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  1. Book ; Thesis: Die Rolle von γδ T-Lymphozyten bei atypischem schwerem kombiniertem Immundefekt

    Tometten, Inga

    2020  

    Title variant Die Rolle von Gamma Delta T-Lymphozyten bei atypischem schwerem kombiniertem Immundefekt
    Author's details vorgelegt 2018 von Inga Ursula Henrike Tometten, geb. Schulte
    Language German
    Size VIII, 110 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Freiburg im Breisgau
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2020
    HBZ-ID HT020912562
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 E 605 order for loan Magazin

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  2. Article ; Online: Odynophagia as the first symptom of monkeypox infection.

    Schröder, Nadja / Buth, Juliane / Drexler, Ingo / Adams, Ortwin / Tometten, Inga / Seidl, Maximilian / Rubbert, Christian / Schipper, Jörg / Kristin, Julia

    HNO

    2023  Volume 71, Issue Suppl 1, Page(s) 50–52

    Abstract: A 50-year-old patient with confirmed monkeypox infection presented with odynophagia and nocturnal dyspnea. Clinically, there was a lesion on the tongue without any skin lesions and fibrinous plaques on the right tonsil with asymmetry of the palatoglossal ...

    Title translation Odynophagie als erstes Symptom bei Affenpocken-Infektion.
    Abstract A 50-year-old patient with confirmed monkeypox infection presented with odynophagia and nocturnal dyspnea. Clinically, there was a lesion on the tongue without any skin lesions and fibrinous plaques on the right tonsil with asymmetry of the palatoglossal arch. Due to a suggested abscess in the CT scan, a tonsillectomy à chaud was performed. By pan-orthopox-specific polymerase chain reaction (PCR) the monkeypox infection was also confirmed in the tonsil tissue. Isolated oral findings may represent a monkeypox infection and should be considered as a currently important differential diagnosis, especially for patients at risks.
    MeSH term(s) Humans ; Middle Aged ; Tonsillitis/surgery ; Mpox (monkeypox)/diagnosis ; Mpox (monkeypox)/pathology ; Palatine Tonsil/pathology ; Tonsillectomy ; Abscess/pathology ; Pain/pathology
    Language English
    Publishing date 2023-06-12
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    DOI 10.1007/s00106-023-01283-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Odynophagie als erstes Symptom bei Affenpocken-Infektion.

    Schröder, Nadja / Buth, Juliane / Drexler, Ingo / Adams, Ortwin / Tometten, Inga / Seidl, Maximilian / Rubbert, Christian / Schipper, Jörg / Kristin, Julia

    HNO

    2023  Volume 71, Issue 5, Page(s) 319–322

    Abstract: A 50-year-old patient with confirmed monkeypox infection presented with odynophagia and nocturnal dyspnea. Clinically, there was a lesion on the tongue without any skin lesions and fibrinous plaques on the right tonsil with asymmetry of the palatoglossal ...

    Title translation Odynophagia as the first symptom of monkeypox infection.
    Abstract A 50-year-old patient with confirmed monkeypox infection presented with odynophagia and nocturnal dyspnea. Clinically, there was a lesion on the tongue without any skin lesions and fibrinous plaques on the right tonsil with asymmetry of the palatoglossal arch. Due to a suggested abscess in the CT scan, a tonsillectomy à chaud was performed. By pan-orthopox-specific polymerase chain reaction (PCR) the monkeypox infection was also confirmed in the tonsil tissue. Isolated oral findings may represent a monkeypox infection and should be considered as a currently important differential diagnosis, especially for patients at risks.
    MeSH term(s) Mpox (monkeypox)/complications ; Mpox (monkeypox)/diagnosis ; Mpox (monkeypox)/drug therapy ; Deglutition Disorders/diagnosis ; Deglutition Disorders/virology ; Palatine Tonsil/diagnostic imaging ; Palatine Tonsil/pathology ; Palatine Tonsil/surgery ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; Monkeypox virus/isolation & purification ; Tonsillectomy ; Pain/diagnosis ; Tomography, X-Ray Computed
    Language German
    Publishing date 2023-03-31
    Publishing country Germany
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    DOI 10.1007/s00106-023-01282-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  4. Article ; Online: Real-world performance of the NeuMoDx™ HCV Quant Test for quantification of hepatitis C virus (HCV)-RNA.

    Lübke, Nadine / Walker, Andreas / Obermeier, Martin / Camdereli, Jennifer / Paluschinski, Martha / Walotka, Lara / Schupp, Anna-Kathrin / Tometten, Inga / Hauka, Sandra / Heger, Eva / Timm, Jörg

    Journal of virological methods

    2024  Volume 327, Page(s) 114937

    Abstract: Quantification of hepatitis C virus (HCV)-RNA in serum or plasma samples is an essential parameter in HCV diagnostics. Here, the NeuMoDx™Molecular System (Qiagen) was tested for the most common HCV genotypes and compared to the cobas c6800 system (Roche). ...

