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  1. Article ; Online: Cordova Formula, A Better Alternative to Martin's Formula for the Calculation of LDL-C in Patients with TG above 350 mg/dL.

    Tomo, Sojit / Sankanagoudar, Shrimanjunath

    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir

    2022  Volume 50, Issue 4, Page(s) 308–309

    MeSH term(s) Cholesterol, LDL ; Humans ; Triglycerides
    Chemical Substances Cholesterol, LDL ; Triglycerides
    Language English
    Publishing date 2022-06-17
    Publishing country Turkey
    Document type Letter ; Comment
    ZDB-ID 1215217-1
    ISSN 1308-4488 ; 1016-5169
    ISSN (online) 1308-4488
    ISSN 1016-5169
    DOI 10.5543/tkda.2022.22368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4156: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Multi-omics integration and interactomics reveals molecular networks and regulators of the beneficial effect of yoga and exercise.

    Khokhar, Manoj / Tomo, Sojit / Gadwal, Ashita / Purohit, Purvi

    International journal of yoga

    2022  Volume 15, Issue 1, Page(s) 25–39

    Abstract: Background: Yoga is a multifaceted spiritual tool that helps in maintaining health, peace of mind, and positive thoughts. In the context of asana, yoga is similar to physical exercise. This study aims to construct a molecular network to find hub genes ... ...

    Abstract Background: Yoga is a multifaceted spiritual tool that helps in maintaining health, peace of mind, and positive thoughts. In the context of asana, yoga is similar to physical exercise. This study aims to construct a molecular network to find hub genes that play important roles in physical exercise and yoga.
    Methodology: We combined differentially expressed genes (DEGs) in yoga and exercise using computational bioinformatics from publicly available gene expression omnibus (GEO) datasets and identified the codifferentially expressed mRNAs with GEO2R. The co-DEGs were divided into four different groups and each group was subjected to protein-protein interaction (PPI) network, pathways analysis, and gene ontology.
    Results: Our study identified immunological modulation as a dominant target of differential expression in yoga and exercise. Yoga predominantly modulated genes affecting the Th1 and NK cells, whereas Cytokines, Macrophage activation, and oxidative stress were affected by exercise. We also observed that while yoga regulated genes for two main physiological functions of the body, namely Circadian Rhythm (BHLHE40) and immunity (LBP, T-box transcription factor 21, CEACAM1), exercise-regulated genes involved in apoptosis (BAG3, protein kinase C alpha), angiogenesis, and cellular adhesion (EPH receptor A1).
    Conclusion: The dissimilarity in the genetic expression patterns in Yoga and exercise highlights the discrete effect of each in biological systems. The integration and convergences of multi-omics signals can provide deeper and comprehensive insights into the various biological mechanisms through which yoga and exercise exert their beneficial effects and opens up potential newer research areas.
    Language English
    Publishing date 2022-03-21
    Publishing country India
    Document type Journal Article
    ISSN 0973-6131
    ISSN 0973-6131
    DOI 10.4103/ijoy.ijoy_146_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cordova Formula for Low-Density Lipoprotein- Cholesterol Estimation: Not Only the Simplest of All But Also Superior to Other Formulae at a Higher Range of Triglyceride.

    Tomo, Sojit / Sankanagoudar, Shrimanjunath / Sharma, Praveen

    Anatolian journal of cardiology

    2022  Volume 26, Issue 7, Page(s) 520–524

    MeSH term(s) Cholesterol, HDL ; Cholesterol, LDL ; Humans ; Triglycerides
    Chemical Substances Cholesterol, HDL ; Cholesterol, LDL ; Triglycerides
    Language English
    Publishing date 2022-07-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2278670-3
    ISSN 2149-2271 ; 2149-2271
    ISSN (online) 2149-2271
    ISSN 2149-2271
    DOI 10.5152/AnatolJCardiol.2022.1356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enhanced ability of Cordova formula for estimation of LDL cholesterol in distinguishing patient requiring lipid lowering treatment.

    Tomo, Sojit / Sankanagoudar, Shrimanjunath / Shukla, Ravindra K

    Minerva endocrinology

    2022  Volume 48, Issue 2, Page(s) 247–250

    MeSH term(s) Humans ; Cholesterol, LDL ; Triglycerides
    Chemical Substances Cholesterol, LDL ; Triglycerides
    Language English
    Publishing date 2022-02-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062786-2
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.22.03697-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Validation of a novel method for determination of low-density lipoprotein cholesterol levels in Indian patients with type 2 diabetes.

