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Article ; Online: Management of West China Hospital Medical Team for COVID-19 in Wuhan

TONG Le, CHEN Xiao-li, YE Lei

Jichu yixue yu linchuang, Vol 40, Iss 5, Pp 598-

2020 Volume 600

Abstract: With the increase of diagnosed COVID-19 cases, the prevention and control of epidemic in Wuhan became tougher. To support Wuhan, West China Hospital of Sichuan University sent the third round of medical team to the city. In order to ensure a safe and ... ...

Abstract	With the increase of diagnosed COVID-19 cases, the prevention and control of epidemic in Wuhan became tougher. To support Wuhan, West China Hospital of Sichuan University sent the third round of medical team to the city. In order to ensure a safe and relax condition for medical team members after busy works, it was crucial to manage the medical team station well comprehensively. This article summarized the management experience of West China Hospital medical team as a reference for others to fight against the epidemic.
Keywords	2019-ncov\|covid-19\|wuhan\|medical team ; Medicine ; R
Language	Chinese
Publishing date	2020-05-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: LiViT-Net: A U-Net-like, lightweight Transformer network for retinal vessel segmentation.

Tong, Le / Li, Tianjiu / Zhang, Qian / Zhang, Qin / Zhu, Renchaoli / Du, Wei / Hu, Pengwei

Computational and structural biotechnology journal

2024 Volume 24, Page(s) 213–224

Abstract: The intricate task of precisely segmenting retinal vessels from images, which is critical for diagnosing various eye diseases, presents significant challenges for models due to factors such as scale variation, complex anatomical patterns, low contrast, ... ...

Abstract	The intricate task of precisely segmenting retinal vessels from images, which is critical for diagnosing various eye diseases, presents significant challenges for models due to factors such as scale variation, complex anatomical patterns, low contrast, and limitations in training data. Building on these challenges, we offer novel contributions spanning model architecture, loss function design, robustness, and real-time efficacy. To comprehensively address these challenges, a new U-Net-like, lightweight Transformer network for retinal vessel segmentation is presented. By integrating MobileViT+ and a novel local representation in the encoder, our design emphasizes lightweight processing while capturing intricate image structures, enhancing vessel edge precision. A novel joint loss is designed, leveraging the characteristics of weighted cross-entropy and Dice loss to effectively guide the model through the task's challenges, such as foreground-background imbalance and intricate vascular structures. Exhaustive experiments were performed on three prominent retinal image databases. The results underscore the robustness and generalizability of the proposed LiViT-Net, which outperforms other methods in complex scenarios, especially in intricate environments with fine vessels or vessel edges. Importantly, optimized for efficiency, LiViT-Net excels on devices with constrained computational power, as evidenced by its fast performance. To demonstrate the model proposed in this study, a freely accessible and interactive website was established (https://hz-t3.matpool.com:28765?token=aQjYR4hqMI), revealing real-time performance with no login requirements.
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2694435-2
ISSN	2001-0370
ISSN	2001-0370
DOI	10.1016/j.csbj.2024.03.003
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Article ; Online: A self-microemulsion enhances oral absorption of docetaxel by inhibiting P-glycoprotein and CYP metabolism.

Tong, Le / Zhou, ZeYang / Wang, Gang / Wu, Chao

Drug delivery and translational research

2022 Volume 13, Issue 4, Page(s) 983–993

Abstract: Oral absorption of docetaxel was limited by drug efflux pump p-glycoprotein (P-gp) and cytochrome P450 enzyme (CYP 450). Therefore, co-loading agent that inhibits P-gp and CYP450 in self-nanoemulsifying drug delivery systems (SMEs) is considered a ... ...

