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Article ; Online: Particle characteristics and tribo-rheological properties of soy protein isolate (SPI) dispersions: Effect of heating and incorporation of flaxseed gum.

Pang, Zhihua / Tong, Fang / Jiang, Siyuan / Chen, Cunshe / Liu, Xinqi

International journal of biological macromolecules

2023 Volume 232, Page(s) 123455

Abstract: To understand the heat treatment and flaxseed gum (FG) on the properties of commercial spray dried soy protein isolate (SPI), SPI dispersions were prepared with mass ratio of 6 %, 9 %, and 12 % in water and the corresponding protein concentrations of 2.2 ...

Abstract	To understand the heat treatment and flaxseed gum (FG) on the properties of commercial spray dried soy protein isolate (SPI), SPI dispersions were prepared with mass ratio of 6 %, 9 %, and 12 % in water and the corresponding protein concentrations of 2.2 %, 3.61 % and 5.23 % were reached after centrifugation. The solutions were treated at different temperatures (25, 75 and 100 °C) and the particle characteristics and physical properties of the resulted samples were determined. The influence of different concentrations (0.05 % to 0.3 %) of FG addition was evaluated in the SPI solution at 5 % protein concentration. The results showed that heating caused decrease of particle size of the SPI proteins and 100 °C heat treatment caused decrease of hydrophobicity and viscosity of the protein dispersions, and increase of their physical stability, and the effect was more marked at high protein concentration; while heat treatment at 75 °C caused substantial increase in protein hydrophobicity and viscosity, and decrease of stability. Addition of FG resulted in increase of particle size, absolute value of zeta potential and hydrophobicity of the protein solutions. The viscosity of the solution was decreased with addition of FG, but higher FG concentration could lead to higher viscosity. The physical stability of the mixed system was improved at low FG concentrations, but decreased at concentration higher than 0.2 %, which was more significant after 100 °C heat treatment. FG incorporation could improve the boundary lubrication of the protein solutions.
MeSH term(s)	Soybean Proteins ; Flax ; Heating ; Rheology ; Hyperthermia, Induced ; Particle Size
Chemical Substances	Soybean Proteins
Language	English
Publishing date	2023-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123455
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Article: Corrigendum: Identification of an autophagy-related 12-lncRNA signature and evaluation of NFYC-AS1 as a pro-cancer factor in lung adenocarcinoma.

Tong, Fang / Xu, Lifa / Xu, Sheng / Zhang, Mingming

Frontiers in genetics

2022 Volume 13, Page(s) 1050296

Abstract: This corrects the article DOI: 10.3389/fgene.2022.834935.]. ...

Abstract	[This corrects the article DOI: 10.3389/fgene.2022.834935.].
Language	English
Publishing date	2022-10-25
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.1050296
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Article: Identification of an autophagy-related 12-lncRNA signature and evaluation of NFYC-AS1 as a pro-cancer factor in lung adenocarcinoma.

Tong, Fang / Xu, Lifa / Xu, Sheng / Zhang, Mingming

Frontiers in genetics

2022 Volume 13, Page(s) 834935

Abstract: ... Objective: ... To develop an autophagy-related lncRNA-based risk signature and corresponding nomogram to predict overall survival (OS) for LUAD patients and investigate the possible meaning of screened factors. ... Methods: ... Differentially expressed ...

Abstract	Objective: To develop an autophagy-related lncRNA-based risk signature and corresponding nomogram to predict overall survival (OS) for LUAD patients and investigate the possible meaning of screened factors. Methods: Differentially expressed lncRNAs and autophagy genes were screened between normal and LUAD tumor samples from the TCGA LUAD dataset. Univariate and multivariate Cox regression analyses were performed to construct the lncRNA-based risk signature and nomogram incorporating clinical information. Then, the accuracy and sensitivity were confirmed by the AUC of ROC curves in both training and validation cohorts. qPCR, immunoblot, shRNA, and ectopic expression were used to verify the positive regulation of NFYC-AS1 on BIRC6. CCK-8, immunofluorescence, and flow cytometry were used to confirm the influence of NFYC-AS1 on cell proliferation, autophagy, and apoptosis via BIRC6. Results: A 12-lncRNA risk signature and a nomogram combining related clinical information were constructed. Furthermore, the abnormal increase of NFYC-AS1 may promote LUAD progression through the autophagy-related gene BIRC6. Conclusion: 12-lncRNA signature may function as a predictive marker for LUAD patients, and NFYC-AS1 along with BIRC6 may function as carcinogenic factors in a combinatorial manner.
Language	English
Publishing date	2022-08-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.834935
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Article ; Online: Antibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor Family in Cancers

