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  1. Article ; Online: Distinct Requirements for Extracellular and Intracellular MMP12 in the Development of the Adult V-SVZ Neural Stem Cell Niche.

    Shan, Xiwei / Tomlinson, Lyl / Yang, Qian / Colognato, Holly

    Stem cell reports

    2018  Volume 10, Issue 3, Page(s) 984–999

    Abstract: The regulatory mechanisms that control neural stem cell (NSC) activation in the adult ventricular-subventricular zone (V-SVZ) stem cell niche have been the focus of intense investigation, yet how the niche first develops and organizes is poorly ... ...

    Abstract The regulatory mechanisms that control neural stem cell (NSC) activation in the adult ventricular-subventricular zone (V-SVZ) stem cell niche have been the focus of intense investigation, yet how the niche first develops and organizes is poorly understood. Here, we examined matrix metalloproteinases (MMPs) for potential roles in V-SVZ stem cell niche development. MMP12 was found to promote appropriate niche cellular arrangements, the formation of specialized niche extracellular matrix, and the translational planar cell polarity of ependymal cells that surround and support niche NSCs. Surprisingly, ependymal cells were found to have an intracellular pool of MMP12 that promoted ependymal cell ciliogenesis by upregulating FOXJ1. In addition, both extracellular and intracellular MMP12 were found to regulate V-SVZ niche output by promoting NSC quiescence. These findings reveal that extracellular and intracellular MMP12 have both unique and overlapping roles that help orchestrate the development of the adult V-SVZ stem cell niche.
    MeSH term(s) Animals ; Cell Polarity/physiology ; Ependyma/metabolism ; Ependyma/physiology ; Extracellular Matrix/metabolism ; Extracellular Matrix/physiology ; Forkhead Transcription Factors/metabolism ; Lateral Ventricles/metabolism ; Lateral Ventricles/physiology ; Matrix Metalloproteinase 12/metabolism ; Mice ; Mice, Inbred C57BL ; Neural Stem Cells/metabolism ; Neural Stem Cells/physiology ; Stem Cell Niche/physiology ; Up-Regulation/physiology
    Chemical Substances Forkhead Transcription Factors ; Matrix Metalloproteinase 12 (EC 3.4.24.65) ; matrix metallopeptidase 12, mouse (EC 3.4.24.65)
    Language English
    Publishing date 2018-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2018.01.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prefrontal cortex NG2 glia undergo a developmental switch in their responsiveness to exercise.

    Tomlinson, Lyl / Huang, Po Hsuan / Colognato, Holly

    Developmental neurobiology

    2018  Volume 78, Issue 7, Page(s) 687–700

    Abstract: Aerobic exercise is known to influence brain function, e.g., enhancing executive function in both children and adults, with many of these influences being attributed to alterations in neurogenesis and neuronal function. Yet oligodendroglia in adult ... ...

    Abstract Aerobic exercise is known to influence brain function, e.g., enhancing executive function in both children and adults, with many of these influences being attributed to alterations in neurogenesis and neuronal function. Yet oligodendroglia in adult brains have also been reported to be highly responsive to exercise, including in the prefrontal cortex (PFC), a late myelinating region implicated in working memory. However, whether exercise affects oligodendroglia or myelination in juveniles, either in the PFC or in other brain regions, remains unknown. To address this, both juvenile and young adult mice were provided free access to running wheels for four weeks followed by an analysis of oligodendrocyte development and myelination in the PFC and the corpus callosum, a major white matter tract. Working memory and PFC NG2+ cell development were both affected by exercise in juvenile mice, yet surprisingly these exercise-mediated effects were distinct in juveniles and young adults. In the PFC, NG2+ cell proliferation was increased in exercising juveniles, but not young adults, whereas newly-born oligodendrocyte production was increased in exercising young adults, but not juveniles. Although no overall changes in myelin genes were found, elevated levels of Monocarboxylate Transporter 1, a glial lactate transporter important during active myelination, were found in the PFC of exercising young adults. Overall our findings reveal that long-term exercise modulates PFC glial development and does so differentially in juvenile and young adult mice, providing insight into the cellular responses that may underlie cognitive benefits to teenagers and young adults in response to exercise. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 687-700, 2018.
    MeSH term(s) Animals ; Antigens/metabolism ; Cell Proliferation/physiology ; Female ; Maze Learning/physiology ; Mice, Inbred C57BL ; Monocarboxylic Acid Transporters/metabolism ; Oligodendroglia/cytology ; Oligodendroglia/metabolism ; Prefrontal Cortex/cytology ; Prefrontal Cortex/growth & development ; Prefrontal Cortex/metabolism ; Proteoglycans/metabolism ; Running/physiology ; Running/psychology ; Symporters/metabolism
    Chemical Substances Antigens ; Monocarboxylic Acid Transporters ; Proteoglycans ; Symporters ; chondroitin sulfate proteoglycan 4 ; monocarboxylate transport protein 1
    Language English
    Publishing date 2018-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity.