Abstract	Oral absorption of docetaxel was limited by drug efflux pump p-glycoprotein (P-gp) and cytochrome P450 enzyme (CYP 450). Therefore, co-loading agent that inhibits P-gp and CYP450 in self-nanoemulsifying drug delivery systems (SMEs) is considered a promising strategy for oral delivery of docetaxel. In this study, curcumin was selected as an inhibitor of P-gp and CYP450, and it was co-encapsuled in SMEs to improve the oral bioavailability of docetaxel. SMEs quickly dispersed in water within 20 s, and the droplet size was 32.23 ± 2.21 nm. The release rate of curcumin from DC-SMEs was higher than that of docetaxel in vitro. Compared with free docetaxel, SMEs significantly increased the permeability of docetaxel by 4.6 times. And competitive experiments showed that the increased permeability was the result of inhibition of p-gp. The half-life and oral bioavailabilty of DC-SMEs increased about 1.7 times and 1.6 times than docetaxel SMEs, which indicated that its good pharmacokinetic behavior was related to the restriction of hepatic first-pass metabolism. In conclusion, DC-SME was an ideal platform to facilitate oral delivery of docetaxel through inhibited P-gp and CYP 450.
MeSH term(s)	Docetaxel ; Curcumin ; Administration, Oral ; Biological Availability ; Cytochrome P-450 Enzyme System/metabolism ; ATP Binding Cassette Transporter, Subfamily B
Chemical Substances	Docetaxel (15H5577CQD) ; Curcumin (IT942ZTH98) ; Cytochrome P-450 Enzyme System (9035-51-2) ; ATP Binding Cassette Transporter, Subfamily B
Language	English
Publishing date	2022-12-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2590155-2
ISSN	2190-3948 ; 2190-393X
ISSN (online)	2190-3948
ISSN	2190-393X
DOI	10.1007/s13346-022-01255-x
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Article ; Online: Clinical characteristics of tuberculous meningitis in older patients compared with younger and middle-aged patients: a retrospective analysis.

Zhu, Xiaolin / He, Na / Tong, Le / Gu, Zhi Han / Li, Hong

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 699

Abstract: Background: Few studies have analyzed the clinical characteristics and adverse factors affecting prognosis in older patients with tuberculous meningitis (TBM). This study aimed to compare the clinical characteristics of TBM in older patients with those ... ...

Abstract	Background: Few studies have analyzed the clinical characteristics and adverse factors affecting prognosis in older patients with tuberculous meningitis (TBM). This study aimed to compare the clinical characteristics of TBM in older patients with those in younger and middle-aged patients. Methods: This single-center retrospective study extracted data on the clinical features, cerebrospinal fluid changes, laboratory results, imaging features, and outcomes of patients with TBM from patient medical records and compared the findings in older patients (aged 60 years and older) with those of younger and middle-aged patients (aged 18-59 years). Results: The study included 197 patients with TBM, comprising 21 older patients aged 60-76 years at onset, and 176 younger and middle-aged patients aged 18-59 years at onset. Fever was common in both older (81%) and younger and middle-aged patients (79%). Compared with younger and middle-aged patients, older patients were more likely to have changes in awareness levels (67% vs. 40%), peripheral nerve dysfunction (57% vs. 29%), changes in cognitive function (48% vs. 20%), and focal seizures (33% vs. 6%), and less likely to have headache (71% vs. 93%), neck stiffness on meningeal stimulation (38% vs. 62%), and vomiting (47% vs. 68%). The Medical Research Council staging on admission of older patients was stage II (52%) and stage III (38%), whereas most younger and middle-aged patients had stage I (33%) and stage II (55%) disease. Neurological function evaluated on the 28th day of hospitalization was more likely to show poor prognosis in older patients than in younger and middle-aged patients (76% vs. 25%). Older patients had significantly higher red blood cell counts and blood glucose levels, and significantly lower serum albumin and sodium levels than those in younger and middle-aged patients. The cerebrospinal fluid protein levels, nucleated cell counts, glucose levels, and chloride levels did not differ significantly by age. Conclusion: In patients with TBM, older patients have more severe clinical manifestations, a higher incidence of hydrocephalus and cerebral infarction, and longer hospital stays than younger and middle-aged patients. Older patients thus require special clinical attention.
MeSH term(s)	Middle Aged ; Humans ; Aged ; Tuberculosis, Meningeal/diagnosis ; Tuberculosis, Meningeal/epidemiology ; Tuberculosis, Meningeal/cerebrospinal fluid ; Retrospective Studies ; Prognosis ; Cerebral Infarction ; Hydrocephalus/etiology
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08700-3
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Article ; Online: Association of blood neutrophil-lymphocyte ratio with short-term prognosis and severity of tuberculosis meningitis patients without HIV infection.