Jinfeng Yu / Tong Fang / Chengyu Yun / Xue Liu / Xiaoqing Cai

Frontiers in Molecular Biosciences, Vol

2022 Volume 9

Abstract: Members of the human epidermal growth factor receptor (HER) family, which includes HER1 (also known as EGFR), HER2, HER3 and HER4, have played a central role in regulating cell proliferation, survival, differentiation and migration. The overexpression of ...

Abstract	Members of the human epidermal growth factor receptor (HER) family, which includes HER1 (also known as EGFR), HER2, HER3 and HER4, have played a central role in regulating cell proliferation, survival, differentiation and migration. The overexpression of the HER family has been recognized as one of the most common cellular dysregulation associated with a wide variety of tumor types. Antibody-drug conjugates (ADCs) represent a new and promising class of anticancer therapeutics that combine the cancer specificity of antibodies with cytotoxicity of chemotherapeutic drugs. Two HER2-directed ADCs, trastuzumane-emtansine (T-DM1) and trastuzumab-deruxtecan (DS-8201a), have been approved for HER2-positive metastatic breast cancer by the U.S. Food and Drug Administration (FDA) in 2013 and 2019, respectively. A third HER2-directed ADC, disitamab vedotin (RC48), has been approved for locally advanced or metastatic gastric or gastroesophageal junction cancer by the NMPA (National Medical Products Administration) of China in 2021. A total of 11 ADCs that target HER family receptors (EGFR, HER2 or HER3) are currently under clinical trials. In this review article, we summarize the three approved ADCs (T-DM1, DS-8201a and RC48), together with the investigational EGFR-directed ADCs (ABT-414, MRG003 and M1231), HER2-directed ADCs (SYD985, ARX-788, A166, MRG002, ALT-P7, GQ1001 and SBT6050) and HER3-directed ADC (U3-1402). Lastly, we discuss the major challenges associated with the development of ADCs, and highlight the possible future directions to tackle these challenges.
Keywords	antibody-drug conjugates ; cancer targeted therapy ; drug resistance ; EGFR ; HER family ; HER2 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Color image encryption scheme based on alternate quantum walk and controlled Rubik’s Cube

Jingbo Zhao / Tian Zhang / Jianwei Jiang / Tong Fang / Hongyang Ma

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 16

Abstract: Abstract Aiming at solving the trouble that digital image information is easily intercepted and tampered during transmission, we proposed a color image encryption scheme based on alternate quantum random walk and controlled Rubik’s Cube transformation. ... ...

Abstract	Abstract Aiming at solving the trouble that digital image information is easily intercepted and tampered during transmission, we proposed a color image encryption scheme based on alternate quantum random walk and controlled Rubik’s Cube transformation. At the first, the color image is separated into three channels: channel R, channel G and channel B. Besides, a random sequence is generated by alternate quantum walk. Then the six faces of the Rubik’s Cube are decomposed and arranged in a specific order on a two-dimensional plane, and each pixel of the image is randomly mapped to the Rubik’s Cube. The whirling of the Rubik’s Cube is controlled by a random sequence to realize image scrambling and encryption. The scrambled image acquired by Rubik’s Cube whirling and the random sequence received by alternate quantum walk are bitwise-XORed to obtain a single-channel encrypted image. Finally the three-channel image is merged to acquire the final encrypted image. The decryption procedure is the reverse procedure of the encryption procedure. The key space of this scheme is theoretically infinite. After simulation experiments, the information entropy after encryption reaches 7.999, the NPCR is 99.5978%, and the UACI is 33.4317%. The encryption scheme with high robustness and security has a excellent encryption effect which is effective to resist statistical attacks, force attacks, and other differential attacks.
Keywords	Medicine ; R ; Science ; Q
Subject code	003
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research on Green Idea in Modern Ceramic Products —— Also Discuss the Construction of VR Technology on Ceramic Product Display

HU Xiao-bing / Zhang Lihui / Tong Fang

E3S Web of Conferences, Vol 236, p

2021 Volume 04048

Abstract: Green design” originated in the 1960s and became a hot issue in modern design research in the 1990s. It embodies the principle of “people-oriented” and becomes the trend of modern design. It evokes modern people’s reflection on the original ecological ... ...

