Article ; Online: Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland Morphogenesis.
The Journal of investigative dermatology
2023 Volume 143, Issue 8, Page(s) 1529–1537.e2
Abstract: XEDAR is a member of the TNF receptor subfamily and a mediator of the ectodysplasin (EDA) pathway. EDA signaling plays evolutionarily conserved roles in the development of the ectodermal appendage organ class, which includes hair, eccrine sweat glands, ... ...
| Abstract | XEDAR is a member of the TNF receptor subfamily and a mediator of the ectodysplasin (EDA) pathway. EDA signaling plays evolutionarily conserved roles in the development of the ectodermal appendage organ class, which includes hair, eccrine sweat glands, and mammary glands. Loss-of-function sequence variants of EDA, which encodes the two major ligand isoforms, EDA-A1 and EDA-A2, result in X-linked hypohidrotic ectodermal dysplasia characterized by defects in two or more types of ectodermal appendages. EDA-A1 and EDA-A2 signal through the receptors EDAR and XEDAR, respectively. Although the contributions of the EDA-A1/EDAR signaling pathway to EDA-dependent ectodermal appendage phenotypes have been extensively characterized, the significance of the EDA-A2/XEDAR branch of the pathway has remained obscure. In this study, we report the phenotypic consequences of disrupting the EDA-A2/XEDAR pathway on mammary gland differentiation and growth. Using a mouse Xedar knockout model, we show that Xedar has a specific and temporally restricted role in promoting late pubertal growth and branching of the mammary epithelium that can be influenced by genetic background. Our findings implicate Xedar in ectodermal appendage development and suggest that the EDA-A2/XEDAR signaling axis contributes to the etiology of EDA-dependent mammary phenotypes. |
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| MeSH term(s) | Ectodysplasins/genetics ; Ectodysplasins/metabolism ; Membrane Proteins/genetics ; Morphogenesis ; Receptors, Tumor Necrosis Factor ; Signal Transduction ; Animals ; Mice |
| Chemical Substances | Ectodysplasins ; Membrane Proteins ; Receptors, Tumor Necrosis Factor |
| Language | English |
| Publishing date | 2023-02-18 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
| ZDB-ID | 80136-7 |
| ISSN | 1523-1747 ; 0022-202X |
| ISSN (online) | 1523-1747 |
| ISSN | 0022-202X |
| DOI | 10.1016/j.jid.2023.02.007 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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