Gu, Zhihan / Liu, Bofu / Yu, Xiaomin / Cheng, Tao / Han, Tianyong / Tong, Le / Cao, Yu

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 449

Abstract: Background: Predicting the short-term prognosis and severity of tuberculosis meningitis (TBM) patients without HIV infection can be challenging, and there have been no prior studies examining the neutrophil lymphocyte ratio (NLR) as a potential ... ...

Abstract	Background: Predicting the short-term prognosis and severity of tuberculosis meningitis (TBM) patients without HIV infection can be challenging, and there have been no prior studies examining the neutrophil lymphocyte ratio (NLR) as a potential predictor of short-term prognosis or its relationship to TBM severity. We hypothesized that NLR might serve as an independent indicator of short-term prognostic significance and that there might be a correlation between NLR and severity. The aim of this study was to investigate the role of NLR as a predictor of short-term prognosis and its relationship to severity of tuberculosis meningitis patients without HIV infection. Methods: We retrospectively collected data from patients diagnosed with TBM in the West China Hospital, Sichuan University, from the period between January 1st, 2018 and August 1st, 2019. Multivariable analysis was executed by the logistic regression model to verify the independence of the 28-day mortality, the discriminative power for predicting short-term prognosis was evaluated using a Receiver Operating Characteristic (ROC) curve, survival outcomes were analyzed using the Kaplan-Meier method and Pearson's correlation analysis was performed to discuss correlation between NLR and the severity of TBM. Results: We collected data from 231 TBM patients without HIV infection. 68 (29.4%) patients are classified as stage (I) 138(59.8%) patients are stage (II) 25(10.8%) patients are stage (III) 16(6.9%) patients died during the follow-up period of 28 days. By multiple logistic regression analyses, the NLR (OR = 1.065, 95% CI = 1.001-1.133, P = 0.045), peripheral neurological deficit (OR 7.335, 95% CI 1.964-27.385, P = 0 0.003) and hydrocephalus (OR 11.338, 95% CI 2.397-53.633, P = 0 0.002) are independent risk factors of 28-day mortality. The area under the ROC curve (AUC) for predicting short prognosis using NLR is 0.683 (95% CI 0.540-0.826, P = 0.015), the optimal cutoff value is 9.99(sensitivity: 56.3%, specificity: 80.9%). The Kaplan-Meier analysis demonstrated that patients with higher NLR(>9.99) had significantly worse survival outcomes(P<0.01).Pearson's correlation analysis presents a significant positive correlation between the severity of TBM and NLR (r = 0.234, P<0.01). Conclusions: NLR, peripheral neurological deficit, and hydrocephalus are independent risk factors of 28-day mortality, NLR can predict the short-term prognosis of TBM patients without HIV infection. NLR is also found to be significantly and positively correlated with the severity of TBM.
MeSH term(s)	Humans ; Neutrophils ; HIV Infections/complications ; Tuberculosis, Meningeal/diagnosis ; Retrospective Studies ; Prognosis ; Lymphocytes ; Hydrocephalus ; ROC Curve
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08438-y
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Article: Effect of nimodipine combined with atorvastatin calcium on microinflammation and oxidative stress levels in patients with cerebral vasospasm after subarachnoid hemorrhage.

Gan, Ning / Jia, Tong-le / Tian, Nan / Liu, Si-Si / Cao, Shan

Pakistan journal of medical sciences

2023 Volume 39, Issue 2, Page(s) 434–438

Abstract: Objective: To evaluate the effect of nimodipine combined with atorvastatin calcium on the micro inflammation and oxidative stress levels in patients with cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) and its clinical implications.: ... ...