Abstract	“Green design” originated in the 1960s and became a hot issue in modern design research in the 1990s. It embodies the principle of “people-oriented” and becomes the trend of modern design. It evokes modern people’s reflection on the original ecological destruction of the environment caused by modern science and technology and culture. Although there are not many contact points between green design and modern ceramic product design, this manuscript introduces the “thinking concept” of “green design” into modern ceramic product design, and deeply studies modern ceramics from various aspects, such as energy, resources, modern family structure, disease prevention and life cycle design of modern ceramic product design. The problem of product design, grasp the development direction of modern ceramic product design, take the road of sustainable development, and open up a new way of ceramic product design that meets the needs of modern social life. This paper also discusses how to use VR technology to construct the display platform of ceramic product design, human-computer interaction and feedback design information, so as to realize green design under VR technology.
Keywords	Environmental sciences ; GE1-350
Subject code	700 ; 670
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An adaptive feature region-based line segment matching method for viewpoint-changed images with discontinuous parallax and poor textures

Min Chen / Wen Li / Tong Fang / Qing Zhu / Bo Xu / Han Hu / Xuming Ge

International Journal of Applied Earth Observations and Geoinformation, Vol 117, Iss , Pp 103209- (2023)

2023

Abstract: Many methods have been proposed to extract line segment (LS) correspondences for images with viewpoint variations. However, the matching performance on images with viewpoint variations is still limited due to the influence of discontinuous parallax and ... ...

Abstract	Many methods have been proposed to extract line segment (LS) correspondences for images with viewpoint variations. However, the matching performance on images with viewpoint variations is still limited due to the influence of discontinuous parallax and poor textures on images. Existing line segment matching (LSM) methods rarely consider the coexistence of these two situations. This study attempts to address this problem by proposing an adaptive feature region (FR)-based LSM method based on the observation that different FRs are suitable for different image scenes under image viewpoint change. In the proposed method, LSs are paired, and two types of FRs, symmetric FR centered on the line-pair intersection and asymmetric FR with the intersection as a vertex, are constructed for every line pair. The asymmetric FR of a line pair is a subregion of its symmetric FR. And the complement region of asymmetric FR in symmetric FR is called complement FR. To choose a suitable FR for the matching of each line pair adaptively, the asymmetric FR-based feature descriptor similarity and epipolar line-based constraints are combined to determine candidate line pair matches firstly. Then, the candidate matches with similar complement FR-based feature descriptors are considered initial matches and used to construct a topological constraint to check other candidates. Finally, we estimate an adaptive influence region-based local homography for each matched line pair to constrain the matching of unmatched individual LSs. The experimental results on the test images with viewpoint changes show that our approach outperforms the state-of-the-art methods in terms of Recall, matching precision (MP), and F-Measure (reflecting the overall matching performance of Recall and MP). Especially, it improves the average Recall and average F-Measure of the best method among the comparison methods by 45.20% and 25.83%, respectively.
Keywords	Line segment matching ; Adaptive feature region ; Hierarchical framework ; Viewpoint change ; Discontinuous parallax ; Poor textures ; Physical geography ; GB3-5030 ; Environmental sciences ; GE1-350
Subject code	004
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Plasma Effects on Properties and Structure of Corn Starch: Characterization and Analysis.

Chen, Cunshe / Tong, Fang / Sun, Ruohao / Yang, Jufang / Pang, Zhihua / Liu, Xinqi

Foods (Basel, Switzerland)

2023 Volume 12, Issue 21

Abstract: This research investigated the impact of air plasma and high-pressure plasma treatments on corn starch. The resulting samples were characterized by particle morphology, molecular polymerization degree, molecular functional groups, and crystallinity. SEM ... ...

Abstract	This research investigated the impact of air plasma and high-pressure plasma treatments on corn starch. The resulting samples were characterized by particle morphology, molecular polymerization degree, molecular functional groups, and crystallinity. SEM analysis revealed that plasma treatment altered the surface morphology of corn starch, with variations observed depending on the duration of treatment. UV/Vis spectroscopy results indicated that longer plasma exposure times increased maximum absorbance values with less complete peak shapes. FTIR results demonstrated that plasma treatment disrupted the crystalline structure of starch, resulting in decreased molecular polymerization. Lastly, XRD results showed a proportional relationship between plasma treatment duration and the intensity of the diffuse peak, indicating that prolonged plasma exposure increased the amorphous nature of starch.
Language	English
Publishing date	2023-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12214042
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Article: Sudden unexpected death in epilepsy: A bibliometric overview.