    Tomlinson, Lyl / Leiton, Cindy V / Colognato, Holly

    Neuropharmacology

    2015  Volume 110, Issue Pt B, Page(s) 548–562

    Abstract: Many behavioral experiences are known to promote hippocampal neurogenesis. In contrast, the ability of behavioral experiences to influence the production of oligodendrocytes and myelin sheath formation remains relatively unknown. However, several recent ... ...

    Abstract Many behavioral experiences are known to promote hippocampal neurogenesis. In contrast, the ability of behavioral experiences to influence the production of oligodendrocytes and myelin sheath formation remains relatively unknown. However, several recent studies indicate that voluntary exercise and environmental enrichment can positively influence both oligodendrogenesis and myelination, and that, in contrast, social isolation can negatively influence myelination. In this review we summarize studies addressing the influence of behavioral experiences on oligodendrocyte lineage cells and myelin, and highlight potential mechanisms including experience-dependent neuronal activity, metabolites, and stress effectors, as well as both local and systemic secreted factors. Although more study is required to better understand the underlying mechanisms by which behavioral experiences regulate oligodendrocyte lineage cells, this exciting and newly emerging field has already revealed that oligodendrocytes and their progenitors are highly responsive to behavioral experiences and suggest the existence of a complex network of reciprocal interactions among oligodendrocyte lineage development, behavioral experiences, and brain function. Achieving a better understanding of these relationships may have profound implications for human health, and in particular, for our understanding of changes in brain function that occur in response to experiences. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Plasticity/physiology ; Environment ; Exercise/physiology ; Humans ; Myelin Sheath/physiology ; Oligodendroglia/physiology ; Social Isolation ; Stem Cells/physiology
    Language English
    Publishing date 2015-09-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2015.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