    Tomo, Sojit / Sankanagoudar, Shrimanjunath / Shukla, Ravindra / Sharma, Praveen

    Diabetes & metabolic syndrome

    2022  Volume 16, Issue 4, Page(s) 102448

    Abstract: Background and aims: LDL-cholesterol (LDL-C), being the primary predictor of cardiovascular disease in Type 2 diabetes (T2D), is associated with cardiovascular risk stratification and requires to be estimated with better accuracy with minimal bias. ... ...

    Abstract Background and aims: LDL-cholesterol (LDL-C), being the primary predictor of cardiovascular disease in Type 2 diabetes (T2D), is associated with cardiovascular risk stratification and requires to be estimated with better accuracy with minimal bias. Different formulae have been devised to calculate the LDL-C from the measured lipid profile parameters.
    Methods: In this analytical cross-sectional study, a total of 150 patients with T2D were studied, and blood samples were subjected for lipid profile analysis at the Central Biochemistry laboratory. Different formulae assessed calculated LDL-C.
    Results: We observed that all formulae, except Ahmadi, underestimated the LDL-C compared to direct assay. A significant difference was observed between all calculated LDL-C and directly measured LDL-C. On linear regression analysis, the newer formula Martin's has a better approximation with direct assay (slope: 0.9708) than Friedewald (slope: 0.9477). Similarly, Martin's formula exhibited lesser bias (-13.56) in calculating LDL-C in patients with T2D compared with Friedewald's formula.
    Conclusions: The study demonstrated that in patients with T2D, all formulae except Ahmadi significantly underestimated the LDL-C when compared with the direct assay. The newer Martin's formula appeared to more precisely calculate LDL-C in T2D when compared with the traditional Friedewald's formula.
    MeSH term(s) Cardiovascular Diseases ; Cholesterol, LDL ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 ; Humans ; Triglycerides
    Chemical Substances Cholesterol, LDL ; Triglycerides
    Language English
    Publishing date 2022-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2022.102448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Calculated small dense LDL-cholesterol and its correlation with the atherogenic index of plasma.

    Tomo, Sojit / Sankanagoudar, Shrimanjunath / Shukla, Ravindra / Sharma, Praveen

    Annals of clinical biochemistry

    2022  Volume 59, Issue 6, Page(s) 454–456

    MeSH term(s) Humans ; Cholesterol, LDL ; Cholesterol, HDL ; Lipoproteins, LDL ; Triglycerides
    Chemical Substances Cholesterol, LDL ; Cholesterol, HDL ; Lipoproteins, LDL ; Triglycerides
    Language English
    Publishing date 2022-05-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 390309-6
    ISSN 1758-1001 ; 0004-5632
    ISSN (online) 1758-1001
    ISSN 0004-5632
    DOI 10.1177/00045632221102767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 889: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: A National Survey of the Prevalence of Anemia and Obesity in Indian School Children.

    Banerjee, Mithu / Bhatti, Brig V K / Roy, Dipayan / Tomo, Sojit

    Journal of community hospital internal medicine perspectives

    2022  Volume 12, Issue 5, Page(s) 48–53

    Abstract: Background: In India, the socioeconomic shift in the past few decades has led to a sedentary lifestyle with poor dietary habits, leading to an increased incidence of overweight and obesity in children. Furthermore, obesity and anemia share some common ... ...

    Abstract Background: In India, the socioeconomic shift in the past few decades has led to a sedentary lifestyle with poor dietary habits, leading to an increased incidence of overweight and obesity in children. Furthermore, obesity and anemia share some common links.
    Objectives: In this study, we have prevalence of anemia and obesity in Indian schoolchildren.
    Methods: The study was carried out on 1675 children and adolescent participants aged 6-18 years for the prevalence of obesity and anemia. Height, weight, waist and hip circumference were taken. Hemoglobin levels was measured for each participant.
    Results: Males and females differed in height (p = 0.007), waist circumference (p = 0.019), waist-to-hip ratio (p < 0.001) and hemoglobin levels (p < 0.001). A total of 294 girls (44.4%) and 283 boys (29.7%) were anemic. There were significant differences between BMI within age groups for both boys (p < 0.001) and girls (p < 0.001). The highest percentage of anemia was observed in the 12-14 years age group in girls (54.2%) and 15-18 years-old boys (54.2%). Among the obese children, 28.2% were anemic, while 29.3% of overweight children were anemic (Pearson's chi-squared = 7.68, p = 0.020).
    Conclusion: This study sheds light on the prevalence of obesity and anemia in Indian schoolchildren and adolescents, while also suggesting an association between the two conditions. Nutritional counselling as well as lifestyle modification should be advocated in school curricula to make an early impact.
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.55729/2000-9666.1110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Klotho: A Possible Role in the Pathophysiology of Nephrotic Syndrome.

