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  1. Article: No Association of

    Nagata, Michelle / Tome, Anne / White, Kami / Wilkens, Lynne R / Park, Song-Yi / Le Marchand, Loïc / Haiman, Christopher / Hernandez, Brenda Y

    Cancers

    2023  Volume 15, Issue 21

    Abstract: The potential involvement of a sexually transmitted agent has been suggested to contribute to the high number of prostate cancers in the United States and worldwide. We investigated the relationship ... ...

    Abstract The potential involvement of a sexually transmitted agent has been suggested to contribute to the high number of prostate cancers in the United States and worldwide. We investigated the relationship of
    Language English
    Publishing date 2023-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15215194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case-control study of the Multiethnic Cohort Study.

    DeRouen, Mindy C / Yang, Juan / Li, Yuqing / Franke, Adrian A / Tome, Anne N / White, Kami K / Hernandez, Brenda Y / Shvetsov, Yurii / Setiawan, Veronica / Wu, Anna H / Wilkens, Lynne R / Le Marchand, Loïc / Loo, Lenora W M / Cheng, Iona

    Breast cancer research : BCR

    2023  Volume 25, Issue 1, Page(s) 95

    Abstract: Background: Laboratory studies have indicated that a cholesterol metabolite and selective estrogen receptor modulator, 27-hydroxycholesterol (27HC), may be important in breast cancer etiology and explain associations between obesity and postmenopausal ... ...

    Abstract Background: Laboratory studies have indicated that a cholesterol metabolite and selective estrogen receptor modulator, 27-hydroxycholesterol (27HC), may be important in breast cancer etiology and explain associations between obesity and postmenopausal breast cancer risk. Epidemiologic evidence for 27HC in breast cancer risk is limited, particularly in multiethnic populations.
    Methods: In a nested case-control study of 1470 breast cancer cases and 1470 matched controls within the Multiethnic Cohort Study, we examined associations of pre-diagnostic circulating 27HC with breast cancer risk among African American, Japanese American, Native Hawaiian, Latino, and non-Latino White postmenopausal females. We used multivariable logistic regression adjusted for age, education, parity, body mass index, and smoking status. Stratified analyses were conducted across racial and ethnic groups, hormone receptor (HR) status, and use of lipid-lowering drugs. We assessed interactions of 27HC with steroid hormones.
    Results: 27HC levels were inversely related to breast cancer risk (odds ratio [OR] 0.80; 95% confidence interval [CI] 0.58, 1.12), but the association was not statistically significant in the full model. Directions of associations differed by racial and ethnic group. Results suggested an inverse association with HR-negative breast cancer (OR 0.46; 95% CI 0.20, 1.06). 27HC interacted with testosterone, but not estrone, on risk of breast cancer; 27HC was only inversely associated with risk among those with the highest levels of testosterone (OR 0.46; 95% CI 0.24, 0.86).
    Conclusion: This is the first US study to examine circulating 27HC and breast cancer risk and reports a weak inverse association that varies across racial and ethnic groups and testosterone level.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Cohort Studies ; Case-Control Studies ; Risk Factors ; Hydroxycholesterols ; Testosterone
    Chemical Substances 27-hydroxycholesterol (6T2NA6P5SQ) ; Hydroxycholesterols ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/s13058-023-01693-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Impact of diet on mortality from stroke: results from the U.S. multiethnic cohort study.

    Sharma, Sangita / Cruickshank, J Kennedy / Green, Deborah M / Vik, Shelly / Tome, Anne / Kolonel, Laurence N

    Journal of the American College of Nutrition

    2013  Volume 32, Issue 3, Page(s) 151–159

    Abstract: Objectives: Stroke is the fourth leading cause of death in the United States and stroke mortality rates vary by ethnicity. The purpose of this study was to examine the associations between food group consumption and risk of death from stroke among 5 ... ...

    Abstract Objectives: Stroke is the fourth leading cause of death in the United States and stroke mortality rates vary by ethnicity. The purpose of this study was to examine the associations between food group consumption and risk of death from stroke among 5 ethnic groups in the United States.
    Methods: The Multiethnic Cohort includes >215,000 participants, the majority of whom are African American, Native Hawaiian, Japanese American, Latino, and Caucasian men and women recruited by mail survey in Hawaii and Los Angeles in 1993-1996. Deaths from stroke were identified by linkage to the state death files and the U.S. National Death Index. Diet was assessed using a validated food frequency questionnaire. Associations were examined using multivariable Cox proportional hazards models, stratified by ethnicity and gender.
    Results: A total of 860 deaths from stroke were identified among the cohort participants. Vegetable intake was associated with a significant reduction in risk for fatal stroke among African American women (relative risk [RR]=0.60; 95% CI: 0.36-0.99). Among Japanese American women only, high fruit intake was significantly associated with a risk reduction for stroke mortality (RR=0.43; 95% confidence interval [CI]: 0.22-0.85), whereas meat intake increased risk (RR=2.36; 95% CI: 1.31-4.26). Among men, a significant reduction in stroke mortality was observed among Native Hawaiians (RR=0.26; 95% CI: 0.07-0.95). After pooling the data for the ethnic groups, the findings support an elevated risk for high meat intake among women overall (RR=1.56; 95% CI: 1.12-2.16); no significant effects of dietary intake on risk for fatal stroke were observed among men.
    Conclusions: Although some variations were observed for the associations between diet and stroke mortality among ethnic groups, the findings suggest that these differences are not substantial and may be due to dietary intake of specific food subgroups. Additional investigations including dietary subgroups and nutrients sources are needed to clarify these findings.
    MeSH term(s) African Americans/statistics & numerical data ; Aged ; Asian Americans/statistics & numerical data ; Cohort Studies ; Diet ; Ethnic Groups/statistics & numerical data ; European Continental Ancestry Group/statistics & numerical data ; Feeding Behavior ; Female ; Follow-Up Studies ; Hawaii ; Hispanic Americans/statistics & numerical data ; Humans ; Los Angeles ; Male ; Middle Aged ; Nutrition Assessment ; Nutrition Surveys ; Proportional Hazards Models ; Risk Factors ; Stroke/mortality ; Surveys and Questionnaires ; Vegetables
    Language English
    Publishing date 2013-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603204-7
    ISSN 1541-1087 ; 0731-5724
    ISSN (online) 1541-1087
    ISSN 0731-5724
    DOI 10.1080/07315724.2013.791798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1759: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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