Abstract	Objective: To evaluate the effect of nimodipine combined with atorvastatin calcium on the micro inflammation and oxidative stress levels in patients with cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) and its clinical implications. Methods: A total of 80 patients with CVS caused by SAH who had been admitted to Baoding First Central Hospital from August 2021 to August 2022 were selected and randomly divided into two groups. The control group underwent conventional symptomatic treatment, while the experimental group was administered nimodipine combined with atorvastatin calcium on the basis of conventional treatment. The changes in the micro inflammatory cytokines and oxidative stress factors in the two groups were compared, as well as the differences in clinical efficacy and incidence of adverse drug reactions. Result: After treatment, the levels of inflammatory cytokines in the experimental group decreased more significantly than those in the control group (p=0.00). After treatment, the serum levels of oxidative stress factors were obviously higher in the experimental group than in the control group (p=0.00). After treatment, the total efficacy was 77.5% in the experimental group and 55% in the control group, and the difference was statistically significant (p=0.04). Conclusions: Nimodipine combined with atorvastatin calcium could significantly improve the clinical symptoms in patients with CVS after SAH, which would be beneficial, safe, and effective for the patient's recovery.
Language	English
Publishing date	2023-01-14
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.39.2.6721
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Article: Regulation of morphology and electronic configuration of NiCo2O4 by aluminum doping for high performance supercapacitors

Chen, Xing / Song, Lili / Zeng, Mengyuan / Tong, Le / Zhang, Chuanxiang / Xie, Kun / Wang, Yuqiao

Journal of colloid and interface science. 2022 Mar. 15, v. 610

2022

Abstract: Morphology engineering and element doping are two effective strategies to boost the capacitive performance of electroactive materials. The morphology control through doping process is conducive to simplifying the preparation process. Herein, an aluminum- ... ...

Abstract	Morphology engineering and element doping are two effective strategies to boost the capacitive performance of electroactive materials. The morphology control through doping process is conducive to simplifying the preparation process. Herein, an aluminum-doped (Al-doped) strategy was used to prepare Al-doped NiCo₂O₄ nanosheet-wire structure (Al-NiCo₂O₄ NSW) by hydrothermal method and subsequent calcination. The nanosheet-wire structure was composed of one-dimensional (1D) nanowires and two-dimensional (2D) ultrathin nanosheets. 1D nanowires can provide efficient pathways for the electrons/ions transport. 2D nanosheets can enlarge the specific surface area and expose more active sites. The Al doping can change the electronic structure of NiCo₂O₄ with enhanced electrical conductivity as revealed by density functional theory (DFT) calculations. Meanwhile, a strong adsorption capacity of OH– was obtained on Al-NiCo₂O₄ NSW for redox reactions. The Al-NiCo₂O₄ NSW electrode demonstrated a high specific capacity of 1441C g⁻¹ (2446F g⁻¹) at 1 A g⁻¹ and excellent cycling stability (87.6% capacity retention at 10 A g⁻¹ for 5000 charge-discharge cycles). The assembled asymmetric supercapacitor manifested a superior energy density of 46.2 Wh Kg⁻¹ at a power density of 800 W kg⁻¹.
Keywords	adsorption ; aluminum ; density functional theory ; electrical conductivity ; electrochemical capacitors ; electrodes ; energy density ; hot water treatment ; nanosheets ; nanowires ; surface area
Language	English
Dates of publication	2022-0315
Size	p. 70-79.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2021.12.049
Database	NAL-Catalogue (AGRICOLA)

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Article: [The origin, development and academic thoughts of the blood-pricking school].

Liu, Bo / Zhou, Ying / Tong, Le / Yang, Feng / Yang, Dian-Hui

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2022 Volume 42, Issue 4, Page(s) 451–456

Abstract: This study sorted out the records of blood-pricking therapy in ancient and modern medical literature, and clarified the origin and development of blood-pricking school. The main stages of the school development included origin and germination stage, the ... ...

