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  1. Book: Pathogenesis and treatment in IgA nephropathy

    Tomino, Yasuhiko

    an international comparison

    2016  

    Author's details Yasuhiko Tomino editor
    Keywords GdIgA1 ; steroid pulse therapy ; IgA1 production ; mucosal immunity
    Language English
    Size xi, 342 Seiten, Illustrationen, Diagramme, Karten, 235 mm x 155 mm, 0 g
    Publisher Springer
    Publishing place Tokyo
    Publishing country Japan
    Document type Book
    HBZ-ID HT018929951
    ISBN 978-4-431-55587-2 ; 978-4-431-55588-9 ; 4-431-55587-0 ; 4-431-55588-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 781 available for loan (reading room) Lesesaal EG

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  2. Book ; Online: IgA nephropathy today

    Tomino, Yasuhiko

    a further step towards unraveling this mysterious disease

    2007  

    Author's details vol. ed.: Yasuhiko Tomino
    Language English
    Size X + 256 S.
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    HBZ-ID TT050388189
    ISBN 978-3-318-01467-9 ; 3-318-01467-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Conference proceedings: IgA nephropathy today

    Tomino, Yasuhiko

    10 tables

    (Contributions to nephrology ; 157)

    2007  

    Event/congress International Symposium on IgA Nephropathy (11, 2006, Tokio)
    Author's details [11th International Symposium on IgA Nephropathy, October 5-7, 2006, Tokyo, Japan]. Vol. ed. Yasuhiko Tomino
    Series title Contributions to nephrology ; 157
    Collection
    Keywords Glomerulonephritis, IgA / etiology ; Glomerulonephritis, IgA / therapy ; Mesangiale Immunglobulin-A-Glomerulonephritis
    Subject Berger-Nephropathie ; IgA-Glomerulonephritis ; IgA-Nephritis ; IgA-Nephropathie
    Language English
    Size X, 255 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT015191847
    ISBN 978-3-8055-8286-5 ; 3-8055-8286-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 3440 order for loan Magazin

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  4. Book ; Online: Type 2 diabetic nephropathy in Japan

    Tomino, Yasuhiko

    from bench to bedside

    2001  

    Author's details vol. ed.: Yasuhiko Tomino
    Language English
    Size VIII + 140 S.
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    HBZ-ID TT050388410
    ISBN 978-3-318-00747-3 ; 3-318-00747-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: How to treat patients with chronic kidney disease: With special focus on IgA nephropathy.

    Tomino, Yasuhiko

    Nephrology (Carlton, Vic.)

    2018  Volume 23 Suppl 4, Page(s) 76–79

    Abstract: Chronic kidney disease has become a worldwide problem. Among chronic kidney disease patients, IgA nephropathy is common in the world. Serum levels of galactose deficient (Gd)-IgA1 and Gd-IgA1-specific antibodies are elevated in most IgA nephropathy ... ...

    Abstract Chronic kidney disease has become a worldwide problem. Among chronic kidney disease patients, IgA nephropathy is common in the world. Serum levels of galactose deficient (Gd)-IgA1 and Gd-IgA1-specific antibodies are elevated in most IgA nephropathy patients. Glomerular Gd-IgA1 deposition has been observed by immunofluorescence. There are many reports that the anti-proteinuric effect is significantly greater in groups who receive tonsillectomy with steroid pulse therapy in IgA nephropathy patients. Furthermore, patients with tonsillectomy with steroid pulse therapy have shown a strong down-regulation of delta serum IgA/C3 per year and have conserved their renal function. New treatments, that is, Atacicept and glucocorticoid budesonide, have been developed for this disease.
    MeSH term(s) Biomarkers/blood ; Glomerulonephritis, IGA/diagnosis ; Glomerulonephritis, IGA/immunology ; Glomerulonephritis, IGA/therapy ; Humans ; Immunoglobulin A/blood ; Immunoglobulin A/immunology ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Kidney Glomerulus/drug effects ; Kidney Glomerulus/immunology ; Kidney Glomerulus/pathology ; Pulse Therapy, Drug ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/immunology ; Renal Insufficiency, Chronic/therapy ; Steroids/administration & dosage ; Steroids/adverse effects ; Tonsillectomy/adverse effects ; Treatment Outcome
    Chemical Substances Biomarkers ; Immunoglobulin A ; Immunosuppressive Agents ; Steroids
    Language English
    Publishing date 2018-10-24
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.13471
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4822: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Sixth Asian Nephrology Forum

    Tomino, Yasuhiko

    held in Tokyo on March 22, 2001

    2002  

    Institution Asian Nephrology Forum
    Author's details ed.: Yasuhiko Tomino
    Language English
    Publishing country Switzerland
    Document type Article
    Note In: Kidney & blood pressure research. - ISSN 1420-4096. - 25 (2002),2, S. 115 - 126
    HBZ-ID HT013401262
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1458 -25- not available for loan Zeitschriften-Lesesaal

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  7. Book: Type-2 diabetic nephropathy in Japan

    Tomino, Yasuhiko

    from bench to bedside ; 18 tables

    (Contributions to nephrology ; 134)

    2001  

    Title variant Type-two diabetic nephropathy in Japan
    Author's details vol. ed. Yasuhiko Tomino
    Series title Contributions to nephrology ; 134
    Collection
    Keywords Diabetic Nephropathies / etiology ; Diabetes Mellitus, Non-Insulin-Dependent / complications ; Japan ; Nephropathia diabetica
    Subject Diabetische Nephropathie
    Language English
    Size VIII, 139 S. : Ill., graph. Darst., 25 cm
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT013171222
    ISBN 3-8055-7274-3 ; 978-3-8055-7274-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 5071 order for loan Magazin

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  8. Article ; Online: IgA Nephropathy: Beyond the Half-Century.

