomic screening of the pollen from the three species. In order to maximize protein recovery and coverage, different protein extraction and isolation strategies during sample preparation were employed.
    Results: As a result, we report 2500-3000 identified proteins per each of the pollen species. Identified proteins were further used for a number of annotation steps, providing insight into differential distribution of peptidases, peptidase inhibitors and other potential allergenic proteins across the three species. Moreover, we carried out functional enrichment analyses that, interestingly, corroborated high species similarity in spite of their relatively distinct protein profiles.
    Conclusion: We provide to our knowledge first insight into proteomes of two very important allergenic pollen types, hazel and alder, where not even transcriptomics data are available, and compared them to birch. Datasets from this study can be readily used as protein databases and as such serve as basis for further functional studies.
    MeSH term(s) Allergens ; Alnus ; Betula ; Corylus ; Humans ; Pollen ; Proteomics ; Trees
    Chemical Substances Allergens
    Language English
    Publishing date 2021-01-15
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14694
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  7. Article ; Online: Septoplasties are unlikely to cause postoperative numbness of the anterior palate.

    Andrianakis, Alexandros / Bachlechner, Magdalena / Kainz, Josef / Herber, Valentin / Payer, Michael / Tomazic, Peter Valentin

    Wiener klinische Wochenschrift

    2021  Volume 134, Issue 7-8, Page(s) 319–323

    Abstract: Background: Septoplasties and septorhinoplasties are very commonly performed surgical procedures in modern aesthetic and functional medicine. Throughout the surgery, close manipulation to the incisive nerves' course is being executed. This retrospective ...

    Abstract Background: Septoplasties and septorhinoplasties are very commonly performed surgical procedures in modern aesthetic and functional medicine. Throughout the surgery, close manipulation to the incisive nerves' course is being executed. This retrospective analysis followed up on potential sensitivity disorders of the anterior palate due to nerve damage.
    Methods: This retrospective review of 2000 patients' charts, who had undergone the procedure of a septoplasty or septorhinoplasty between June 2013 and January 2019 was conducted at the Department of General Otorhinolaryngology, Medical University of Graz. Medical records of all included patients were reviewed with special attention to postoperative numbness of the anterior palate.
    Results: Among the 2000 included patients, a septoplasty was performed in 48% (n = 955), a septorhinoplasty in 35% (n = 703) and a septoplasty in combination with a functional endoscopic sinus surgery in 17% (n = 342). In total, 86% (n = 1721) showed no complications at all during the follow-up period. In 0.25% (n = 5) a sensitivity disorder of the anterior palate occurred. Of the five cases with a postoperative numbness of the anterior palate four occurred after a septoplasty and the fifth occurred following a septorhinoplasty.
    Conclusion: At this current time, this is the largest study investigating postoperative numbness of the anterior palate retracing septoplasty or septorhinoplasty. As a result, the currently used techniques for the operations do not pose a risk for the incisive nerve despite close surgical manipulation to the nerves' course. Nevertheless, patients should be informed and educated about the possibility of an occurring sensitivity disorder regarding the anterior palate during informed consent.
    MeSH term(s) Humans ; Hypesthesia/diagnosis ; Hypesthesia/etiology ; Hypesthesia/surgery ; Nasal Septum/surgery ; Palate/surgery ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Retrospective Studies ; Rhinoplasty/adverse effects ; Rhinoplasty/methods
    Language English
    Publishing date 2021-01-09
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-020-01800-z
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  8. Article ; Online: Sinonasal mucosal melanoma: treatment strategies and survival rates for a rare disease entity : A single center experience and review of literature.

    Andrianakis, Alexandros / Kiss, Peter / Pomberger, Markus / Wolf, Axel / Thurnher, Dietmar / Tomazic, Peter Valentin

    Wiener klinische Wochenschrift

    2021  Volume 133, Issue 21-22, Page(s) 1137–1147

    Abstract: Background: Sinonasal mucosal melanoma (SNMM) is a rare disease entity comprising 0.4-1.3% of all melanomas. Surgery with free margins has been the primary treatment over decades. Neither the addition of radiotherapy nor chemotherapy could significantly ...

    Abstract Background: Sinonasal mucosal melanoma (SNMM) is a rare disease entity comprising 0.4-1.3% of all melanomas. Surgery with free margins has been the primary treatment over decades. Neither the addition of radiotherapy nor chemotherapy could significantly improve outcome rates of this devastating malignancy. This study presents our clinical experience with SNMM over a 19-year period and summarizes the current body of literature on SNMM.
    Methods: This retrospective analysis included 12 patients with SNMM treated from 2001 to 2019 at an academic center. Additionally, a literature review of the last 29 years on treatment and survival data of SNMM was conducted.
    Results: Main initial symptoms were epistaxis and nasal obstruction. Of the patients 9 underwent endoscopic surgery, 6 received adjuvant therapy. 3 patients who did not undergo surgery, received chemoradiotherapy, radiotherapy alone, and chemotherapy alone, respectively. At the time of diagnosis 2 patients had distant metastases and 4 patients developed distant metastases during the course of the disease. Mean overall survival (OS) was 30.6 months, 3‑year and 5‑year OS were 25%, and 18.2%, respectively.
    Conclusion: Unspecific symptoms and hidden anatomic locations lead to delayed diagnosis and increased rates of metastatic dissemination. Distant metastasis is the main treatment failure in SNMM. Surgery with free margins remains the primary treatment for SNMM. Adjuvant radiotherapy might improve local control in individual cases but efficient systemic therapy is needed to improve outcome rates. To evaluate and define more effective targeted treatment options and improve outcome rates, homogeneous data and prospective multicentric analysis are needed.
    MeSH term(s) Humans ; Melanoma/therapy ; Nasal Mucosa ; Paranasal Sinus Neoplasms/therapy ; Prospective Studies ; Rare Diseases ; Retrospective Studies ; Survival Rate
    Language English
    Publishing date 2021-04-12
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-021-01847-6
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  9. Article ; Online: Optic nerve injury in preoperative imaging is associated with visual improvement outcome in endoscopic optic nerve decompression.