Tong, Fang / Lin, Jian / Zeng, Zixuan / Wang, Qi / Yang, Zhifang / Lv, Yehui

Frontiers in neurology

2023 Volume 14, Page(s) 1139521

Abstract: The mechanism of sudden unexpected death in epilepsy (SUDEP) is elusive and many questions remain unanswered. Autopsy is generally unhelpful in providing evidence for the cause of death, as pathological changes may be on the molecular level. Although ... ...

Abstract	The mechanism of sudden unexpected death in epilepsy (SUDEP) is elusive and many questions remain unanswered. Autopsy is generally unhelpful in providing evidence for the cause of death, as pathological changes may be on the molecular level. Although histopathological examination occasionally demonstrates pathology such as vascular malformation, old traumatic injury, and tumor, in most cases of SUDEP, the examination is negative. We examined the current status of SUDEP research by performing a bibliometric analysis of studies in the Web of Science Core Collection database published between 2002 and 2022. Our aim was to demonstrate areas of interest and frontiers of SUDEP research. A total of 1803 papers were included in the analysis. The number of published papers focused on SUDEP has been increasing since 2002. Main areas of interest include clinical manifestations, prevalence, treatment, and underlying mechanisms. Research teams from the United States and Europe are leading the way in SUDEP research, while Asia trails behind. Future studies regarding the mechanism and neuropathology of SUDEP are warranted.
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1139521
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Article ; Online: Trehalose‐6‐phosphate phosphatases are involved in trehalose synthesis and metamorphosis in Bactrocera minax

Wang, Jia / Fan, Huan / Li, Ying / Zhang, Tong‐Fang / Liu, Ying‐Hong

Insect Science. 2022 Dec., v. 29, no. 6 p.1643-1658

2022

Abstract: Trehalose is the principal sugar circulating in the hemolymph of insects, and trehalose synthesis is catalyzed by trehalose‐6‐phosphate synthase (TPS) and trehalose‐6‐phosphate phosphatase (TPP). Insect TPS is a fused enzyme containing both TPS domain ... ...

Abstract	Trehalose is the principal sugar circulating in the hemolymph of insects, and trehalose synthesis is catalyzed by trehalose‐6‐phosphate synthase (TPS) and trehalose‐6‐phosphate phosphatase (TPP). Insect TPS is a fused enzyme containing both TPS domain and TPP domain. Thus, many insects do not possess TPP genes as TPSs have replaced the function of TPPs. However, TPPs are widely distributed across the dipteran insects, while the roles they play remain largely unknown. In this study, 3 TPP genes from notorious dipteran pest Bactrocera minax (BmiTPPB, BmiTPPC1, and BmiTPPC2) were identified and characterized. The different temporal‐spatial expression patterns of 3 BmiTPPs implied that they exert different functions in B. minax. Recombinant BmiTPPs were heterologously expressed in yeast cells, and all purified proteins exhibited enzymatic activities, despite the remarkable disparity in performance between BmiTPPB and BmiTPPCs. RNA interference revealed that all BmiTPPs were successfully downregulated after double‐stranded RNA injection, leading to decreased trehalose content and increased glucose content. Also, suppression of BmiTPPs significantly affected expression of downstream genes and increased the mortality and malformation rate. Collectively, these results indicated that all 3 BmiTPPs in B. minax are involved in trehalose synthesis and metamorphosis. Thus, these genes could be evaluated as insecticidal targets for managing B. minax, and even for other dipteran pests.
Keywords	Bactrocera ; RNA interference ; abnormal development ; alpha,alpha-trehalose-phosphate synthase (UDP-forming) ; double-stranded RNA ; glucose ; hemolymph ; insects ; metamorphosis ; mortality ; pests ; trehalose ; trehalose-phosphatase ; yeasts
Language	English
Dates of publication	2022-12
Size	p. 1643-1658.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2179775-4
ISSN	1744-7917 ; 1672-9609
ISSN (online)	1744-7917
ISSN	1672-9609
DOI	10.1111/1744-7917.13010
Database	NAL-Catalogue (AGRICOLA)

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