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  1. Article ; Online: In outpatients with mild to moderate COVID-19, low-dose fluvoxamine did not reduce time to sustained recovery.

    Clark, Jeremy / Tong, Steven Y C

    Annals of internal medicine

    2023  Volume 176, Issue 5, Page(s) JC52

    Abstract: Source citation: McCarthy MW, Naggie S, Boulware DR, et al. ...

    Abstract Source citation: McCarthy MW, Naggie S, Boulware DR, et al.
    MeSH term(s) Humans ; Fluvoxamine/therapeutic use ; Fluvoxamine/adverse effects ; Outpatients ; COVID-19 ; COVID-19 Drug Treatment ; Double-Blind Method
    Chemical Substances Fluvoxamine (O4L1XPO44W)
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J23-0025
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  2. Article ; Online: Heterogeneity in Risk of Newly Classified "Typical" Streptococci as Causes of Infective Endocarditis.

    Xie, Ouli / Tong, Steven Y C

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 8, Page(s) 1219–1220

    MeSH term(s) Humans ; Endocarditis, Bacterial/epidemiology ; Endocarditis/epidemiology ; Streptococcus
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad392
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  3. Article ; Online: Web Exclusive. Annals for Hospitalists Inpatient Notes - Clinical Pearls-Methicillin-Resistant

    Tong, Steven Y C

    Annals of internal medicine

    2021  Volume 174, Issue 5, Page(s) HO2–HO3

    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M21-1491
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  4. Article ; Online: Are we enrolling the right patients? A scoping review of external validity and generalizability of clinical trials in bloodstream infections.

    Ong, Sean W X / Tong, Steven Y C / Daneman, Nick

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  

    Abstract: Background: Having a representative population in randomized clinical trials (RCTs) improves external validity and generalizability of trial results. There are limited data examining differences between RCT-enrolled and real-world populations in ... ...

    Abstract Background: Having a representative population in randomized clinical trials (RCTs) improves external validity and generalizability of trial results. There are limited data examining differences between RCT-enrolled and real-world populations in bloodstream infections (BSI).
    Objectives: We conducted a scoping review aiming to review studies assessing generalizability of BSI RCT populations, to identify sub-groups that have been systematically under-represented and to explore approaches to improve external validity of future RCTs.
    Sources: MEDLINE, Embase, and Cochrane Library databases were searched for terms related to external validity or generalizability, BSI, and clinical trials in papers published up to 1 August 2023. Studies comparing enrolled versus nonenrolled patients, or papers discussing external validity or generalizability in the context of BSI RCTs were included.
    Content: Sixteen papers were included in the final review. Five compared RCT-enrolled and nonenrolled participants from the same source population. There were significant differences between the two groups in all studies, with nonenrolled patients having a greater comorbidity burden and consistently worse outcomes including mortality. We identified several barriers to improving generalizability of RCT populations and outlined potential approaches to reduce these barriers, such as alternative/simplified consent processes, streamlining eligibility criteria and follow-up procedures, quota-based sampling techniques, and ensuring diversity in site and study team selection.
    Implications: Study cohorts in BSI RCTs are not representative of the general BSI patient population. As we increasingly adopt large pragmatic trials in infectious diseases, it is important to recognize the importance of maximizing generalizability to ensure that our research findings are of direct relevance to our patients.
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.08.019
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  5. Article ; Online: Which trial do we need? Highly bioavailable oral β-lactams versus quinolones or trimethoprim-sulfamethoxazole for gram-negative bacteraemia.

    Tong, Steven Y C / Yahav, Dafna / Daneman, Nick

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 9, Page(s) 1110–1113

    MeSH term(s) Humans ; Trimethoprim, Sulfamethoxazole Drug Combination ; Quinolones/therapeutic use ; beta-Lactams/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy
    Chemical Substances Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) ; Quinolones ; beta-Lactams ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.04.011
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  6. Article ; Online: Tofacitinib reduced death or respiratory failure at 28 d in patients hospitalized with COVID-19 pneumonia.

    Tong, Steven Y C / Petersiel, Neta

    Annals of internal medicine

    2021  Volume 174, Issue 10, Page(s) JC111

    Abstract: Source citation: Guimarães PO, Quirk D, Furtado RH, et al. ...

    Abstract Source citation: Guimarães PO, Quirk D, Furtado RH, et al.
    MeSH term(s) COVID-19 ; Humans ; Piperidines ; Pyrimidines ; Respiratory Insufficiency ; SARS-CoV-2
    Chemical Substances Piperidines ; Pyrimidines ; tofacitinib (87LA6FU830)
    Language English
    Publishing date 2021-10-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202110190-111
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  7. Article ; Online: Shortening the Duration of Therapy for Staphylococcus aureus Bacteremia: Opening the Overton Window.

    Tong, Steven Y C / Walls, Genevieve

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 5, Page(s) 873–875

    MeSH term(s) Bacteremia/drug therapy ; Duration of Therapy ; Humans ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus
    Language English
    Publishing date 2021-03-06
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab205
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  8. Article ; Online: Repurposing antibiotic resistance surveillance data to support treatment of recurrent infections in a remote setting.