    Shimizu, Yoshio / Tomino, Yasuhiko / Suzuki, Yusuke

    Medicina (Kaunas, Lithuania)

    2023  Volume 60, Issue 1

    Abstract: In 1968, Jean Berger first introduced the medical world to IgA nephropathy (IgAN). Fifty-five years later, its pathogenesis is still unclear, but treatments such as renin-angiotensin-aldosterone system inhibitors (RAAS-Is), tonsillectomies, and ... ...

    Abstract In 1968, Jean Berger first introduced the medical world to IgA nephropathy (IgAN). Fifty-five years later, its pathogenesis is still unclear, but treatments such as renin-angiotensin-aldosterone system inhibitors (RAAS-Is), tonsillectomies, and glucocorticoids are currently used worldwide. There have been great strides in the past 20 years since the discoveries of the specific dysregulation of mucosal immunity, galactose-deficient IgA1 (Gd-IgA1), and Gd-IgA1 immune complexes in patients with IgAN. According to these findings, a multi-hit hypothesis was developed, and this multi-hit hypothesis has provided several putative therapeutic targets. A number of novel agents, including molecularly targeted drugs for targets such as APRIL, plasma cells, complement systems, and endothelin, are undergoing clinical trials. Some candidate drugs have been found to be effective, with minimal side effects. Over half a century after the discovery of IgAN, these therapies will soon be available for clinical use.
    MeSH term(s) Humans ; Glomerulonephritis, IGA/drug therapy ; Drug Delivery Systems ; Glucocorticoids ; Plasma Cells
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-12-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60010054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Pitavastatin Compared with Differential Intervention Trial by Standard Therapy on Cardiovascular Events in Patients with Dyslipidemia on Chronic Hemodialysis (DIALYSIS): A Randomized Controlled Trial.

    Hamada, Chieko / Okuda, Masumi / Tomino, Yasuhiko

    Blood purification

    2023  Volume 52, Issue 5, Page(s) 483–492

    Abstract: Introduction: Statin has been reported to reduce cardiovascular events. However, the comparative efficacy of statin with standard therapy on cardiovascular events has not been sufficiently reported in patients on chronic hemodialysis. Thus, this study ... ...

    Abstract Introduction: Statin has been reported to reduce cardiovascular events. However, the comparative efficacy of statin with standard therapy on cardiovascular events has not been sufficiently reported in patients on chronic hemodialysis. Thus, this study aimed to compare the effects of pitavastatin and standard therapy on mortality and cardiovascular events in chronic hemodialysis patients with dyslipidemia in Japan.
    Methods: Patients on chronic hemodialysis with dyslipidemia were randomized into pitavastatin-administered (pitavastatin group) or dietary therapy as standard therapy (control) group. Primary outcomes are all-cause mortality and myocardial infarction; secondary outcomes are cardiac arrest and fatal myocardial infarction. The composite outcomes included the incidence of coronary intervention, stroke, fracture, and hospitalization due to heart failure and unstable angina. The clinical outcome analyses used a logistic regression model to categorize the variables. A p value of <0.05 was considered statistically significant.
    Results: This study included 848 patients (422 in the control group and 426 in the pitavastatin group) from 79 health facilities. The mean age of the patients was 60.1±10.3 years, and the dialysis period was 7.2±7.6 years. The mean observation period was 36.5 months. The low-density lipoprotein cholesterol level was significantly lower than the baseline value in the pitavastatin group after 12 months of trial (79.8±26.1 vs. 107.8±25.5 mg/dL, p < 0.001). Moreover, the total number of deaths was 85, of which 50 occurred in the control group and 35 in the pitavastatin group. In an analysis adjusted for confounding factors due to participant attributes, there was a significant difference between the control group and the pitavastatin group in the primary and composite endpoints (p = 0.007 and p = 0.022, respectively).
    Conclusion: Our study has demonstrated that aggressive intervention with pitavastatin is more effective than the standard (dietary) therapy for improving the clinical outcomes in patients with dyslipidemia on chronic hemodialysis.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Cholesterol, LDL ; Renal Dialysis/adverse effects ; Dyslipidemias/drug therapy ; Dyslipidemias/etiology ; Myocardial Infarction/chemically induced ; Myocardial Infarction/drug therapy ; Treatment Outcome
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; pitavastatin (M5681Q5F9P) ; Cholesterol, LDL
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000528763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book: Laboratory techniques in renal cell and molecular biology

    Tomino, Yasuhiko

    3 tables

    2000  

    Author's details ed. Yasuhiko Tomino
    Keywords Nierenkrankheit ; Molekularbiologie ; Labortechnik ; Immuncytochemie
    Subject Laboratorium ; Laboratoriumstechnik ; Labormethode ; Immunhistochemie ; Immunocytochemie ; Immunzytochemie ; Immunozytochemie ; Nephropathie ; Nierenerkrankung ; Nierenerkrankungen ; Niere ; Renopathie ; Molekulare Biologie
    Language English
    Size VII, 209 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Note Aus d. Japan. übers.
    HBZ-ID HT011235423
    ISBN 3-8055-6998-X ; 978-3-8055-6998-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 1045 order for loan Magazin

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