Abstract	This study sorted out the records of blood-pricking therapy in ancient and modern medical literature, and clarified the origin and development of blood-pricking school. The main stages of the school development included origin and germination stage, the theoretical development stage, the experience accumulation stage, the theoretical innovation and characteristic formation stage, the continuous improvement and maturity stage and the unprecedented development stage. The main academic thoughts included the idea of resolutely eliminating the blood-excess, the idea of completely expelling evil, the idea of simultaneous application of acupuncture-moxibustion and medication and the idea of focusing the use of
MeSH term(s)	Acupuncture ; Acupuncture Therapy ; Moxibustion ; Schools
Language	Chinese
Publishing date	2022-04-10
Publishing country	China
Document type	Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20210110-k0002
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Article ; Online: NK cells and solid tumors: therapeutic potential and persisting obstacles.

Tong, Le / Jiménez-Cortegana, Carlos / Tay, Apple H M / Wickström, Stina / Galluzzi, Lorenzo / Lundqvist, Andreas

Molecular cancer

2022 Volume 21, Issue 1, Page(s) 206

Abstract: Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic activity, have recently attracted attention as potential anticancer therapeutics. While NK cells mediate encouraging responses in patients with leukemia, the ... ...

Abstract	Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic activity, have recently attracted attention as potential anticancer therapeutics. While NK cells mediate encouraging responses in patients with leukemia, the therapeutic effects of NK cell infusion in patients with solid tumors are limited. Preclinical and clinical data suggest that the efficacy of NK cell infusion against solid malignancies is hampered by several factors including inadequate tumor infiltration and persistence/activation in the tumor microenvironment (TME). A number of metabolic features of the TME including hypoxia as well as elevated levels of adenosine, reactive oxygen species, and prostaglandins negatively affect NK cell activity. Moreover, cancer-associated fibroblasts, tumor-associated macrophages, myeloid-derived suppressor cells, and regulatory T cells actively suppress NK cell-dependent anticancer immunity. Here, we review the metabolic and cellular barriers that inhibit NK cells in solid neoplasms as we discuss potential strategies to circumvent such obstacles towards superior therapeutic activity.
MeSH term(s)	Humans ; Killer Cells, Natural ; Tumor Microenvironment ; Neoplasms/metabolism ; Myeloid-Derived Suppressor Cells/metabolism
Language	English
Publishing date	2022-11-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2091373-4
ISSN	1476-4598 ; 1476-4598
ISSN (online)	1476-4598
ISSN	1476-4598
DOI	10.1186/s12943-022-01672-z
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Article ; Online: Deciphering the Role of p60AmotL2 in Epithelial Extrusion and Cell Detachment.

Cui, Weiyingqi / Subramani, Aravindh / Fonseca, Pedro / Zhang, Yumeng / Tong, Le / Zhang, Yuanyuan / Egevad, Lars / Lundqvist, Andreas / Holmgren, Lars

Cells

2023 Volume 12, Issue 17

Abstract: Preserving an accurate cell count is crucial for maintaining homeostasis. Apical extrusion, a process in which redundant cells are eliminated by neighboring cells, plays a key role in this regard. Recent studies have revealed that apical extrusion can ... ...

Abstract	Preserving an accurate cell count is crucial for maintaining homeostasis. Apical extrusion, a process in which redundant cells are eliminated by neighboring cells, plays a key role in this regard. Recent studies have revealed that apical extrusion can also be triggered in cells transformed by oncogenes, suggesting it may be a mechanism through which tumor cells escape their microenvironment. In previous work, we demonstrated that p60AmotL2 modulates the E-cadherin function by inhibiting its connection to radial actin filaments. This isoform of AmotL2 is expressed in invasive breast and colon tumors and promotes invasion in vitro and in vivo. Transcriptionally regulated by c-Fos, p60AmotL2 is induced by local stress signals such as severe hypoxia. In this study, we investigated the normal role of p60AmotL2 in epithelial tissues. We found that this isoform is predominantly expressed in the gut, where cells experience rapid turnover. Through time-lapse imaging, we present evidence that cells expressing p60AmotL2 are extruded by their normal neighboring cells. Based on these findings, we hypothesize that tumor cells exploit this pathway to detach from normal epithelia and invade surrounding tissues.
MeSH term(s)	Humans ; Actin Cytoskeleton ; Cell Count ; Colonic Neoplasms ; Epithelium ; Homeostasis ; Tumor Microenvironment
Language	English
Publishing date	2023-08-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12172158
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