    Tomo, Sojit / Birdi, Amandeep / Yadav, Dharmveer / Chaturvedi, Manish / Sharma, Praveen

    EJIFCC

    2022  Volume 33, Issue 1, Page(s) 3–10

    Abstract: Klotho, encoded by ... ...

    Abstract Klotho, encoded by the
    Language English
    Publishing date 2022-04-11
    Publishing country Italy
    Document type Journal Article ; Review
    ISSN 1650-3414
    ISSN (online) 1650-3414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Selenium to selenoproteins - role in COVID-19.

    Tomo, Sojit / Saikiran, Gangam / Banerjee, Mithu / Paul, Sushmita

    EXCLI journal

    2021  Volume 20, Page(s) 781–791

    Abstract: The disruption of antioxidant defense has been demonstrated in severe acute respiratory syndrome due to SARS-CoV infection. Selenium plays a major role in decreasing the ROS produced in response to various viral infections. Selenoprotein enzymes are ... ...

    Abstract The disruption of antioxidant defense has been demonstrated in severe acute respiratory syndrome due to SARS-CoV infection. Selenium plays a major role in decreasing the ROS produced in response to various viral infections. Selenoprotein enzymes are essential in combating oxidative stress caused due to excessive generation of ROS. Selenium also has a role in inhibiting the activation of NF-κB, thus alleviating inflammation. In viral infections, selenoproteins have also been found to inhibit type I interferon responses, modulate T cell proliferation and oxidative burst in macrophages, and inhibit viral transcriptional activators. Potential virally encoded selenoproteins have been identified by computational analysis in different viral genomes like HIV-1, Japanese encephalitis virus (JEV), and hepatitis C virus. This review discusses the role and the possible mechanisms of selenium, selenoproteins, and virally encoded selenoproteins in the pathogenicity of viral infections. Identification of potential selenoproteins in the COVID 19 genome by computational tools will give insights further into their role in the pathogenesis of viral infections.
    Language English
    Publishing date 2021-04-16
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2021-3530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: MicroRNAs based regulation of cytokine regulating immune expressed genes and their transcription factors in COVID-19.

    Khokhar, Manoj / Tomo, Sojit / Purohit, Purvi

    Meta gene

    2021  Volume 31, Page(s) 100990

    Abstract: Background: Coronavirus disease 2019 is characterized by the elevation of a broad spectrum of inflammatory mediators associated with poor disease outcomes. We aimed at an in-silico analysis of regulatory microRNA and their transcription factors (TF) for ...

    Abstract Background: Coronavirus disease 2019 is characterized by the elevation of a broad spectrum of inflammatory mediators associated with poor disease outcomes. We aimed at an in-silico analysis of regulatory microRNA and their transcription factors (TF) for these inflammatory genes that may help to devise potential therapeutic strategies in the future.
    Methods: The cytokine regulating immune-expressed genes (CRIEG) were sorted from literature and the GEO microarray dataset. Their co-differentially expressed miRNA and transcription factors were predicted from publicly available databases. Enrichment analysis was done through mienturnet, MiEAA, Gene Ontology, and pathways predicted by KEGG and Reactome pathways. Finally, the functional and regulatory features were analyzed and visualized through Cytoscape.
    Results: Sixteen CRIEG were observed to have a significant protein-protein interaction network. The ontological analysis revealed significantly enriched pathways for biological processes, molecular functions, and cellular components. The search performed in the miRNA database yielded ten miRNAs that are significantly involved in regulating these genes and their transcription factors.
    Conclusion: An in-silico representation of a network involving miRNAs, CRIEGs, and TF, which take part in the inflammatory response in COVID-19, has been elucidated. Thus, these regulatory factors may have potentially critical roles in the inflammatory response in COVID-19 and may be explored further to develop targeted therapeutic strategies and mechanistic validation.
    Language English
    Publishing date 2021-10-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2743632-9
    ISSN 2214-5400
    ISSN 2214-5400
    DOI 10.1016/j.mgene.2021.100990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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