    Sanford, James A / Nogiec, Christopher D / Lindholm, Malene E / Adkins, Joshua N / Amar, David / Dasari, Surendra / Drugan, Jonelle K / Fernández, Facundo M / Radom-Aizik, Shlomit / Schenk, Simon / Snyder, Michael P / Tracy, Russell P / Vanderboom, Patrick / Trappe, Scott / Walsh, Martin J / Evans, Charles R / Fernandez, Facundo M / Li, Yafeng / Tomlinson, Lyl /
    Lee Alekel, D / Bekirov, Iddil / Boyce, Amanda T / Boyington, Josephine / Fleg, Jerome L / Joseph, Lyndon J.O / Laughlin, Maren R / Maruvada, Padma / Morris, Stephanie A / McGowan, Joan A / Nierras, Concepcion / Pai, Vinay / Peterson, Charlotte / Ramos, Ed / Roary, Mary C / Williams, John P / Xia, Ashley / Cornell, Elaine / Rooney, Jessica / Miller, Michael E / Ambrosius, Walter T / Rushing, Scott / Stowe, Cynthia L / Jack Rejeski, W / Nicklas, Barbara J / Pahor, Marco / Lu, Ching-ju / Trappe, Todd / Chambers, Toby / Raue, Ulrika / Lester, Bridget / Bergman, Bryan C / Bessesen, David H / Jankowski, Catherine M / Kohrt, Wendy M / Melanson, Edward L / Moreau, Kerrie L / Schauer, Irene E / Schwartz, Robert S / Kraus, William E / Slentz, Cris A / Huffman, Kim M / Johnson, Johanna L / Willis, Leslie H / Kelly, Leslie / Houmard, Joseph A / Dubis, Gabriel / Broskey, Nick / Goodpaster, Bret H / Sparks, Lauren M / Coen, Paul M / Cooper, Dan M / Haddad, Fadia / Rankinen, Tuomo / Ravussin, Eric / Johannsen, Neil / Harris, Melissa / Jakicic, John M / Newman, Anne B / Forman, Daniel D / Kershaw, Erin / Rogers, Renee J / Nindl, Bradley C / Page, Lindsay C / Stefanovic-Racic, Maja / Barr, Susan L / Rasmussen, Blake B / Moro, Tatiana / Paddon-Jones, Doug / Volpi, Elena / Spratt, Heidi / Musi, Nicolas / Espinoza, Sara / Patel, Darpan / Serra, Monica / Gelfond, Jonathan / Burns, Aisling / Bamman, Marcas M / Buford, Thomas W / Cutter, Gary R / Bodine, Sue C / Esser, Karyn / Farrar, Rodger P / Goodyear, Laurie J / Hirshman, Michael F / Albertson, Brent G / Qian, Wei-Jun / Piehowski, Paul / Gritsenko, Marina A / Monore, Matthew E / Petyuk, Vladislav A / McDermott, Jason E / Hansen, Joshua N / Hutchison, Chelsea / Moore, Samuel / Gaul, David A / Clish, Clary B / Avila-Pacheco, Julian / Dennis, Courtney / Kellis, Manolis / Carr, Steve / Jean-Beltran, Pierre M / Keshishian, Hasmik / Mani, D.R / Clauser, Karl / Krug, Karsten / Mundorff, Charlie / Pearce, Cadence / Ivanova, Anna A / Ortlund, Eric A / Maner-Smith, Kristal / Uppal, Karan / Zhang, Tiantian / Sealfon, Stuart C / Zaslavsky, Elena / Nair, Venugopalan / Li, SiDe / Jain, Nimisha / Ge, YongChao / Sun, Yifei / Nudelman, German / Ruf-zamojski, Frederique / Smith, Gregory / Pincas, Nhanna / Rubenstein, Aliza / Anne Amper, Mary / Seenarine, Nitish / Lappalainen, Tuuli / Lanza, Ian R / Sreekumaran Nair, K / Klaus, Katherine / Montgomery, Stephen B / Smith, Kevin S / Gay, Nicole R / Zhao, Bingqing / Hung, Chia-Jiu / Zebarjadi, Navid / Balliu, Brunilda / Fresard, Laure / Burant, Charles F / Li, Jun Z / Kachman, Maureen / Soni, Tanu / Raskind, Alexander B / Gerszten, Robert / Robbins, Jeremy / Ilkayeva, Olga / Muehlbauer, Michael J / Newgard, Christopher B / Ashley, Euan A / Wheeler, Matthew T / Jimenez-Morales, David / Raja, Archana / Dalton, Karen P / Zhen, Jimmy / Suk Kim, Young / Christle, Jeffrey W / Marwaha, Shruti / Chin, Elizabeth T / Hershman, Steven G / Hastie, Trevor / Tibshirani, Robert / Rivas, Manuel A

    Cell. 2020 June 25, v. 181, no. 7

    2020  

    Abstract: Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. ...

    Institution the Molecular Transducers of Physical Activity Consortium
    Abstract Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
    Keywords bioinformatics ; clinical trials ; databases ; disease control ; mortality ; risk ; strength training
    Language English
    Dates of publication 2020-0625
    Size p. 1464-1474.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.06.004
    Database NAL-Catalogue (AGRICOLA)

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