    Leitner, Isabella / Andrianakis, Alexandros / Gellner, Verena / Kiss, Peter / Andrianakis, Damianos / Tomazic, Peter Valentin

    Wiener klinische Wochenschrift

    2021  Volume 134, Issue 5-6, Page(s) 185–194

    Abstract: Objective: To evaluate potential clinical parameters having an impact on visual outcome after endoscopic optic nerve decompression in acute optic neuropathy patients.: Methods: A retrospective chart review of patients with acute optic neuropathy, who ...

    Abstract Objective: To evaluate potential clinical parameters having an impact on visual outcome after endoscopic optic nerve decompression in acute optic neuropathy patients.
    Methods: A retrospective chart review of patients with acute optic neuropathy, who underwent endoscopic optic nerve decompression between June 2001 and November 2018 at an academic center was performed. Patients were divided into groups according to visual improvement after surgical treatment (yes/no). Following clinical parameters were compared between groups: perioperative steroid use, evidence of optic nerve affection in preoperative neuroimaging, additional optic nerve sheath incision, surgery delay and preoperative C-reactive protein (CRP) levels. Further subgroups analyses were conducted based on etiology (trauma/tumor).
    Results: Among 32 included cases, 16 patients (50%) reported visual improvement after endoscopic optic nerve decompression. There was no significant difference in visual improvement between etiology subgroups (trauma: n = 9/20 (45%) vs. tumor: n = 7/12 (58.3%), p = 0.465). Tumor subgroup patients with visual improvement had a significantly higher prevalence of optic nerve affection in preoperative neuroimaging than those without visual improvement (p = 0.018, φ = 0.683). Perioperative steroid administration was negatively associated with visual outcome (p = 0.034, φ = 0.375). Nerve sheath incision, surgery delay and preoperative CRP levels did not have a significant impact on visual outcome (p > 0.05).
    Conclusion: Radiological findings can help as an indicator for surgical treatment since an affected optic nerve in preoperative neuroimaging resulted in better visual outcome after surgery. The use of steroids should be considered more carefully since it did not show any beneficial effect.
    MeSH term(s) Decompression, Surgical/methods ; Humans ; Optic Nerve/diagnostic imaging ; Optic Nerve/surgery ; Optic Nerve Injuries/complications ; Optic Nerve Injuries/diagnosis ; Optic Nerve Injuries/surgery ; Retrospective Studies ; Treatment Outcome ; Visual Acuity
    Language English
    Publishing date 2021-08-03
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-021-01915-x
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  10. Article ; Online: 3D endoscopy shows enhanced anatomical details and depth perception vs 2D: a multicentre study.

    Tomazic, Peter Valentin / Sommer, Fabian / Treccosti, Andreas / Briner, Hans Rudolf / Leunig, Andreas

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2020  Volume 278, Issue 7, Page(s) 2321–2326

    Abstract: Purpose: The current standard endoscopic technique is a high resolution visualisation up to Full HD and even 4 K. A recent development are 3D endoscopes providing a 3-dimensional picture, which supposedly gives additional information of depth, ... ...

    Abstract Purpose: The current standard endoscopic technique is a high resolution visualisation up to Full HD and even 4 K. A recent development are 3D endoscopes providing a 3-dimensional picture, which supposedly gives additional information of depth, anatomical details and orientation in the surgical field. Since the 3D-endoscopic technique is new, little scientific evidence is known whether the new technique provides advantages for the surgeon compared to the 2D-endoscopic standard technique in FESS. This study compares the standard 2D-endoscopic surgical technique with the new commercially available 3D-endoscopic technique.
    Methods: The prospective randomized interventional multicenter study included a total of 80 referred patients with chronic rhinosinusitis with and without polyps without prior surgery. A bilateral FESS procedure was performed, one side with the 2D-endoscopic technique, the other side with the 3D-endoscopic technique. The time of duration was measured. Additionally, a questionnaire containing 20 items was completed by 4 different surgeons judging subjective impression of visualisation and handling.
    Results: 2D imaging was superior to 3D apart from "recognition of details", "depth perception" and "3D effect". For usability properties 2D was superior to 3D apart from "weight of endoscopes". Mean duration for surgery was 26.1 min for 2D and 27.4 min. for 3D without statistical significance (P = 0.219).
    Conclusion: Three-dimensional endoscopy features improved depth perception and recognition of anatomic details but worse overall picture quality. It is useful for teaching purposes, yet 2D techniques provide a better outcome in terms of feasibility for routine endoscopic approaches.
    MeSH term(s) Depth Perception ; Endoscopes ; Endoscopy ; Humans ; Imaging, Three-Dimensional ; Prospective Studies
    Language English
    Publishing date 2020-12-29
    Publishing country Germany
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-020-06495-6
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