    Cuningham, Will / Perera, Shalinie / Coulter, Sonali / Wang, Zhiqiang / Tong, Steven Y C / Wozniak, Teresa M

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2414

    Abstract: In northern Australia, a region with limited access to healthcare and a substantial population living remotely, antibiotic resistance adds to the complexity of treating infections. Focussing on Escherichia coli urinary tract infections (UTIs) and ... ...

    Abstract In northern Australia, a region with limited access to healthcare and a substantial population living remotely, antibiotic resistance adds to the complexity of treating infections. Focussing on Escherichia coli urinary tract infections (UTIs) and Staphylococcus aureus skin & soft tissue infections (SSTIs) captured by a northern Australian antibiotic resistance surveillance system, we used logistic regression to investigate predictors of a subsequent resistant isolate during the same infection episode. We also investigated predictors of recurrent infection. Our analysis included 98,651 E. coli isolates and 121,755 S. aureus isolates from 70,851 patients between January 2007 and June 2020. Following an initially susceptible E. coli UTI, subsequent recovery of a cefazolin (8%) or ampicillin (13%) -resistant isolate during the same infection episode was more common than a ceftriaxone-resistant isolate (2%). For an initially susceptible S. aureus SSTI, subsequent recovery of a methicillin-resistant isolate (8%) was more common than a trimethoprim-sulfamethoxazole-resistant isolate (2%). For UTIs and SSTIs, prior infection with a resistant pathogen was a strong predictor of both recurrent infection and resistance in future infection episodes. This multi-centre study demonstrates an association between antibiotic resistance and an increased likelihood of recurrent infection. Particularly in remote areas, a patient's past antibiograms should guide current treatment choices since recurrent infection will most likely be at least as resistant as previous infection episodes. Using population-level surveillance data in this way can also help clinicians decide if they should switch antibiotics for patients with ongoing symptoms, while waiting for diagnostic results.
    MeSH term(s) Humans ; Staphylococcus aureus ; Escherichia coli ; Reinfection/drug therapy ; Australia ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Staphylococcal Infections/drug therapy ; Methicillin Resistance ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/epidemiology ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50008-4
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  9. Article: Combination of Antistaphylococcal β-Lactam With Standard Therapy Compared to Standard Therapy Alone for the Treatment of Methicillin-Resistant

    Petersiel, Neta / Davis, Joshua S / Meagher, Niamh / Price, David J / Tong, Steven Y C

    Open forum infectious diseases

    2024  Volume 11, Issue 5, Page(s) ofae181

    Abstract: Background: Desirability of outcome ranking (DOOR) is an emerging approach to clinical trial outcome measurement using an ordinal scale to incorporate efficacy and safety endpoints.: Methods: We applied a previously validated DOOR endpoint to a ... ...

    Abstract Background: Desirability of outcome ranking (DOOR) is an emerging approach to clinical trial outcome measurement using an ordinal scale to incorporate efficacy and safety endpoints.
    Methods: We applied a previously validated DOOR endpoint to a cohort of CAMERA2 trial participants with methicillin-resistant
    Results: Participants assigned combination therapy had a 54.5% (95% confidence interval [CI], 48.9%-60.1%;
    Conclusions: When considering both efficacy and safety, treatment of MRSAB with a combination of standard therapy and a β-lactam likely results in a worse clinical outcome than standard therapy. However, a small benefit of combination therapy cannot be excluded. Most likely the toxicity of combination therapy outweighed any benefit from faster clearance of bacteremia.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae181
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  10. Article ; Online: How I manage severe bacterial infections in people who inject drugs.

    Stewardson, Andrew J / Davis, Joshua S / Dunlop, Adrian J / Tong, Steven Y C / Matthews, Gail V

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2024  

    Abstract: Background: Injecting drug use is a risk factor for severe bacterial infection, but there is limited high-quality evidence to guide clinicians providing care to people who inject drugs. Management can be complicated by mistrust, stigma, and competing ... ...

    Abstract Background: Injecting drug use is a risk factor for severe bacterial infection, but there is limited high-quality evidence to guide clinicians providing care to people who inject drugs. Management can be complicated by mistrust, stigma, and competing patient priorities.
    Objectives: To review the management of severe infections in people who inject drugs, using an illustrative clinical scenario of complicated Staphylococcus aureus bloodstream infection.
    Sources: The discussion is based on recent literature searches of relevant topics. Very few randomized clinical trials have focussed specifically on the management of severe bacterial infections among people who inject drugs. Most recommendations are, therefore, based on observational studies, extrapolation from other patient groups, and the experience and opinions of the authors.
    Content: We discuss evidence and options regarding the following management issues for severe bacterial infections among people who inject drugs: initial management of sepsis; indications for surgical management; assessment and management of substance dependence; approaches to antibiotic administration following clinical stability; opportunistic health promotion; and secondary prevention of bacterial infections. Throughout, we highlight the importance of harm reduction and strategies to optimize patient engagement in care through a patient-centred approach.
    Implications: We advocate for a multi-disciplinary trauma-informed approach to the management of severe bacterial infection among people who inject drugs. We emphasize the need for pragmatic trials to inform management guidelines, including those that are co-designed with the community. In particular, research is needed to establish the comparative effectiveness, safety, and cost-effectiveness of inpatient intravenous antibiotics vs. early oral antibiotic switch, outpatient parenteral therapy, and long-acting lipoglycopeptide antibiotics in this scenario.
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2024.01.022
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