    Abstract Quantification of hepatitis C virus (HCV)-RNA in serum or plasma samples is an essential parameter in HCV diagnostics. Here, the NeuMoDx™Molecular System (Qiagen) was tested for the most common HCV genotypes and compared to the cobas c6800 system (Roche). HCV-RNA from 131 plasma/serum samples from chronically infected patients was determined in parallel on the NeuMoDx and c6800 systems. Linearity was analysed using the four most common HCV genotypes (1-4) in our cohort. The coefficient of variation (CV) within (intra-assay) and between (inter-assay) runs was calculated based on HCV-RNA concentration. Quantitative HCV-RNA results were highly correlated on both test systems (R
    Language English
    Publishing date 2024-04-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2024.114937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Factors Associated With Vaccine-Induced T-Cell Immune Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Kidney Transplant Recipients.

    Tometten, Inga / Landmann, Sinje / Kantauskaite, Marta / Lamberti, Joshua / Hillebrandt, Jonas / Müller, Lisa / Kittel, Margarethe / Kolb, Thilo / Ivens, Katrin / Schmitz, Michael / Voges, Anja / Adams, Ortwin / Andrée, Marcel / Schaal, Heiner / Lübke, Nadine / Königshausen, Eva / Rump, Lars Christian / Stegbauer, Johannes / Timm, Jörg

    The Journal of infectious diseases

    2022  Volume 227, Issue 5, Page(s) 641–650

    Abstract: Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important prophylactic measure in kidney transplant recipients (KTRs), but the immune response is often impaired. Here, we examined the T-cell immune response against ... ...

    Abstract Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important prophylactic measure in kidney transplant recipients (KTRs), but the immune response is often impaired. Here, we examined the T-cell immune response against SARS-CoV-2 in 148 KTRs after 3 or 4 vaccine doses, including 35 KTRs with subsequent SARS-CoV-2 infection. The frequency of spike-specific T cells was lower in KTRs than in immunocompetent controls and was correlated with the level of spike-specific antibodies. Positive predictors for detection of vaccine-induced T cells were detection of spike-specific antibodies, heterologous immunization with messenger RNA and a vector vaccine, and longer time after transplantation. In vaccinated KTRs with subsequent SARS-CoV-2 infection, the T-cell response was greatly enhanced and was significantly higher than in vaccinated KTRs without SARS-CoV-2 infection. Overall, the data show a correlation between impaired humoral and T-cell immunity to SARS-CoV-2 vaccination and provide evidence for greater robustness of hybrid immunity in KTRs.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; COVID-19 Vaccines ; Kidney Transplantation ; T-Lymphocytes ; Vaccines ; Transplant Recipients ; Antibodies ; Immunity
    Chemical Substances COVID-19 Vaccines ; Vaccines ; Antibodies
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Increased proportions of γδ T lymphocytes in atypical SCID associate with disease manifestations.

    Tometten, Inga / Felgentreff, Kerstin / Hönig, Manfred / Hauck, Fabian / Albert, Michael H / Niehues, Tim / Perez, Ruy / Ghosh, Sujal / Picard, Capucine / Stary, Jan / Formankova, Renata / Worth, Austen / Soler-Palacín, Pere / García-Prat, Marina / Allende, Luis M / Gonzalez-Granado, Luis Ignacio / Stepensky, Polina / Di Cesare, Silvia / Scarselli, Alessia /
    Cancrini, Caterina / Speckmann, Carsten / Gilmour, Kimberly / Notarangelo, Luigi / Ehl, Stephan / Rohr, Jan C

    Clinical immunology (Orlando, Fla.)

    2019  Volume 201, Page(s) 30–34

    Abstract: Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, ... ...

    Abstract Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, it is unknown whether these γδ T cells modulate or reflect the patient's clinical phenotype. We investigated the frequency of elevated γδ T cell proportions and associations with clinical disease manifestations in a cohort of 76 atypical SCID patients. Increased proportions of γδ T lymphocytes were present in approximately 60% of these patients. Furthermore, we identified positive correlations between elevated proportions of γδ T cells and the occurrence of CMV infections and autoimmune cytopenias. We discuss that CMV infections might trigger an expansion of γδ T lymphocytes, which could drive the development of autoimmune cytopenias. We advocate that atypical SCID patients should be screened for elevated proportions of γδ T lymphocytes, CMV infection and autoimmune cytopenias.
    MeSH term(s) Cytomegalovirus Infections/immunology ; Hematologic Diseases/immunology ; Humans ; Intraepithelial Lymphocytes/immunology ; Lymphocyte Count ; Severe Combined Immunodeficiency/immunology
    Language English
    Publishing date 2019-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2018.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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