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  1. Article ; Online: Endoscopic ultrasound sclerotherapy for refractory hepatic encephalopathy associated with rectal varices.

    Tominaga, Shintaro / Kobayashi, Makoto / Kato, Hiroki

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2024  Volume 36, Issue 3, Page(s) 382–383

    MeSH term(s) Humans ; Sclerotherapy ; Hepatic Encephalopathy/diagnostic imaging ; Hepatic Encephalopathy/etiology ; Hepatic Encephalopathy/therapy ; Varicose Veins/complications ; Varicose Veins/diagnostic imaging ; Varicose Veins/therapy ; Rectum ; Esophageal and Gastric Varices/complications ; Esophageal and Gastric Varices/diagnostic imaging ; Gastrointestinal Hemorrhage/diagnostic imaging ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Recurrence
    Language English
    Publishing date 2024-01-30
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Endoscopic cutting-wave biopsy for submucosal tumors smaller than 20 mm.

    Tominaga, Shintaro / Kobayashi, Makoto / Maruyama, Akihiro / Yano, Motoyoshi

    Endoscopy

    2021  Volume 54, Issue 8, Page(s) E439–E440

    MeSH term(s) Biopsy ; Endoscopic Mucosal Resection ; Humans ; Retrospective Studies ; Stomach Neoplasms/pathology ; Treatment Outcome
    Language English
    Publishing date 2021-09-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1625-2382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Endoscopic cutting-wave biopsy for submucosal tumors smaller than 20 mm

    Tominaga, Shintaro / Kobayashi, Makoto / Maruyama, Akihiro / Yano, Motoyoshi

    Endoscopy

    2021  Volume 54, Issue 08, Page(s) E439–E440

    Language English
    Publishing date 2021-09-17
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1625-2382
    Database Thieme publisher's database

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  4. Article ; Online: Efficacy of Endoscopic Resection for Rectal Neuroendocrine Tumors Smaller than 15 mm.

    Hamada, Yasuhiko / Tanaka, Kyosuke / Mukai, Katsumi / Baba, Youichirou / Kobayashi, Makoto / Tominaga, Shintaro / Kawabata, Hiroyuki / Sawai, Shoma / Kaneko, Masabumi / Sugimoto, Shinya / Inoue, Hidekazu / Mimuro, Maya / Tamaru, Satoshi / Nakagawa, Hayato

    Digestive diseases and sciences

    2023  Volume 68, Issue 7, Page(s) 3148–3157

    Abstract: Background: Local resection, including endoscopic resection, is recommended for rectal neuroendocrine tumors (NETs) < 15 mm in patients without risk factors for metastasis, though the short- and long-term outcomes are unclear.: Aims: This study ... ...

    Abstract Background: Local resection, including endoscopic resection, is recommended for rectal neuroendocrine tumors (NETs) < 15 mm in patients without risk factors for metastasis, though the short- and long-term outcomes are unclear.
    Aims: This study investigates the efficacy of endoscopic resection for rectal NETs < 15 mm.
    Methods: The short- and long-term outcomes of patients with rectal NETs < 15 mm who underwent endoscopic resection and the outcomes of each endoscopic technique were analyzed. The tumors were stratified as < 10 mm (small-size group, SSG) and 10-14 mm (intermediate-size group, IMG).
    Results: Overall, 139 lesions (SSG, n = 118; IMG, n = 21) were analyzed. All tumors were classified as G1 (n = 135) or G2 (n = 4) according to the 2019 World Health Organization grading criteria. The complete resection rate was not different between the groups (P = 0.151). Endoscopic submucosal dissection (ESD) and endoscopic submucosal resection with a ligation device (ESMR-L) achieved complete resection rates > 90% in the SSG. The ESMR-L procedure time (P < 0.001) and hospitalized period (P < 0.001) were significantly shorter than those of ESD. ESD achieved a complete resection rate of 80.0% in the IMG. The tumor size did not affect the overall survival or rate of lymph node/distant metastases.
    Conclusions: Endoscopic resection is a feasible and effective treatment for patients with rectal NETs < 15 mm without the risk factors of metastasis. ESMR-L and ESD are optimal techniques for resecting tumors smaller than 10 mm and 10-14 mm, respectively.
    MeSH term(s) Humans ; Neuroendocrine Tumors/surgery ; Neuroendocrine Tumors/pathology ; Retrospective Studies ; Rectal Neoplasms/pathology ; Endoscopic Mucosal Resection/methods ; Treatment Outcome ; Lymphatic Metastasis/pathology ; Intestinal Mucosa/pathology
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-07914-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Development of a real-time imaging system for hypoxic cell apoptosis.

    Kagiya, Go / Ogawa, Ryohei / Hyodo, Fuminori / Yamashita, Kei / Nakamura, Mizuki / Ishii, Ayumi / Sejimo, Yukihiko / Tominaga, Shintaro / Murata, Masaharu / Tanaka, Yoshikazu / Hatashita, Masanori

    Molecular therapy. Methods & clinical development

    2016  Volume 5, Page(s) 16009

    Abstract: Hypoxic regions within the tumor form due to imbalances between cell proliferation and angiogenesis; specifically, temporary closure or a reduced flow due to abnormal vasculature. They create environments where cancer cells acquire resistance to ... ...

    Abstract Hypoxic regions within the tumor form due to imbalances between cell proliferation and angiogenesis; specifically, temporary closure or a reduced flow due to abnormal vasculature. They create environments where cancer cells acquire resistance to therapies. Therefore, the development of therapeutic approaches targeting the hypoxic cells is one of the most crucial challenges for cancer regression. Screening potential candidates for effective diagnostic modalities even under a hypoxic environment would be an important first step. In this study, we describe the development of a real-time imaging system to monitor hypoxic cell apoptosis for such screening. The imaging system is composed of a cyclic luciferase (luc) gene under the control of an improved hypoxic-responsive promoter. The cyclic luc gene product works as a caspase-3 (cas-3) monitor as it gains luc activity in response to cas-3 activation. The promoter composed of six hypoxic responsible elements and the CMV IE1 core promoter drives the effective expression of the cyclic luc gene in hypoxic conditions, enhancing hypoxic cell apoptosis visualization. We also confirmed real-time imaging of hypoxic cell apoptosis in the spheroid, which shares properties with the tumor. Thus, this constructed system could be a powerful tool for the development of effective anticancer diagnostic modalities.
    Language English
    Publishing date 2016-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2872938-9
    ISSN 2329-0501 ; 2329-0501
    ISSN (online) 2329-0501
    ISSN 2329-0501
    DOI 10.1038/mtm.2016.9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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